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Arthroscopic Management of Primary Synovial Chondromatosis of the Ankle: A Case Report and Review of the Literature. 踝关节原发性滑膜软骨瘤病的关节镜治疗:1例报告及文献复习。
IF 2.3 Q2 ORTHOPEDICS Pub Date : 2026-01-23 eCollection Date: 2026-01-01 DOI: 10.2147/ORR.S544850
Antoine Saber, Hafez Saade, Firas Hassan, Hady Ezzeddine, Wendy Ghanem, Ramzi Moucharafieh, Riad R Fakih

Synovial chondromatosis (SC) is a rare, benign condition characterized by the formation of cartilaginous nodules within the synovial membrane of joints. We present a case of primary SC of the ankle in a 49-year-old female who experienced persistent ankle pain and restricted range of motion. She was successfully treated with arthroscopic removal of loose bodies and synovial debridement. A review of the literature since 2010 was conducted to compare outcomes between open and arthroscopic management of ankle SC. The findings suggest that while both approaches are effective and have similar long term outcomes, arthroscopy may offer slight advantage in terms of reduced morbidity, faster rehabilitation, and improved patient satisfaction.

滑膜软骨瘤病(SC)是一种罕见的良性疾病,其特征是在关节滑膜内形成软骨结节。我们提出一个病例原发性SC的踝关节在一个49岁的女性谁经历了持续的踝关节疼痛和限制的活动范围。她成功地接受了关节镜下游离体去除和滑膜清创治疗。对2010年以来的文献进行了回顾,比较了开放和关节镜治疗踝关节SC的结果。研究结果表明,虽然两种方法都是有效的,并且具有相似的长期结果,但关节镜在降低发病率、更快的康复和提高患者满意度方面可能有轻微的优势。
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引用次数: 0
Open Tibial Fractures Part 2: A Narrative Review of Definitive Treatment and Potential Applicability to the Southern African Context. 开放性胫骨骨折第2部分:决定性治疗的叙述性回顾和对南部非洲背景的潜在适用性。
IF 2.3 Q2 ORTHOPEDICS Pub Date : 2026-01-08 eCollection Date: 2026-01-01 DOI: 10.2147/ORR.S553515
Erik Hohmann, Maketo Molepo, Maritz Laubscher, Kevin Tetsworth

The purpose of this study was to conduct a review of contemporary definitive treatment options, potential complications and clinical outcomes for open tibial shaft fractures and while assessing their relevance and applicability within South African context. Treatment options available in high-income countries may not be accessible in low-resource settings, requiring adaptations to the treatment approach based on local conditions. Only one African country has attempted to establish principal guidelines for the treatment of open tibial fractures through a consensus-based approach. These guidelines cover primary assessment, antibiotics, initial stabilization, referral criteria, debridement and irrigation, documentation, wound closure, soft-tissue management, amputation, and definitive internal fixation. Unfortunately, definitive fracture management recommendations for African low-resource countries are not yet available. There is a lack of data regarding the treatment of open tibial fractures in low-resource countries, particularly in regional and rural areas. Existing guidelines address antibiotic prophylaxis and treatment, debridement and lavage, initial surgical fixation, wound closure (both primary and definitive), soft-tissue management (including flap coverage), and bone fragment retention, all adapted to local resource availability. However, guidelines for definitive treatment remain unavailable. Treatment options recommended by high-income countries are largely unsuitable, and Southern African nations should focus on developing guidelines tailored to their available resources.

本研究的目的是对开放性胫干骨折的当代明确治疗方案、潜在并发症和临床结果进行回顾,同时评估其在南非的相关性和适用性。高收入国家提供的治疗方案可能无法在资源匮乏的环境中获得,需要根据当地情况调整治疗方法。只有一个非洲国家试图通过协商一致的方法建立开放性胫骨骨折治疗的主要指导方针。这些指南包括初步评估、抗生素、初步稳定、转诊标准、清创和冲洗、文献记录、伤口闭合、软组织处理、截肢和最终内固定。不幸的是,目前还没有针对非洲资源匮乏国家的明确的骨折管理建议。在资源匮乏的国家,特别是在地区和农村地区,缺乏关于开放性胫骨骨折治疗的数据。现有的指南涉及抗生素预防和治疗、清创和灌洗、初始手术固定、伤口愈合(原发性和终性)、软组织处理(包括皮瓣覆盖)和骨碎片保留,所有这些都根据当地资源的可用性进行了调整。然而,目前尚无明确的治疗指南。高收入国家推荐的治疗方案在很大程度上是不合适的,南部非洲国家应该把重点放在制定适合其现有资源的指南上。
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引用次数: 0
Extensile Posterolateral Novel Approach Through the Anconeus Muscle for an Atypical Coronal Shear Fracture of the Capitellum with Associated Lateral Epicondyle and Olecranon Fractures: A Case Report. 经肘肌后外侧可伸入路治疗小头冠状面剪切骨折伴外侧上髁及鹰嘴骨折1例。
IF 2.3 Q2 ORTHOPEDICS Pub Date : 2026-01-08 eCollection Date: 2026-01-01 DOI: 10.2147/ORR.S549745
Abdulaziz Ahmed Abdulaziz, Osama Mohammed Qasim, Abdullah Hesham Alsawaf, Abdulraheem A Almokhtar, Khalid Jubran Idris, Atif Ahmed Labban, Khalid Ibrahim Najjar

A 70-year-old female with a history of hypertension presented with a complex elbow injury following a fall. Imaging revealed fractures of the capitellum, lateral epicondyle, and olecranon. The fractures were managed using an extensile posterolateral approach through the anconeus muscle, achieving anatomical reduction and satisfactory functional outcomes 110° of flexion and full pronation/supination and Mayo Elbow Performance Score (MEPS) indicated an excellent outcome. This approach preserved the extensor origin and facilitated access for fixation, suggesting its potential as an alternative for managing such rare injuries.

一位70岁女性,有高血压病史,在跌倒后出现复杂的肘部损伤。影像学显示肱骨小头、外侧上髁和鹰嘴骨折。骨折采用后外侧可伸入路,经踝关节肌处理,获得解剖复位和满意的功能结果。110°屈曲和完全旋前/旋后,梅奥肘关节功能评分(MEPS)显示预后良好。该入路保留了伸肌起始点,方便了固定,表明其作为治疗此类罕见损伤的替代方法的潜力。
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引用次数: 0
First Clinical Experience with Robotic-Assisted Total Knee Arthroplasty in Indonesia: Early Results and Comparison with Global Evidence. 印度尼西亚机器人辅助全膝关节置换术的首次临床经验:早期结果和与全球证据的比较。
IF 2.3 Q2 ORTHOPEDICS Pub Date : 2025-12-22 eCollection Date: 2025-01-01 DOI: 10.2147/ORR.S561904
Andre Yanuar

Objective: This study evaluated early clinical and radiographic outcomes of robotic-assisted total knee arthroplasty (RA-TKA) in Indonesia using the ROSA® Knee System, hypothesizing that outcomes would be comparable to high-income countries.

Methods: A retrospective observational study was conducted including patients undergoing primary RA-TKA between July 2024 and July 2025. Perioperative variables, radiographic alignment, postoperative mobilization, and patient satisfaction were assessed. Outcomes were compared qualitatively with published benchmarks. All procedures were performed by a single surgeon.

Results: A total of 40 patients (44 knees) were included. Median operative time was 110 minutes. Standing long-leg radiographs demonstrated mechanical alignment within ±3° of neutral in all knees. Median time to ambulation was 6 hours (unilateral) and 19.5 hours (bilateral). No intraoperative complications occurred. Overall satisfaction was 95%. Outcomes were consistent with reports from high-income countries.

Conclusion: RA-TKA can be safely and effectively implemented within a developing healthcare system, achieving alignment accuracy, mobilization times, and satisfaction rates comparable to global benchmarks.

目的:本研究评估印度尼西亚使用ROSA®膝关节系统的机器人辅助全膝关节置换术(RA-TKA)的早期临床和影像学结果,假设结果与高收入国家相当。方法:对2024年7月至2025年7月间接受RA-TKA的患者进行回顾性观察研究。评估围手术期变量、x线对准、术后活动和患者满意度。结果与已发表的基准进行定性比较。所有手术均由一名外科医生完成。结果:共纳入患者40例(44膝)。中位手术时间为110分钟。站立长腿x线片显示所有膝关节的机械对齐在中性±3°。平均下床时间为6小时(单侧)和19.5小时(双侧)。无术中并发症发生。总体满意度为95%。结果与高收入国家的报告一致。结论:RA-TKA可以在发展中的医疗保健系统中安全有效地实施,实现对齐精度、动员时间和满意度可与全球基准相媲美。
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引用次数: 0
Peroneal Artery "Terminal" Perforator Pedicled Flap for Surrounding Soft Tissue Defects: A Retrospective Cohort Study. 腓动脉“末端”穿支蒂皮瓣修复周围软组织缺损:回顾性队列研究。
IF 2.3 Q2 ORTHOPEDICS Pub Date : 2025-12-22 eCollection Date: 2025-01-01 DOI: 10.2147/ORR.S565208
Yiming Lu, Peng Jin, Bin Wang, Jiaxiang Gu, Hongjun Liu

Purpose: To introduce a technique to reconstruct soft tissue defects around the space of lateral malleolus by using the peroneal artery "terminal" perforator flap (the lowest perforating branch of the peroneal in the posterior compartment artery of lateral malleolus), and to report its effectiveness.

Methods: From January 2018 to April 2020, 7 patients with soft tissue defects around the space of lateral malleolus were treated with the peroneal artery "terminal" perforator flap. Ultrasound was used to determine the perforating site of the peroneal artery. The lowest perforating branch adjacent to the wound margin was used as the rotation point to design the peroneal artery perforator flap.

Results: One case had venous crisis. However, no urgent operative revision was performed. All of the 7 flaps survived completely. The grafted skins at donor site survived, and primary healing of incision was obtained. The follow-up period was 6 to 17 months with an average of 10.7 months. The flaps exhibited favorable color, texture, and overall appearance. The ability to wear shoes remained unaffected, and ankle mobility was not restricted. Surgeries for thinning the flaps were not necessary. All of the patients were satisfied with the cosmetic and functional result.

Conclusion: The peroneal artery terminal perforator flap is a useful and reliable choice for coverage of soft tissue defects around the space of lateral malleolus in clinical application.

目的:介绍腓动脉“末端”穿支皮瓣(外踝后腔室动脉腓底穿支)修复外踝间隙周围软组织缺损的方法,并报道其效果。方法:2018年1月~ 2020年4月,采用腓动脉“末端”穿支皮瓣修复外踝周围软组织缺损7例。超声确定腓动脉穿孔部位。以靠近创面边缘的最低穿支为旋转点设计腓动脉穿支皮瓣。结果:1例出现静脉危象。然而,没有进行紧急手术翻修。7个皮瓣全部存活。供区移植皮肤成活,切口初步愈合。随访6 ~ 17个月,平均10.7个月。皮瓣表现出良好的颜色、质地和整体外观。穿鞋的能力没有受到影响,脚踝的活动也没有受到限制。手术使皮瓣变薄是不必要的。所有患者均对美容和功能效果满意。结论:腓动脉末端穿支皮瓣是修复外踝周围软组织缺损的一种有效、可靠的方法。
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引用次数: 0
Trifocal Ilizarov Bone Transport for a 21-cm Tibial Defect in a Chronic Smoker with Longstanding Osteomyelitis: A Complex Limb Salvage Case. 三焦Ilizarov骨运输21厘米胫骨缺损的慢性吸烟者长期骨髓炎:一个复杂的肢体抢救病例。
IF 2.3 Q2 ORTHOPEDICS Pub Date : 2025-12-08 eCollection Date: 2025-01-01 DOI: 10.2147/ORR.S547786
Umar Hayat, Abdulaziz A Abdulaziz, Faisal A Alghamdi, Khalid Ahmad Alnofeay, Hassan Ghazi Ashry, Atif Ahmed Labban

This case study presents the successful management of a 21-cm tibial defect in a 38-year-old man smoker with longstanding osteomyelitis using trifocal Ilizarov bone transport. Despite the complexities posed by chronic infection and extensive bone loss, a meticulously planned staged reconstructive protocol involving aggressive debridement, targeted antimicrobial therapy, and advanced bone transport techniques culminated in remarkable limb salvage and functional recovery. Integration of low-intensity pulsed ultrasound (LIPUS) further optimized bone healing in this intricate scenario. This case report addresses these gaps by detailing a successful trifocal Ilizarov strategy augmented with LIPUS in a chronic smoker with an exceptionally large tibial defect.

本病例研究介绍了使用三局灶Ilizarov骨运输成功治疗一名患有长期骨髓炎的38岁男性吸烟者21厘米胫骨缺损。尽管慢性感染和大面积骨质流失带来了复杂性,但精心策划的分阶段重建方案包括积极清创、靶向抗菌治疗和先进的骨运输技术,最终实现了显著的肢体保留和功能恢复。在这种复杂的情况下,低强度脉冲超声(LIPUS)的整合进一步优化了骨愈合。本病例报告通过详细介绍一种成功的三焦Ilizarov策略与LIPUS结合治疗一名患有特大胫骨缺损的慢性吸烟者,解决了这些差距。
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引用次数: 0
Analysis of the Effect of Integrated Orthopedic Rehabilitation Programs on Elbow Joint Function Recovery After Ulnar Olecranon Fracture Surgery. 综合骨科康复方案对尺骨鹰嘴骨折术后肘关节功能恢复的影响分析。
IF 2.3 Q2 ORTHOPEDICS Pub Date : 2025-12-06 eCollection Date: 2025-01-01 DOI: 10.2147/ORR.S545214
Xu Hu, Zhuojin Wu, Shangtuan Zheng

Objective: This study aimed to evaluate the effect of an integrated orthopedic rehabilitation program on elbow joint function recovery in patients after surgical treatment for ulnar olecranon fractures, compared to conventional rehabilitation.

Methods: A retrospective cohort study was conducted on 87 patients who underwent surgery for ulnar olecranon fractures. Based on the standard of care at the time of admission, patients were assigned to a control group (n=42) receiving conventional rehabilitation or an observation group (n=45) receiving an integrated rehabilitation program. The integrated program comprised preoperative education, standardized in-hospital training, a structured 24-week home-based protocol with phased goals, and monitored follow-up. The primary outcome was the Mayo Elbow Performance Score (MEPS). Secondary outcomes included elbow range of motion (ROM), Activities of Daily Living (ADL) score, Visual Analog Scale (VAS) for pain, and complication rates.

Results: The observation group showed a significantly higher rehabilitation effectiveness rate (97.78% vs 80.95%, p=0.026). They also achieved superior MEPS (75.31 vs 53.85, p<0.001), ADL scores (62.64 vs 55.17, p<0.001), and lower VAS scores (2.36 vs 4.36, p<0.001). Elbow ROM improvements in flexion, extension, pronation, and supination were all significantly greater in the observation group (all p<0.001). Complication rates did not differ significantly (6.67% vs 9.52%, p=0.924).

Conclusion: The integrated orthopedic rehabilitation program is superior to conventional rehabilitation in promoting functional recovery, improving range of motion, enhancing daily living activities, and alleviating pain in patients after ulnar olecranon fracture surgery. However, these findings should be interpreted with caution due to the limitations of a retrospective design and a modest sample size. Integrated rehabilitation represents a highly effective postoperative management strategy for these patients.

目的:本研究旨在评价综合骨科康复方案对尺骨鹰嘴骨折术后患者肘关节功能恢复的影响,并与常规康复方案进行比较。方法:对87例尺尺骨鹰嘴骨折患者进行回顾性队列研究。根据入院时的护理标准,将患者分为接受常规康复治疗的对照组(n=42)和接受综合康复治疗的观察组(n=45)。综合方案包括术前教育、标准化的住院培训、有组织的24周家庭协议和阶段性目标,以及监测随访。主要结果为Mayo肘部表现评分(MEPS)。次要结果包括肘关节活动度(ROM)、日常生活活动(ADL)评分、疼痛视觉模拟量表(VAS)和并发症发生率。结果:观察组患者康复有效率显著高于对照组(97.78% vs 80.95%, p=0.026)。结论:综合骨科康复方案在促进尺尺骨鹰嘴骨折术后患者功能恢复、提高活动范围、增强日常生活活动能力、减轻疼痛等方面优于常规康复方案。然而,由于回顾性设计的局限性和适度的样本量,这些发现应该谨慎解释。综合康复是一种非常有效的术后管理策略。
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引用次数: 0
Effectiveness of Microfracture Augmentation in the Intercondylar Notch on Meniscal Healing: A Retrospective Comparative Study of Patients with Bucket-Handle and Longitudinal Meniscal Tears. 髁间切迹微骨折增强对半月板愈合的效果:桶柄型和纵向半月板撕裂患者的回顾性比较研究。
IF 2.3 Q2 ORTHOPEDICS Pub Date : 2025-12-04 eCollection Date: 2025-01-01 DOI: 10.2147/ORR.S551256
Ahmad Shakib Mohebi, Basira Bek, Emal Wardak, Nommanudien Naibkhil, Meena Obaide

Purpose: This study aimed to evaluate the effectiveness of microfracture augmentation in the intercondylar notch on healing outcomes after arthroscopic meniscal repair, with stratification by meniscal tear type (bucket-handle vs longitudinal).

Background: Meniscal tears are common knee injuries with variable healing potential. Microfracture augmentation, which involves small perforations in the intercondylar notch to release marrow elements, has been proposed as an adjunct to enhance meniscal repair. However, the impact of this technique across different tear types remains under investigation.

Patients and methods: In this retrospective cohort study, 173 patients aged 18-40 years with isolated bucket-handle or longitudinal meniscal tears undergoing arthroscopic repair were included. Patients were divided into two groups: microfracture-augmented repair (n = 87) and non-microfracture repair without augmentation (n = 86). All surgeries were performed by a single senior orthopedic surgeon, and postoperative rehabilitation protocols were standardized. Healing was assessed at 12 months using Barrett's criteria, the Apley Grinding Test, and clinical evaluation. Statistical analyses included chi-square tests, odds ratios, risk ratios, ROC curve analysis, and binary logistic regression to evaluate associations between surgical technique, tear type, and postoperative outcomes.

Results: Microfracture augmentation was associated with significantly higher overall healing rates compared to non-microfracture repair (88.5% vs 64.0%, p < 0.001). Stratified by tear type, microfracture had the greatest benefit in bucket-handle tears (79.4% vs 37.8%, p < 0.001; OR = 6.353, 95% CI: 2.275-17.737; RR = 3.022, 95% CI: 1.503-6.076), while healing rates were similar for longitudinal tears between techniques (94.3% vs 92.7%, p = 0.745). Age, gender, and side of injury were not significant predictors of outcomes.

Conclusion: Microfracture augmentation enhances healing after arthroscopic meniscal repair, particularly in bucket-handle tears, while longitudinal tear outcomes are favorable regardless of augmentation. These findings emphasize the importance of tear type in guiding the choice of surgical technique.

目的:本研究旨在评估髁间切迹微骨折增强对关节镜下半月板修复后愈合效果的有效性,并按半月板撕裂类型(桶柄型与纵向型)分层。背景:半月板撕裂是常见的膝关节损伤,具有不同的愈合潜力。微骨折增强术,包括在髁间切迹上穿孔以释放骨髓元素,已被提议作为增强半月板修复的辅助手段。然而,该技术对不同撕裂类型的影响仍在研究中。患者和方法:在这项回顾性队列研究中,173例年龄18-40岁的孤立桶柄撕裂或纵向半月板撕裂接受关节镜修复。患者分为微骨折增强修复(n = 87)和非微骨折不增强修复(n = 86)两组。所有手术均由一名高级骨科医生完成,术后康复方案标准化。在12个月时使用Barrett’s标准、Apley Grinding Test和临床评估来评估愈合情况。统计分析包括卡方检验、优势比、风险比、ROC曲线分析和二元logistic回归来评估手术技术、撕裂类型和术后结果之间的关系。结果:与非微骨折修复相比,微骨折增强术的总愈合率明显更高(88.5%比64.0%,p < 0.001)。按撕裂类型分层,微骨折在桶柄撕裂中获益最大(79.4% vs 37.8%, p < 0.001; OR = 6.353, 95% CI: 2.1975 -17.737; RR = 3.022, 95% CI: 1.503-6.076),而纵向撕裂的愈合率在不同技术之间相似(94.3% vs 92.7%, p = 0.745)。年龄、性别和损伤部位不是预后的显著预测因素。结论:微骨折增强术可促进关节镜下半月板修复后的愈合,尤其是桶柄撕裂,而纵向撕裂的结果是有利的,无论增强术如何。这些发现强调了撕裂类型在指导手术技术选择中的重要性。
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引用次数: 0
Effects on Prolonged Screen Time on Postural Health and Visual Health in Children and Adolescents: A Scoping Review. 屏幕时间延长对儿童和青少年体位健康和视觉健康的影响:一项范围综述。
IF 2.3 Q2 ORTHOPEDICS Pub Date : 2025-11-19 eCollection Date: 2025-01-01 DOI: 10.2147/ORR.S519541
Natalia Ellis Sandoval, Maria Isabel Peña Martinez, Ana Belen Fernandez Cea, Erwin Hernando Hernandez Rincon

Purpose: To explore the long-term impact of prolonged screen exposure on postural and visual health in children and adolescents.

Patients and methods: A scoping review was conducted in December 2024 using PubMed, Scopus, and BIREME, focusing on articles from 2019 to 2024 in English and Spanish. The studies were categorized into visual and postural health domains and synthesized through graphs and tables. A total of 27 articles were analyzed. The snowball method was used to complement the literature search.

Results: The studies revealed a 55.3% increase in the use of portable electronic devices following the COVID-19 pandemic. Reported consequences included eye strain, computer vision syndrome, and musculoskeletal pain, especially in the cervical and lumbar regions. These effects were more prevalent in urban populations in Asia.

Conclusion: Prolonged screen time significantly affects children's visual and postural health. These findings highlight the need for public health policies to guide and regulate screen use in young populations and to educate parents, caregivers, and healthcare professionals.

目的:探讨长时间屏幕暴露对儿童和青少年姿势和视觉健康的长期影响。患者和方法:于2024年12月使用PubMed、Scopus和BIREME进行了范围综述,重点关注2019年至2024年的英语和西班牙语文章。这些研究分为视觉健康和姿势健康两个领域,并通过图表进行综合。共分析了27篇文章。采用滚雪球法对文献检索进行补充。结果:研究显示,在COVID-19大流行之后,便携式电子设备的使用增加了55.3%。报告的后果包括眼疲劳、计算机视觉综合征和肌肉骨骼疼痛,特别是在颈椎和腰椎区域。这些影响在亚洲城市人口中更为普遍。结论:屏幕时间延长对儿童的视觉和姿势健康有显著影响。这些发现强调需要制定公共卫生政策来指导和规范年轻人使用筛查,并对父母、照顾者和医疗保健专业人员进行教育。
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引用次数: 0
Opportunistic Screening with Radiomics Model Based on CT Imaging of Adrenal Adenoma to Assess Bone Mass Change. 基于CT成像的肾上腺腺瘤放射组学模型的机会性筛查评估骨量变化。
IF 2.3 Q2 ORTHOPEDICS Pub Date : 2025-11-15 eCollection Date: 2025-01-01 DOI: 10.2147/ORR.S548365
Cheng Jia, Ling Jiang, Yue Zhang, Tiantian Yang, Datian Su, Mingxin Song, Heqi Yang, Jian Qin, Changqin Li, Hui Yang

Purpose: There was a strong correlation between adrenal adenoma and osteoporosis, the primary objective of this research was to establish and authenticate a radiomics nomogram using CT scan of adrenal adenoma to screen abnormal bone mineral density (BMD) opportunistically.

Methods and materials: A total of 161 patients with adrenal adenomas who underwent thoracoabdominal CT and quantitative CT (QCT) were enrolled retrospectively. The radiomics features were chosen from the cross-sectional CT images of adrenal adenomas and the nomogram models that including patient's clinical and radiomics features were then established. The receiver operating characteristic (ROC) curve was performed to evaluate the performance of the model and the decision curve analysis (DCA) was used to assess the clinical usefulness.

Results: To build a radiomics model, 11 radiomics features based on CT scans of adrenal adenomas were selected and showed good performance in distinguishing abnormal BMD from normal BMD. Moreover, the radiomics nomogram model demonstrated excellent ability to identify abnormal BMD of adrenal adenoma patients with area under the curve (AUC) of 0.87 (95% CI, 0.80-0.93) in training cohort and 0.85 (95% CI, 0.74-0.96) in validation cohort. The accuracy, sensitivity, specificity of the nomogram model were 79.7%, 78.3%, 81.1% in training cohort, and 72.9%, 67.7%, 82.4% in validation cohort respectively.

Conclusion: The radiomics nomogram based on clinical and radiomics features of adrenal adenoma CT images had a satisfying predictive ability and can be an opportunistic effective tool for identifying bone mass change.

目的:肾上腺腺瘤与骨质疏松症有很强的相关性,本研究的主要目的是利用肾上腺腺瘤的CT扫描建立并验证放射组学成像,以机会性地筛查异常骨密度(BMD)。方法与材料:回顾性分析161例经胸腹CT和定量CT (QCT)检查的肾上腺腺瘤患者。从肾上腺腺瘤的横断CT图像中选择放射组学特征,建立包括患者临床特征和放射组学特征的nomogram模型。采用受试者工作特征(ROC)曲线评价模型的性能,采用决策曲线分析(DCA)评价模型的临床有效性。结果:为了建立放射组学模型,选择了11个基于肾上腺腺瘤CT扫描的放射组学特征,这些特征在区分异常骨密度和正常骨密度方面表现良好。此外,放射组学nomogram模型对肾上腺腺瘤患者异常BMD的识别能力较好,训练组的曲线下面积(AUC)为0.87 (95% CI, 0.80-0.93),验证组的AUC为0.85 (95% CI, 0.74-0.96)。训练组nomogram模型的准确率为79.7%,灵敏度为78.3%,特异度为81.1%;验证组nomogram模型的准确率为72.9%,灵敏度为67.7%,特异度为82.4%。结论:基于肾上腺腺瘤CT影像临床和放射组学特征的放射组学影像学检查具有较好的预测能力,可作为鉴别骨量变化的机会性有效工具。
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引用次数: 0
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Orthopedic Research and Reviews
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