Pub Date : 2021-10-30DOI: 10.9734/bpi/rdmmr/v11/13953d
Sharadendu Bali, A. Choudhary, V. Saini
Immunosenescence has been postulated by many workers to be the prime reason behind the increased mortality observed in the ageing population during the ongoing SARS-CoV 2 pandemic. SARS-CoV 2 infection results in a range of effects, from mostly asymptomatic and mild cases to more severe manifestations. Defects and dysfunctions of the primary immune cells are being considered as the most important factor in the patients who develop the more serious form of the disease. These defects may be in the efficient and early recognition of PAMPs by the PRRs of the Dendritic cells or in the delayed and hyper-inflammatory cytokine release by the monocytes and macrophages in the lung. The innate immune system response is now being advanced as the critical factor in disease outcome. While Immunosenescence is considered irreversible, yet it is a dynamic process and as such it is amenable to re-conditioning and enhancements. One agent that can revitalize the ageing immune system is Gold nanoparticles (GNP) which have recently been studied because of their ability to act as carriers of vaccines and chemotherapeutic agents. Use of GNP in rats has caused increase in lymphocyte cell populations and induced activation of dendritic cells and macrophages. Since immunosenescence causes a depletion of naive T and B lymphocytes, use of GNP can have a salutary role. Improved recognition of PAMPs by Dendritic cells and Macrophages can help in mounting a more efficient response to the invading virus. Elemental gold formulations have been used in India for millennia, for diseases ranging from fevers and memory loss to senility. Some formulations are prescribed for infants, hence their safety is not suspect. If employed with suitable modifications, such formulations can play the vital role of oral vaccines against not just Covid 19, but also the vast range of other influenza viruses.
{"title":"Ayurvedic NanoGold Formulation as a Shield against Coronaviruses: Including SARS CoV 2","authors":"Sharadendu Bali, A. Choudhary, V. Saini","doi":"10.9734/bpi/rdmmr/v11/13953d","DOIUrl":"https://doi.org/10.9734/bpi/rdmmr/v11/13953d","url":null,"abstract":"Immunosenescence has been postulated by many workers to be the prime reason behind the increased mortality observed in the ageing population during the ongoing SARS-CoV 2 pandemic. SARS-CoV 2 infection results in a range of effects, from mostly asymptomatic and mild cases to more severe manifestations. Defects and dysfunctions of the primary immune cells are being considered as the most important factor in the patients who develop the more serious form of the disease. These defects may be in the efficient and early recognition of PAMPs by the PRRs of the Dendritic cells or in the delayed and hyper-inflammatory cytokine release by the monocytes and macrophages in the lung. The innate immune system response is now being advanced as the critical factor in disease outcome. While Immunosenescence is considered irreversible, yet it is a dynamic process and as such it is amenable to re-conditioning and enhancements. One agent that can revitalize the ageing immune system is Gold nanoparticles (GNP) which have recently been studied because of their ability to act as carriers of vaccines and chemotherapeutic agents. Use of GNP in rats has caused increase in lymphocyte cell populations and induced activation of dendritic cells and macrophages. Since immunosenescence causes a depletion of naive T and B lymphocytes, use of GNP can have a salutary role. Improved recognition of PAMPs by Dendritic cells and Macrophages can help in mounting a more efficient response to the invading virus. Elemental gold formulations have been used in India for millennia, for diseases ranging from fevers and memory loss to senility. Some formulations are prescribed for infants, hence their safety is not suspect. If employed with suitable modifications, such formulations can play the vital role of oral vaccines against not just Covid 19, but also the vast range of other influenza viruses.","PeriodicalId":197171,"journal":{"name":"Recent Developments in Medicine and Medical Research Vol. 11","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115724375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-10-30DOI: 10.9734/bpi/rdmmr/v11/13241d
Debajani Deka
{"title":"Various Sites of Supranuclear Facial Nerve Lesion: A Case Study","authors":"Debajani Deka","doi":"10.9734/bpi/rdmmr/v11/13241d","DOIUrl":"https://doi.org/10.9734/bpi/rdmmr/v11/13241d","url":null,"abstract":"","PeriodicalId":197171,"journal":{"name":"Recent Developments in Medicine and Medical Research Vol. 11","volume":"68 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122823463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-10-30DOI: 10.9734/bpi/rdmmr/v11/13929d
Qazi Najeeb Ahmad
{"title":"Determining the Levels of Glycated Hemoglobin, Serum Calcium, Magnesium, Phosphate, Uric Acid and Microalbuminuria in Patients with Newly Diagnosed Type 2 Diabetes Mellitus","authors":"Qazi Najeeb Ahmad","doi":"10.9734/bpi/rdmmr/v11/13929d","DOIUrl":"https://doi.org/10.9734/bpi/rdmmr/v11/13929d","url":null,"abstract":"","PeriodicalId":197171,"journal":{"name":"Recent Developments in Medicine and Medical Research Vol. 11","volume":"14 5","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114115616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-10-30DOI: 10.9734/bpi/rdmmr/v11/14044d
S. Garg, Nisha Malik, V. Sharma
{"title":"Determining the Role of Aspiration Cytology in Splenic Lesions","authors":"S. Garg, Nisha Malik, V. Sharma","doi":"10.9734/bpi/rdmmr/v11/14044d","DOIUrl":"https://doi.org/10.9734/bpi/rdmmr/v11/14044d","url":null,"abstract":"","PeriodicalId":197171,"journal":{"name":"Recent Developments in Medicine and Medical Research Vol. 11","volume":"60 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125513115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-10-30DOI: 10.9734/bpi/rdmmr/v11/1994c
Suchandra Ray, C. Das, S. Roy
{"title":"The Role of IRF (Immature Reticulocyte Fraction) in Pancytopenia","authors":"Suchandra Ray, C. Das, S. Roy","doi":"10.9734/bpi/rdmmr/v11/1994c","DOIUrl":"https://doi.org/10.9734/bpi/rdmmr/v11/1994c","url":null,"abstract":"","PeriodicalId":197171,"journal":{"name":"Recent Developments in Medicine and Medical Research Vol. 11","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133435070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-10-30DOI: 10.9734/bpi/rdmmr/v11/4133f
J. Kamenoff
{"title":"Transient Analysis of the Therapeutic Effect of Turbulence Laser Medicine in the Treatment of Pathological Changes in TMJ Due to Occlusal Trauma","authors":"J. Kamenoff","doi":"10.9734/bpi/rdmmr/v11/4133f","DOIUrl":"https://doi.org/10.9734/bpi/rdmmr/v11/4133f","url":null,"abstract":"","PeriodicalId":197171,"journal":{"name":"Recent Developments in Medicine and Medical Research Vol. 11","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116504539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-10-30DOI: 10.9734/bpi/rdmmr/v11/14452d
K. Ikemoto
{"title":"Multi-Particulate High Intensity Finding of Brain MRI in 30’s Male Heavy Smoker Suicidal Attempt Case Following Mild COVID-19 Pneumonia: A Case Report","authors":"K. Ikemoto","doi":"10.9734/bpi/rdmmr/v11/14452d","DOIUrl":"https://doi.org/10.9734/bpi/rdmmr/v11/14452d","url":null,"abstract":"","PeriodicalId":197171,"journal":{"name":"Recent Developments in Medicine and Medical Research Vol. 11","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132033030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-10-30DOI: 10.9734/bpi/rdmmr/v11/13856d
Onur Bayrakçı
{"title":"Clinical Charactesistics and Surgical Treatment of Chylothorax","authors":"Onur Bayrakçı","doi":"10.9734/bpi/rdmmr/v11/13856d","DOIUrl":"https://doi.org/10.9734/bpi/rdmmr/v11/13856d","url":null,"abstract":"","PeriodicalId":197171,"journal":{"name":"Recent Developments in Medicine and Medical Research Vol. 11","volume":"162 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123369024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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