Pub Date : 2022-06-05DOI: 10.18524/2304-0947.2022.1(81).255834
A. Yegorova, Y. Scrypynets, I. Leonenko, D. Aleksandrova, S. M. Kashutskуy, I. V. Umetskaya
Establishing the biopharmaceutical equivalence of generic drugs is a necessary component of the relevant drug dossier. Determination of in vitro equivalence is a test designed to assess the equivalence of the dissolution profiles of the study and reference drugs in three dissolution media with pH values of 1.2; 4.5 and 6.8. A value of f2 in the range from 50 to 100 guarantees the similarity or equivalence of the two profiles and the equivalence of the pharmacological action of the test drug and the reference drug. A method for the quantitative determination of the fabomotizole dihydrochloride by spectrophotometric method has been developed, which is suitable for studying the dissolution profiles of BAFAZOL IC tablets, 10 mg tablets. Measure the absorbance of the test solution and the reference solution in a 1 cm cell relative to the compensation solution at wavelength: 302 nm for 0.1 M hydrochloric acid solution and 296 nm for acetate buffer pH 4.5 and phosphate buffer pH 6 8. The method was validated on the parameters of specificity, accuracy, correctness, linearity in the studied range of concentrations. Excipients do not interfere on the determination of the fabomotizole dihydrochloride. The absorption spectra of the test solution and the reference solution coincide in nature and position of the maximum. This also confirms the specificity of the method. Linearity was investigated on model mixtures in different dissolution media inthe range of 10. – 130%. The coefficients of linear dependences in the studied concentration ranges correspond to the allowable values. The stability of the tested solutions and reference solutions in the case of their storage at room temperature for 8 hours was confirmed. The release of more than 85% of fabomotizole dihydrochloride in 15 min in all dissolution media indicates the similarity of the dissolution profiles and does not require the calculation of the similarity factor f2.
{"title":"DEVELOPMENT AND VALIDATION OF SPECTROPHOTOMETRIC METHOD FOR DETERMINATION OF FABOMOTIZOLE DIHYDROCHLORIDE FOR STUDY OF DISSOLUTION PROFILES","authors":"A. Yegorova, Y. Scrypynets, I. Leonenko, D. Aleksandrova, S. M. Kashutskуy, I. V. Umetskaya","doi":"10.18524/2304-0947.2022.1(81).255834","DOIUrl":"https://doi.org/10.18524/2304-0947.2022.1(81).255834","url":null,"abstract":"Establishing the biopharmaceutical equivalence of generic drugs is a necessary component of the relevant drug dossier. Determination of in vitro equivalence is a test designed to assess the equivalence of the dissolution profiles of the study and reference drugs in three dissolution media with pH values of 1.2; 4.5 and 6.8. A value of f2 in the range from 50 to 100 guarantees the similarity or equivalence of the two profiles and the equivalence of the pharmacological action of the test drug and the reference drug. A method for the quantitative determination of the fabomotizole dihydrochloride by spectrophotometric method has been developed, which is suitable for studying the dissolution profiles of BAFAZOL IC tablets, 10 mg tablets. Measure the absorbance of the test solution and the reference solution in a 1 cm cell relative to the compensation solution at wavelength: 302 nm for 0.1 M hydrochloric acid solution and 296 nm for acetate buffer pH 4.5 and phosphate buffer pH 6 8. The method was validated on the parameters of specificity, accuracy, correctness, linearity in the studied range of concentrations. Excipients do not interfere on the determination of the fabomotizole dihydrochloride. The absorption spectra of the test solution and the reference solution coincide in nature and position of the maximum. This also confirms the specificity of the method. Linearity was investigated on model mixtures in different dissolution media inthe range of 10. – 130%. The coefficients of linear dependences in the studied concentration ranges correspond to the allowable values. The stability of the tested solutions and reference solutions in the case of their storage at room temperature for 8 hours was confirmed. The release of more than 85% of fabomotizole dihydrochloride in 15 min in all dissolution media indicates the similarity of the dissolution profiles and does not require the calculation of the similarity factor f2.","PeriodicalId":19451,"journal":{"name":"Odesa National University Herald. Chemistry","volume":"44 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80895234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-05DOI: 10.18524/2304-0947.2022.1(81).255832
D. Snigur, D. Barbalat, O. Zhukovetska, O. Guzenko, T. M. Scherbakova, O. M. Chebotarev
In the current study, the peculiarities of the complexation of Bi(III) with 6,7-dihyroxy‑4-carboxyl‑2-phenylbenzopyrylium perchlorate (CDC) in binary systems and in the presence of cationic surfactants (Surf) were studied. Using classical spectrophotometric methods of molar ratios and equilibrium shift, it was found that in two systems two complexes with stoichiometry Bi(III): CDC are formed: 1:2 and 1:3 at pH 2.0 and pH 4.5, respectively. Molar light absorption coefficients were calculated for Bi(III) complexes with CDC, which are 1.4⸱104 and 1.0⸱104, respectively. It is shown that in the presence of cetylpyridinium chloride or cetyltrimetrylammonium bromide complexes with a molar ratio of Bi(III): CDC: Surf =1:3:3 are formed. In the presence of cationic surfactants there is no shift in the optimal pH of complexation, but there is an increase in the number of coordinated reagent molecules due to the loosening of the hydrate shell of the ion Bi(III) due to hydrophobic hydration of the complex. In addition, the introduction of cationic surfactants leads to a batochromic shift of the absorption band by 10–15 nm and an increase in the molar absorption coefficient to 3.1⸱104 and 4.1⸱104 when using cetylpyridinium chloride or cetyltrimetrylammonium bromide, respectively. Methods of spectrophotometric determination of Bi(III) with the use of analytical forms based on complexes of 1:2 and ternary complex 1:3:3 were developed, which were tested in the analysis of pharmaceuticals, alloys and model solutions. It is noted that the proposed methods are characterized by satisfactory reproducibility and are not inferior in sensitivity to known analogues.
{"title":"SPECTROPHOTOMETRIC DETERMINATION OF BISMUTH (III) WITH 6,7-DIHYDROXY‑4-CARBOXYL‑2-PHENYLBENZOPYRILIUM PERCHLORATE","authors":"D. Snigur, D. Barbalat, O. Zhukovetska, O. Guzenko, T. M. Scherbakova, O. M. Chebotarev","doi":"10.18524/2304-0947.2022.1(81).255832","DOIUrl":"https://doi.org/10.18524/2304-0947.2022.1(81).255832","url":null,"abstract":"In the current study, the peculiarities of the complexation of Bi(III) with 6,7-dihyroxy‑4-carboxyl‑2-phenylbenzopyrylium perchlorate (CDC) in binary systems and in the presence of cationic surfactants (Surf) were studied. Using classical spectrophotometric methods of molar ratios and equilibrium shift, it was found that in two systems two complexes with stoichiometry Bi(III): CDC are formed: 1:2 and 1:3 at pH 2.0 and pH 4.5, respectively. Molar light absorption coefficients were calculated for Bi(III) complexes with CDC, which are 1.4⸱104 and 1.0⸱104, respectively. It is shown that in the presence of cetylpyridinium chloride or cetyltrimetrylammonium bromide complexes with a molar ratio of Bi(III): CDC: Surf =1:3:3 are formed. In the presence of cationic surfactants there is no shift in the optimal pH of complexation, but there is an increase in the number of coordinated reagent molecules due to the loosening of the hydrate shell of the ion Bi(III) due to hydrophobic hydration of the complex. In addition, the introduction of cationic surfactants leads to a batochromic shift of the absorption band by 10–15 nm and an increase in the molar absorption coefficient to 3.1⸱104 and 4.1⸱104 when using cetylpyridinium chloride or cetyltrimetrylammonium bromide, respectively. Methods of spectrophotometric determination of Bi(III) with the use of analytical forms based on complexes of 1:2 and ternary complex 1:3:3 were developed, which were tested in the analysis of pharmaceuticals, alloys and model solutions. It is noted that the proposed methods are characterized by satisfactory reproducibility and are not inferior in sensitivity to known analogues.","PeriodicalId":19451,"journal":{"name":"Odesa National University Herald. Chemistry","volume":"88 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81060425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-05DOI: 10.18524/2304-0947.2022.1(81).255828
І. Мечникова, вул. Дворянська
The novel developed synthesis methods allowed to obtain three Ge(IV)-Co(II) coordination compounds with 1- hydroxyethylidenediphosphonic acid and 2,2`-bipyridine [{Co(bipy)3}2{Co(bipy)(H2O)4}2][{Ge(μ-OH)(μ-hedp)}6Cl2]∙2H2O (1), [Co(bipy)3]4[{Ge(μ-OH)(μ-hedp)}6Cl2]∙30H2O (2), [Co(bipy)3]3[{Ge(μ-OH)(μ-hedp)}6]⋅20Н2О⋅2CH3COOH (3). Complexes are characterized by the methods of elemental analysis, IR-, Diffuse Reflectance spectroscopy, thermogravimetric analysis. All absorption bands presented in the IR-spectra of compounds 1-3 are highlighted in the Table 2. Absorption bands of the P-O bond are detected at ~1053 and ~970 сm-1, that indicates the presence of the fully deprotonated PO32- groups in the composition of complexes. Furthermore, n(OH), ν(Ge–Ophosph), d(Ge–OH) bands characteristic for all the previously synthesized compounds with [Ge6(m-OH)6(m-hedp)6]6-anion is detected in the IR spectra of 1-3. Presence of the crystal water molecules is confirmed by the ν(OH) at 3400 сm-1. A set of the bands usual for the aromatic molecules (n(C–Harom), n(C–Carom), das(CH3), ds(CH3), n(С–N)) is assigned with 2,2`-bipyridine in the structure of all compounds. A special feature of the IR-spectra of 1 is presence of COOH absorption band at 1700 сm-1, that indicates the location of solvated acetic acid. Complex 1 also contains coordination water molecules, confirmed by the d(H2O) at 1642 сm-1 in its IR-spectrum. Absorption bands of Co–N and Со-О bonds evidence that 2,2`-bipyridine and H2O molecules are coordinated to the cobalt atom. Thermal decomposition of 1-3 differs a lot. Variable interval and temperature of the first endoeffect is explained by the different nature of water in them – crystal (1-3) and coordinated (1). In the diffuse reflection spectra of compounds 1-3, two bands corresponding to the following transitions are observed: 4T1g(F)→ 4T2g (1 – 7250, 2 – 7100, 3 – 7300 сm-1), 4T1g(F)→ 4T1g(P) (1 – 13800, 2 – 14200, 3 – 14000 сm-1). Such results confirm an octahedral configuration of cobalt atom. There was also established, how composition and structure of the synthesized compounds depend from the molar ratio of the reagents and anion of the initial Co(II) salt (chloride, acetate).
{"title":"DOUBLE Ge(IV)-Co(ІІ) COMPLEXES WITH 1-HYDROXYETHYLIDENEDIPHOSPHONIC ACID AND 2,2-BIPYRIDINE","authors":"І. Мечникова, вул. Дворянська","doi":"10.18524/2304-0947.2022.1(81).255828","DOIUrl":"https://doi.org/10.18524/2304-0947.2022.1(81).255828","url":null,"abstract":"The novel developed synthesis methods allowed to obtain three Ge(IV)-Co(II) coordination compounds with 1- hydroxyethylidenediphosphonic acid and 2,2`-bipyridine [{Co(bipy)3}2{Co(bipy)(H2O)4}2][{Ge(μ-OH)(μ-hedp)}6Cl2]∙2H2O (1), [Co(bipy)3]4[{Ge(μ-OH)(μ-hedp)}6Cl2]∙30H2O (2), [Co(bipy)3]3[{Ge(μ-OH)(μ-hedp)}6]⋅20Н2О⋅2CH3COOH (3). Complexes are characterized by the methods of elemental analysis, IR-, Diffuse Reflectance spectroscopy, thermogravimetric analysis. All absorption bands presented in the IR-spectra of compounds 1-3 are highlighted in the Table 2. Absorption bands of the P-O bond are detected at ~1053 and ~970 сm-1, that indicates the presence of the fully deprotonated PO32- groups in the composition of complexes. Furthermore, n(OH), ν(Ge–Ophosph), d(Ge–OH) bands characteristic for all the previously synthesized compounds with [Ge6(m-OH)6(m-hedp)6]6-anion is detected in the IR spectra of 1-3. Presence of the crystal water molecules is confirmed by the ν(OH) at 3400 сm-1. A set of the bands usual for the aromatic molecules (n(C–Harom), n(C–Carom), das(CH3), ds(CH3), n(С–N)) is assigned with 2,2`-bipyridine in the structure of all compounds. A special feature of the IR-spectra of 1 is presence of COOH absorption band at 1700 сm-1, that indicates the location of solvated acetic acid. Complex 1 also contains coordination water molecules, confirmed by the d(H2O) at 1642 сm-1 in its IR-spectrum. Absorption bands of Co–N and Со-О bonds evidence that 2,2`-bipyridine and H2O molecules are coordinated to the cobalt atom. Thermal decomposition of 1-3 differs a lot. Variable interval and temperature of the first endoeffect is explained by the different nature of water in them – crystal (1-3) and coordinated (1). In the diffuse reflection spectra of compounds 1-3, two bands corresponding to the following transitions are observed: 4T1g(F)→ 4T2g (1 – 7250, 2 – 7100, 3 – 7300 сm-1), 4T1g(F)→ 4T1g(P) (1 – 13800, 2 – 14200, 3 – 14000 сm-1). Such results confirm an octahedral configuration of cobalt atom. There was also established, how composition and structure of the synthesized compounds depend from the molar ratio of the reagents and anion of the initial Co(II) salt (chloride, acetate).","PeriodicalId":19451,"journal":{"name":"Odesa National University Herald. Chemistry","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73011781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-29DOI: 10.18524/2304-0947.2022.1(81).248297
A. Ennan, R. Khoma, R. Dlubovskii, Y. Zakharenko, T.S. Benkovska, I. M. Knysh
This paper summarizes the data on the development of import-substituting impregnated This paper summarizes the data on the development of import-substituting impregnated fibrous chemisorbents (IFCS) intended for equipping gas cleaning equipment and personal respiratory protection equipment against gaseous toxicants of various chemical nature. To obtain IFCS of the basic gases (ammonia, organic amines), aqueous solutions of polybasic acids (citric, tartaric and hydroxyethylenediphosphonic) are used as impregnating reagents. IFCS absorb toxicants due to neutralization reactions. The absorption of ammonia and amines of IFCS obtained by impregnation of fibrous carriers (FC) with aqueous solutions of 3d-metals (Ni2+, Co2+ and Cu2+) salts occurs due to complex formation reactions. To obtain IFCS of acidic gases, aqueous solutions of sodium carbonate and urotropine (HMTA) containing structuring additives were used. Impregnating aqueous solutions based on monoethanolamine (MEA) and polyethylenepolyamine (PEPA) have also been developed using their non-volatile derivatives with a higher molar mass. A significant improvement of the IFCS protective characteristics was achieved by introducing of various modifying additives – promoters into the composition of these solutions. Single-layer IFCS -ampholytes (IFCS-A) for respiratory purposes have been developed, which depending on the circumstances are able to absorb both acidic and basic gases (vapours), for example SO2 and NH3. Impregnation solutions include complex compounds of 3d-metals (Ni2+, Co2+ and Cu2+) with MEA, ethylenediamine, HMTA and PEPA at various molar ratios of components or buffer mixtures based on polybasic acids and organic bases (MEA and PEPA) of medium strength salts. Chemisorbents for acidic and/or basic gases (IFCS-I, IFCS-AI) have been developed, the moment of “response” of the dynamic absorption capacity of which can be visually determined by the change in color of the gas mask elements during the “breakthrough” of the sorbate, obtained by impregnating of FC with solutions containing acid-base indicators.
{"title":"MONO- AND BIFUNCTIONAL IMPREGNATED FIBER CHEMOSORBENTS FOR RESPIRATORY PURPOSE","authors":"A. Ennan, R. Khoma, R. Dlubovskii, Y. Zakharenko, T.S. Benkovska, I. M. Knysh","doi":"10.18524/2304-0947.2022.1(81).248297","DOIUrl":"https://doi.org/10.18524/2304-0947.2022.1(81).248297","url":null,"abstract":"This paper summarizes the data on the development of import-substituting impregnated This paper summarizes the data on the development of import-substituting impregnated fibrous chemisorbents (IFCS) intended for equipping gas cleaning equipment and personal respiratory protection equipment against gaseous toxicants of various chemical nature. To obtain IFCS of the basic gases (ammonia, organic amines), aqueous solutions of polybasic acids (citric, tartaric and hydroxyethylenediphosphonic) are used as impregnating reagents. IFCS absorb toxicants due to neutralization reactions. The absorption of ammonia and amines of IFCS obtained by impregnation of fibrous carriers (FC) with aqueous solutions of 3d-metals (Ni2+, Co2+ and Cu2+) salts occurs due to complex formation reactions. To obtain IFCS of acidic gases, aqueous solutions of sodium carbonate and urotropine (HMTA) containing structuring additives were used. Impregnating aqueous solutions based on monoethanolamine (MEA) and polyethylenepolyamine (PEPA) have also been developed using their non-volatile derivatives with a higher molar mass. A significant improvement of the IFCS protective characteristics was achieved by introducing of various modifying additives – promoters into the composition of these solutions. Single-layer IFCS -ampholytes (IFCS-A) for respiratory purposes have been developed, which depending on the circumstances are able to absorb both acidic and basic gases (vapours), for example SO2 and NH3. Impregnation solutions include complex compounds of 3d-metals (Ni2+, Co2+ and Cu2+) with MEA, ethylenediamine, HMTA and PEPA at various molar ratios of components or buffer mixtures based on polybasic acids and organic bases (MEA and PEPA) of medium strength salts. Chemisorbents for acidic and/or basic gases (IFCS-I, IFCS-AI) have been developed, the moment of “response” of the dynamic absorption capacity of which can be visually determined by the change in color of the gas mask elements during the “breakthrough” of the sorbate, obtained by impregnating of FC with solutions containing acid-base indicators.","PeriodicalId":19451,"journal":{"name":"Odesa National University Herald. Chemistry","volume":"2020 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74296998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-29DOI: 10.18524/2304-0947.2021.4(80).248296
D. Snigur
The specificity of the dispersive liquid-liquid semi-microextraction of Copper (II) complex with 6,7-dihydroxy-4-methyl-2-phenylbenzopyryl chloride has been studied. It is noted that the transition to semi-microextraction technology can significantly reduce the toxic organic solvents consumption, and the use of dispersion solvent can intensify the complex extraction of Сopper (II) complex with 6,7-dihydroxy-4-methyl-2-phenylbenzopyryl chloride. Optimal conditions for spectrophotometric determination of Сopper (II) after dispersive liquid-liquid semi-microextraction of its complex with 6,7-dihydroxy-4-methyl-2-phenylbenzopyrylium chloride were found to be: 1.5 mL of chloroform, 1.5 mL of methanol, pH 4.5, λmax = 535 nm, l = 1 cm. The main analytical characteristics of the developed dispersive liquid-liquid semi-microextraction-spectrophotometric method are calculated: the calibration graph is linear in the wide range of concentrations of 17-480 μg/L, and the limit of detection and limit of determination are 5 and 17 μg/L, respectively. The molar ratios Copper (II) : interferer, in which there is no effect on the quantitative determination of Copper(II) by the proposed dispersive liquid-liquid semi-microextraction-spectrophotometric method have been established. The proposed method for Copper (II) spectrophotometric quantification after preconcentration via dispersive liquid-liquid semi-microextraction as a complex with 6,7-dihydroxy-4-methyl-2-phenylbenzopyrilium chloride was tested in the analysis of model solutions and water samples. The accuracy of the developed dispersive liquid-liquid semi-microextraction-spectrophotometric method was checked by the "spiked-found" method and the relative standard deviation does not exceed 3.9%. The proposed technique is simple, sensitive and environmentally friendly.
{"title":"SPECTROPHOTOMETRIC DETERMINATION OF COPPER (II) AFTER DISPERSIVE LIQUID-LIQUID EXTRACTION OF ITS COMPLEX WITH 6,7-DIHYDROXY-4-METHYL-2-PHENYLBENZOPYRYLIUM CHLORIDE","authors":"D. Snigur","doi":"10.18524/2304-0947.2021.4(80).248296","DOIUrl":"https://doi.org/10.18524/2304-0947.2021.4(80).248296","url":null,"abstract":"The specificity of the dispersive liquid-liquid semi-microextraction of Copper (II) complex with 6,7-dihydroxy-4-methyl-2-phenylbenzopyryl chloride has been studied. It is noted that the transition to semi-microextraction technology can significantly reduce the toxic organic solvents consumption, and the use of dispersion solvent can intensify the complex extraction of Сopper (II) complex with 6,7-dihydroxy-4-methyl-2-phenylbenzopyryl chloride. Optimal conditions for spectrophotometric determination of Сopper (II) after dispersive liquid-liquid semi-microextraction of its complex with 6,7-dihydroxy-4-methyl-2-phenylbenzopyrylium chloride were found to be: 1.5 mL of chloroform, 1.5 mL of methanol, pH 4.5, λmax = 535 nm, l = 1 cm. The main analytical characteristics of the developed dispersive liquid-liquid semi-microextraction-spectrophotometric method are calculated: the calibration graph is linear in the wide range of concentrations of 17-480 μg/L, and the limit of detection and limit of determination are 5 and 17 μg/L, respectively. The molar ratios Copper (II) : interferer, in which there is no effect on the quantitative determination of Copper(II) by the proposed dispersive liquid-liquid semi-microextraction-spectrophotometric method have been established. The proposed method for Copper (II) spectrophotometric quantification after preconcentration via dispersive liquid-liquid semi-microextraction as a complex with 6,7-dihydroxy-4-methyl-2-phenylbenzopyrilium chloride was tested in the analysis of model solutions and water samples. The accuracy of the developed dispersive liquid-liquid semi-microextraction-spectrophotometric method was checked by the \"spiked-found\" method and the relative standard deviation does not exceed 3.9%. The proposed technique is simple, sensitive and environmentally friendly.","PeriodicalId":19451,"journal":{"name":"Odesa National University Herald. Chemistry","volume":"23 7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83620518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-29DOI: 10.18524/2304-0947.2021.4(80).248293
O. V. Shevchenko, K. Burenkova
The radical polymerization of styrene and methyl methacrylate (MMA) initiated by benzoyl peroxide (BР) with the addition of 10, 20, 50, and 80% of acetylacetone (AA) mixed with a monomer was studied. It was found that the rate of the polymerization process increases in the presence of a certain amount of AA in the system (³ 50% of the monomer). This is due to the fact that AA accelerates the decomposition of BP, while removing it from the system in the form of non-radical products, and the initiating function is performed by acetylacetonate radicals, which are formed upon interaction with BP. The incorporation of acac fragments into the polymer chain has been proved by IR and 1H NMR spectroscopy. It was found that these groups in the composition of the polymer interact with the p-system of benzene rings of polystyrene. The second reason for the accelerating action is the formation of complexes between the monomer and AA, in which the additive has an acceptor effect, leading to the facilitation of the breaking of double bonds in the monomer. It was shown that MMA has a stronger effect on AA polymerization, because forms stronger complexes with the enol form of AA, which requires a longer time for the radical to leave the complex. In this regard, during its polymerization, induction periods are observed, the duration of which is directly proportional to the concentration of AA in a mixture with MMA. It was revealed that another feature of the effect of AA on radical polymerization is its participation in chain transfer reactions, which does not decrease the rate of the process, but only leads to a decrease in the molecular weight of the products. This makes it an effective regulator of polymer molecular weights. The paper proposes a scheme for the polymerization of vinyl monomers, initiated by BP with the addition of AA.
{"title":"EFFECT OF ACETYL ACETONE ON RADICAL POLYMERIZATION OF VINYL MONOMERS INITIATED BY BENZOYL PEROXIDE","authors":"O. V. Shevchenko, K. Burenkova","doi":"10.18524/2304-0947.2021.4(80).248293","DOIUrl":"https://doi.org/10.18524/2304-0947.2021.4(80).248293","url":null,"abstract":"The radical polymerization of styrene and methyl methacrylate (MMA) initiated by benzoyl peroxide (BР) with the addition of 10, 20, 50, and 80% of acetylacetone (AA) mixed with a monomer was studied. It was found that the rate of the polymerization process increases in the presence of a certain amount of AA in the system (³ 50% of the monomer). This is due to the fact that AA accelerates the decomposition of BP, while removing it from the system in the form of non-radical products, and the initiating function is performed by acetylacetonate radicals, which are formed upon interaction with BP. The incorporation of acac fragments into the polymer chain has been proved by IR and 1H NMR spectroscopy. It was found that these groups in the composition of the polymer interact with the p-system of benzene rings of polystyrene. The second reason for the accelerating action is the formation of complexes between the monomer and AA, in which the additive has an acceptor effect, leading to the facilitation of the breaking of double bonds in the monomer. It was shown that MMA has a stronger effect on AA polymerization, because forms stronger complexes with the enol form of AA, which requires a longer time for the radical to leave the complex. In this regard, during its polymerization, induction periods are observed, the duration of which is directly proportional to the concentration of AA in a mixture with MMA. It was revealed that another feature of the effect of AA on radical polymerization is its participation in chain transfer reactions, which does not decrease the rate of the process, but only leads to a decrease in the molecular weight of the products. This makes it an effective regulator of polymer molecular weights. The paper proposes a scheme for the polymerization of vinyl monomers, initiated by BP with the addition of AA.","PeriodicalId":19451,"journal":{"name":"Odesa National University Herald. Chemistry","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72685619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-29DOI: 10.18524/2304-0947.2021.4(80).248288
E. Martsinko, E. Chebanenko, I. Seifullina
Authors have developed optimal conditions and synthetic methods in water-organic solutions for ten heterometallic – mixed-ligand complexes of germanium(IV) and 3d-metals with gallic acid (Н2Gal) and 1,10-phenanthroline (phen), their composition and structure [M(phen)3][Ge(H2O)(HGal)2]∙nH2O (M = Mn (1), Co (2), Ni (3), Zn(5)); [CuCl(phen)2]2[Ge(H2O)(HGal)2]∙2H2O (4). Comparative analysis of their IR-spectra and spectra gallic acid and 1,10-phenanthroline with involvement diffuse reflection spectra allowed to establish coordination sphere of germanium and 3-metals. IR-spectra of complexes 1-5 are similar, therefore coordination of ligands in them is the same. Comparatively to the IR-spectrum of gallic acid, there are absent valence absorption bands of free carboxylic groups while two bands of asymmetric and symmetric oscillation of C-O groups in carboxylate ions CОО- appear in the spectra of complexes. Deformation bands d(Сarom-О-Н) are shifted to the low-frequency region for 50-40 cm-1, which indicates deprotonation and binding to the complexing agent of OH-groups from gallic acid. Appearance of deformation bands d(H2О) at 1625 сm-1 is characteristic for the coordination water in composition of complexes. Presence of coordination and crystalline water as well as unbonded OH-group are confirmed with the band n(Ge-О) at 620 сm-1. Thermal decomposition of mixed-metal complexes starts with an endothermic effect in the temperature range 80-160°С where elimination of certain number of water molecules takes place: two – for 1 and 4, three – for 2 and 5, four – for 3. On the thermogravigrams of all compounds one more endoeffect in the temperature range 160-220°С is presented, where removal of one coordination water molecule happens. It was established, that coordination polyhedron of germanium was formed by five oxygen atoms of deprotonated hydroxyl groups from two molecules of gallic acid and one water molecule in all compounds. Second ligand – 1,10-phenanthroline is coordinated to 3d-metal through heterocyclic nitrogen atoms with formation of cations with different composition [M(phen)3]2+ (M = Mn, Co, Ni, Zn) та [CuCl(phen)2]+.
作者开发了十种锗(IV)和3d金属与没食子酸(Н2Gal)和1,10-菲罗啉(phen)的杂金属混合配体配合物在水-有机溶液中的最佳合成条件和方法，它们的组成和结构[M(phen)3][Ge(H2O)(HGal)2]∙nH2O (M = Mn (1)， Co (2)， Ni (3)， Zn(5));[CuCl(phen)2]2[Ge(H2O)(HGal)2]∙2H2O(4).对它们的红外光谱与没食子酸和1,10-菲罗啉的光谱进行了对比分析，建立了锗与3金属的配位球。配合物1-5的红外光谱相似，说明其配位相同。与没食子酸的红外光谱相比，配合物的光谱中没有游离羧基的价吸收带，而羧酸离子中C-O基的不对称和对称振荡带CОО-出现。变形带d(Сarom-О-Н)在50-40 cm-1范围内移至低频区，表明没食子酸的oh -基团脱质子并与络合剂结合。变形带d(H2О)在1625 -1处的出现是配合物中配位水的特征。在620 μ m-1的n(Ge-О)波段证实了配位和结晶水以及未键oh基团的存在。混合金属配合物的热分解始于80-160°С温度范围内的吸热效应，在此温度范围内，一定数量的水分子被消除:2 -用于1和4,3 -用于2和5,4 -用于3。在所有化合物的热重图上，在160-220°С温度范围内出现了一个内效应，其中一个配位水分子发生了去除。确定了锗的配位多面体是由两个没食子酸分子和一个水分子的去质子化羟基的5个氧原子构成的。第二配体- 1,10-菲罗啉通过杂环氮原子与三维金属配位，形成不同组成的阳离子[M(phen)3]2+ (M = Mn, Co, Ni, Zn) та [CuCl(phen)2]+。
{"title":"SYNTHESIS AND STRUCTURE OF HETEROMETALLIC – MIXED-LIGAND Ge(IV) – 3d-METAL COMPLEXES WITH GALLIC ACID AND 1,10-PHENANTHROLINE","authors":"E. Martsinko, E. Chebanenko, I. Seifullina","doi":"10.18524/2304-0947.2021.4(80).248288","DOIUrl":"https://doi.org/10.18524/2304-0947.2021.4(80).248288","url":null,"abstract":"Authors have developed optimal conditions and synthetic methods in water-organic solutions for ten heterometallic – mixed-ligand complexes of germanium(IV) and 3d-metals with gallic acid (Н2Gal) and 1,10-phenanthroline (phen), their composition and structure [M(phen)3][Ge(H2O)(HGal)2]∙nH2O (M = Mn (1), Co (2), Ni (3), Zn(5)); [CuCl(phen)2]2[Ge(H2O)(HGal)2]∙2H2O (4). Comparative analysis of their IR-spectra and spectra gallic acid and 1,10-phenanthroline with involvement diffuse reflection spectra allowed to establish coordination sphere of germanium and 3-metals. IR-spectra of complexes 1-5 are similar, therefore coordination of ligands in them is the same. Comparatively to the IR-spectrum of gallic acid, there are absent valence absorption bands of free carboxylic groups while two bands of asymmetric and symmetric oscillation of C-O groups in carboxylate ions CОО- appear in the spectra of complexes. Deformation bands d(Сarom-О-Н) are shifted to the low-frequency region for 50-40 cm-1, which indicates deprotonation and binding to the complexing agent of OH-groups from gallic acid. Appearance of deformation bands d(H2О) at 1625 сm-1 is characteristic for the coordination water in composition of complexes. Presence of coordination and crystalline water as well as unbonded OH-group are confirmed with the band n(Ge-О) at 620 сm-1. Thermal decomposition of mixed-metal complexes starts with an endothermic effect in the temperature range 80-160°С where elimination of certain number of water molecules takes place: two – for 1 and 4, three – for 2 and 5, four – for 3. On the thermogravigrams of all compounds one more endoeffect in the temperature range 160-220°С is presented, where removal of one coordination water molecule happens. It was established, that coordination polyhedron of germanium was formed by five oxygen atoms of deprotonated hydroxyl groups from two molecules of gallic acid and one water molecule in all compounds. Second ligand – 1,10-phenanthroline is coordinated to 3d-metal through heterocyclic nitrogen atoms with formation of cations with different composition [M(phen)3]2+ (M = Mn, Co, Ni, Zn) та [CuCl(phen)2]+.\u0000 ","PeriodicalId":19451,"journal":{"name":"Odesa National University Herald. Chemistry","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75070728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-29DOI: 10.18524/2304-0947.2021.4(80).248292
R. Khoma, A. Ennan, T. S. Ben’kovs’ka, E. Y. Bugova, L. T. Osadchiy, E. M. Menchuk
The influence of hydrochloric, chloric, sulfuric and sulfurous acids (HCl, HClO4, H2SO4 and SO2×H2O, respectively) on protolytic equilibria in the system monoethanolamine (MEA) – tropeolin OOO (TrOOO) – water (CMEA = 0.1 M; pH = 1.0 ÷ 9.5) was studied by pH-metric, spectrophotometric and colorimetric methods. The acid-base behavior of the HOCH2CH2NH2 – TrOOO – H2O system was investigated at CTrOOO = 1,12 ×10-4 М, CMEA = 1,0×10-4 ÷ 1,0 М (pH = 8,25 ÷ 12,05), T = 293 K. TrOOO in this system exists in two tautomeric forms due to acid-base dissociation of the 4-OH group and associates formed by H-bonding with MEA molecules. There is a direct ratio between the pH values of solutions and the total color difference (ΔE76), in contrast to the specific color difference (SCD). The difference in the behavior of the H2SO4 – HOCH2CH2NH2 – TrOOO – H2O system from the systems with HCl and HClO4 is due to the fact that the interaction of the first acid with MEA (8,0 £ pH) forms an ionic associate [HOCH2СH2NH3]2(SO4), which is more stable than ionic pairs [[HOCH2СH2NH3](HSO4), [HOCH2СH2NH3](ClO4), [HOCH2СH2NH3]Cl и [HOCH2СH2NH3](O3S-C10H6-N=N-C6H4-SO3)[H3NCH2СH2OH]. Acid-base dissociation constants in systems significantly depend on the structure and physicochemical parameters of the mineral acid. In the electronic absorption spectra of the SO2 – MEA – TrOOO – H2O system (pH £ 7,5), there is a pronounced isobestic point at 415 nm, due to the dynamic equilibrium between ion-molecular forms. The coincidence of the maxima on the curves ΔE76 = f(pH) and SCD = f(pH) for the indicated system, in contrast to others studied in this work, was stated. The difference between the spectrophotometric and colorimetric behavior of the SO2 – MEA – TrOOO – H2O system from behavior of the systems with HCl, HClO4, and H2SO4 systems is due to the sulfur(IV)oxyanions with an azo indicator redox interaction.
{"title":"HOCH2CH2NH2 – TROPEOLIN OOO – H2O SYSTEM ACID-BASIC PROPERTIES IN THE PRESENCE OF HCl, HClO4, H2SO4 AND SO2H2O","authors":"R. Khoma, A. Ennan, T. S. Ben’kovs’ka, E. Y. Bugova, L. T. Osadchiy, E. M. Menchuk","doi":"10.18524/2304-0947.2021.4(80).248292","DOIUrl":"https://doi.org/10.18524/2304-0947.2021.4(80).248292","url":null,"abstract":"The influence of hydrochloric, chloric, sulfuric and sulfurous acids (HCl, HClO4, H2SO4 and SO2×H2O, respectively) on protolytic equilibria in the system monoethanolamine (MEA) – tropeolin OOO (TrOOO) – water (CMEA = 0.1 M; pH = 1.0 ÷ 9.5) was studied by pH-metric, spectrophotometric and colorimetric methods.\u0000The acid-base behavior of the HOCH2CH2NH2 – TrOOO – H2O system was investigated at CTrOOO = 1,12 ×10-4 М, CMEA = 1,0×10-4 ÷ 1,0 М (pH = 8,25 ÷ 12,05), T = 293 K. TrOOO in this system exists in two tautomeric forms due to acid-base dissociation of the 4-OH group and associates formed by H-bonding with MEA molecules. There is a direct ratio between the pH values of solutions and the total color difference (ΔE76), in contrast to the specific color difference (SCD). The difference in the behavior of the H2SO4 – HOCH2CH2NH2 – TrOOO – H2O system from the systems with HCl and HClO4 is due to the fact that the interaction of the first acid with MEA (8,0 £ pH) forms an ionic associate [HOCH2СH2NH3]2(SO4), which is more stable than ionic pairs [[HOCH2СH2NH3](HSO4), [HOCH2СH2NH3](ClO4), [HOCH2СH2NH3]Cl и [HOCH2СH2NH3](O3S-C10H6-N=N-C6H4-SO3)[H3NCH2СH2OH]. Acid-base dissociation constants in systems significantly depend on the structure and physicochemical parameters of the mineral acid. In the electronic absorption spectra of the SO2 – MEA – TrOOO – H2O system (pH £ 7,5), there is a pronounced isobestic point at 415 nm, due to the dynamic equilibrium between ion-molecular forms. The coincidence of the maxima on the curves ΔE76 = f(pH) and SCD = f(pH) for the indicated system, in contrast to others studied in this work, was stated. The difference between the spectrophotometric and colorimetric behavior of the SO2 – MEA – TrOOO – H2O system from behavior of the systems with HCl, HClO4, and H2SO4 systems is due to the sulfur(IV)oxyanions with an azo indicator redox interaction.","PeriodicalId":19451,"journal":{"name":"Odesa National University Herald. Chemistry","volume":"116 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73024977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-29DOI: 10.18524/2304-0947.2021.4(80).248290
N. Fedko, V. F. Anikin, V. V. Veduta, V. V. Stankevich, A. V. Balatska
4-Monosubstituted and 4,5-disubstituted halogeno- and nitro- N-(4-carboxyphenylnaphthalimides) were synthesized by imidation of the corresponding 4-monosubstituted and 4,5-disubstituted naphthalic anhydrides with para-aminobenzoic acid using acetic acid as solvent with 75-85% yields. 4-Amino-N- (4-carboxyphenyl)naphthalimide and 4,5-diamino-N-(4-carboxyphenyl)naphthalimide were obtained by reduction of corresponding nitrosubstituted N-(4-carboxyphenyl)naphthalimides using sodium dithionite as reducing agent in mixed ethanol-water solvent. The completion of reaction was monitored by thin layer chromatography with disappearance of the spot of the corresponding starting naphthalic anhydride. Starting 4-monosubstituted and 4,5-disubstituted naphthalic anhydrides were obtained by oxidation of corresponding substituted acenaphthenes with sodium dichromate in acetic acid. The synthesized N-carboxyphenylnaphthalimides with chlorine and bromine in positions 4 or 4 and 5 are yellow crystal substances with blue fluorescence; 4-nitro- and 4,5-dinitro-N-carboxyphenylnaphthalimides are orange crystal substances without fluorescence; 4-amino-, 4-dimethylamino and 4,5-diamino-N-carboxyphenylnaphthalimides are orange crystal substances with orange fluorescence. The structure of all the synthesized products was confirmed by IR and NMR 1H spectroscopy. The results of computer screening of the synthesized compounds using the PASS Online Internet service confirm a wide range of biological activity of N-carboxyphenylnaphthalimides, which makes them promising substances for further biological testing.
以对氨基苯甲酸为溶剂，以4-单取代和4- 5-二取代萘酸酐为原料，合成了4-单取代和4,5-二取代卤化萘和硝基N-(4-羧基苯基萘酰亚胺)，产率为75 ~ 85%。以二亚硫酸钠为还原剂，在乙醇-水混合溶剂中还原相应的硝基取代N-(4-羧基苯基)萘酰亚胺，得到4-氨基-N-(4-羧基苯基)萘酰亚胺和4,5-二氨基-N-(4-羧基苯基)萘酰亚胺。用薄层色谱法监测反应的完成情况，相应的萘酸酐起始点消失。用重铬酸钠在乙酸中氧化取代萘，得到4-单取代萘和4,5-二取代萘酸酐。合成的4位氯和5位溴的n -羧基苯基萘酰亚胺为黄色晶体物质，荧光为蓝色;4-硝基和4,5-二硝基-n -羧基苯基萘酰亚胺为无荧光的橙色晶体物质;4-氨基，4-二甲胺和4,5-二胺- n -羧基苯基萘酰亚胺是具有橙色荧光的橙色晶体物质。所有合成产物的结构均经红外光谱和核磁共振1H谱证实。利用PASS在线互联网服务对合成化合物进行计算机筛选的结果证实了n -羧基苯基萘酰亚胺具有广泛的生物活性，这使它们成为进一步生物学测试的有希望的物质。
{"title":"SYNTHESIS AND PROPERTIES OF IMIDATION PRODUCTS OF MONOSUBSTITUTED AND DISUBSTITUTED NAPHTHALIC ANHYDRIDES WITH P-AMINOBENZOIC ACID","authors":"N. Fedko, V. F. Anikin, V. V. Veduta, V. V. Stankevich, A. V. Balatska","doi":"10.18524/2304-0947.2021.4(80).248290","DOIUrl":"https://doi.org/10.18524/2304-0947.2021.4(80).248290","url":null,"abstract":"4-Monosubstituted and 4,5-disubstituted halogeno- and nitro- N-(4-carboxyphenylnaphthalimides) were synthesized by imidation of the corresponding 4-monosubstituted and 4,5-disubstituted naphthalic anhydrides with para-aminobenzoic acid using acetic acid as solvent with 75-85% yields. 4-Amino-N- (4-carboxyphenyl)naphthalimide and 4,5-diamino-N-(4-carboxyphenyl)naphthalimide were obtained by reduction of corresponding nitrosubstituted N-(4-carboxyphenyl)naphthalimides using sodium dithionite as reducing agent in mixed ethanol-water solvent. The completion of reaction was monitored by thin layer chromatography with disappearance of the spot of the corresponding starting naphthalic anhydride. Starting 4-monosubstituted and 4,5-disubstituted naphthalic anhydrides were obtained by oxidation of corresponding substituted acenaphthenes with sodium dichromate in acetic acid. The synthesized N-carboxyphenylnaphthalimides with chlorine and bromine in positions 4 or 4 and 5 are yellow crystal substances with blue fluorescence; 4-nitro- and 4,5-dinitro-N-carboxyphenylnaphthalimides are orange crystal substances without fluorescence; 4-amino-, 4-dimethylamino and 4,5-diamino-N-carboxyphenylnaphthalimides are orange crystal substances with orange fluorescence. The structure of all the synthesized products was confirmed by IR and NMR 1H spectroscopy. The results of computer screening of the synthesized compounds using the PASS Online Internet service confirm a wide range of biological activity of N-carboxyphenylnaphthalimides, which makes them promising substances for further biological testing.","PeriodicalId":19451,"journal":{"name":"Odesa National University Herald. Chemistry","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89688010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-26DOI: 10.18524/2304-0947.2021.4(80).250930
E. Streltsova, O. Voliuvach, E. Bondar’
The surface tension of aqueous solutions of cationic (dodecylammonium and dodecylpyridinium chlorides) and anionic (sodium dodecylsulfate) surfactants was measured in the presence of polyacrylamide in the solution. A synergistic effect of reducing the surface tension of mixed solutions of cationic surfactants, in the region of sufficiently high concentrations of mixed solutions of sodium dodecyl sulfate, with polyacrylamide in the range of molar ratios of the mixture components - n (Surfactants : PAA) = 1: 1; 1: 0.25 was established. The values of the maximum adsorption, the values of the area per molecule or associate of surfactants in the adsorption layer, as well as the standard Gibbs free energy of adsorption of surfactant - PAA associates are calculated. In accordance with Rosen's model, the composition of mixed adsorption layers at the solution-air interface is calculated, as well as the parameter of intermolecular interaction in adsorption layers between molecules, cationic and anionic ions surfactants and PAA. The values of the critical micelle concentration (CMC) of individual surfactants in aqueous solutions exceed the CMC of the studied surfactants in the presence of PAA, which promotes micelle formation.
{"title":"SURFACE TENSION AND ASSOCIATION IN AQUEOUS SOLUTION SURFACTANTS IN THE PRESENCE OF POLYACRYLAMIDE","authors":"E. Streltsova, O. Voliuvach, E. Bondar’","doi":"10.18524/2304-0947.2021.4(80).250930","DOIUrl":"https://doi.org/10.18524/2304-0947.2021.4(80).250930","url":null,"abstract":"The surface tension of aqueous solutions of cationic (dodecylammonium and dodecylpyridinium chlorides) and anionic (sodium dodecylsulfate) surfactants was measured in the presence of polyacrylamide in the solution. A synergistic effect of reducing the surface tension of mixed solutions of cationic surfactants, in the region of sufficiently high concentrations of mixed solutions of sodium dodecyl sulfate, with polyacrylamide in the range of molar ratios of the mixture components - n (Surfactants : PAA) = 1: 1; 1: 0.25 was established. The values of the maximum adsorption, the values of the area per molecule or associate of surfactants in the adsorption layer, as well as the standard Gibbs free energy of adsorption of surfactant - PAA associates are calculated. In accordance with Rosen's model, the composition of mixed adsorption layers at the solution-air interface is calculated, as well as the parameter of intermolecular interaction in adsorption layers between molecules, cationic and anionic ions surfactants and PAA. The values of the critical micelle concentration (CMC) of individual surfactants in aqueous solutions exceed the CMC of the studied surfactants in the presence of PAA, which promotes micelle formation.","PeriodicalId":19451,"journal":{"name":"Odesa National University Herald. Chemistry","volume":"88 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80299001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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