Pub Date : 2022-01-01DOI: 10.15227/orgsyn.099.0159
Dominick C. Witkowski
{"title":"Synthesis of Phenanthridinones via the Palladium-Catalyzed Annulation of Benzyne","authors":"Dominick C. Witkowski","doi":"10.15227/orgsyn.099.0159","DOIUrl":"https://doi.org/10.15227/orgsyn.099.0159","url":null,"abstract":"","PeriodicalId":19576,"journal":{"name":"Organic Syntheses","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67341788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.15227/orgsyn.099.0305
Ana S Bulger
A. N-Methyl-N-phenyl benzamide (3). A single-necked (24/40 joint) 500 mL round-bottomed flask is equipped with a Teflon-coated magnetic stir bar (3 cm, oval-shaped). The flask is dried in an oven (105 °C) for 16 h. The flask is brought out of the oven, sealed immediately with a rubber septum, and allowed to cool to room temperature (23 °C) in a desiccator (Note 2). The flask is purged with argon by connecting to an argon manifold using a needle (18G), and via another needle (18G) to a gas outlet terminating in an oil bubbler. The atmosphere is maintained under a slight positive pressure of argon for the duration of the reaction (Note 3). The flask is then charged with triethylamine (6.5 mL, 47 mmol, 1.3 equiv) (Note 4) using a plastic syringe Et3N CH2Cl2, 0 °C to 23 °C 1
A. n-甲基-n -苯基苯酰胺(3)。单颈(24/40关节)500 mL圆底烧瓶配有特氟龙涂层的磁性搅拌棒(3厘米，椭圆形)。烧瓶在烤箱(105°C)中干燥16小时。烧瓶从烤箱中取出，立即用橡胶隔片密封，并允许在干燥器中冷却到室温(23°C)(注2)。烧瓶用氩气清洗，使用针(18G)连接到氩气歧管，并通过另一根针(18G)连接到气出口，终止于油起泡器。在反应过程中，气氛保持在氩气的轻微正压下(注3)。然后使用塑料注射器Et3N CH2Cl2, 0°C至23°C，向烧瓶注入三乙胺(6.5 mL, 47 mmol, 1.3当量)(注4)
{"title":"Synthesis of Carboxylic Acids from Benzamide Precursors Using Nickel Catalysis","authors":"Ana S Bulger","doi":"10.15227/orgsyn.099.0305","DOIUrl":"https://doi.org/10.15227/orgsyn.099.0305","url":null,"abstract":"A. N-Methyl-N-phenyl benzamide (3). A single-necked (24/40 joint) 500 mL round-bottomed flask is equipped with a Teflon-coated magnetic stir bar (3 cm, oval-shaped). The flask is dried in an oven (105 °C) for 16 h. The flask is brought out of the oven, sealed immediately with a rubber septum, and allowed to cool to room temperature (23 °C) in a desiccator (Note 2). The flask is purged with argon by connecting to an argon manifold using a needle (18G), and via another needle (18G) to a gas outlet terminating in an oil bubbler. The atmosphere is maintained under a slight positive pressure of argon for the duration of the reaction (Note 3). The flask is then charged with triethylamine (6.5 mL, 47 mmol, 1.3 equiv) (Note 4) using a plastic syringe Et3N CH2Cl2, 0 °C to 23 °C 1","PeriodicalId":19576,"journal":{"name":"Organic Syntheses","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67341869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.15227/orgsyn.099.0039
R. Shishido
{"title":"Transition-Metal-Free Synthesis of an Aryl Boronate Ester through Base-Mediated Boryl Substitution of an Aryl Halide with a Silylborane","authors":"R. Shishido","doi":"10.15227/orgsyn.099.0039","DOIUrl":"https://doi.org/10.15227/orgsyn.099.0039","url":null,"abstract":"","PeriodicalId":19576,"journal":{"name":"Organic Syntheses","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67340937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.15227/orgsyn.099.0015
Qianyi Liu
¶College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China; ‡WuXi AppTec (Tianjin) Co., Ltd., Tianjin 300457, China; ∥Tianjin Key Laboratory of Structure and Performance for Functional Molecules, College of Chemistry, Tianjin Normal University, Tianjin 300387, China; †Department of Chemistry and Biochemistry, University of California Santa Barbara, California 93106, USA; §School of Materials Science and Engineering, Peking University, Beijing 100871, China aThese authors contributed equally.
{"title":"Synthesis of Alkylboronic Esters from Alkyl Iodides","authors":"Qianyi Liu","doi":"10.15227/orgsyn.099.0015","DOIUrl":"https://doi.org/10.15227/orgsyn.099.0015","url":null,"abstract":"¶College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China; ‡WuXi AppTec (Tianjin) Co., Ltd., Tianjin 300457, China; ∥Tianjin Key Laboratory of Structure and Performance for Functional Molecules, College of Chemistry, Tianjin Normal University, Tianjin 300387, China; †Department of Chemistry and Biochemistry, University of California Santa Barbara, California 93106, USA; §School of Materials Science and Engineering, Peking University, Beijing 100871, China aThese authors contributed equally.","PeriodicalId":19576,"journal":{"name":"Organic Syntheses","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67341095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.15227/orgsyn.099.0363
N. R. Dhatrak
{"title":"Preparation of 1,2:5,6-Di-O-cyclohexylidene-D-mannitol and 2,3-Cyclohexylidene-D-glyceraldehyde","authors":"N. R. Dhatrak","doi":"10.15227/orgsyn.099.0363","DOIUrl":"https://doi.org/10.15227/orgsyn.099.0363","url":null,"abstract":"","PeriodicalId":19576,"journal":{"name":"Organic Syntheses","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67341909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.15227/orgsyn.099.0326
Akash Mishra
{"title":"Stereoselective Synthesis of Dimethyl 4(S)-Allyl-N-Boc-L-glutamate and Related Congeners","authors":"Akash Mishra","doi":"10.15227/orgsyn.099.0326","DOIUrl":"https://doi.org/10.15227/orgsyn.099.0326","url":null,"abstract":"","PeriodicalId":19576,"journal":{"name":"Organic Syntheses","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67341927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.15227/orgsyn.099.0342
Christopher B. Kelly
† Chemical Process R&D, Discovery Process Research, Janssen Research & Development LLC, 1400 McKean Rd., Spring House, PA 19477, USA ‡ Department of Biological and Chemical Sciences, College of Life Sciences, Thomas Jefferson University, 4201 Henry Ave., Philadelphia, PA 19144, USA § Chemical Process R&D, Discovery Process Research, Janssen Pharmaceutica N.V., Turnhoutseweg 30, B-2340 Beerse, Belgium
†化学过程研发，发现过程研究，杨森研究与发展有限责任公司，1400 McKean Rd.， Spring House, PA 19477，美国;生物与化学科学系，生命科学学院，Thomas Jefferson大学，4201 Henry Ave.，费城，PA 19144，美国;化学过程研发，发现过程研究，杨森制药公司，Turnhoutseweg 30, B-2340 Beerse，比利时
{"title":"Discussion Addendum for: Preparation of Diisopropylammonium Bis(catecholato)cyclohexylsilicate","authors":"Christopher B. Kelly","doi":"10.15227/orgsyn.099.0342","DOIUrl":"https://doi.org/10.15227/orgsyn.099.0342","url":null,"abstract":"† Chemical Process R&D, Discovery Process Research, Janssen Research & Development LLC, 1400 McKean Rd., Spring House, PA 19477, USA ‡ Department of Biological and Chemical Sciences, College of Life Sciences, Thomas Jefferson University, 4201 Henry Ave., Philadelphia, PA 19144, USA § Chemical Process R&D, Discovery Process Research, Janssen Pharmaceutica N.V., Turnhoutseweg 30, B-2340 Beerse, Belgium","PeriodicalId":19576,"journal":{"name":"Organic Syntheses","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67342337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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