Neurology最新文献

{"title":"Teaching Video NeuroImage: Flame Pattern on the Density Spectral Array: Electrographic Seizures in Hepatic Encephalopathy.","authors":"Ryuga Maki, Shuichiro Neshige, Narumi Ohno, Hirofumi Maruyama","doi":"10.1212/WNL.0000000000214736","DOIUrl":"https://doi.org/10.1212/WNL.0000000000214736","url":null,"abstract":"","PeriodicalId":19256,"journal":{"name":"Neurology","volume":"106 4","pages":"e214736"},"PeriodicalIF":8.5,"publicationDate":"2026-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145985231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic Role of Ventricular Size and Its Dynamics in Patients With Leptomeningeal Metastasis From Solid Tumors.","authors":"Emilie Le Rhun, Patrick Devos, Katharina Seystahl, Joost Louis Jongen, Dorothee Gramatzki, Patrick Roth, Martin J van den Bent, Luca Regli, Dieta Brandsma, Michael Weller","doi":"10.1212/WNL.0000000000214653","DOIUrl":"https://doi.org/10.1212/WNL.0000000000214653","url":null,"abstract":"","PeriodicalId":19256,"journal":{"name":"Neurology","volume":"106 4","pages":"e214653"},"PeriodicalIF":8.5,"publicationDate":"2026-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145985278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Value of Isolated vs Multiple Malignant EEG Criteria to Reduce Prognostic Uncertainty in Comatose Patients After Cardiac Arrest.","authors":"Sarah Benghanem, Jan Novy, Alain Cariou, Estelle Pruvost-Robieux, Nawfel Ben-Hamouda, Andrea O Rossetti","doi":"10.1212/WNL.0000000000214690","DOIUrl":"https://doi.org/10.1212/WNL.0000000000214690","url":null,"abstract":"","PeriodicalId":19256,"journal":{"name":"Neurology","volume":"106 4","pages":"e214690"},"PeriodicalIF":8.5,"publicationDate":"2026-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145985291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating Prehospital Stroke Scales for Large Vessel Occlusion: A Systematic Review and Network Meta-Analysis.","authors":"Noah Lee Ahmad Nawabi, Esteban Rivera Rivera, Daniel de Wilde, John L Kilgallon, David I Nawabi, Varun M Bhave, Patrick Emedom-Nnamdi, Ari Kappel, Shivani D Rangwala, Rodolfo E Alcedo Guardia, Juan Vicenty-Padilla, Saef Izzy, Nirav J Patel, Rose Du, Adam A Dmytriw, Toby Gropen, David S Liebeskind, Edoardo Gaude, Alfred Pokmeng See, Mohammed Ali Aziz-Sultan, Joshua D Bernstock","doi":"10.1212/WNL.0000000000214484","DOIUrl":"https://doi.org/10.1212/WNL.0000000000214484","url":null,"abstract":"<p><strong>Background and objectives: </strong>Ischemic stroke remains a leading cause of death and disability worldwide, with large vessel occlusion (LVO) accounting for a disproportionate share of poststroke morbidity. Early identification of LVO is essential for timely intervention with endovascular thrombectomy; however, the clinical scales currently used for triage vary widely in their application and accuracy. This study assesses the diagnostic performance of clinical stroke scales in predicting LVO.</p><p><strong>Methods: </strong>A systematic review was conducted to identify studies evaluating the diagnostic accuracy of prehospital stroke scales for detecting LVO. Pooled sensitivity and specificity were estimated using a bivariate random-effects model, with diagnostic performance further assessed through summary receiver operating characteristic (ROC) curves and area under the curve (AUC) analysis. A Bayesian network meta-analysis was conducted to rank the scales using surface under the cumulative ranking (SUCRA) probabilities, and post hoc analyses were performed to evaluate publication bias.</p><p><strong>Results: </strong>A total of 58 studies comprising 58,381 patients and 33 unique stroke scales were included in the final analysis. The studies, published between 2014 and 2023, were primarily conducted in North America (50%) and Europe (26%), with a median sample size of 473 participants. Pooled sensitivity ranged from 0.30 (HEMIPARESIS) to 0.99 (LARIO) while specificity varied from 0.34 (FANG) to 0.94 (HEMIPLEGIA). Among the highest-performing scales overall were LARIO (AUC = 0.983), FPSS (AUC = 0.896), FACE2AD (AUC = 0.876), and ACT-FAST (AUC = 0.873). In prehospital settings, FPSS (AUC = 0.896), FAST VAN (AUC = 0.878), and FACE2AD (AUC = 0.876) demonstrated strong performance while LARIO (AUC = 0.983) and ACT-FAST (AUC = 0.883) showed the highest accuracy in hospital settings. Bayesian network meta-analysis identified POMONA (SUCRA = 0.877), NIHSS (0.856), sNIHSS EMS (0.854), G-FAST (0.823), and SAFE (0.788) as the top-ranked scales. Funnel plot analysis revealed minimal publication bias among the most frequently evaluated tools, including RACE, CPSS, and NIHSS.</p><p><strong>Discussion: </strong>Numerous clinical scales are available for detecting LVO in the prehospital setting. While several demonstrate strong performance in specific contexts, there remains a clear need for a simple, accurate, and generalizable tool to reliably identify patients with LVO across diverse clinical environments.</p>","PeriodicalId":19256,"journal":{"name":"Neurology","volume":"106 4","pages":"e214484"},"PeriodicalIF":8.5,"publicationDate":"2026-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146106615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"White Matter Free Water and PSMD as Neuroimaging Biomarkers of Cerebral Amyloid Angiopathy Severity.","authors":"Suzete N Farias Da Guarda, Maria Clara Zanon Zotin, Pauline Maillard, Hilde van den Brink, Ana Ponciano, Lara C Oliveira, Dorothée Schoemaker, Anthipa Chokesuwattanaskul, Steven M Greenberg, Anand Viswanathan","doi":"10.1212/WNL.0000000000214650","DOIUrl":"https://doi.org/10.1212/WNL.0000000000214650","url":null,"abstract":"","PeriodicalId":19256,"journal":{"name":"Neurology","volume":"106 4","pages":"e214650"},"PeriodicalIF":8.5,"publicationDate":"2026-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145985244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Physical Exercise With Structural Brain Changes and Cognitive Decline in Patients With Early Parkinson Disease.","authors":"Patricia Diaz-Galvan, Pablo Franco-Rosado, Jesus Silva-Rodriguez, Sandra Castro-Labrador, Miguel Angel Labrador-Espinosa, Laura Muñoz-Delgado, Michel J Grothe, Pablo Mir","doi":"10.1212/WNL.0000000000214455","DOIUrl":"https://doi.org/10.1212/WNL.0000000000214455","url":null,"abstract":"","PeriodicalId":19256,"journal":{"name":"Neurology","volume":"106 4","pages":"e214455"},"PeriodicalIF":8.5,"publicationDate":"2026-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145985306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Getting Patients With a Large Vessel Occlusion From the Field to Treatment: The Next Frontier.","authors":"Jonathan R Crowe","doi":"10.1212/WNL.0000000000214638","DOIUrl":"https://doi.org/10.1212/WNL.0000000000214638","url":null,"abstract":"","PeriodicalId":19256,"journal":{"name":"Neurology","volume":"106 4","pages":"e214638"},"PeriodicalIF":8.5,"publicationDate":"2026-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146106545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Teaching Video NeuroImage: Jaw Closing Dystonia After Years of Excessive Gum Chewing.","authors":"Ruvarashe Sharara, Heather Rigby","doi":"10.1212/WNL.0000000000214468","DOIUrl":"https://doi.org/10.1212/WNL.0000000000214468","url":null,"abstract":"","PeriodicalId":19256,"journal":{"name":"Neurology","volume":"106 3","pages":"e214468"},"PeriodicalIF":8.5,"publicationDate":"2026-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145878647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spinal Cord Herniation.","authors":"Albert Antar, Melanie Alfonzo Horowitz, Nicholas Theodore, Francis Deng","doi":"10.1212/WNL.0000000000214609","DOIUrl":"https://doi.org/10.1212/WNL.0000000000214609","url":null,"abstract":"","PeriodicalId":19256,"journal":{"name":"Neurology","volume":"106 3","pages":"e214609"},"PeriodicalIF":8.5,"publicationDate":"2026-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145934461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Author Response: Tenecteplase vs Alteplase in Acute Ischemic Stroke Within 4.5 Hours: A Systematic Review and Meta-Analysis of Randomized Trials.","authors":"Lina Palaiodimou, Georgios Tsivgoulis","doi":"10.1212/WNL.0000000000213324","DOIUrl":"https://doi.org/10.1212/WNL.0000000000213324","url":null,"abstract":"","PeriodicalId":19256,"journal":{"name":"Neurology","volume":"106 3","pages":"e213324"},"PeriodicalIF":8.5,"publicationDate":"2026-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145934551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}