Pub Date : 2022-03-11DOI: 10.1007/s00424-022-02677-9
H. Adrogue, A. Awan, N. Madias
{"title":"Determinants of hypokalemia following hypertonic sodium bicarbonate infusion","authors":"H. Adrogue, A. Awan, N. Madias","doi":"10.1007/s00424-022-02677-9","DOIUrl":"https://doi.org/10.1007/s00424-022-02677-9","url":null,"abstract":"","PeriodicalId":19762,"journal":{"name":"Pflügers Archiv - European Journal of Physiology","volume":"11 1","pages":"603 - 612"},"PeriodicalIF":0.0,"publicationDate":"2022-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73079694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-09DOI: 10.1007/s00424-022-02681-z
K. Overgaard, William Gittings, R. Vandenboom
{"title":"Potentiation of force by extracellular potassium and posttetanic potentiation are additive in mouse fast-twitch muscle in vitro","authors":"K. Overgaard, William Gittings, R. Vandenboom","doi":"10.1007/s00424-022-02681-z","DOIUrl":"https://doi.org/10.1007/s00424-022-02681-z","url":null,"abstract":"","PeriodicalId":19762,"journal":{"name":"Pflügers Archiv - European Journal of Physiology","volume":"36 1","pages":"637 - 646"},"PeriodicalIF":0.0,"publicationDate":"2022-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83096286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-03DOI: 10.1007/s00424-022-02680-0
D. V. van Helden
{"title":"Insights into permeability control of the fenestrated endothelium of the jejunal microvasculature","authors":"D. V. van Helden","doi":"10.1007/s00424-022-02680-0","DOIUrl":"https://doi.org/10.1007/s00424-022-02680-0","url":null,"abstract":"","PeriodicalId":19762,"journal":{"name":"Pflügers Archiv - European Journal of Physiology","volume":"20 1","pages":"485 - 486"},"PeriodicalIF":0.0,"publicationDate":"2022-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74741389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-02DOI: 10.1007/s00424-022-02675-x
R. Felix, David Muñoz-Herrera, Alejandra Corzo-López, Miriam Fernández-Gallardo, M. Leyva-Leyva, R. González-Ramírez, Alejandro Sandoval
{"title":"Ion channel long non-coding RNAs in neuropathic pain","authors":"R. Felix, David Muñoz-Herrera, Alejandra Corzo-López, Miriam Fernández-Gallardo, M. Leyva-Leyva, R. González-Ramírez, Alejandro Sandoval","doi":"10.1007/s00424-022-02675-x","DOIUrl":"https://doi.org/10.1007/s00424-022-02675-x","url":null,"abstract":"","PeriodicalId":19762,"journal":{"name":"Pflügers Archiv - European Journal of Physiology","volume":"4 1","pages":"457 - 468"},"PeriodicalIF":0.0,"publicationDate":"2022-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78414617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-02DOI: 10.1007/s00424-022-02678-8
L. Sommese, María Florencia Racioppi, Xin Shen, A. Orlowski, C. Valverde, W. Louch, M. Vila Petroff, L. Gonano
{"title":"Discordant Ca2+ release in cardiac myocytes: characterization and susceptibility to pharmacological RyR2 modulation","authors":"L. Sommese, María Florencia Racioppi, Xin Shen, A. Orlowski, C. Valverde, W. Louch, M. Vila Petroff, L. Gonano","doi":"10.1007/s00424-022-02678-8","DOIUrl":"https://doi.org/10.1007/s00424-022-02678-8","url":null,"abstract":"","PeriodicalId":19762,"journal":{"name":"Pflügers Archiv - European Journal of Physiology","volume":"207 1","pages":"625 - 636"},"PeriodicalIF":0.0,"publicationDate":"2022-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80466441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-02-28DOI: 10.1007/s00424-022-02679-7
Ľ. Lacinová
{"title":"Electrophysiology of nociception: understanding of signaling pathways forms a basis for potential treatment","authors":"Ľ. Lacinová","doi":"10.1007/s00424-022-02679-7","DOIUrl":"https://doi.org/10.1007/s00424-022-02679-7","url":null,"abstract":"","PeriodicalId":19762,"journal":{"name":"Pflügers Archiv - European Journal of Physiology","volume":"93 1","pages":"365 - 366"},"PeriodicalIF":0.0,"publicationDate":"2022-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74749152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-10-01DOI: 10.1101/2021.09.30.462664
Victor De la Rosa, M. Guzmán-Hernández, Elisa Carrillo
KCNQ channels participate in the physiology of several cell types. In neurons of the central nervous system, the primary subunits are KCNQ2, 3, and 5. Activation of these channels silence the neurons, limiting action potential duration and preventing high-frequency action potential burst. Loss-of-function mutations of the KCNQ channels are associated with a wide spectrum of phenotypes characterized by hyperexcitability. Hence, pharmacological activation of these channels is an attractive strategy to treat epilepsy and other hyperexcitability conditions as are the evolution of stroke and traumatic brain injury. In this work we show that triclosan, a bactericide widely used in personal care products, activates the KCNQ3 channels but not the KCNQ2. Triclosan induces a voltage shift in the activation, increases the conductance, and slows the closing of the channel. The response is independent of PIP2. Molecular docking simulations together with site-directed mutagenesis suggest that the putative binding site is in the voltage sensor domain. Our results indicate that triclosan is a new activator for KCNQ channels.
{"title":"Triclosan is a KCNQ3 potassium channel activator","authors":"Victor De la Rosa, M. Guzmán-Hernández, Elisa Carrillo","doi":"10.1101/2021.09.30.462664","DOIUrl":"https://doi.org/10.1101/2021.09.30.462664","url":null,"abstract":"KCNQ channels participate in the physiology of several cell types. In neurons of the central nervous system, the primary subunits are KCNQ2, 3, and 5. Activation of these channels silence the neurons, limiting action potential duration and preventing high-frequency action potential burst. Loss-of-function mutations of the KCNQ channels are associated with a wide spectrum of phenotypes characterized by hyperexcitability. Hence, pharmacological activation of these channels is an attractive strategy to treat epilepsy and other hyperexcitability conditions as are the evolution of stroke and traumatic brain injury. In this work we show that triclosan, a bactericide widely used in personal care products, activates the KCNQ3 channels but not the KCNQ2. Triclosan induces a voltage shift in the activation, increases the conductance, and slows the closing of the channel. The response is independent of PIP2. Molecular docking simulations together with site-directed mutagenesis suggest that the putative binding site is in the voltage sensor domain. Our results indicate that triclosan is a new activator for KCNQ channels.","PeriodicalId":19762,"journal":{"name":"Pflügers Archiv - European Journal of Physiology","volume":"71 1","pages":"721 - 732"},"PeriodicalIF":0.0,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77848888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-06-01DOI: 10.1007/s00424-020-02409-x
H. Murer, Carsten A. Wagner
{"title":"Gerhard Giebisch (1927–2020): a pioneer of kidney physiology","authors":"H. Murer, Carsten A. Wagner","doi":"10.1007/s00424-020-02409-x","DOIUrl":"https://doi.org/10.1007/s00424-020-02409-x","url":null,"abstract":"","PeriodicalId":19762,"journal":{"name":"Pflügers Archiv - European Journal of Physiology","volume":"69 1","pages":"637 - 638"},"PeriodicalIF":0.0,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84317439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-11-28DOI: 10.1007/s00424-019-02332-w
Lærke Bertholdt, Anders Gudiksen, S. Ringholm, H. Pilegaard
{"title":"Impact of skeletal muscle IL-6 on subcutaneous and visceral adipose tissue metabolism immediately after high- and moderate-intensity exercises","authors":"Lærke Bertholdt, Anders Gudiksen, S. Ringholm, H. Pilegaard","doi":"10.1007/s00424-019-02332-w","DOIUrl":"https://doi.org/10.1007/s00424-019-02332-w","url":null,"abstract":"","PeriodicalId":19762,"journal":{"name":"Pflügers Archiv - European Journal of Physiology","volume":"1 1","pages":"217 - 233"},"PeriodicalIF":0.0,"publicationDate":"2019-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82380008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-11-22DOI: 10.1007/s00424-019-02334-8
J. Fandrey, J. Schödel, K. Eckardt, D. Katschinski, Roland H. Wenger
{"title":"Now a Nobel gas: oxygen","authors":"J. Fandrey, J. Schödel, K. Eckardt, D. Katschinski, Roland H. Wenger","doi":"10.1007/s00424-019-02334-8","DOIUrl":"https://doi.org/10.1007/s00424-019-02334-8","url":null,"abstract":"","PeriodicalId":19762,"journal":{"name":"Pflügers Archiv - European Journal of Physiology","volume":"126 1","pages":"1343 - 1358"},"PeriodicalIF":0.0,"publicationDate":"2019-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76701553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：