Paediatrics and International Child Health最新文献

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Early congenital syphilis: missed opportunities in a mother owing to many problems during pregnancy – a case report 早期先天性梅毒:由于怀孕期间的许多问题，母亲错过了机会-一个病例报告

IF 1.8 4区医学 Q3 PEDIATRICS

Paediatrics and International Child Health

Pub Date : 2022-04-03 DOI: 10.1080/20469047.2022.2044676

Shilpa Krishnapura Lakshminarayana, S. Devadas, K. Bharath, Mallesh Kariyappa, Bindushree Byadarahalli Keshavamurthy, Megha S Bagewadi, Sushma Veeranna Sajjan, Dadegal Vineet, Thanzir Mohammed

ABSTRACT Untreated syphilis in pregnancy can result in an adverse outcome for the fetus. A multigravida woman with a previously poor obstetric history of early neonatal death, abortion and stillbirth was admitted in labour in the 7th month of pregnancy. On admission, syphilis screening with the qualitative rapid plasma reagin (RPR) test was negative. The infant had macules on the chest, abdomen and extremities, desquamating bullous skin lesions on the palms and soles, bilateral cataracts, an enlarged liver and spleen, anaemia, thrombocytopenia and conjugated hyperbilirubinaemia. A quantitative RPR test in the infant was positive in a 1:64 dilution and was subsequently positive in the mother in a 1:16 dilution after congenital syphilis was diagnosed. The mother later reported the father’s high-risk behaviour and her previous visits to healthcare facilities for genital ulcers. The quantitative RPR test in the father was positive in a 1:32 dilution, and the parents and infant were treated for syphilis. The case demonstrates the importance of timely identification of high-risk pregnant women, early screening, repetition of the non-treponemal test on diluted serum when a routine screening test is negative, proper advice from the laboratory regarding selection of the most appropriate tests, and screening with the treponemal test first (reverse) algorithm utilising an automated enzyme immunoassay/chemiluminescence assay for the initial screening in high-risk cases, even in resource-limited settings to prevent a missed diagnosis. Abbreviations: ANC, antenatal care; BPG, benzathine penicillin G; CS, congenital syphilis; CSF, cerebrospinal fluid; CIA, chemiluminescence assay; EIA, enzyme immunoassay; HIC: high-income countries; IgM, immunoglobulin M; LMIC, low- and middle-income countries; MTCT: mother-to-child transmission; NTT, non-treponemal test; POC, point of care; RPR, rapid plasma reagin; RST, rapid syphilis test; STI, sexually transmitted infections; TT, treponemal test; TPHA, Treponema pallidum haemagglutination assay; VDRL, venereal disease research laboratory; WHO, World Health Organization.

摘要妊娠期未经治疗的梅毒可能会给胎儿带来不良后果。一名多重妊娠妇女在怀孕第7个月分娩时入院，她之前有新生儿早期死亡、堕胎和死产的不良产科病史。入院时，用快速血浆反应蛋白（RPR）定性检测梅毒的结果为阴性。婴儿胸部、腹部和四肢有黄斑，手掌和足底有脱屑性大疱性皮肤损伤，双侧白内障，肝脾肿大，贫血，血小板减少症和合并高胆红素血症。婴儿的定量RPR测试在1:64稀释液中呈阳性，随后在诊断为先天性梅毒后，母亲的RPR测试以1:16稀释液呈阳性。这位母亲后来报告了父亲的高危行为，以及她之前因生殖器溃疡去医疗机构就诊的情况。父亲的定量RPR测试在1:32稀释后呈阳性，父母和婴儿接受了梅毒治疗。该病例证明了及时识别高危孕妇、早期筛查、在常规筛查检测呈阴性时对稀释血清重复非密螺旋体检测、实验室就选择最合适的检测提出适当建议的重要性，以及使用密螺旋体检测第一（反向）算法进行筛查，该算法利用自动酶免疫测定/化学发光测定法对高危病例进行初步筛查，即使在资源有限的情况下也是如此，以防止漏诊。缩写：ANC，产前护理；BPG、苄星青霉素G；CS，先天性梅毒；CSF、脑脊液；CIA，化学发光法；酶免疫分析；HIC：高收入国家；IgM、免疫球蛋白M；低收入和中等收入国家；MTCT：母婴传播；NTT，非密螺旋体试验；POC，护理点；RPR，快速血浆反应蛋白；RST，快速梅毒检测；STI，性传播感染；TT，密螺旋体试验；梅毒螺旋体血凝试验；性病研究实验室；世界卫生组织，世界卫生组织。

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引用次数: 2

An infant of 26 weeks gestation with congenital miliary tuberculosis complicated by chronic lung disease requiring CPAP was diagnosed on Day 104 of life: congenital tuberculosis was confirmed by detection of calcified ovaries in his mother 一名妊娠26周的先天性军性肺结核合并慢性肺病需要CPAP的婴儿在出生第104天被诊断为先天性肺结核:通过检测其母亲卵巢钙化证实了先天性肺结核

IF 1.8 4区医学 Q3 PEDIATRICS

Paediatrics and International Child Health

Pub Date : 2022-04-03 DOI: 10.1080/20469047.2022.2076030

Akina Matsuda, N. Nishizaki, Hanako Abe, Akira Mizutani, T. Niizuma, K. Obinata, K. Oguma, S. Makino, Makoto Ishitate, Toshiaki Shimizu

ABSTRACT Introduction Early diagnosis of tuberculosis (TB) in infants is important but is commonly missed because the symptoms are often non-specific. Case presentation A Nepalese male infant born at 26 weeks gestation and weighing 1227 g (97th centile) was admitted to the neonatal intensive care unit (NICU) immediately after birth for the management of his prematurity. After extubation on Day 8, his oxygen saturation became unstable and he required nasal continuous positive airway pressure with oxygen for 3 months. On Day 104, further detailed evaluation was required because there was no improvement in his respiratory condition. A computed tomography (CT) scan demonstrated scattered miliary nodules in both lung fields. Acid-fast staining for the mycobacteria and TB polymerase chain reaction (PCR) of the sputum obtained directly by laryngeal aspiration confirmed Mycobacterium tuberculosis. On Day 105, he was therefore transferred to a tertiary care hospital for further intensive care. Pathology findings suggested placental involvement with TB owing to chronic endometrial infection. In addition, a maternal abdominal CT scan demonstrated bilateral calcified lesions in the ovaries. He completed antituberculous chemotherapy and was discharged 3 months later. At 18 months of age there are no sequelae and his development is almost normal. None of the infants or medical personnel who were exposed in the NICU developed secondary TB. Conclusion In neonates with persistent respiratory distress, neonatologists should consider TB infection as a differential diagnosis. Abbreviations CLD: chronic lung disease; CRP: C-reactive protein; CT: computed tomography; IGRA: interferon-γ release assay; IVF-ET: in vitro fertilisation-embryo transfer; N-CPAP: nasal continuous positive airway pressure; NICU: neonatal intensive care unit; PCR: polymerase chain reaction; PROM: premature rupture of membranes; TB: tuberculosis; WBC: white blood cells.

婴儿结核病(TB)的早期诊断很重要，但由于其症状通常是非特异性的，因此经常被遗漏。病例介绍:一名尼泊尔男婴在妊娠26周出生，体重1227 g(第97厘位)，出生后立即被送入新生儿重症监护病房(NICU)进行早产治疗。第8天拔管后，患者血氧饱和度变得不稳定，需要鼻腔持续气道正压供氧3个月。在第104天，由于呼吸状况没有改善，需要进一步的详细评估。计算机断层扫描显示双肺野散在的粟粒性结节。喉部直接吸痰的结核分枝杆菌和结核聚合酶链反应(PCR)的抗酸染色证实结核分枝杆菌。因此，在第105天，他被转到三级医院接受进一步的重症监护。病理结果提示由于慢性子宫内膜感染而累及胎盘结核。此外，母体腹部CT扫描显示双侧卵巢钙化病变。完成抗结核化疗，3个月后出院。在18个月大的时候，没有任何后遗症，他的发育几乎正常。在新生儿重症监护室暴露的婴儿或医务人员没有发生继发性结核病。结论对于持续呼吸窘迫的新生儿，儿科医生应将结核感染作为鉴别诊断。CLD:慢性肺病;CRP: c反应蛋白;CT:计算机断层扫描;IGRA:干扰素γ释放试验;IVF-ET:体外受精-胚胎移植;N-CPAP:鼻腔持续气道正压通气;NICU:新生儿重症监护病房;PCR:聚合酶链反应;PROM:膜早破;结核病:肺结核;WBC:白细胞。

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引用次数: 0

A rare cause of stroke in young children: minor head trauma associated with mineralising lenticulostriate angiopathy in three patients 幼儿脑卒中的一种罕见原因：三名患者的轻微头部创伤伴矿化性豆纹血管病

IF 1.8 4区医学 Q3 PEDIATRICS

Paediatrics and International Child Health

Pub Date : 2022-04-03 DOI: 10.1080/20469047.2022.2066386

Kiruthiga Sugumar, A. Chidambaram, B. Deepthi, S. Krishnamurthy, C. Delhikumar

ABSTRACT Acute basal ganglia infarct following minor head trauma in association with mineralisation of lenticulostriate arteries is an increasingly recognised entity in childhood stroke. Three cases with a classical history and phenotypical features of mineralising angiopathy are described. Case 1 was a 2-year-old girl who presented with acute onset hemiparesis with a same-side upper motor neuron (UMN)-type facial palsy following minor head trauma. Case 2 was a 14-month-old boy who presented with a left side hemiparesis and a left UMN-type facial nerve palsy following a minor fall. Case 3 was an 8-month-old boy who, following a fall from his cot, had a sudden-onset hemiparesis on the right side and deviation of the angle of the mouth to the left. In brain computed tomography, all three cases demonstrated characteristic basal ganglia calcification of the mineralising angiopathy. Magnetic resonance imaging of the brain demonstrated features supportive of acute infarcts in the lentiform nucleus, caudate nucleus and putamen. Two of the patients had iron deficiency anaemia with haemoglobin of 7.0 g/dL and 7.8 g/dL, respectively. On follow-up, Case 1 had mild residual weakness and the other two made a complete recovery. None of the patients had a recurrence of stroke. Basal ganglia stroke with mineralising angiopathy should be considered in toddlers presenting with sudden-onset focal neurological deficits preceded by minor head trauma. Abbreviations: ADC: apparent diffusion coefficient; CT: computed tomography; DWI: diffusion-weighted imaging; Hb: haemoglobin; IDA: iron deficiency anaemia; MRI: magnetic resonance imaging; SLV: sonographic lenticulostriate vasculopathy; SWI: susceptibility weighted imaging; UMN: upper motor neuron.

摘要轻微头部创伤后并发豆纹动脉矿化的急性基底节梗死在儿童中风中越来越被认可。描述了三例矿化血管病的经典病史和表型特征。病例1是一名2岁女孩，她在轻微头部创伤后出现急性发作性偏瘫，伴有同侧上运动神经元（UMN）型面瘫。病例2是一名14个月大的男孩，在轻微跌倒后出现左侧偏瘫和左侧UMN型面神经麻痹。病例3是一名8个月大的男孩，他从婴儿床上摔下来后，突然出现右侧偏瘫和嘴角向左偏离。在大脑计算机断层扫描中，所有三个病例都表现出矿化血管病的基底节钙化特征。大脑的磁共振成像显示了支持豆状核、尾状核和壳核急性梗死的特征。其中两名患者患有缺铁性贫血，血红蛋白分别为7.0 g/dL和7.8 g/dL。在随访中，病例1有轻微的残余虚弱，另外两例完全康复。没有一个病人中风复发。基底节卒中伴矿化血管病变的幼儿应考虑在轻微头部创伤之前出现突发性局灶性神经功能缺损。缩写：ADC：表观扩散系数；CT：计算机断层扫描；DWI：扩散加权成像；Hb：血红蛋白；IDA：缺铁性贫血；MRI：磁共振成像；SLV：超声显示的豆纹状血管病；SWI：磁化率加权成像；UMN：上运动神经元。

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引用次数: 1

A 17-year-old boy who presented with acute mononeuropathy was found to have Type 1 diabetes 一个17岁的男孩谁提出急性单神经病变被发现有1型糖尿病

IF 1.8 4区医学 Q3 PEDIATRICS

Paediatrics and International Child Health

Pub Date : 2022-04-03 DOI: 10.1080/20469047.2022.2059879

Fatma Özgüç Çömlek, Y. Karal, Filiz Tütüncüler

ABSTRACT Diabetic neuropathy in children and adolescents with Type 1 diabetes mellitus is rare and is usually subclinical and a complication of the late diabetes period. A 17-year-old boy admitted with a right foot drop of sudden onset was diagnosed with peroneal nerve palsy. He had had osmotic polyuria, polydipsia and weight loss for the past 2 months; his blood glucose was 25 mmol/L (<7.8), HbA1c 15.2% (4.0–5.6) and vitamin B12 125 pg/ml (180–914). The peroneal nerve palsy resolved within 3 months with blood glucose regulation and B12 supplementation. Diabetes should be borne in mind in the differential diagnosis of unusual cases of mononeuropathy. Abbreviations: DCCTS: Diabetes Control and Complications Trial Study; DM: diabetes mellitus; DN: diabetic neuropathy; GAD: glutamic acid decarboxylase; PN: peripheral neuropathy; T1DM: Type 1 diabetes mellitus.

摘要1型糖尿病儿童和青少年的糖尿病神经病变是罕见的，通常是亚临床的，是糖尿病晚期的并发症。一名17岁男孩因右脚突然下垂入院，被诊断为腓神经麻痹。在过去的两个月里，他有渗透性多尿、多饮和体重减轻；他的血糖为25 mmol/L（<7.8），HbA1c为15.2%（4.0-5.6），维生素B12为125 pg/ml（180-914）。通过血糖调节和补充B12，腓神经麻痹在3个月内得到缓解。在对不寻常的单神经病病例进行鉴别诊断时，应牢记糖尿病。缩写：DCCTS：糖尿病控制和并发症试验研究；DM：糖尿病；DN：糖尿病性神经病；GAD：谷氨酸脱羧酶；PN：周围神经病变；T1DM：1型糖尿病。

引用次数: 3

Concomitant rapidly progressive glomerulonephritis and acute rheumatic fever after streptococcus infection: a case report 链球菌感染后并发快速进行性肾小球肾炎和急性风湿热1例

IF 1.8 4区医学 Q3 PEDIATRICS

Paediatrics and International Child Health

Pub Date : 2022-03-17 DOI: 10.1080/20469047.2022.2046966

Suwanna Pornrattanarungsi, S. Eursiriwan, Y. Amornchaicharoensuk, C. Chavanisakun, O. Sirimongkolchaiyakul

ABSTRACT Acute post-streptococcal glomerulonephritis (APSGN) and acute rheumatic fever (ARF) are common immune-mediated complications after group A streptococcus (GAS) infection. The causative antigenic epitopes on GAS are different for APSGN and ARF, and their simultaneous occurrence is uncommon. A 12-year-old boy presented with fever and gross haematuria. He had subcutaneous nodules on the dorsum of both feet along with a new holosystolic murmur at the apex, and he developed hypertension and generalised oedema after admission. Investigation confirmed the diagnosis of ARF with APSGN. He received a corticosteroid to control inflammation of both the conditions. His clinical signs gradually improved but he still had rheumatic heart disease. As both diseases can occur in the same patient, treatment should be provided for both conditions. Abbreviations: APSGN: acute post-streptococcal glomerulonephritis; ARF: acute rheumatic fever; ASO: antistreptolysin O; Cr: serum creatinine; CRP: C-reactive protein; ESR: erythrocyte sedimentation rate; GAS: group A streptococcus; RBC: red blood cells; RPGN: rapidly progressive glomerulonephritis; S1: first heart sound; S2: second heart sound; TTE: transthoracic echocardiogram.

摘要急性链球菌后肾小球肾炎（APSGN）和急性风湿热（ARF）是A组链球菌（GAS）感染后常见的免疫介导并发症。对于APSGN和ARF，GAS上的致病抗原表位是不同的，并且它们同时发生是罕见的。一名12岁男孩出现发烧和严重血尿。他双脚背有皮下结节，尖端有新的全收缩杂音，入院后出现高血压和全身水肿。研究证实了APSGN对ARF的诊断。他接受了皮质类固醇来控制这两种情况的炎症。他的临床症状逐渐好转，但他仍然患有风湿性心脏病。由于这两种疾病都可能发生在同一名患者身上，因此应为这两种情况提供治疗。缩写：APSGN：急性链球菌性肾小球肾炎；ARF：急性风湿热；ASO：抗链球菌溶素O；Cr：血清肌酐；CRP：C反应蛋白；ESR：红细胞沉降率；GAS：A组链球菌；RBC：红细胞；RPGN：快速进行性肾小球肾炎；S1：第一心音；S2：第二心音；TTE：经胸超声心动图。

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引用次数: 0

Trichobezoar presenting as an acute abdominal obstruction in a 17-year-old girl 毛牛黄表现为一名17岁女孩的急性腹部梗阻

IF 1.8 4区医学 Q3 PEDIATRICS

Paediatrics and International Child Health

Pub Date : 2022-03-06 DOI: 10.1080/20469047.2022.2045691

Z. Bayramoğlu, R. Comert, B. Erginel, Abdulkadir Baziki

ABSTRACT Trichobezoars are hairballs that combine with food residue in the digestive tract as a result of ingesting hair. A 17-year-old girl was admitted to the emergency department with abdominal pain and vomiting for 3 days. She had been having digestive difficulty and bloating for the previous 2 months. An abdominal radiograph demonstrated air-fluid levels consistent with ileus, and an ultrasound showed hyperechoic material in the stomach and ileum. Computed tomography demonstrated images of trapped air which was considered diagnostic of a bezoar. At laparotomy, a large mass was removed from the stomach. As the bezoar extended through the pylorus and duodenum and there were mobile masses palpable in the ileum, it required a second incision to remove them. For some years she had had a habit of swallowing hair which she found on her pillow and there was a history of an obsessive personality trait and hyperactivity for which she agreed to attend a psychiatric clinic. Abbreviations: BMI: body mass index; CT: computed tomography; Hb: haemoglobin; IV: intravenous; WHO: World Health Organization

摘要毛霉菌是一种毛球，由于摄入毛发而在消化道中与食物残渣结合。一名17岁女孩因腹痛和呕吐入院3天。在过去的两个月里，她一直有消化困难和腹胀。腹部X光片显示空气液体水平与回肠一致，超声波显示胃和回肠中有高回声物质。计算机断层扫描显示了被困空气的图像，这被认为是牛黄的诊断。在剖腹手术中，从胃中取出了一个大肿块。由于牛黄延伸穿过幽门和十二指肠，回肠中有可触及的活动肿块，因此需要第二次切开将其切除。几年来，她一直有吞咽枕头上发现的头发的习惯，而且有强迫症和多动症的病史，为此她同意去精神科诊所。缩写：BMI：体重指数；CT：计算机断层扫描；Hb：血红蛋白；IV：静脉注射；世界卫生组织：世界卫生组织

引用次数: 0

Splenic rupture presenting with marked scrotal ecchymosis in a 2-day-old newborn. 脾破裂表现为明显的阴囊淤血在一个2天大的新生儿。

IF 1.8 4区医学 Q3 PEDIATRICS

Paediatrics and International Child Health

Pub Date : 2022-02-01 Epub Date: 2021-09-13 DOI: 10.1080/20469047.2021.1971923

Gaffari Tunc, Cengiz Güney, Utku Aygüneş

Splenic rupture is a rare and severe condition in neonates. The signs and symptoms are vague and non-specific and are often not recognised before the onset of hypovolaemic shock or death. A 2-day-old infant presented with scrotal ecchymosis, and ultrasonography detected haemorrhage in the scrotal, right inguinal and adrenal regions. Computed tomography demonstrated a peri-splenic haematoma. Haemoglobin (Hb) was 2.79 g/dL and, despite repeated transfusions, the Hb level could not be sustained. Exploratory laparotomy detected a large haematoma in the splenic region, and, because of the uncontrolled haemorrhage, splenectomy was required.

脾破裂是一种罕见且严重的新生儿疾病。体征和症状模糊且无特异性，在低血容量性休克或死亡发生前往往无法识别。一个2天大的婴儿表现为阴囊淤斑，超声检查发现阴囊、右腹股沟和肾上腺区出血。计算机断层显示脾周血肿。血红蛋白(Hb)为2.79 g/dL，尽管多次输血，Hb水平仍无法维持。剖腹探查发现脾区有一个大血肿，由于出血无法控制，需要脾切除术。

引用次数: 0

Acute demyelination of the medulla oblongata owing to scrub typhus in a 7-year-old boy: case report. 7岁男童因恙虫病致延髓急性脱髓鞘:个案报告。

IF 1.8 4区医学 Q3 PEDIATRICS

Paediatrics and International Child Health

Pub Date : 2022-02-01 Epub Date: 2022-02-08 DOI: 10.1080/20469047.2022.2035622

Srinanda Majumder, Moumita Samanta, Tapan Kumar Sinha Mahapatra

Abbreviations: ADEM: acute disseminated encephalomyelitis; CT: computed tomography; MRI: magnetic resonance imaging; PGCS: paediatric Glasgow coma scale; PICU: paediatric intensive care unit.

ADEM:急性播散性脑脊髓炎;CT:计算机断层扫描;MRI:磁共振成像;PGCS:儿童格拉斯哥昏迷量表;PICU:儿科重症监护病房。

引用次数: 0

Co-existing sickle cell anaemia and inflammatory bowel disease: case report and review of the literature. 并存的镰状细胞性贫血和炎症性肠病:病例报告和文献回顾。

IF 1.8 4区医学 Q3 PEDIATRICS

Paediatrics and International Child Health

Pub Date : 2022-02-01 Epub Date: 2021-09-03 DOI: 10.1080/20469047.2021.1936393

A A Adepoju, A Akere, G O Ogun, B O Ogunbosi, A O Asinobi, O Bello, A E Orimadegun, S Allen, O O Akinyinka

Sickle cell anaemia (SCA) is a chronic haemolytic anaemia associated with vaso-occlusive painful crises which may affect several systems including the gastro-intestinal system, resulting in abdominal pain. The concurrence of inflammatory bowel disease and haemoglobinopathy is rare. No previously reported concurrent cases of both SCA and ulcerative colitis (UC) in sub-Saharan Africa were found in the literature. A 16-year-old girl with concurrent SCA and UC is presented. She was admitted to University College Hospital, Ibadan with a 1-year history of recurrent peri-umbilical pain and bloody stools. These symptoms were mainly attributed to SCA at the referring hospital, and she was managed for chronic tropical diarrhoea without a remarkable clinical response. This case illustrates the concurrent presentation of SCA and ulcerative colitis which led to the missed and delayed diagnosis of ulcerative colitis.

镰状细胞性贫血(SCA)是一种慢性溶血性贫血，与血管闭塞性疼痛危机相关，可影响包括胃肠道系统在内的多个系统，导致腹痛。炎症性肠病和血红蛋白病同时发生是罕见的。文献中未发现撒哈拉以南非洲地区SCA和溃疡性结肠炎(UC)同时发生的病例。一个16岁的女孩同时患有SCA和UC。她因复发性脐周疼痛和便血病史1年而入住伊巴丹大学学院医院。这些症状主要归因于转诊医院的SCA，她被治疗为慢性热带腹泻，但没有显著的临床反应。本病例说明SCA和溃疡性结肠炎同时出现，导致溃疡性结肠炎的漏诊和延迟诊断。

引用次数: 2

Iron-deficiency anaemia in childhood: a risk factor for severe venous thrombosis? 儿童缺铁性贫血:严重静脉血栓形成的危险因素?

IF 1.8 4区医学 Q3 PEDIATRICS

Paediatrics and International Child Health

Pub Date : 2022-02-01 Epub Date: 2021-05-18 DOI: 10.1080/20469047.2021.1923301

Antonietta Curatola, Serena Ferretti, Antonio Gatto, Piero Valentini, Ilaria Lazzareschi

Iron deficiency anaemia is a common disorder in the paediatric age-group. The association between iron deficiency and venous thrombosis in children without an underlying illness is rare. Two cases are described. A 17-year-old girl had been taking oestrogen-progestogen therapy for contraception for about 2 years and developed a lower-limb deep vein thrombosis associated with pulmonary embolism. A 3-year-old girl was admitted to the paediatric emergency department with pallor, weakness and vomiting, and a cerebral CT showed a recent cerebral venous thrombosis. Both cases had severe iron-deficiency anaemia which increases a thrombotic tendency and could be a further crucial trigger of venous thrombosis in patients at low risk; therefore, in cases of unexplained thrombosis, it must always be considered to be a risk factor.Abbreviations APCR: activated protein C resistance; CMV: cytomegalovirus; CT: computerised tomography; CVST: cerebral venous sinus thrombosis; CVT: cerebral venous thrombosis; DVT: deep vein thrombosis; DOACs: direct oral anticoagulants; EBV: Epstein-Barr virus; ID: iron deficiency; IDA: iron deficiency anaemia; LMWH: low molecular weight heparin; PE: pulmonary embolism; RDW: red blood cell distribution width; VT: venous thrombosis.

缺铁性贫血是一种常见的疾病在儿科年龄组。在没有基础疾病的儿童中，缺铁和静脉血栓形成之间的联系是罕见的。本文描述了两个案例。一个17岁的女孩服用雌激素-孕激素治疗避孕约2年，并发下肢深静脉血栓并肺栓塞。一名3岁女孩因面色苍白、虚弱和呕吐被送入儿科急诊科，脑CT显示近期脑静脉血栓形成。这两个病例都有严重的缺铁性贫血，这增加了血栓形成的倾向，可能是低风险患者静脉血栓形成的进一步关键触发因素;因此，在不明原因血栓形成的情况下，必须始终将其视为一个危险因素。APCR:活化蛋白C抗性;巨细胞病毒:巨细胞病毒;CT:计算机断层扫描;CVST:脑静脉窦血栓形成;CVT:脑静脉血栓形成;DVT:深静脉血栓;DOACs:直接口服抗凝剂;eb: eb病毒;ID:缺铁;IDA:缺铁性贫血;LMWH:低分子肝素;PE:肺栓塞;RDW:红细胞分布宽度;VT:静脉血栓。

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引用次数: 2

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