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The Comparison of Intraarticular Bipolar Pulsed Radiofrequency and Genicular Nerve Thermal Radiofrequency Ablation for Pain Caused by Osteoarthritis of the Knee. 关节内双极脉冲射频与膝神经热射频消融治疗膝关节骨性关节炎疼痛的比较。
IF 2.5 2区 医学 Q2 ANESTHESIOLOGY Pub Date : 2025-12-01
Cigdem Yalcin, Mehmet Alper Salman
<p><strong>Background: </strong>Information on the use of intraarticular bipolar pulsed radiofrequency (IA-bPRF) for treating knee osteoarthritis (KOA) is currently limited, and the effectiveness of this technique is not well established. The most effective nonsurgical approach for alleviating pain caused by KOA is still not well-defined.</p><p><strong>Objectives: </strong>Our aim was to investigate the effects of genicular radiofrequency (G-RFT) and IA-bPRF on pain relief and functional improvement in patients with advanced KOA.</p><p><strong>Study design: </strong>Records of 86 patients with KOA who received either G-RFT or IA-bPRF were evaluated retrospectively.</p><p><strong>Setting: </strong>The pain clinic of a state hospital.</p><p><strong>Methods: </strong>KOA patients who received either G-RFT or IA-bPRF were included in the study. The files of patients who were given such interventions between September 2021 and February 2024 were analyzed. Walking pain was evaluated on the numeric rating scale (NRS). Functional assessments were performed using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and the Lequesne Algofunctional Index for Knee (LAI-knee). These evaluations were carried out before the intervention, as well as 2 weeks and 6 months after it.</p><p><strong>Results: </strong>The IA-bPRF group showed significant improvement in NRS scores when pre-intervention scores were compared to those recorded at the sixth month after the surgery, dropping from 8.62 ± 1.01 to 3.81 ± 1.18, while the scores of the G-RFT group improved from 8.90 ± 1.20 to 5.25 ± 3.40. At the sixth month, WOMAC scores decreased from 75.79 ± 16.00 to 34.21 ± 23.12 in the IA-bPRF group and from 79.02 ± 14.73 to 48.43 ± 30.87 in the G-RFT group. From the pre-intervention period to the sixth month after the procedure, LAI-knee scores went from 18.64 ± 4.16 to 9.90 ± 5.78 in the IA-bPRF group and from 18.89 ± 3.84 to 12.55 ± 7.33 in the G-RFT group. All decreases were significant (P < 0.05). However, WOMAC physical function scores decreased more in the IA-bPRF group than in the G-RFT group (P < 0.05). No serious adverse events occurred.</p><p><strong>Limitations: </strong>Our study is subject to several limitations. Primarily, there is a paucity of extensive literature regarding the application of IA-bPRF for KOA. Additionally, our study's sample size is relatively small. This study was conducted at a single center and was retrospective in nature, rather than prospective and randomized, making it challenging to fully control for nuisance variables. Finally, there is a scarcity of comparable studies. These factors may constrain the external validity of our findings.</p><p><strong>Conclusions: </strong>Pain incurred while walking on flat surfaces and up and down stairs was further reduced with IA-bPRF. IA-bPRF is as effective as G-RFT and even more effective than the latter in some subheadings. Furthermore, the former is a safe alternative for r
背景:目前关于关节内双极脉冲射频(IA-bPRF)治疗膝骨关节炎(KOA)的信息有限,该技术的有效性尚未得到很好的证实。缓解KOA引起的疼痛的最有效的非手术方法仍然没有明确的定义。目的:我们的目的是研究遗传射频(G-RFT)和IA-bPRF对晚期KOA患者疼痛缓解和功能改善的影响。研究设计:回顾性评价86例接受G-RFT或IA-bPRF治疗的KOA患者的记录。环境:国立医院的疼痛门诊。方法:将接受G-RFT或IA-bPRF治疗的KOA患者纳入研究。分析了2021年9月至2024年2月期间接受此类干预的患者档案。采用数字评定量表(NRS)对行走疼痛进行评定。使用西安大略和麦克马斯特大学骨关节炎指数(WOMAC)和膝关节Lequesne算法功能指数(LAI-knee)进行功能评估。这些评估在干预前以及干预后2周和6个月进行。结果:IA-bPRF组干预前NRS评分较术后6个月有明显改善,由8.62±1.01降至3.81±1.18,G-RFT组由8.90±1.20降至5.25±3.40。6个月时,IA-bPRF组WOMAC评分从75.79±16.00降至34.21±23.12,G-RFT组从79.02±14.73降至48.43±30.87。从干预前到手术后6个月,IA-bPRF组lai -膝关节评分从18.64±4.16上升到9.90±5.78,G-RFT组从18.89±3.84上升到12.55±7.33。均显著降低(P < 0.05)。IA-bPRF组WOMAC身体功能评分下降幅度大于G-RFT组(P < 0.05)。未发生严重不良事件。局限性:本研究存在一些局限性。首先,缺乏关于IA-bPRF在KOA中的应用的广泛文献。此外,我们的研究样本量相对较小。本研究在单中心进行,本质上是回顾性的,而不是前瞻性和随机的,因此很难完全控制有害变量。最后,缺乏可比较的研究。这些因素可能会限制我们研究结果的外部有效性。结论:IA-bPRF进一步减轻了在平面上行走和上下楼梯时产生的疼痛。IA-bPRF与G-RFT一样有效,在某些副标题中甚至比后者更有效。此外,前者是一个安全的选择,减轻疼痛和改善个人的日常生活与高级KOA。随着进一步的研究,IA-bPRF可能会被纳入治疗慢性KOA疼痛的未来指南中。
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引用次数: 0
2025 Index by Content. 2025按内容索引。
IF 2.5 2区 医学 Q2 ANESTHESIOLOGY Pub Date : 2025-12-01
Asipp
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引用次数: 0
2025 Index by Key Words. 2025关键词指数。
IF 2.5 2区 医学 Q2 ANESTHESIOLOGY Pub Date : 2025-12-01
Asipp
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引用次数: 0
2025 Index by Author. 2025作者索引。
IF 2.5 2区 医学 Q2 ANESTHESIOLOGY Pub Date : 2025-12-01
Asipp
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引用次数: 0
Impact of Lead-shielding on the Utilization of Magnetic Resonance Imaging Among Patients with Spinal Cord Stimulation Systems: A Study of Retrospective Claims in the US. 铅屏蔽对脊髓刺激系统患者使用磁共振成像的影响:美国回顾性研究
IF 2.5 2区 医学 Q2 ANESTHESIOLOGY Pub Date : 2025-12-01
Yair Safriel, Nomen Azeem, Samir Sheth, Marilyn Moucharite, Nicolas Gasquet, Charlotte Wu, Christine Ricker
<p><strong>Background: </strong>Spinal cord stimulation (SCS) is an effective approach to managing chronic, intractable pain. However, even when the designs of SCS devices are compatible with magnetic resonance imaging (MRI), migration and the fracture or wire breakage of epidural leads can result in increased lead impedance and a requirement that the devices be explanted before safe imaging can take place. Selected SCS systems are designed with other technical features. Specifically, lead shielding (lead wires are encased in a matrix-like tantalum shield) serves to dissipate radiofrequency energy along the lead to reduce the risk of thermal tissue damage during MRI scans- even when lead impedance is out of range.</p><p><strong>Objectives: </strong>To compare the rates of MRI and SCS device explantation in patients who had SCS systems with lead-shielding SCS (LS-SCS) to those who had systems without lead-shielding SCS (non-LS-SCS), and to understand the clinical implications of those findings.</p><p><strong>Study design: </strong>A retrospective study of noninterventional administrative-claims data.</p><p><strong>Setting: </strong>The Center for Medicare and Medicaid Services (CMS) Research Identifiable Files (RIF).</p><p><strong>Methods: </strong>Any patient with continuous coverage who underwent implantation of an SCS system within the year 2018 and had no prior history of SCS, a failed neuromodulation device, or peripheral nerve stimulation was eligible. The analysis time frame included a one-year, pre-implantation baseline period and a 3-year post-implantation follow-up period. Claims were analyzed for post-implantation MRI use, SCS-system explantation, and post-MRI diagnoses. The measurements consisted of the time until the first MRI, the anatomic location of the MRI, the post-MRI diagnosis, the incidence of SCS explantation, and the time from explantation to MRI.</p><p><strong>Results: </strong>Of the 27,636 patients (59% female, 72% aged 65 years or older, and 91% white) who met the eligibility criteria, 18% were implanted with LS-SCS, and 82% were implanted with non-LS-SCS devices between Jan 1 and Dec 31, 2018. Significantly more patients (37.6%) with LS-SCS devices underwent MRI than did patients with non-LS-SCS devices (24.3%; 54.7% relative difference, P = 0.0007), and significantly fewer LS-SCS patients underwent explantation followed by MRI than did patients in the non-LS-SCS cohort (18.9% vs. 28.8%, P < 0.001). Approximately half of the MRI procedures were for spinal imaging in both cohorts, and the most common new diagnoses in the 30 days after the MRI included osteoarthritis, non-VCF injury/fractures, and cancer. Bivariate survival analysis showed that patients with LS-SCS devices had a significantly higher probability of undergoing MRI sooner than patients with non-LS-SCS devices  (71.6% higher in adjusted hazard analysis; P < 0.001).</p><p><strong>Limitations: </strong>This study was a retrospective claims analysis, subject to
背景:脊髓刺激(SCS)是治疗慢性顽固性疼痛的有效方法。然而,即使SCS设备的设计与磁共振成像(MRI)兼容,硬膜外引线的迁移和断裂或断线也会导致引线阻抗增加,并且需要在进行安全成像之前将设备取出。选定的SCS系统设计具有其他技术特征。具体来说,铅屏蔽(引线被包裹在一个类似矩阵的钽屏蔽中)用于消散沿引线的射频能量,以减少MRI扫描期间热组织损伤的风险-即使在引线阻抗超出范围时也是如此。目的:比较具有铅屏蔽SCS (LS-SCS)的SCS系统与没有铅屏蔽SCS(非LS-SCS)的SCS系统患者的MRI和SCS装置外植率,并了解这些发现的临床意义。研究设计:对非干预性行政索赔数据进行回顾性研究。设置:医疗保险和医疗补助服务中心(CMS)研究可识别文件(RIF)。方法:任何在2018年内接受SCS系统植入且既往无SCS病史、神经调节装置失败或周围神经刺激的连续覆盖患者均符合条件。分析时间框架包括1年的植入前基线期和3年的植入后随访期。对植入后MRI使用、scs系统外植和MRI后诊断的索赔进行分析。测量包括到第一次MRI的时间,MRI的解剖位置,MRI后诊断,SCS外植的发生率,以及从外植到MRI的时间。结果:在2018年1月1日至12月31日期间,符合资格标准的27,636例患者(59%为女性,72%为65岁或以上,91%为白人)中,18%植入了LS-SCS, 82%植入了非LS-SCS装置。使用LS-SCS装置的患者接受MRI的比例(37.6%)明显高于非LS-SCS装置的患者(24.3%;相对差异为54.7%,P = 0.0007),并且与非LS-SCS队列患者相比,移植后MRI的LS-SCS患者显著减少(18.9% vs. 28.8%, P < 0.001)。在两个队列中,大约一半的MRI检查是用于脊柱成像的,MRI检查后30天内最常见的新诊断包括骨关节炎、非vcf损伤/骨折和癌症。双变量生存分析显示,使用LS-SCS装置的患者比未使用LS-SCS装置的患者更早接受MRI的可能性显著更高(校正风险分析高71.6%,P < 0.001)。局限性:这项研究是一项回顾性的索赔分析,在数据质量和完整性、编码、研究变量的可用性以及无法区分相关性和因果关系方面存在潜在的不一致性。结论:与非LS-SCS治疗的患者相比,使用LS-SCS装置的患者使用MRI的比例更高,近四分之一的scs装置外植体可能与促进MRI安全使用有关。研究结果表明,MRI兼容性具有潜在的影响,在选择SCS系统时应考虑到这一点。
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引用次数: 0
Lumbar Medial Branch Radiofrequency Ablation: Technical Suggestions Based on Emerging Ex-Vivo Evidence. 腰椎内侧支射频消融:基于离体证据的技术建议。
IF 2.5 2区 医学 Q2 ANESTHESIOLOGY Pub Date : 2025-12-01
Kevin S Batti, Joshua B Lewis, Ugur Yener, Alan D Kaye, Sayed E Wahezi

Background: Facetogenic pain accounts for 5-50% of chronic low back pain (CLBP) cases, and the prevalence of this pain increases with age. Because of poor imaging correlation, the diagnosis is challenging and relies on symptoms, exam findings, and "gold standard" diagnostic blocks, though optimal protocols remain debated. National societies have issued treatment recommendations for the condition, yet controversy persists. The present investigation focuses on medial branch block radiofrequency ablation (RFA) and highlights key factors for optimizing technique to improve patient outcomes.

Objectives: To demonstrate proper technique and factors that clinicians should consider to maximize the effectiveness of MBN RFA.

Study design: Development of methodology integrating ex vivo evidence and clinical approach.

Setting: An academic healthcare institution.

Methods: A PubMed review of article published between 2020 and 2025 was performed using the keywords "ex vivo," "radiofrequency ablation," and "lesion size." RFA of medial branch nerves (MBNs) relies on precise anatomical knowledge to ensure proper needle placement. Recent studies have demonstrated that there are multiple factors to consider in MBN RFA. When compared to muscle, adipose reduces lesion size in relation to lower thermal conductivity. Adipose around the needle decreases lesion size, which may explain the reduced efficacy of RFA in obese patients. Commonly used solutions impact lesion dimensions: 2% lidocaine increases lesional width, while iohexol 240 increases length. In addition, a probe's proximity to bone increases lesion size, as poor thermal conductance traps energy in adjacent tissues. Therefore, shape and size can be modified in accordance with medication selection and the active tip's juxtaposition to tissue.

Limitations: Despite advancements, significant knowledge gaps remain in understanding the effectiveness of RFA, since most studies focus on tumor ablation rather than neurolysis, and lack in-vivo data. To improve real-world clinical outcomes, future research should evaluate functional outcomes and pain relief in patients undergoing individualized procedures tailored to their unique anatomy.

Conclusions: RFA of MBNs is a valuable way to treat axial, facetogenic low back pain. The technique should be optimized to best account for the unique anatomy of each patient and thereby maximize the effectiveness of the procedure.

背景:脸源性疼痛占慢性腰痛(CLBP)病例的5-50%,这种疼痛的患病率随着年龄的增长而增加。由于影像相关性差,诊断具有挑战性,依赖于症状、检查结果和“金标准”诊断块,尽管最佳方案仍存在争议。国家协会已经发布了针对这种情况的治疗建议,但争议仍然存在。目前的研究重点是内侧分支阻断射频消融(RFA),并强调了优化技术以改善患者预后的关键因素。目的:展示适当的技术和临床医生应该考虑的因素,以最大限度地提高MBN射频消融的有效性。研究设计:发展结合离体证据和临床方法的方法学。环境:学术医疗机构。方法:使用关键词“离体”、“射频消融”和“病变大小”对2020年至2025年间发表的文章进行PubMed回顾。内侧支神经(MBNs)的射频消融依赖于精确的解剖学知识来确保针的正确放置。最近的研究表明,MBN RFA有多种因素需要考虑。当与肌肉相比,脂肪减少病变大小与较低的热导率。针周围的脂肪减少了病变的大小,这可能解释了RFA在肥胖患者中的疗效降低。常用溶液影响病变尺寸:2%利多卡因增加病变宽度,而碘己醇240增加病变长度。此外,探针靠近骨骼会增加病变的大小,因为差的热导会将能量困在邻近的组织中。因此,可以根据药物的选择和活动尖端与组织的并置来修改形状和大小。局限性:尽管取得了进展,但在了解RFA的有效性方面仍存在显著的知识差距,因为大多数研究侧重于肿瘤消融而不是神经松解,并且缺乏体内数据。为了改善现实世界的临床结果,未来的研究应该评估患者在接受个性化手术时的功能结果和疼痛缓解情况。结论:MBNs RFA是治疗轴向、面源性腰痛的有效方法。该技术应优化,以最好地考虑到每个病人的独特解剖结构,从而最大限度地提高手术的有效性。
{"title":"Lumbar Medial Branch Radiofrequency Ablation: Technical Suggestions Based on Emerging Ex-Vivo Evidence.","authors":"Kevin S Batti, Joshua B Lewis, Ugur Yener, Alan D Kaye, Sayed E Wahezi","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Facetogenic pain accounts for 5-50% of chronic low back pain (CLBP) cases, and the prevalence of this pain increases with age. Because of poor imaging correlation, the diagnosis is challenging and relies on symptoms, exam findings, and \"gold standard\" diagnostic blocks, though optimal protocols remain debated. National societies have issued treatment recommendations for the condition, yet controversy persists. The present investigation focuses on medial branch block radiofrequency ablation (RFA) and highlights key factors for optimizing technique to improve patient outcomes.</p><p><strong>Objectives: </strong>To demonstrate proper technique and factors that clinicians should consider to maximize the effectiveness of MBN RFA.</p><p><strong>Study design: </strong>Development of methodology integrating ex vivo evidence and clinical approach.</p><p><strong>Setting: </strong>An academic healthcare institution.</p><p><strong>Methods: </strong>A PubMed review of article published between 2020 and 2025 was performed using the keywords \"ex vivo,\" \"radiofrequency ablation,\" and \"lesion size.\" RFA of medial branch nerves (MBNs) relies on precise anatomical knowledge to ensure proper needle placement. Recent studies have demonstrated that there are multiple factors to consider in MBN RFA. When compared to muscle, adipose reduces lesion size in relation to lower thermal conductivity. Adipose around the needle decreases lesion size, which may explain the reduced efficacy of RFA in obese patients. Commonly used solutions impact lesion dimensions: 2% lidocaine increases lesional width, while iohexol 240 increases length. In addition, a probe's proximity to bone increases lesion size, as poor thermal conductance traps energy in adjacent tissues. Therefore, shape and size can be modified in accordance with medication selection and the active tip's juxtaposition to tissue.</p><p><strong>Limitations: </strong>Despite advancements, significant knowledge gaps remain in understanding the effectiveness of RFA, since most studies focus on tumor ablation rather than neurolysis, and lack in-vivo data. To improve real-world clinical outcomes, future research should evaluate functional outcomes and pain relief in patients undergoing individualized procedures tailored to their unique anatomy.</p><p><strong>Conclusions: </strong>RFA of MBNs is a valuable way to treat axial, facetogenic low back pain. The technique should be optimized to best account for the unique anatomy of each patient and thereby maximize the effectiveness of the procedure.</p>","PeriodicalId":19841,"journal":{"name":"Pain physician","volume":"28 S7","pages":"S137-S143"},"PeriodicalIF":2.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145892767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Letter to all MACs regarding Proposed LCD - Peripheral Nerve Blocks and Procedures for Chronic Pain. 致所有mac关于建议LCD -周围神经阻滞和慢性疼痛的程序的信。
IF 2.5 2区 医学 Q2 ANESTHESIOLOGY Pub Date : 2025-12-01
Laxmaiah Manchikanti, Mahendra Sanapati, Annu Navani, Amol Soin
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引用次数: 0
Six-Month Interim Outcomes of the SPARTAN Study: A Prospective, Multicenter, Post-Market Surveillance Study on a Modular SI Joint Fusion System. SPARTAN研究的六个月中期结果:模块化SI关节融合系统的前瞻性、多中心、上市后监测研究。
IF 2.5 2区 医学 Q2 ANESTHESIOLOGY Pub Date : 2025-12-01
Samuel P Brown, Lee James, Gregory Moore, Caitlin Tourje, Farid Kia, Alireza Katouzian, Philip Sasso, Emmanuel Gage, Robert Michael Hullander, Michael Drass, Brian Durkin
<p><strong>Background: </strong>Low back pain (LBP) is the most common type of pain reported by adults and the leading cause of disability globally. The sacroiliac joint (SIJ)-the large, load-bearing joint that connects the pelvis and lower spine-is one of the most underrecognized causes of LBP and has been determined to be a source of the condition in 10-38% of cases. While SIJ fusion has been shown to be a superior alternative to the long-term conservative management of SIJ dysfunction, many early SIJ fusion techniques have resulted in high incidences of adverse events (AEs) and serious adverse events (SAEs), long recovery times, and, often, the need for revision surgeries.</p><p><strong>Objectives: </strong>To prospectively assess the effectiveness of a minimally invasive lateral oblique approach to SIJ fusion that uses TransLoc 3DTM Sacroiliac Joint Fusion System (CornerLoc™) compression screws, based on patient-reported outcome measures of pain and functional improvement.</p><p><strong>Study design: </strong>Prospective study.</p><p><strong>Setting: </strong>Seventeen pain centers across the United States.</p><p><strong>Methods: </strong>Between November 13, 2023, and December 31, 2024, 114 patients underwent SIJ fusion via TransLoc 3DTM SIJ fusion compression screws in a procedure that used a minimally invasive lateral oblique approach. Outcomes for pain and functional improvement were assessed both before the procedure and at 3 (n = 85) and 6 (n = 72) months after it. Those outcomes were measured on the Numeric Rating Scale (NRS), Oswestry Disability Index (ODI), and Quebec Back Pain Disability Scale (QBPDS). Additionally, the safety and efficacy of the procedure were assessed using a composite endpoint comprising improvement in both NRS and ODI scores as well as the absence of AEs or SAEs. Comparisons between the groups of patients were performed using Student's t-test for continuous data or Fisher's exact test for categorical data. Mixed models for repeat measures were used to model factors associated with each endpoint longitudinally and generalized linear models for interim tests. All patients provided consent to participate in the study, and approval was obtained from the institutional review board (approval number 1356747).</p><p><strong>Results: </strong>The average age of the patients at the baseline was 67.1 ± 10.5 years, and 70.8% were female. Our results show significant improvements in pain and functional outcomes from the baseline, as assessed by both the composite endpoint and individual measures (i.e., NRS, ODI, and QBPDS), 3 and 6 months after the procedure (P < 2.2 e-16 for all measures). Furthermore, 72.94% of patients reported improvements in both their NRS pain scores and ODI function scores within 3 months, while 90.3% reported an improvement at 6 months. Additionally, 84.7% of patients reported an improvement in their QBPDS scores within 6 months. A significant majority of patients experienced greater than 20% improve
背景:腰痛(LBP)是成年人报告的最常见的疼痛类型,也是全球致残的主要原因。骶髂关节(SIJ)——连接骨盆和下脊柱的大而承重的关节——是腰痛最不为人所知的病因之一,已确定是10-38%病例的病因。虽然SIJ融合已被证明是SIJ功能障碍长期保守治疗的一种优越选择,但许多早期SIJ融合技术导致不良事件(ae)和严重不良事件(sae)的发生率高,恢复时间长,并且通常需要翻修手术。目的:基于患者报告的疼痛和功能改善的结果测量,前瞻性评估微创侧斜入路使用TransLoc 3DTM骶髂关节融合系统(CornerLoc™)加压螺钉进行SIJ融合的有效性。研究设计:前瞻性研究。背景:全美有17个疼痛中心。方法:在2023年11月13日至2024年12月31日期间,114例患者采用微创侧斜入路,通过TransLoc 3DTM SIJ融合压缩螺钉行SIJ融合。术前和术后3个月(n = 85)和6个月(n = 72)分别评估疼痛和功能改善的结果。这些结果通过数字评定量表(NRS)、Oswestry残疾指数(ODI)和魁北克背痛残疾量表(QBPDS)进行测量。此外,使用复合终点评估该手术的安全性和有效性,包括NRS和ODI评分的改善以及ae或sae的缺失。患者组间比较采用连续数据的学生t检验或分类数据的Fisher精确检验。重复测量的混合模型用于纵向模拟与每个终点相关的因素,并用于中期试验的广义线性模型。所有患者均同意参与研究,并获得机构审查委员会的批准(批准号1356747)。结果:基线时患者平均年龄为67.1±10.5岁,女性占70.8%。我们的结果显示,在手术后3个月和6个月,通过综合终点和单项测量(即NRS、ODI和QBPDS)评估,疼痛和功能结果较基线有显著改善(所有测量的P < 2.2 e-16)。此外,72.94%的患者报告在3个月内NRS疼痛评分和ODI功能评分均有改善,而90.3%的患者报告在6个月内有所改善。此外,84.7%的患者报告他们的QBPDS评分在6个月内有所改善。绝大多数患者在3个月和6个月时的所有结局指标改善均超过20% (P < 2.16e-16)。SIJ融合术无不良反应或不良反应报告。局限性:患者报告了结果,并且分析只有单组。结论:本研究的结果表明,使用3d打印钛压缩螺钉的微创侧斜入路SIJ融合患者获得了显着的益处。
{"title":"Six-Month Interim Outcomes of the SPARTAN Study: A Prospective, Multicenter, Post-Market Surveillance Study on a Modular SI Joint Fusion System.","authors":"Samuel P Brown, Lee James, Gregory Moore, Caitlin Tourje, Farid Kia, Alireza Katouzian, Philip Sasso, Emmanuel Gage, Robert Michael Hullander, Michael Drass, Brian Durkin","doi":"","DOIUrl":"","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Low back pain (LBP) is the most common type of pain reported by adults and the leading cause of disability globally. The sacroiliac joint (SIJ)-the large, load-bearing joint that connects the pelvis and lower spine-is one of the most underrecognized causes of LBP and has been determined to be a source of the condition in 10-38% of cases. While SIJ fusion has been shown to be a superior alternative to the long-term conservative management of SIJ dysfunction, many early SIJ fusion techniques have resulted in high incidences of adverse events (AEs) and serious adverse events (SAEs), long recovery times, and, often, the need for revision surgeries.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Objectives: &lt;/strong&gt;To prospectively assess the effectiveness of a minimally invasive lateral oblique approach to SIJ fusion that uses TransLoc 3DTM Sacroiliac Joint Fusion System (CornerLoc™) compression screws, based on patient-reported outcome measures of pain and functional improvement.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Study design: &lt;/strong&gt;Prospective study.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Setting: &lt;/strong&gt;Seventeen pain centers across the United States.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;Between November 13, 2023, and December 31, 2024, 114 patients underwent SIJ fusion via TransLoc 3DTM SIJ fusion compression screws in a procedure that used a minimally invasive lateral oblique approach. Outcomes for pain and functional improvement were assessed both before the procedure and at 3 (n = 85) and 6 (n = 72) months after it. Those outcomes were measured on the Numeric Rating Scale (NRS), Oswestry Disability Index (ODI), and Quebec Back Pain Disability Scale (QBPDS). Additionally, the safety and efficacy of the procedure were assessed using a composite endpoint comprising improvement in both NRS and ODI scores as well as the absence of AEs or SAEs. Comparisons between the groups of patients were performed using Student's t-test for continuous data or Fisher's exact test for categorical data. Mixed models for repeat measures were used to model factors associated with each endpoint longitudinally and generalized linear models for interim tests. All patients provided consent to participate in the study, and approval was obtained from the institutional review board (approval number 1356747).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;The average age of the patients at the baseline was 67.1 ± 10.5 years, and 70.8% were female. Our results show significant improvements in pain and functional outcomes from the baseline, as assessed by both the composite endpoint and individual measures (i.e., NRS, ODI, and QBPDS), 3 and 6 months after the procedure (P &lt; 2.2 e-16 for all measures). Furthermore, 72.94% of patients reported improvements in both their NRS pain scores and ODI function scores within 3 months, while 90.3% reported an improvement at 6 months. Additionally, 84.7% of patients reported an improvement in their QBPDS scores within 6 months. A significant majority of patients experienced greater than 20% improve","PeriodicalId":19841,"journal":{"name":"Pain physician","volume":"28 S7","pages":"S191-S202"},"PeriodicalIF":2.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145892798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comprehensive Evidence-Based Guidelines for Regenerative Therapies in the Management of Chronic Low Back Pain: 2025 Update from the American Society Of Interventional Pain Physicians (ASIPP). 美国介入性疼痛医师学会(ASIPP)发布的《慢性腰痛再生治疗综合循证指南:2025年更新》。
IF 2.5 2区 医学 Q2 ANESTHESIOLOGY Pub Date : 2025-12-01
Laxmaiah Manchikanti, Riya Navani, Annu Navani, Mahendra Sanapati, Alan D Kaye, Adam M Kaye, Amol Soin, Devi Nampiaparampil, Kenneth D Candido, Alaa Abd-Elsayed, Theodore T Sand, Navneet Boddu, Sairam Atluri, Anss Annie Augustine, Dajie Wang, John Santa Ana, Lady Christine Ong Sio, Vidyasagar Pampati, Michael Khadavi, Nebojsa Nick Knezevic, Robert Farhat, Shivam S Shah, Shounuck J Patel, Tom Nabity, Alexander Bautista, Aaron K Calodney, Joseph Cabaret, Miles R Day, Paul J Christo, Sanjay Bakshi, Shalini Shah, Sheldon Jordan, Sheri L Albers, Vivek Manocha, Joshua A Hirsch
<p><strong>Background: </strong>Regenerative medicine is an evolving medical subspecialty dedicated to enhancing the body's natural healing mechanisms to repair or replace damaged tissues. By using autologous or allogeneic biologics, it offers the potential to restore function where conventional therapies have shown limited success. While this field holds great promise and continues to generate enthusiasm among both patients and clinicians, it remains in early stages of clinical validation. Therefore, it must be approached with careful optimism and responsible application, ensuring that its presentation, promotion, and use in clinical settings are grounded in evidence and ethical standards.</p><p><strong>Objective: </strong>To provide updated, evidence-based recommendations for the role of regenerative therapies in managing moderate to severe chronic low back pain.</p><p><strong>Methods: </strong>A multidisciplinary panel of experts, convened by the American Society of Interventional Pain Physicians (ASIPP), systematically reviewed the current evidence and incorporated patient perspectives to develop practical, evidence-informed recommendations. The process included defining key clinical questions, reviewing the literature, formulating evidence-based statements, and reaching consensus through structured discussions and formal voting.</p><p><strong>Results: </strong>A total of 35 authors contributed to the development of these guidelines, with 33 experts participating in the formal consensus process. Altogether, 19 recommendations were generated, with all of them achieving 100% agreement. These recommendations were informed by a comprehensive review of systematic reviews, randomized controlled trials (RCTs), and observational studies encompassing a broad range of regenerative therapies.Evidence was appraised using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) methodology to determine certainty levels. Both qualitative and quantitative analyses were applied to synthesize the best available data, resulting in evidence-based recommendations summarized below.Intradiscal Injections (PRP): Evidence Level: III, Fair; Consensus-Based Clinical Recommendation: ModerateIntradiscal Injections (BMAC): Evidence Level: III, Fair; Consensus-Based Clinical Recommendation: ModerateEpidural Injections (PRP): Evidence Level: III, Fair; Consensus-Based Clinical Recommendation: ModerateFacet Joint Injections (PRP and MSCs): Evidence Level: IV, Limited; Consensus-Based Clinical Recommendation: Moderate Sacroiliac Joint Injections (PRP): Evidence Level: IV, Limited; Consensus-Based Clinical Recommendation:  Low Functional Spine Unit Injections Evidence Level: Very Low; Consensus-Based Clinical Recommendation:Low.</p><p><strong>Limitations: </strong>The primary limitation of these guidelines is the scarcity of high-quality studies, with much of the available evidence derived from small or heterogeneous trials.</p><p><strong>Precautions: </
背景:再生医学是一个不断发展的医学分支,致力于增强人体的自然愈合机制,以修复或替换受损组织。通过使用自体或同种异体生物制剂,它提供了恢复功能的潜力,而传统疗法已经显示出有限的成功。虽然这一领域有着巨大的前景,并继续在患者和临床医生中产生热情,但它仍处于临床验证的早期阶段。因此,必须以谨慎乐观和负责任的态度对待它,确保其在临床环境中的介绍、推广和使用以证据和道德标准为基础。目的:为再生疗法在中重度慢性腰痛治疗中的作用提供最新的循证建议。方法:由美国介入性疼痛医师学会(ASIPP)召集的多学科专家小组系统地回顾了当前的证据,并结合患者的观点来制定实用的、循证的建议。该过程包括确定关键临床问题,回顾文献,制定基于证据的陈述,并通过有组织的讨论和正式投票达成共识。结果:共有35位作者参与了这些指南的制定,33位专家参与了正式的共识过程。总共产生了19项建议,所有建议都获得了100%的同意。这些建议是通过对系统评价、随机对照试验(rct)和包括广泛再生疗法的观察性研究的综合评价得出的。采用建议分级评估、发展和评价(GRADE)方法对证据进行评价,以确定确定性水平。采用了定性和定量分析来综合现有的最佳数据,得出以下总结的循证建议。椎间盘内注射(PRP):证据等级:III,一般;基于共识的临床推荐:中度椎间盘内注射(BMAC):证据水平:III,一般;基于共识的临床推荐:中度硬膜外注射(PRP):证据水平:III,公平;基于共识的临床推荐:中度关节突关节注射(PRP和MSCs):证据水平:IV,有限;基于共识的临床推荐:中度骶髂关节注射(PRP):证据水平:IV,有限;基于共识的临床推荐:低功能脊柱单元注射证据水平:非常低;基于共识的临床推荐:低。局限性:这些指南的主要局限性是缺乏高质量的研究,许多现有证据来自小型或异质试验。注意事项:只有在彻底的诊断评估确认临床需要后才应考虑再生治疗。治疗决定必须考虑到病人的医疗状况、偏好和期望。患者应充分了解再生治疗的性质、潜在的益处、风险和费用,其中大多数不在商业保险范围内。这些疗法可以单独使用,也可以与其他循证模式结合使用,如有组织的锻炼、物理治疗、行为治疗或传统的医疗管理。临床医生必须遵守所有适用的美国食品和药物管理局(FDA)法规,并遵守本指南中概述的安全和道德标准。结论:根据目前的证据,腰椎间盘内注射富血小板血浆(PRP)和间充质干细胞(MSCs)是III级证据支持的。腰椎硬膜外PRP注射也有III级证据支持,而腰椎小关节和骶髂关节的PRP注射有IV级证据支持。鉴于生物制剂治疗的新兴状态和现有研究的有限质量,专家组对所有生物制剂在腰椎治疗中的使用提供了温和的、基于共识的建议。
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引用次数: 0
Updated Analysis of Decline of 16.8% in Utilization of Interventional Pain Management Techniques Among Traditional (Fee-for-Service) Medicare Beneficiaries from 2019 to 2024. 2019年至2024年传统(按服务收费)医疗保险受益人介入性疼痛管理技术使用率下降16.8%的最新分析
IF 2.5 2区 医学 Q2 ANESTHESIOLOGY Pub Date : 2025-12-01
Laxmaiah Manchikanti, Vidyasagar Pampati, Mahendra Sanapati, Nebojsa Nick Knezevic, Alan D Kaye, Amol Soin, Alaa Abd-Elsayed, Joshua A Hirsch

Background: In recent years, rising costs associated with managing spinal pain and other musculoskeletal disorders have been well documented. Prior to the COVID-19 pandemic, the use of interventional techniques to manage spinal pain and other musculoskeletal disorders had steadily increased. However, the pandemic disrupted chronic pain management, including interventional procedures and opioid use, reflecting a broader reduction in healthcare services.

Objectives: To provide an updated assessment of interventional technique utilization for chronic pain management in the U.S. Medicare population from 2000 to 2024.

Study design: Retrospective cohort study examining trends and factors influencing interventional technique use for chronic pain management within the traditional fee-for-service (FFS) Medicare population in the United States between 2000 and 2024.

Methods: Data were obtained from the Centers for Medicare & Medicaid Services (CMS) master database, specifically the physician/supplier procedure summary, covering the years 2000 through 2024.

Results: Service rates for interventional pain management per 100,000 Medicare beneficiaries significantly declined by 16.8% cumulatively from 2019 to 2024, corresponding to an average annual decrease of 3.6%. This contrasts with the 2010-2019 period, during which a cumulative increase of 14.5% was observed, along with an average annual growth rate of 1.5%. The steepest decline occurred between 2019 and 2020, with a 15.4% reduction coinciding with the onset of the COVID-19 pandemic.

Limitations: The analysis is limited to traditional (FFS) Medicare beneficiaries, excluding Medicare Advantage Plans, which represented nearly 54% of Medicare enrollment in 2024. Additionally, as with all retrospective claims-based studies, inherent limitations of coding accuracy and incomplete clinical detail apply.

Conclusion: From 2019 to 2024, the use of interventional pain management techniques declined significantly. Contributing factors likely include the lingering effects of COVID-19, economic pressures, the Affordable Care Act, and evolving local coverage determination (LCD) policies.

背景:近年来,与治疗脊柱疼痛和其他肌肉骨骼疾病相关的成本上升已被充分记录。在2019冠状病毒病大流行之前,使用介入性技术来治疗脊柱疼痛和其他肌肉骨骼疾病的情况稳步增加。然而,大流行扰乱了慢性疼痛管理,包括介入性手术和阿片类药物的使用,反映出卫生保健服务的广泛减少。目的:提供2000年至2024年美国医疗保险人群慢性疼痛管理介入技术应用的最新评估。研究设计:回顾性队列研究,探讨2000年至2024年间美国传统收费医疗保险(FFS)人群中介入技术用于慢性疼痛管理的趋势和影响因素。方法:数据来自美国医疗保险和医疗补助服务中心(CMS)主数据库,特别是医生/供应商程序摘要,涵盖2000年至2024年。结果:从2019年到2024年,每10万名医疗保险受益人的介入性疼痛管理服务率累计下降16.8%,平均每年下降3.6%。这与2010-2019年期间形成鲜明对比,在此期间观察到的累计增长率为14.5%,年均增长率为1.5%。下降幅度最大的是2019年至2020年,下降了15.4%,恰逢2019冠状病毒病大流行爆发。局限性:该分析仅限于传统的(FFS)医疗保险受益人,不包括医疗保险优势计划(Medicare Advantage Plans),后者占2024年医疗保险登记人数的近54%。此外,与所有基于回顾性索赔的研究一样,编码准确性的固有局限性和不完整的临床细节也适用。结论:从2019年到2024年,介入性疼痛管理技术的使用明显下降。造成这种情况的因素可能包括COVID-19的持续影响、经济压力、《平价医疗法案》(Affordable Care Act)以及不断发展的地方覆盖决定(LCD)政策。
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引用次数: 0
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Pain physician
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