Pub Date : 2024-05-01Epub Date: 2024-02-26DOI: 10.1097/MPA.0000000000002314
Mohamed Ebrahim, Mikkel Parsberg Werge, Srdan Novovic, Nadia Emad Lotfi Amin, John Gásdal Karstensen, Henrik Løvendahl Jørgensen
Background and aims: Pancreatic walled-off necrosis (WON) carries significant mortality and morbidity risks, often necessitating intensive care unit (ICU) admission. This retrospective study aimed to evaluate whether routine biochemical parameters at the time of the index endoscopic procedure could predict ICU admission and 1-year mortality following endoscopic treatment of WON.
Materials and methods: We retrospectively identified 201 consecutive patients who underwent endoscopic drainage for WON between January 1, 2010, and December 31, 2020. Associations between routine biochemical blood tests and outcomes were assessed using logistic regression models.
Results: Within 1 year of the index endoscopy, 31 patients (15.4%) died, and 40 (19.9%) were admitted to the ICU due to sepsis. Preoperative electrolyte disturbances were more prevalent among ICU-admitted patients and nonsurvivors. Hyperkalemia, hypoalbuminemia, and elevated urea were significant predictors of 1-year mortality, while hypernatremia, elevated serum creatinine, and hypoalbuminemia predicted ICU admission. Predictive models exhibited good discriminative ability, with an AUC of 0.84 (95% CI,0,75-0.93) for 1-year mortality and 0.86 (95%CI, 0.79-0.92) for ICU admission.
Conclusions: Preoperative imbalances in routine blood tests effectively predict adverse outcomes in endoscopically treated WON patients.
{"title":"Prediction of Admission to Intensive Care Unit and 1-Year Mortality After Acute Pancreatitis With Walled-Off Pancreatic Necrosis: A Retrospective, Single-Center Cohort Study.","authors":"Mohamed Ebrahim, Mikkel Parsberg Werge, Srdan Novovic, Nadia Emad Lotfi Amin, John Gásdal Karstensen, Henrik Løvendahl Jørgensen","doi":"10.1097/MPA.0000000000002314","DOIUrl":"10.1097/MPA.0000000000002314","url":null,"abstract":"<p><strong>Background and aims: </strong>Pancreatic walled-off necrosis (WON) carries significant mortality and morbidity risks, often necessitating intensive care unit (ICU) admission. This retrospective study aimed to evaluate whether routine biochemical parameters at the time of the index endoscopic procedure could predict ICU admission and 1-year mortality following endoscopic treatment of WON.</p><p><strong>Materials and methods: </strong>We retrospectively identified 201 consecutive patients who underwent endoscopic drainage for WON between January 1, 2010, and December 31, 2020. Associations between routine biochemical blood tests and outcomes were assessed using logistic regression models.</p><p><strong>Results: </strong>Within 1 year of the index endoscopy, 31 patients (15.4%) died, and 40 (19.9%) were admitted to the ICU due to sepsis. Preoperative electrolyte disturbances were more prevalent among ICU-admitted patients and nonsurvivors. Hyperkalemia, hypoalbuminemia, and elevated urea were significant predictors of 1-year mortality, while hypernatremia, elevated serum creatinine, and hypoalbuminemia predicted ICU admission. Predictive models exhibited good discriminative ability, with an AUC of 0.84 (95% CI,0,75-0.93) for 1-year mortality and 0.86 (95%CI, 0.79-0.92) for ICU admission.</p><p><strong>Conclusions: </strong>Preoperative imbalances in routine blood tests effectively predict adverse outcomes in endoscopically treated WON patients.</p>","PeriodicalId":19733,"journal":{"name":"Pancreas","volume":" ","pages":"e386-e394"},"PeriodicalIF":2.9,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139990791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-01DOI: 10.1097/MPA.0000000000002342
Othman Saleh, Hani Shihadeh, Ahmad Yousef, Hana Erekat, Fatima Abdallh, Ahmad Al-Leimon, Rawan Elsalhy, Abdalrahman Altiti, Majd Dajani, Majd M AlBarakat
Background and objectives: Pancreatic cancer is one of the most lethal malignancies. Even though many substantial improvements in the survival rates for other major cancer forms were made, pancreatic cancer survival rates have remained relatively unchanged since the 1960s. Even more, no standard classification system for pancreatic cancer is based on cellular biomarkers. This review will discuss and provide updates about the role of stem cells in the progression of PC, the genetic changes associated with it, and the promising biomarkers for diagnosis.
Materials and methods: The search process used PubMed, Cochrane Library, and Scopus databases to identify the relevant and related articles. Articles had to be published in English to be considered.
Results: The increasing number of studies in recent years has revealed that the diversity of cancer-associated fibroblasts is far greater than previously acknowledged, which highlights the need for further research to better understand the various cancer-associated fibroblast subpopulations. Despite the huge diversity in pancreatic cancer, some common features can be noted to be shared among patients. Mutations involving CDKN2, P53, and K-RAS can be seen in a big number of patients, for example. Similarly, some patterns of genes and biomarkers expression and the level of their expression can help in predicting cancer behavior such as metastasis and drug resistance. The current trend in cancer research, especially with the advancement in technology, is to sequence everything in hopes of finding disease-related mutations.
Conclusion: Optimizing pancreatic cancer treatment requires clear classification, understanding CAF roles, and exploring stroma reshaping approaches.
{"title":"The Effect of Intratumor Heterogeneity in Pancreatic Ductal Adenocarcinoma Progression and Treatment.","authors":"Othman Saleh, Hani Shihadeh, Ahmad Yousef, Hana Erekat, Fatima Abdallh, Ahmad Al-Leimon, Rawan Elsalhy, Abdalrahman Altiti, Majd Dajani, Majd M AlBarakat","doi":"10.1097/MPA.0000000000002342","DOIUrl":"10.1097/MPA.0000000000002342","url":null,"abstract":"<p><strong>Background and objectives: </strong>Pancreatic cancer is one of the most lethal malignancies. Even though many substantial improvements in the survival rates for other major cancer forms were made, pancreatic cancer survival rates have remained relatively unchanged since the 1960s. Even more, no standard classification system for pancreatic cancer is based on cellular biomarkers. This review will discuss and provide updates about the role of stem cells in the progression of PC, the genetic changes associated with it, and the promising biomarkers for diagnosis.</p><p><strong>Materials and methods: </strong>The search process used PubMed, Cochrane Library, and Scopus databases to identify the relevant and related articles. Articles had to be published in English to be considered.</p><p><strong>Results: </strong>The increasing number of studies in recent years has revealed that the diversity of cancer-associated fibroblasts is far greater than previously acknowledged, which highlights the need for further research to better understand the various cancer-associated fibroblast subpopulations. Despite the huge diversity in pancreatic cancer, some common features can be noted to be shared among patients. Mutations involving CDKN2, P53, and K-RAS can be seen in a big number of patients, for example. Similarly, some patterns of genes and biomarkers expression and the level of their expression can help in predicting cancer behavior such as metastasis and drug resistance. The current trend in cancer research, especially with the advancement in technology, is to sequence everything in hopes of finding disease-related mutations.</p><p><strong>Conclusion: </strong>Optimizing pancreatic cancer treatment requires clear classification, understanding CAF roles, and exploring stroma reshaping approaches.</p>","PeriodicalId":19733,"journal":{"name":"Pancreas","volume":"53 5","pages":"e450-e465"},"PeriodicalIF":1.7,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140904879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-01DOI: 10.1097/mpa.0000000000002357
Morgan T Walcheck, Patrick B Schwartz, Noah D Carrillo, Kristina A Matkowsky, Manabu Nukaya, Christopher A Bradfield, Sean M Ronnekleiv-Kelly
The pathogenesis of pancreas cancer (PDAC) remains poorly understood, hindering efforts to develop a more effective therapy for PDAC. Recent discoveries show the aryl hydrocarbon receptor (AHR) plays a crucial role in the development of several cancers, and can be targeted for therapeutic effect. However, its involvement in the pathogenesis of PDAC remains unclear. To address this gap, we evaluated the role of AHR in the development of PDAC pre-cancerous lesions in vivo.
{"title":"Aryl hydrocarbon receptor knockout accelerates PanIN formation and fibro-inflammation in a mutant Kras-driven pancreatic cancer model.","authors":"Morgan T Walcheck, Patrick B Schwartz, Noah D Carrillo, Kristina A Matkowsky, Manabu Nukaya, Christopher A Bradfield, Sean M Ronnekleiv-Kelly","doi":"10.1097/mpa.0000000000002357","DOIUrl":"https://doi.org/10.1097/mpa.0000000000002357","url":null,"abstract":"The pathogenesis of pancreas cancer (PDAC) remains poorly understood, hindering efforts to develop a more effective therapy for PDAC. Recent discoveries show the aryl hydrocarbon receptor (AHR) plays a crucial role in the development of several cancers, and can be targeted for therapeutic effect. However, its involvement in the pathogenesis of PDAC remains unclear. To address this gap, we evaluated the role of AHR in the development of PDAC pre-cancerous lesions in vivo.","PeriodicalId":19733,"journal":{"name":"Pancreas","volume":"11 1","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140836297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-01DOI: 10.1097/mpa.0000000000002349
Simon Sirtl, Katharina Bretthauer, Mahmood Ahmad, Eric Hohmann, Vanessa F Schmidt, Prince Allawadhi, Marlies Vornhülz, Sarah Klauss, Elisabetta Goni, Jakob Vielhauer, Elisabeth Orgler, Didem Saka, Mathilda Knoblauch, Felix O Hofmann, Jörg Schirra, Christian Schulz, Georg Beyer, Ujjwal M Mahajan, Julia Mayerle, Michal Zorniak
Severity of microlithiasis and sludge-induced pancreatitis in comparison to gallstone-induced pancreatitis has never been studied for a lack of definition. In order to understand whether bile duct obstruction or other mechanisms contribute to biliary pancreatitis severity we performed a monocentric, retrospective cohort study.
{"title":"Severity of gallstone, sludge or microlithiasis induced pancreatitis - all of the same?","authors":"Simon Sirtl, Katharina Bretthauer, Mahmood Ahmad, Eric Hohmann, Vanessa F Schmidt, Prince Allawadhi, Marlies Vornhülz, Sarah Klauss, Elisabetta Goni, Jakob Vielhauer, Elisabeth Orgler, Didem Saka, Mathilda Knoblauch, Felix O Hofmann, Jörg Schirra, Christian Schulz, Georg Beyer, Ujjwal M Mahajan, Julia Mayerle, Michal Zorniak","doi":"10.1097/mpa.0000000000002349","DOIUrl":"https://doi.org/10.1097/mpa.0000000000002349","url":null,"abstract":"Severity of microlithiasis and sludge-induced pancreatitis in comparison to gallstone-induced pancreatitis has never been studied for a lack of definition. In order to understand whether bile duct obstruction or other mechanisms contribute to biliary pancreatitis severity we performed a monocentric, retrospective cohort study.","PeriodicalId":19733,"journal":{"name":"Pancreas","volume":"6 1","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140836306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-01DOI: 10.1097/mpa.0000000000002350
Anastasiia M Zub, Bohdan O Manko, Volodymyr V Manko
Amino acids play an essential role in protein synthesis, metabolism and survival of pancreatic acini. Adequate nutritional support is important for acute pancreatitis treatment. However, high concentrations of arginine and lysine may induce acute pancreatitis. The study aimed to identify the most suitable L-amino acids as safe energy sources for pancreatic acinar cells.
{"title":"Screening of amino acids as a safe energy source for isolated rat pancreatic acini.","authors":"Anastasiia M Zub, Bohdan O Manko, Volodymyr V Manko","doi":"10.1097/mpa.0000000000002350","DOIUrl":"https://doi.org/10.1097/mpa.0000000000002350","url":null,"abstract":"Amino acids play an essential role in protein synthesis, metabolism and survival of pancreatic acini. Adequate nutritional support is important for acute pancreatitis treatment. However, high concentrations of arginine and lysine may induce acute pancreatitis. The study aimed to identify the most suitable L-amino acids as safe energy sources for pancreatic acinar cells.","PeriodicalId":19733,"journal":{"name":"Pancreas","volume":"8 1","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140836396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-01DOI: 10.1097/mpa.0000000000002344
Connor F Stewart, Esther A Adeniran, Dhiraj Yadav, Fred S Gorelick, Rodger A Liddle, Bechien Wu, Stephen J Pandol, Christie Y Jeon
Acute pancreatitis (AP) is a complex disease representing a significant portion of gastrointestinal-related hospitalizations in the U.S. Understanding risk factors of AP might provide attractive therapeutic targets. We evaluated hypophosphatemia as a risk factor for worse outcomes in AP.
{"title":"Early Hypophosphatemia as a Prognostic Marker in Acute Pancreatitis.","authors":"Connor F Stewart, Esther A Adeniran, Dhiraj Yadav, Fred S Gorelick, Rodger A Liddle, Bechien Wu, Stephen J Pandol, Christie Y Jeon","doi":"10.1097/mpa.0000000000002344","DOIUrl":"https://doi.org/10.1097/mpa.0000000000002344","url":null,"abstract":"Acute pancreatitis (AP) is a complex disease representing a significant portion of gastrointestinal-related hospitalizations in the U.S. Understanding risk factors of AP might provide attractive therapeutic targets. We evaluated hypophosphatemia as a risk factor for worse outcomes in AP.","PeriodicalId":19733,"journal":{"name":"Pancreas","volume":"44 1","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140836312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-01DOI: 10.1097/mpa.0000000000002345
Juanita N Chui, William A Ziaziaris, Christopher B Nahm, Talia Fuchs, Sumit Sahni, Christopher S H Lim, Anthony J Gill, Jaswinder S Samra DPhil, Anubhav Mittal
Postoperative pancreatic fistula(POPF) represents a leading cause of morbidity and mortality following major pancreatic resections. This study aimed to evaluate the use of post-operative drain fluid lipase-to-amylase ratio(LAR) for the prediction of clinically relevant fistulae(CR-POPF).
{"title":"Lipase-to-Amylase Ratio for the Prediction of Clinically Relevant Postoperative Pancreatic Fistula following Pancreaticoduodenectomy.","authors":"Juanita N Chui, William A Ziaziaris, Christopher B Nahm, Talia Fuchs, Sumit Sahni, Christopher S H Lim, Anthony J Gill, Jaswinder S Samra DPhil, Anubhav Mittal","doi":"10.1097/mpa.0000000000002345","DOIUrl":"https://doi.org/10.1097/mpa.0000000000002345","url":null,"abstract":"Postoperative pancreatic fistula(POPF) represents a leading cause of morbidity and mortality following major pancreatic resections. This study aimed to evaluate the use of post-operative drain fluid lipase-to-amylase ratio(LAR) for the prediction of clinically relevant fistulae(CR-POPF).","PeriodicalId":19733,"journal":{"name":"Pancreas","volume":"1 1","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140836169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-01DOI: 10.1097/mpa.0000000000002366
Antti Turunen, Krista Kuuliala, Antti Kuuliala, Pauli Puolakkainen, Leena Kylänpää, Johanna Hästbacka, Outi Lindström
To study fluid balance and endothelial glycocalyx degradation, reflected by syndedan-1 and heparan sulfate (HS) levels, in early stages of acute pancreatitis (AP).
研究急性胰腺炎（AP）早期的体液平衡和内皮糖萼降解（通过辛迪丹-1和硫酸肝素（HS）水平反映）。
{"title":"Syndecan-1 Levels and Early Positive Fluid Balance Are Associated with Disease Severity in Acute Pancreatitis.","authors":"Antti Turunen, Krista Kuuliala, Antti Kuuliala, Pauli Puolakkainen, Leena Kylänpää, Johanna Hästbacka, Outi Lindström","doi":"10.1097/mpa.0000000000002366","DOIUrl":"https://doi.org/10.1097/mpa.0000000000002366","url":null,"abstract":"To study fluid balance and endothelial glycocalyx degradation, reflected by syndedan-1 and heparan sulfate (HS) levels, in early stages of acute pancreatitis (AP).","PeriodicalId":19733,"journal":{"name":"Pancreas","volume":"1 1","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140842352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-01DOI: 10.1097/MPA.0000000000002348
Pamela O Emengo, Michelle K Kim, Celia M Divino
{"title":"Second Primary Neuroendocrine Tumors: A Case Series.","authors":"Pamela O Emengo, Michelle K Kim, Celia M Divino","doi":"10.1097/MPA.0000000000002348","DOIUrl":"10.1097/MPA.0000000000002348","url":null,"abstract":"","PeriodicalId":19733,"journal":{"name":"Pancreas","volume":"53 5","pages":"e467-e469"},"PeriodicalIF":1.7,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140904856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-01DOI: 10.1097/MPA.0000000000002347
Amedeo Sciarra, Alina Lungu, Charles Bénière, Sofia Facchi, Maria Grazia Tibiletti, Anna Maria Chiaravalli, Ian Fournier, Jean-Philippe Rey, Igor Letovanec, Stefano La Rosa
{"title":"Molecular Demonstration of the Tumorigenic Role of APC in Pancreatic Solid Pseudopapillary Neoplasm Widens the Spectrum of FAP-Associated Neoplasms.","authors":"Amedeo Sciarra, Alina Lungu, Charles Bénière, Sofia Facchi, Maria Grazia Tibiletti, Anna Maria Chiaravalli, Ian Fournier, Jean-Philippe Rey, Igor Letovanec, Stefano La Rosa","doi":"10.1097/MPA.0000000000002347","DOIUrl":"10.1097/MPA.0000000000002347","url":null,"abstract":"","PeriodicalId":19733,"journal":{"name":"Pancreas","volume":"53 5","pages":"e466-e467"},"PeriodicalIF":2.9,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140904890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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