<p><strong>Background: </strong>Information on the use of intraarticular bipolar pulsed radiofrequency (IA-bPRF) for treating knee osteoarthritis (KOA) is currently limited, and the effectiveness of this technique is not well established. The most effective nonsurgical approach for alleviating pain caused by KOA is still not well-defined.</p><p><strong>Objectives: </strong>Our aim was to investigate the effects of genicular radiofrequency (G-RFT) and IA-bPRF on pain relief and functional improvement in patients with advanced KOA.</p><p><strong>Study design: </strong>Records of 86 patients with KOA who received either G-RFT or IA-bPRF were evaluated retrospectively.</p><p><strong>Setting: </strong>The pain clinic of a state hospital.</p><p><strong>Methods: </strong>KOA patients who received either G-RFT or IA-bPRF were included in the study. The files of patients who were given such interventions between September 2021 and February 2024 were analyzed. Walking pain was evaluated on the numeric rating scale (NRS). Functional assessments were performed using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and the Lequesne Algofunctional Index for Knee (LAI-knee). These evaluations were carried out before the intervention, as well as 2 weeks and 6 months after it.</p><p><strong>Results: </strong>The IA-bPRF group showed significant improvement in NRS scores when pre-intervention scores were compared to those recorded at the sixth month after the surgery, dropping from 8.62 ± 1.01 to 3.81 ± 1.18, while the scores of the G-RFT group improved from 8.90 ± 1.20 to 5.25 ± 3.40. At the sixth month, WOMAC scores decreased from 75.79 ± 16.00 to 34.21 ± 23.12 in the IA-bPRF group and from 79.02 ± 14.73 to 48.43 ± 30.87 in the G-RFT group. From the pre-intervention period to the sixth month after the procedure, LAI-knee scores went from 18.64 ± 4.16 to 9.90 ± 5.78 in the IA-bPRF group and from 18.89 ± 3.84 to 12.55 ± 7.33 in the G-RFT group. All decreases were significant (P < 0.05). However, WOMAC physical function scores decreased more in the IA-bPRF group than in the G-RFT group (P < 0.05). No serious adverse events occurred.</p><p><strong>Limitations: </strong>Our study is subject to several limitations. Primarily, there is a paucity of extensive literature regarding the application of IA-bPRF for KOA. Additionally, our study's sample size is relatively small. This study was conducted at a single center and was retrospective in nature, rather than prospective and randomized, making it challenging to fully control for nuisance variables. Finally, there is a scarcity of comparable studies. These factors may constrain the external validity of our findings.</p><p><strong>Conclusions: </strong>Pain incurred while walking on flat surfaces and up and down stairs was further reduced with IA-bPRF. IA-bPRF is as effective as G-RFT and even more effective than the latter in some subheadings. Furthermore, the former is a safe alternative for r
{"title":"The Comparison of Intraarticular Bipolar Pulsed Radiofrequency and Genicular Nerve Thermal Radiofrequency Ablation for Pain Caused by Osteoarthritis of the Knee.","authors":"Cigdem Yalcin, Mehmet Alper Salman","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Information on the use of intraarticular bipolar pulsed radiofrequency (IA-bPRF) for treating knee osteoarthritis (KOA) is currently limited, and the effectiveness of this technique is not well established. The most effective nonsurgical approach for alleviating pain caused by KOA is still not well-defined.</p><p><strong>Objectives: </strong>Our aim was to investigate the effects of genicular radiofrequency (G-RFT) and IA-bPRF on pain relief and functional improvement in patients with advanced KOA.</p><p><strong>Study design: </strong>Records of 86 patients with KOA who received either G-RFT or IA-bPRF were evaluated retrospectively.</p><p><strong>Setting: </strong>The pain clinic of a state hospital.</p><p><strong>Methods: </strong>KOA patients who received either G-RFT or IA-bPRF were included in the study. The files of patients who were given such interventions between September 2021 and February 2024 were analyzed. Walking pain was evaluated on the numeric rating scale (NRS). Functional assessments were performed using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and the Lequesne Algofunctional Index for Knee (LAI-knee). These evaluations were carried out before the intervention, as well as 2 weeks and 6 months after it.</p><p><strong>Results: </strong>The IA-bPRF group showed significant improvement in NRS scores when pre-intervention scores were compared to those recorded at the sixth month after the surgery, dropping from 8.62 ± 1.01 to 3.81 ± 1.18, while the scores of the G-RFT group improved from 8.90 ± 1.20 to 5.25 ± 3.40. At the sixth month, WOMAC scores decreased from 75.79 ± 16.00 to 34.21 ± 23.12 in the IA-bPRF group and from 79.02 ± 14.73 to 48.43 ± 30.87 in the G-RFT group. From the pre-intervention period to the sixth month after the procedure, LAI-knee scores went from 18.64 ± 4.16 to 9.90 ± 5.78 in the IA-bPRF group and from 18.89 ± 3.84 to 12.55 ± 7.33 in the G-RFT group. All decreases were significant (P < 0.05). However, WOMAC physical function scores decreased more in the IA-bPRF group than in the G-RFT group (P < 0.05). No serious adverse events occurred.</p><p><strong>Limitations: </strong>Our study is subject to several limitations. Primarily, there is a paucity of extensive literature regarding the application of IA-bPRF for KOA. Additionally, our study's sample size is relatively small. This study was conducted at a single center and was retrospective in nature, rather than prospective and randomized, making it challenging to fully control for nuisance variables. Finally, there is a scarcity of comparable studies. These factors may constrain the external validity of our findings.</p><p><strong>Conclusions: </strong>Pain incurred while walking on flat surfaces and up and down stairs was further reduced with IA-bPRF. IA-bPRF is as effective as G-RFT and even more effective than the latter in some subheadings. Furthermore, the former is a safe alternative for r","PeriodicalId":19841,"journal":{"name":"Pain physician","volume":"28 S7","pages":"S179-S189"},"PeriodicalIF":2.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145892861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"2025 Index by Content.","authors":"Asipp","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":19841,"journal":{"name":"Pain physician","volume":"28 S7","pages":"S251-S268"},"PeriodicalIF":2.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145893070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"2025 Index by Key Words.","authors":"Asipp","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":19841,"journal":{"name":"Pain physician","volume":"28 S7","pages":"S275-S279"},"PeriodicalIF":2.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145893139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"2025 Index by Author.","authors":"Asipp","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":19841,"journal":{"name":"Pain physician","volume":"28 S7","pages":"S269-S274"},"PeriodicalIF":2.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145893161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yair Safriel, Nomen Azeem, Samir Sheth, Marilyn Moucharite, Nicolas Gasquet, Charlotte Wu, Christine Ricker
<p><strong>Background: </strong>Spinal cord stimulation (SCS) is an effective approach to managing chronic, intractable pain. However, even when the designs of SCS devices are compatible with magnetic resonance imaging (MRI), migration and the fracture or wire breakage of epidural leads can result in increased lead impedance and a requirement that the devices be explanted before safe imaging can take place. Selected SCS systems are designed with other technical features. Specifically, lead shielding (lead wires are encased in a matrix-like tantalum shield) serves to dissipate radiofrequency energy along the lead to reduce the risk of thermal tissue damage during MRI scans- even when lead impedance is out of range.</p><p><strong>Objectives: </strong>To compare the rates of MRI and SCS device explantation in patients who had SCS systems with lead-shielding SCS (LS-SCS) to those who had systems without lead-shielding SCS (non-LS-SCS), and to understand the clinical implications of those findings.</p><p><strong>Study design: </strong>A retrospective study of noninterventional administrative-claims data.</p><p><strong>Setting: </strong>The Center for Medicare and Medicaid Services (CMS) Research Identifiable Files (RIF).</p><p><strong>Methods: </strong>Any patient with continuous coverage who underwent implantation of an SCS system within the year 2018 and had no prior history of SCS, a failed neuromodulation device, or peripheral nerve stimulation was eligible. The analysis time frame included a one-year, pre-implantation baseline period and a 3-year post-implantation follow-up period. Claims were analyzed for post-implantation MRI use, SCS-system explantation, and post-MRI diagnoses. The measurements consisted of the time until the first MRI, the anatomic location of the MRI, the post-MRI diagnosis, the incidence of SCS explantation, and the time from explantation to MRI.</p><p><strong>Results: </strong>Of the 27,636 patients (59% female, 72% aged 65 years or older, and 91% white) who met the eligibility criteria, 18% were implanted with LS-SCS, and 82% were implanted with non-LS-SCS devices between Jan 1 and Dec 31, 2018. Significantly more patients (37.6%) with LS-SCS devices underwent MRI than did patients with non-LS-SCS devices (24.3%; 54.7% relative difference, P = 0.0007), and significantly fewer LS-SCS patients underwent explantation followed by MRI than did patients in the non-LS-SCS cohort (18.9% vs. 28.8%, P < 0.001). Approximately half of the MRI procedures were for spinal imaging in both cohorts, and the most common new diagnoses in the 30 days after the MRI included osteoarthritis, non-VCF injury/fractures, and cancer. Bivariate survival analysis showed that patients with LS-SCS devices had a significantly higher probability of undergoing MRI sooner than patients with non-LS-SCS devices (71.6% higher in adjusted hazard analysis; P < 0.001).</p><p><strong>Limitations: </strong>This study was a retrospective claims analysis, subject to
背景:脊髓刺激(SCS)是治疗慢性顽固性疼痛的有效方法。然而,即使SCS设备的设计与磁共振成像(MRI)兼容,硬膜外引线的迁移和断裂或断线也会导致引线阻抗增加,并且需要在进行安全成像之前将设备取出。选定的SCS系统设计具有其他技术特征。具体来说,铅屏蔽(引线被包裹在一个类似矩阵的钽屏蔽中)用于消散沿引线的射频能量,以减少MRI扫描期间热组织损伤的风险-即使在引线阻抗超出范围时也是如此。目的:比较具有铅屏蔽SCS (LS-SCS)的SCS系统与没有铅屏蔽SCS(非LS-SCS)的SCS系统患者的MRI和SCS装置外植率,并了解这些发现的临床意义。研究设计:对非干预性行政索赔数据进行回顾性研究。设置:医疗保险和医疗补助服务中心(CMS)研究可识别文件(RIF)。方法:任何在2018年内接受SCS系统植入且既往无SCS病史、神经调节装置失败或周围神经刺激的连续覆盖患者均符合条件。分析时间框架包括1年的植入前基线期和3年的植入后随访期。对植入后MRI使用、scs系统外植和MRI后诊断的索赔进行分析。测量包括到第一次MRI的时间,MRI的解剖位置,MRI后诊断,SCS外植的发生率,以及从外植到MRI的时间。结果:在2018年1月1日至12月31日期间,符合资格标准的27,636例患者(59%为女性,72%为65岁或以上,91%为白人)中,18%植入了LS-SCS, 82%植入了非LS-SCS装置。使用LS-SCS装置的患者接受MRI的比例(37.6%)明显高于非LS-SCS装置的患者(24.3%;相对差异为54.7%,P = 0.0007),并且与非LS-SCS队列患者相比,移植后MRI的LS-SCS患者显著减少(18.9% vs. 28.8%, P < 0.001)。在两个队列中,大约一半的MRI检查是用于脊柱成像的,MRI检查后30天内最常见的新诊断包括骨关节炎、非vcf损伤/骨折和癌症。双变量生存分析显示,使用LS-SCS装置的患者比未使用LS-SCS装置的患者更早接受MRI的可能性显著更高(校正风险分析高71.6%,P < 0.001)。局限性:这项研究是一项回顾性的索赔分析,在数据质量和完整性、编码、研究变量的可用性以及无法区分相关性和因果关系方面存在潜在的不一致性。结论:与非LS-SCS治疗的患者相比,使用LS-SCS装置的患者使用MRI的比例更高,近四分之一的scs装置外植体可能与促进MRI安全使用有关。研究结果表明,MRI兼容性具有潜在的影响,在选择SCS系统时应考虑到这一点。
{"title":"Impact of Lead-shielding on the Utilization of Magnetic Resonance Imaging Among Patients with Spinal Cord Stimulation Systems: A Study of Retrospective Claims in the US.","authors":"Yair Safriel, Nomen Azeem, Samir Sheth, Marilyn Moucharite, Nicolas Gasquet, Charlotte Wu, Christine Ricker","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Spinal cord stimulation (SCS) is an effective approach to managing chronic, intractable pain. However, even when the designs of SCS devices are compatible with magnetic resonance imaging (MRI), migration and the fracture or wire breakage of epidural leads can result in increased lead impedance and a requirement that the devices be explanted before safe imaging can take place. Selected SCS systems are designed with other technical features. Specifically, lead shielding (lead wires are encased in a matrix-like tantalum shield) serves to dissipate radiofrequency energy along the lead to reduce the risk of thermal tissue damage during MRI scans- even when lead impedance is out of range.</p><p><strong>Objectives: </strong>To compare the rates of MRI and SCS device explantation in patients who had SCS systems with lead-shielding SCS (LS-SCS) to those who had systems without lead-shielding SCS (non-LS-SCS), and to understand the clinical implications of those findings.</p><p><strong>Study design: </strong>A retrospective study of noninterventional administrative-claims data.</p><p><strong>Setting: </strong>The Center for Medicare and Medicaid Services (CMS) Research Identifiable Files (RIF).</p><p><strong>Methods: </strong>Any patient with continuous coverage who underwent implantation of an SCS system within the year 2018 and had no prior history of SCS, a failed neuromodulation device, or peripheral nerve stimulation was eligible. The analysis time frame included a one-year, pre-implantation baseline period and a 3-year post-implantation follow-up period. Claims were analyzed for post-implantation MRI use, SCS-system explantation, and post-MRI diagnoses. The measurements consisted of the time until the first MRI, the anatomic location of the MRI, the post-MRI diagnosis, the incidence of SCS explantation, and the time from explantation to MRI.</p><p><strong>Results: </strong>Of the 27,636 patients (59% female, 72% aged 65 years or older, and 91% white) who met the eligibility criteria, 18% were implanted with LS-SCS, and 82% were implanted with non-LS-SCS devices between Jan 1 and Dec 31, 2018. Significantly more patients (37.6%) with LS-SCS devices underwent MRI than did patients with non-LS-SCS devices (24.3%; 54.7% relative difference, P = 0.0007), and significantly fewer LS-SCS patients underwent explantation followed by MRI than did patients in the non-LS-SCS cohort (18.9% vs. 28.8%, P < 0.001). Approximately half of the MRI procedures were for spinal imaging in both cohorts, and the most common new diagnoses in the 30 days after the MRI included osteoarthritis, non-VCF injury/fractures, and cancer. Bivariate survival analysis showed that patients with LS-SCS devices had a significantly higher probability of undergoing MRI sooner than patients with non-LS-SCS devices (71.6% higher in adjusted hazard analysis; P < 0.001).</p><p><strong>Limitations: </strong>This study was a retrospective claims analysis, subject to ","PeriodicalId":19841,"journal":{"name":"Pain physician","volume":"28 S7","pages":"S169-S177"},"PeriodicalIF":2.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145891936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kevin S Batti, Joshua B Lewis, Ugur Yener, Alan D Kaye, Sayed E Wahezi
Background: Facetogenic pain accounts for 5-50% of chronic low back pain (CLBP) cases, and the prevalence of this pain increases with age. Because of poor imaging correlation, the diagnosis is challenging and relies on symptoms, exam findings, and "gold standard" diagnostic blocks, though optimal protocols remain debated. National societies have issued treatment recommendations for the condition, yet controversy persists. The present investigation focuses on medial branch block radiofrequency ablation (RFA) and highlights key factors for optimizing technique to improve patient outcomes.
Objectives: To demonstrate proper technique and factors that clinicians should consider to maximize the effectiveness of MBN RFA.
Study design: Development of methodology integrating ex vivo evidence and clinical approach.
Setting: An academic healthcare institution.
Methods: A PubMed review of article published between 2020 and 2025 was performed using the keywords "ex vivo," "radiofrequency ablation," and "lesion size." RFA of medial branch nerves (MBNs) relies on precise anatomical knowledge to ensure proper needle placement. Recent studies have demonstrated that there are multiple factors to consider in MBN RFA. When compared to muscle, adipose reduces lesion size in relation to lower thermal conductivity. Adipose around the needle decreases lesion size, which may explain the reduced efficacy of RFA in obese patients. Commonly used solutions impact lesion dimensions: 2% lidocaine increases lesional width, while iohexol 240 increases length. In addition, a probe's proximity to bone increases lesion size, as poor thermal conductance traps energy in adjacent tissues. Therefore, shape and size can be modified in accordance with medication selection and the active tip's juxtaposition to tissue.
Limitations: Despite advancements, significant knowledge gaps remain in understanding the effectiveness of RFA, since most studies focus on tumor ablation rather than neurolysis, and lack in-vivo data. To improve real-world clinical outcomes, future research should evaluate functional outcomes and pain relief in patients undergoing individualized procedures tailored to their unique anatomy.
Conclusions: RFA of MBNs is a valuable way to treat axial, facetogenic low back pain. The technique should be optimized to best account for the unique anatomy of each patient and thereby maximize the effectiveness of the procedure.
{"title":"Lumbar Medial Branch Radiofrequency Ablation: Technical Suggestions Based on Emerging Ex-Vivo Evidence.","authors":"Kevin S Batti, Joshua B Lewis, Ugur Yener, Alan D Kaye, Sayed E Wahezi","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Facetogenic pain accounts for 5-50% of chronic low back pain (CLBP) cases, and the prevalence of this pain increases with age. Because of poor imaging correlation, the diagnosis is challenging and relies on symptoms, exam findings, and \"gold standard\" diagnostic blocks, though optimal protocols remain debated. National societies have issued treatment recommendations for the condition, yet controversy persists. The present investigation focuses on medial branch block radiofrequency ablation (RFA) and highlights key factors for optimizing technique to improve patient outcomes.</p><p><strong>Objectives: </strong>To demonstrate proper technique and factors that clinicians should consider to maximize the effectiveness of MBN RFA.</p><p><strong>Study design: </strong>Development of methodology integrating ex vivo evidence and clinical approach.</p><p><strong>Setting: </strong>An academic healthcare institution.</p><p><strong>Methods: </strong>A PubMed review of article published between 2020 and 2025 was performed using the keywords \"ex vivo,\" \"radiofrequency ablation,\" and \"lesion size.\" RFA of medial branch nerves (MBNs) relies on precise anatomical knowledge to ensure proper needle placement. Recent studies have demonstrated that there are multiple factors to consider in MBN RFA. When compared to muscle, adipose reduces lesion size in relation to lower thermal conductivity. Adipose around the needle decreases lesion size, which may explain the reduced efficacy of RFA in obese patients. Commonly used solutions impact lesion dimensions: 2% lidocaine increases lesional width, while iohexol 240 increases length. In addition, a probe's proximity to bone increases lesion size, as poor thermal conductance traps energy in adjacent tissues. Therefore, shape and size can be modified in accordance with medication selection and the active tip's juxtaposition to tissue.</p><p><strong>Limitations: </strong>Despite advancements, significant knowledge gaps remain in understanding the effectiveness of RFA, since most studies focus on tumor ablation rather than neurolysis, and lack in-vivo data. To improve real-world clinical outcomes, future research should evaluate functional outcomes and pain relief in patients undergoing individualized procedures tailored to their unique anatomy.</p><p><strong>Conclusions: </strong>RFA of MBNs is a valuable way to treat axial, facetogenic low back pain. The technique should be optimized to best account for the unique anatomy of each patient and thereby maximize the effectiveness of the procedure.</p>","PeriodicalId":19841,"journal":{"name":"Pain physician","volume":"28 S7","pages":"S137-S143"},"PeriodicalIF":2.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145892767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Samuel P Brown, Lee James, Gregory Moore, Caitlin Tourje, Farid Kia, Alireza Katouzian, Philip Sasso, Emmanuel Gage, Robert Michael Hullander, Michael Drass, Brian Durkin
<p><strong>Background: </strong>Low back pain (LBP) is the most common type of pain reported by adults and the leading cause of disability globally. The sacroiliac joint (SIJ)-the large, load-bearing joint that connects the pelvis and lower spine-is one of the most underrecognized causes of LBP and has been determined to be a source of the condition in 10-38% of cases. While SIJ fusion has been shown to be a superior alternative to the long-term conservative management of SIJ dysfunction, many early SIJ fusion techniques have resulted in high incidences of adverse events (AEs) and serious adverse events (SAEs), long recovery times, and, often, the need for revision surgeries.</p><p><strong>Objectives: </strong>To prospectively assess the effectiveness of a minimally invasive lateral oblique approach to SIJ fusion that uses TransLoc 3DTM Sacroiliac Joint Fusion System (CornerLoc™) compression screws, based on patient-reported outcome measures of pain and functional improvement.</p><p><strong>Study design: </strong>Prospective study.</p><p><strong>Setting: </strong>Seventeen pain centers across the United States.</p><p><strong>Methods: </strong>Between November 13, 2023, and December 31, 2024, 114 patients underwent SIJ fusion via TransLoc 3DTM SIJ fusion compression screws in a procedure that used a minimally invasive lateral oblique approach. Outcomes for pain and functional improvement were assessed both before the procedure and at 3 (n = 85) and 6 (n = 72) months after it. Those outcomes were measured on the Numeric Rating Scale (NRS), Oswestry Disability Index (ODI), and Quebec Back Pain Disability Scale (QBPDS). Additionally, the safety and efficacy of the procedure were assessed using a composite endpoint comprising improvement in both NRS and ODI scores as well as the absence of AEs or SAEs. Comparisons between the groups of patients were performed using Student's t-test for continuous data or Fisher's exact test for categorical data. Mixed models for repeat measures were used to model factors associated with each endpoint longitudinally and generalized linear models for interim tests. All patients provided consent to participate in the study, and approval was obtained from the institutional review board (approval number 1356747).</p><p><strong>Results: </strong>The average age of the patients at the baseline was 67.1 ± 10.5 years, and 70.8% were female. Our results show significant improvements in pain and functional outcomes from the baseline, as assessed by both the composite endpoint and individual measures (i.e., NRS, ODI, and QBPDS), 3 and 6 months after the procedure (P < 2.2 e-16 for all measures). Furthermore, 72.94% of patients reported improvements in both their NRS pain scores and ODI function scores within 3 months, while 90.3% reported an improvement at 6 months. Additionally, 84.7% of patients reported an improvement in their QBPDS scores within 6 months. A significant majority of patients experienced greater than 20% improve
{"title":"Six-Month Interim Outcomes of the SPARTAN Study: A Prospective, Multicenter, Post-Market Surveillance Study on a Modular SI Joint Fusion System.","authors":"Samuel P Brown, Lee James, Gregory Moore, Caitlin Tourje, Farid Kia, Alireza Katouzian, Philip Sasso, Emmanuel Gage, Robert Michael Hullander, Michael Drass, Brian Durkin","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Low back pain (LBP) is the most common type of pain reported by adults and the leading cause of disability globally. The sacroiliac joint (SIJ)-the large, load-bearing joint that connects the pelvis and lower spine-is one of the most underrecognized causes of LBP and has been determined to be a source of the condition in 10-38% of cases. While SIJ fusion has been shown to be a superior alternative to the long-term conservative management of SIJ dysfunction, many early SIJ fusion techniques have resulted in high incidences of adverse events (AEs) and serious adverse events (SAEs), long recovery times, and, often, the need for revision surgeries.</p><p><strong>Objectives: </strong>To prospectively assess the effectiveness of a minimally invasive lateral oblique approach to SIJ fusion that uses TransLoc 3DTM Sacroiliac Joint Fusion System (CornerLoc™) compression screws, based on patient-reported outcome measures of pain and functional improvement.</p><p><strong>Study design: </strong>Prospective study.</p><p><strong>Setting: </strong>Seventeen pain centers across the United States.</p><p><strong>Methods: </strong>Between November 13, 2023, and December 31, 2024, 114 patients underwent SIJ fusion via TransLoc 3DTM SIJ fusion compression screws in a procedure that used a minimally invasive lateral oblique approach. Outcomes for pain and functional improvement were assessed both before the procedure and at 3 (n = 85) and 6 (n = 72) months after it. Those outcomes were measured on the Numeric Rating Scale (NRS), Oswestry Disability Index (ODI), and Quebec Back Pain Disability Scale (QBPDS). Additionally, the safety and efficacy of the procedure were assessed using a composite endpoint comprising improvement in both NRS and ODI scores as well as the absence of AEs or SAEs. Comparisons between the groups of patients were performed using Student's t-test for continuous data or Fisher's exact test for categorical data. Mixed models for repeat measures were used to model factors associated with each endpoint longitudinally and generalized linear models for interim tests. All patients provided consent to participate in the study, and approval was obtained from the institutional review board (approval number 1356747).</p><p><strong>Results: </strong>The average age of the patients at the baseline was 67.1 ± 10.5 years, and 70.8% were female. Our results show significant improvements in pain and functional outcomes from the baseline, as assessed by both the composite endpoint and individual measures (i.e., NRS, ODI, and QBPDS), 3 and 6 months after the procedure (P < 2.2 e-16 for all measures). Furthermore, 72.94% of patients reported improvements in both their NRS pain scores and ODI function scores within 3 months, while 90.3% reported an improvement at 6 months. Additionally, 84.7% of patients reported an improvement in their QBPDS scores within 6 months. A significant majority of patients experienced greater than 20% improve","PeriodicalId":19841,"journal":{"name":"Pain physician","volume":"28 S7","pages":"S191-S202"},"PeriodicalIF":2.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145892798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Laxmaiah Manchikanti, Riya Navani, Annu Navani, Mahendra Sanapati, Alan D Kaye, Adam M Kaye, Amol Soin, Devi Nampiaparampil, Kenneth D Candido, Alaa Abd-Elsayed, Theodore T Sand, Navneet Boddu, Sairam Atluri, Anss Annie Augustine, Dajie Wang, John Santa Ana, Lady Christine Ong Sio, Vidyasagar Pampati, Michael Khadavi, Nebojsa Nick Knezevic, Robert Farhat, Shivam S Shah, Shounuck J Patel, Tom Nabity, Alexander Bautista, Aaron K Calodney, Joseph Cabaret, Miles R Day, Paul J Christo, Sanjay Bakshi, Shalini Shah, Sheldon Jordan, Sheri L Albers, Vivek Manocha, Joshua A Hirsch
<p><strong>Background: </strong>Regenerative medicine is an evolving medical subspecialty dedicated to enhancing the body's natural healing mechanisms to repair or replace damaged tissues. By using autologous or allogeneic biologics, it offers the potential to restore function where conventional therapies have shown limited success. While this field holds great promise and continues to generate enthusiasm among both patients and clinicians, it remains in early stages of clinical validation. Therefore, it must be approached with careful optimism and responsible application, ensuring that its presentation, promotion, and use in clinical settings are grounded in evidence and ethical standards.</p><p><strong>Objective: </strong>To provide updated, evidence-based recommendations for the role of regenerative therapies in managing moderate to severe chronic low back pain.</p><p><strong>Methods: </strong>A multidisciplinary panel of experts, convened by the American Society of Interventional Pain Physicians (ASIPP), systematically reviewed the current evidence and incorporated patient perspectives to develop practical, evidence-informed recommendations. The process included defining key clinical questions, reviewing the literature, formulating evidence-based statements, and reaching consensus through structured discussions and formal voting.</p><p><strong>Results: </strong>A total of 35 authors contributed to the development of these guidelines, with 33 experts participating in the formal consensus process. Altogether, 19 recommendations were generated, with all of them achieving 100% agreement. These recommendations were informed by a comprehensive review of systematic reviews, randomized controlled trials (RCTs), and observational studies encompassing a broad range of regenerative therapies.Evidence was appraised using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) methodology to determine certainty levels. Both qualitative and quantitative analyses were applied to synthesize the best available data, resulting in evidence-based recommendations summarized below.Intradiscal Injections (PRP): Evidence Level: III, Fair; Consensus-Based Clinical Recommendation: ModerateIntradiscal Injections (BMAC): Evidence Level: III, Fair; Consensus-Based Clinical Recommendation: ModerateEpidural Injections (PRP): Evidence Level: III, Fair; Consensus-Based Clinical Recommendation: ModerateFacet Joint Injections (PRP and MSCs): Evidence Level: IV, Limited; Consensus-Based Clinical Recommendation: Moderate Sacroiliac Joint Injections (PRP): Evidence Level: IV, Limited; Consensus-Based Clinical Recommendation: Low Functional Spine Unit Injections Evidence Level: Very Low; Consensus-Based Clinical Recommendation:Low.</p><p><strong>Limitations: </strong>The primary limitation of these guidelines is the scarcity of high-quality studies, with much of the available evidence derived from small or heterogeneous trials.</p><p><strong>Precautions: </
{"title":"Comprehensive Evidence-Based Guidelines for Regenerative Therapies in the Management of Chronic Low Back Pain: 2025 Update from the American Society Of Interventional Pain Physicians (ASIPP).","authors":"Laxmaiah Manchikanti, Riya Navani, Annu Navani, Mahendra Sanapati, Alan D Kaye, Adam M Kaye, Amol Soin, Devi Nampiaparampil, Kenneth D Candido, Alaa Abd-Elsayed, Theodore T Sand, Navneet Boddu, Sairam Atluri, Anss Annie Augustine, Dajie Wang, John Santa Ana, Lady Christine Ong Sio, Vidyasagar Pampati, Michael Khadavi, Nebojsa Nick Knezevic, Robert Farhat, Shivam S Shah, Shounuck J Patel, Tom Nabity, Alexander Bautista, Aaron K Calodney, Joseph Cabaret, Miles R Day, Paul J Christo, Sanjay Bakshi, Shalini Shah, Sheldon Jordan, Sheri L Albers, Vivek Manocha, Joshua A Hirsch","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Regenerative medicine is an evolving medical subspecialty dedicated to enhancing the body's natural healing mechanisms to repair or replace damaged tissues. By using autologous or allogeneic biologics, it offers the potential to restore function where conventional therapies have shown limited success. While this field holds great promise and continues to generate enthusiasm among both patients and clinicians, it remains in early stages of clinical validation. Therefore, it must be approached with careful optimism and responsible application, ensuring that its presentation, promotion, and use in clinical settings are grounded in evidence and ethical standards.</p><p><strong>Objective: </strong>To provide updated, evidence-based recommendations for the role of regenerative therapies in managing moderate to severe chronic low back pain.</p><p><strong>Methods: </strong>A multidisciplinary panel of experts, convened by the American Society of Interventional Pain Physicians (ASIPP), systematically reviewed the current evidence and incorporated patient perspectives to develop practical, evidence-informed recommendations. The process included defining key clinical questions, reviewing the literature, formulating evidence-based statements, and reaching consensus through structured discussions and formal voting.</p><p><strong>Results: </strong>A total of 35 authors contributed to the development of these guidelines, with 33 experts participating in the formal consensus process. Altogether, 19 recommendations were generated, with all of them achieving 100% agreement. These recommendations were informed by a comprehensive review of systematic reviews, randomized controlled trials (RCTs), and observational studies encompassing a broad range of regenerative therapies.Evidence was appraised using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) methodology to determine certainty levels. Both qualitative and quantitative analyses were applied to synthesize the best available data, resulting in evidence-based recommendations summarized below.Intradiscal Injections (PRP): Evidence Level: III, Fair; Consensus-Based Clinical Recommendation: ModerateIntradiscal Injections (BMAC): Evidence Level: III, Fair; Consensus-Based Clinical Recommendation: ModerateEpidural Injections (PRP): Evidence Level: III, Fair; Consensus-Based Clinical Recommendation: ModerateFacet Joint Injections (PRP and MSCs): Evidence Level: IV, Limited; Consensus-Based Clinical Recommendation: Moderate Sacroiliac Joint Injections (PRP): Evidence Level: IV, Limited; Consensus-Based Clinical Recommendation: Low Functional Spine Unit Injections Evidence Level: Very Low; Consensus-Based Clinical Recommendation:Low.</p><p><strong>Limitations: </strong>The primary limitation of these guidelines is the scarcity of high-quality studies, with much of the available evidence derived from small or heterogeneous trials.</p><p><strong>Precautions: </","PeriodicalId":19841,"journal":{"name":"Pain physician","volume":"28 S7","pages":"S1-S119"},"PeriodicalIF":2.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145893149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Laxmaiah Manchikanti, Vidyasagar Pampati, Mahendra Sanapati, Nebojsa Nick Knezevic, Alan D Kaye, Amol Soin, Alaa Abd-Elsayed, Joshua A Hirsch
Background: In recent years, rising costs associated with managing spinal pain and other musculoskeletal disorders have been well documented. Prior to the COVID-19 pandemic, the use of interventional techniques to manage spinal pain and other musculoskeletal disorders had steadily increased. However, the pandemic disrupted chronic pain management, including interventional procedures and opioid use, reflecting a broader reduction in healthcare services.
Objectives: To provide an updated assessment of interventional technique utilization for chronic pain management in the U.S. Medicare population from 2000 to 2024.
Study design: Retrospective cohort study examining trends and factors influencing interventional technique use for chronic pain management within the traditional fee-for-service (FFS) Medicare population in the United States between 2000 and 2024.
Methods: Data were obtained from the Centers for Medicare & Medicaid Services (CMS) master database, specifically the physician/supplier procedure summary, covering the years 2000 through 2024.
Results: Service rates for interventional pain management per 100,000 Medicare beneficiaries significantly declined by 16.8% cumulatively from 2019 to 2024, corresponding to an average annual decrease of 3.6%. This contrasts with the 2010-2019 period, during which a cumulative increase of 14.5% was observed, along with an average annual growth rate of 1.5%. The steepest decline occurred between 2019 and 2020, with a 15.4% reduction coinciding with the onset of the COVID-19 pandemic.
Limitations: The analysis is limited to traditional (FFS) Medicare beneficiaries, excluding Medicare Advantage Plans, which represented nearly 54% of Medicare enrollment in 2024. Additionally, as with all retrospective claims-based studies, inherent limitations of coding accuracy and incomplete clinical detail apply.
Conclusion: From 2019 to 2024, the use of interventional pain management techniques declined significantly. Contributing factors likely include the lingering effects of COVID-19, economic pressures, the Affordable Care Act, and evolving local coverage determination (LCD) policies.
背景:近年来,与治疗脊柱疼痛和其他肌肉骨骼疾病相关的成本上升已被充分记录。在2019冠状病毒病大流行之前,使用介入性技术来治疗脊柱疼痛和其他肌肉骨骼疾病的情况稳步增加。然而,大流行扰乱了慢性疼痛管理,包括介入性手术和阿片类药物的使用,反映出卫生保健服务的广泛减少。目的:提供2000年至2024年美国医疗保险人群慢性疼痛管理介入技术应用的最新评估。研究设计:回顾性队列研究,探讨2000年至2024年间美国传统收费医疗保险(FFS)人群中介入技术用于慢性疼痛管理的趋势和影响因素。方法:数据来自美国医疗保险和医疗补助服务中心(CMS)主数据库,特别是医生/供应商程序摘要,涵盖2000年至2024年。结果:从2019年到2024年,每10万名医疗保险受益人的介入性疼痛管理服务率累计下降16.8%,平均每年下降3.6%。这与2010-2019年期间形成鲜明对比,在此期间观察到的累计增长率为14.5%,年均增长率为1.5%。下降幅度最大的是2019年至2020年,下降了15.4%,恰逢2019冠状病毒病大流行爆发。局限性:该分析仅限于传统的(FFS)医疗保险受益人,不包括医疗保险优势计划(Medicare Advantage Plans),后者占2024年医疗保险登记人数的近54%。此外,与所有基于回顾性索赔的研究一样,编码准确性的固有局限性和不完整的临床细节也适用。结论:从2019年到2024年,介入性疼痛管理技术的使用明显下降。造成这种情况的因素可能包括COVID-19的持续影响、经济压力、《平价医疗法案》(Affordable Care Act)以及不断发展的地方覆盖决定(LCD)政策。
{"title":"Updated Analysis of Decline of 16.8% in Utilization of Interventional Pain Management Techniques Among Traditional (Fee-for-Service) Medicare Beneficiaries from 2019 to 2024.","authors":"Laxmaiah Manchikanti, Vidyasagar Pampati, Mahendra Sanapati, Nebojsa Nick Knezevic, Alan D Kaye, Amol Soin, Alaa Abd-Elsayed, Joshua A Hirsch","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>In recent years, rising costs associated with managing spinal pain and other musculoskeletal disorders have been well documented. Prior to the COVID-19 pandemic, the use of interventional techniques to manage spinal pain and other musculoskeletal disorders had steadily increased. However, the pandemic disrupted chronic pain management, including interventional procedures and opioid use, reflecting a broader reduction in healthcare services.</p><p><strong>Objectives: </strong>To provide an updated assessment of interventional technique utilization for chronic pain management in the U.S. Medicare population from 2000 to 2024.</p><p><strong>Study design: </strong>Retrospective cohort study examining trends and factors influencing interventional technique use for chronic pain management within the traditional fee-for-service (FFS) Medicare population in the United States between 2000 and 2024.</p><p><strong>Methods: </strong>Data were obtained from the Centers for Medicare & Medicaid Services (CMS) master database, specifically the physician/supplier procedure summary, covering the years 2000 through 2024.</p><p><strong>Results: </strong>Service rates for interventional pain management per 100,000 Medicare beneficiaries significantly declined by 16.8% cumulatively from 2019 to 2024, corresponding to an average annual decrease of 3.6%. This contrasts with the 2010-2019 period, during which a cumulative increase of 14.5% was observed, along with an average annual growth rate of 1.5%. The steepest decline occurred between 2019 and 2020, with a 15.4% reduction coinciding with the onset of the COVID-19 pandemic.</p><p><strong>Limitations: </strong>The analysis is limited to traditional (FFS) Medicare beneficiaries, excluding Medicare Advantage Plans, which represented nearly 54% of Medicare enrollment in 2024. Additionally, as with all retrospective claims-based studies, inherent limitations of coding accuracy and incomplete clinical detail apply.</p><p><strong>Conclusion: </strong>From 2019 to 2024, the use of interventional pain management techniques declined significantly. Contributing factors likely include the lingering effects of COVID-19, economic pressures, the Affordable Care Act, and evolving local coverage determination (LCD) policies.</p>","PeriodicalId":19841,"journal":{"name":"Pain physician","volume":"28 S7","pages":"S121-S136"},"PeriodicalIF":2.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145892806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}