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Prevalence and Risk Factors for Persistent Spinal Pain Syndrome Type II Following Spinal Surgery: A Nationwide Retrospective Cohort Study. 脊柱手术后持续性脊柱疼痛综合征II型的患病率和危险因素:一项全国回顾性队列研究
IF 2.6 2区 医学 Q2 ANESTHESIOLOGY Pub Date : 2024-11-01
Tak Kyu Oh, In-Ae Song

Background: Persistent Spinal Pain Syndrome Type II (PSPS II) is a major health concern in patients undergoing spinal surgery. However, there are little data on the prevalence and risk factors of PSPS II post spinal surgery.

Objectives: We examined the prevalence and factors associated with diagnosing PSPS II post spinal surgery using a nationwide database in the Republic of Korea.

Study design: A retrospective, population-based cohort study.

Setting: Nationwide cohort study in the Republic of Korea.

Methods: Adult patients who underwent spinal surgery under general anesthesia from January 1, 2016 through December 31, 2020 were included. Patients previously diagnosed with PSPS II were excluded from the study in order to focus only on patients who were newly diagnosed post spinal surgery. We determined that a PSPS II diagnosis must be made within  one year of the date of spinal surgery, with an additional evaluation for diagnoses occurring within 2 years to capture longer-term cases. A multivariate logistic regression model was developed to identify the factors associated with diagnosing PSPS II post spinal surgery.

Results: In total, 530,644 patients who underwent spinal surgery were included. Of these, 25.6% and 31.5% were diagnosed with PSPS II within one and 2 years post spinal surgery, respectively. The multivariate logistic regression model indicated that being a woman, old age, being a member of a medical aid program group, an increased Charlson Comorbidity Index score, discectomy, laminectomy, and lumbar level surgery were associated with an increased prevalence of PSPS II within one year post spinal surgery. Similar results were observed in the multivariate logistic regression model for PSPS II within 2 years post spinal surgery.

Limitation: Our study's retrospective cohort design is a limitation.

Conclusions: This population-based cohort analysis found a 25.6% prevalence of PSPS II within one year post spinal surgery and 31.5% within two years post spinal surgery. Identified risk factors include old age, being a woman, economic poverty, comorbid status, underlying disability, type of surgery, and lumbar-level surgery. A large dataset was used to document the prevalence and risk factors for PSPS II post spinal surgery.

背景:持续性脊柱疼痛综合征II型(PSPS II)是脊柱手术患者的主要健康问题。然而,关于脊柱手术后PSPS II的患病率和危险因素的数据很少。目的:我们使用韩国的全国数据库检查脊柱手术后PSPS II的患病率和与诊断相关的因素。研究设计:回顾性、基于人群的队列研究。背景:韩国全国队列研究。方法:纳入2016年1月1日至2020年12月31日在全身麻醉下接受脊柱手术的成年患者。先前诊断为PSPS II的患者被排除在研究之外,以便仅关注脊柱手术后新诊断的患者。我们确定PSPS II诊断必须在脊柱手术之日起一年内做出,并对2年内发生的诊断进行额外评估,以捕获长期病例。建立多变量logistic回归模型以确定脊柱手术后诊断PSPS II的相关因素。结果:共纳入530,644例脊柱手术患者。其中,25.6%和31.5%分别在脊柱手术后1年和2年内被诊断为PSPS II。多变量logistic回归模型显示,女性、老年、医疗救助组成员、Charlson共病指数评分增加、椎间盘切除术、椎板切除术和腰椎手术与脊柱手术后一年内PSPS II患病率增加相关。在脊柱术后2年内PSPS II的多变量logistic回归模型中也观察到类似的结果。局限性:本研究的回顾性队列设计存在局限性。结论:这项基于人群的队列分析发现,脊柱手术后一年内PSPS II患病率为25.6%,脊柱手术后两年内患病率为31.5%。确定的危险因素包括老年、女性、经济贫困、合并症、潜在残疾、手术类型和腰椎手术。一个大型数据集被用来记录脊柱手术后PSPS II的患病率和危险因素。
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引用次数: 0
Regional Analgesia Techniques Following Thoracic Surgery: A Systematic Review and Network Meta-analysis. 胸外科手术后局部镇痛技术:系统综述和网络荟萃分析。
IF 2.6 2区 医学 Q2 ANESTHESIOLOGY Pub Date : 2024-11-01
Meijuan Yang, Xiaomei Zhang, Gang Liu, Xingwang Zhang, Wenjun Yan, Dong Zhang
<p><strong>Background: </strong>Regional analgesia techniques have become the basis of multimodal analgesia for acute and chronic pain. They are widely used in thoracic surgery, but the best treatment is still uncertain.</p><p><strong>Objectives: </strong>We aimed to compare and rank the effectiveness of regional analgesia techniques for thoracic surgery.</p><p><strong>Study design: </strong>A systematic review and network meta-analysis.</p><p><strong>Methods: </strong>PubMed, MEDLINE, Embase, Cochrane Library, Science-Direct, and Web of Science were searched for articles published from inception through the end of January 2023. The network meta-analysis was conducted using Stata 15.1 software (StataCorp, LLC). The certainty of evidence was assessed by using Confidence in Network Meta-analysis (CINeMA https://cinema.ispm.unibe.ch/ A (unibe.ch). The primary outcome was cumulative opioid consumption within postoperative 24 hours. The secondary outcomes included pain scores at postoperative 6 hours, 12 hours, and 24 hours.</p><p><strong>Results: </strong>A total of 32 trials with 1,996 patients and 11 techniques were included. No major network inconsistency or heterogeneity were found. Postoperative opioid consumption within postoperative 24 hours was decreased most by continuous extrapleural block (cEPB) (standardized mean difference [SMD] = 0.00; 95% CI,: 0.00-0.00), followed by continuous thoracic epidural analgesia (cTEA) and continuous serratus plane block (cSAPB). In the postoperative 6 hour analysis, pain scores were  decreased most by cTEA (SMD = 0.16; 95% CI,: 0.05-0.49), followed by thoracic paravertebral block (TPVB) and ESPB (erector spinae plane block). In the postoperative 12 hour analysis, pain scores were decreased most by cSAPB (SMD = 0.12; 95% CI, 0.011.84), followed by TPVB and cTEA. In the postoperative 24 hour analysis, pain scores were decreased most by ESPB (SMD = 0.09; 95% CI, 0.030.32), followed by cSAPB and continuous thoracic paravertebral block (cTPVB).</p><p><strong>Limitations: </strong>Our study has several limitations. First, 4 enrolled studies had a sample size of less than 40 patients. Second, the different regimens were potential factors contributing to heterogeneity, such as local anesthetic dose and volume, infusion time, infusion mode, adding adjuncts, and rescue analgesic regimens. Third, the number of primary and secondary outcomes is limited. Fourth, the number of randomized controlled trials for cEPB is limited.</p><p><strong>Conclusions: </strong>The cTEA and cSAPB techniques are more likely to reduce the cumulative opioid consumption within 24 hours. The cTEA, cSAPB, ESPB techniques were more likely to improve pain at postoperative 6, 12, and 24 hours. Therefore, cTEA, cSAPB, and ESPB are the first choices for pain relief post thoracic surgery, whereas wound infiltration, intercostal block, continuous wound infiltration, and continuous intercostal block were less likely to be effective. We need more high-q
背景:局部镇痛技术已成为急性和慢性疼痛多模式镇痛的基础。它们广泛用于胸外科手术,但最佳治疗方法仍不确定。目的:我们的目的是比较和排名区域镇痛技术在胸外科手术的有效性。研究设计:系统回顾和网络荟萃分析。方法:检索PubMed、MEDLINE、Embase、Cochrane Library、Science- direct和Web of Science从成立到2023年1月底发表的文章。网络meta分析采用Stata 15.1软件(StataCorp, LLC)进行。采用网络meta分析(CINeMA https://cinema.ispm.unibe.ch/ A (unibeh .ch))对证据的确定性进行评估。主要终点是术后24小时内阿片类药物的累积消耗。次要结局包括术后6小时、12小时和24小时的疼痛评分。结果:共纳入32项试验,1996例患者和11种技术。没有发现主要的网络不一致或异质性。术后24小时内持续胸腔外阻滞(cEPB)减少阿片类药物消耗最多(标准化平均差[SMD] = 0.00;95% CI, 0.00-0.00),然后是连续胸廓硬膜外镇痛(cTEA)和连续锯肌平面阻滞(cSAPB)。术后6小时分析中,cTEA组疼痛评分降低最多(SMD = 0.16;95% CI, 0.05-0.49),其次是胸椎旁阻滞(TPVB)和竖脊平面阻滞(ESPB)。在术后12小时分析中,cSAPB组疼痛评分降低最多(SMD = 0.12;95% CI, 0.011.84),其次是TPVB和cTEA。术后24小时分析中,ESPB组疼痛评分降低最多(SMD = 0.09;95% CI, 0.030.32),其次是cSAPB和连续胸椎旁阻滞(cTPVB)。局限性:我们的研究有几个局限性。首先,4项入组研究的样本量少于40名患者。其次,不同的方案是造成异质性的潜在因素,如局麻剂量和体积、输注时间、输注方式、添加辅助药物、抢救镇痛方案等。第三,主要和次要结果的数量有限。第四,cEPB的随机对照试验数量有限。结论:cTEA和cSAPB技术更有可能减少24小时内阿片类药物的累积消耗。cTEA、cSAPB和ESPB技术更有可能改善术后6、12和24小时的疼痛。因此,cTEA、cSAPB和ESPB是胸术后缓解疼痛的首选,而伤口浸润、肋间阻滞、持续伤口浸润和连续肋间阻滞的效果较差。我们需要更多高质量、大样本量的随机对照试验来验证我们的结果,并确定理想的局部镇痛技术和最佳的药物配方。
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引用次数: 0
Comparison of Robot-Assisted and Fluoroscopy-Assisted Percutaneous Kyphoplasty for Bone Cement Distribution and Clinical Efficacy. 机器人辅助与透视辅助下经皮后凸成形术对骨水泥分布及临床疗效的比较。
IF 2.6 2区 医学 Q2 ANESTHESIOLOGY Pub Date : 2024-11-01
Hui Tao, Zhiwei Huang, Shanzhong Shao, Ruoyu Yang, Kun Yang, Yinshun Zhang, Wei Li, Fulong Dong, Jun Qian, Cailiang Shen
<p><strong>Background: </strong>The distribution of bone cement after percutaneous kyphoplasty (PKP) affects its clinical efficacy in patients with osteoporosis. Robotic and traditional treatment of osteoporotic vertebral compression fractures (OVCFs) have both been established as effective, but no studies have compared these 2 modalities in terms of bone cement distribution and clinical outcomes.</p><p><strong>Objective: </strong>To compare the bone cement distribution and clinical efficacy of robot-assisted percutaneous kyphoplasty to those of fluoroscopy-assisted percutaneous kyphoplasty for the treatment of OVCFs.</p><p><strong>Setting: </strong>Department of Orthopedics and Spine Surgery, First Affiliated Hospital of Anhui Medical University, Hefei, China.</p><p><strong>Study design: </strong>A single-center, retrospective observational study.</p><p><strong>Methods: </strong>Data from 151 patients with OVCFs who underwent PKP between January 2020 and July 2022 were analyzed retrospectively. The patients were divided into 3 groups: robot-assisted unipedicular percutaneous kyphoplasty (RAUPK), fluoroscopy-assisted unipedicular percutaneous kyphoplasty (FAUPK), and fluoroscopy-assisted bipedicular percutaneous kyphoplasty (FABPK). The operation time, intraoperative blood loss, bone cement injection volume, bone cement distribution, and complications (vascular and nerve injury, bone cement leakage, and re-fracture) of each procedure were recorded. The visual analog scale (VAS) score, Oswestry Disability Index (ODI) score, Cobb angle, and anterior height of the injured vertebrae were compared among the 3 groups preoperatively, one day postoperatively, and at the final follow-up.</p><p><strong>Results: </strong>No puncture failures occurred in any of the 3 groups. The mean follow-up period was 20.0 ± 5.2 months. The postoperative VAS scores, ODI, anterior vertebral heights, and Cobb angles of all patients were significantly improved compared to the preoperative values (P < 0.05). There were no significant differences in the VAS score, ODI score, Cobb angle, anterior vertebral height ratio preoperatively or one day postoperatively among the 3 groups (P > 0.05). The groups' comparative rates of intraoperative blood loss and complications also showed no significant differences (P > 0.05). At the last follow-up, the VAS and ODI scores of the RAUPK group were lower than those of the FAUPK group (P < 0.05), as were the anterior height of the injured vertebra and Cobb angle of the RAUPK group (P < 0.05). The operation time, bone cement injection volume, and bone cement distribution in the RAUPK group were superior to those in the FAUPK group (P < 0.05). Nevertheless, there were no significant differences in the VAS, ODI, Cobb angle, or anterior vertebral height at the last follow-up between the FABPK group and the RAUPK group (P > 0.05). Those 2 groups also showed no significant difference in operation time, intraoperative blood loss, bone cement distrib
背景:经皮后凸成形术(PKP)后骨水泥的分布影响骨质疏松症患者的临床疗效。机器人和传统治疗骨质疏松性椎体压缩性骨折(OVCFs)都是有效的,但没有研究比较这两种方式在骨水泥分布和临床结果方面的差异。目的:比较机器人辅助下经皮后凸成形术与透视辅助下经皮后凸成形术治疗OVCFs的骨水泥分布及临床疗效。单位:安徽医科大学第一附属医院骨科脊柱外科,合肥。研究设计:单中心回顾性观察性研究。方法:回顾性分析2020年1月至2022年7月期间接受PKP治疗的151例ovcf患者的数据。患者分为3组:机器人辅助单椎弓根经皮后凸成形术(RAUPK)、透视辅助单椎弓根经皮后凸成形术(FAUPK)和透视辅助双椎弓根经皮后凸成形术(FABPK)。记录每次手术的手术时间、术中出血量、骨水泥注射量、骨水泥分布、并发症(血管神经损伤、骨水泥漏出、再骨折)。比较三组患者术前、术后1 d及末次随访时视觉模拟评分(VAS)、Oswestry残疾指数(ODI)评分、Cobb角、损伤椎体前高度。结果:三组均未发生穿刺失败。平均随访20.0±5.2个月。术后所有患者的VAS评分、ODI、椎体前高度、Cobb角均较术前显著改善(P < 0.05)。3组患者术前及术后1 d的VAS评分、ODI评分、Cobb角、椎体前高度比比较,差异均无统计学意义(P < 0.05)。两组术中出血量及并发症发生率比较,差异无统计学意义(P < 0.05)。末次随访时,RAUPK组的VAS、ODI评分低于FAUPK组(P < 0.05),损伤椎体前高度和Cobb角低于raaupk组(P < 0.05)。RAUPK组手术时间、骨水泥注射量、骨水泥分布均优于FAUPK组(P < 0.05)。然而,FABPK组与RAUPK组在末次随访时VAS、ODI、Cobb角、椎体前高度均无显著差异(P < 0.05)。两组手术时间、术中出血量、骨水泥分布、并发症发生率差异无统计学意义(P < 0.05)。RAUPK组骨水泥注射体积明显大于FABPK组(P < 0.05)。局限性:这是一项单中心、回顾性、非随机研究,这是一个主要的局限性。结论:机器人辅助经皮后凸成形术可通过单椎弓根入路建立最佳路径,从而有效降低血管神经和皮质骨损伤的潜在风险。此外,RAUPK确保骨水泥更有利的分布,并为患者提供更好的疼痛缓解。此外,RAUPK比FAUPK具有更大的长期疗效。
{"title":"Comparison of Robot-Assisted and Fluoroscopy-Assisted Percutaneous Kyphoplasty for Bone Cement Distribution and Clinical Efficacy.","authors":"Hui Tao, Zhiwei Huang, Shanzhong Shao, Ruoyu Yang, Kun Yang, Yinshun Zhang, Wei Li, Fulong Dong, Jun Qian, Cailiang Shen","doi":"","DOIUrl":"","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;The distribution of bone cement after percutaneous kyphoplasty (PKP) affects its clinical efficacy in patients with osteoporosis. Robotic and traditional treatment of osteoporotic vertebral compression fractures (OVCFs) have both been established as effective, but no studies have compared these 2 modalities in terms of bone cement distribution and clinical outcomes.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;To compare the bone cement distribution and clinical efficacy of robot-assisted percutaneous kyphoplasty to those of fluoroscopy-assisted percutaneous kyphoplasty for the treatment of OVCFs.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Setting: &lt;/strong&gt;Department of Orthopedics and Spine Surgery, First Affiliated Hospital of Anhui Medical University, Hefei, China.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Study design: &lt;/strong&gt;A single-center, retrospective observational study.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;Data from 151 patients with OVCFs who underwent PKP between January 2020 and July 2022 were analyzed retrospectively. The patients were divided into 3 groups: robot-assisted unipedicular percutaneous kyphoplasty (RAUPK), fluoroscopy-assisted unipedicular percutaneous kyphoplasty (FAUPK), and fluoroscopy-assisted bipedicular percutaneous kyphoplasty (FABPK). The operation time, intraoperative blood loss, bone cement injection volume, bone cement distribution, and complications (vascular and nerve injury, bone cement leakage, and re-fracture) of each procedure were recorded. The visual analog scale (VAS) score, Oswestry Disability Index (ODI) score, Cobb angle, and anterior height of the injured vertebrae were compared among the 3 groups preoperatively, one day postoperatively, and at the final follow-up.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;No puncture failures occurred in any of the 3 groups. The mean follow-up period was 20.0 ± 5.2 months. The postoperative VAS scores, ODI, anterior vertebral heights, and Cobb angles of all patients were significantly improved compared to the preoperative values (P &lt; 0.05). There were no significant differences in the VAS score, ODI score, Cobb angle, anterior vertebral height ratio preoperatively or one day postoperatively among the 3 groups (P &gt; 0.05). The groups' comparative rates of intraoperative blood loss and complications also showed no significant differences (P &gt; 0.05). At the last follow-up, the VAS and ODI scores of the RAUPK group were lower than those of the FAUPK group (P &lt; 0.05), as were the anterior height of the injured vertebra and Cobb angle of the RAUPK group (P &lt; 0.05). The operation time, bone cement injection volume, and bone cement distribution in the RAUPK group were superior to those in the FAUPK group (P &lt; 0.05). Nevertheless, there were no significant differences in the VAS, ODI, Cobb angle, or anterior vertebral height at the last follow-up between the FABPK group and the RAUPK group (P &gt; 0.05). Those 2 groups also showed no significant difference in operation time, intraoperative blood loss, bone cement distrib","PeriodicalId":19841,"journal":{"name":"Pain physician","volume":"27 8","pages":"E953-E963"},"PeriodicalIF":2.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142771196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Peripheral Nerve Stimulation Using High-Frequency Electromagnetic Coupling Technology to Power an Implanted Neurostimulator with a Separate Receiver at the Superior Cluneal Nerve for Treatment of Chronic Back Pain Due to Neuralgia: A Retrospective Study. 利用高频电磁耦合技术刺激周围神经,为植入式神经刺激器提供动力,并在髌上神经处放置单独的接收器,用于治疗神经痛引起的慢性背痛:一项回顾性研究。
IF 2.6 2区 医学 Q2 ANESTHESIOLOGY Pub Date : 2024-11-01
David Lindley, Adrianna Anders

Background: Low back pain is a highly prevalent condition with substantial costs. Superior cluneal neuralgia is present in up to 14% of low back pain cases. This etiology of back pain is often overlooked because the symptoms of superior cluneal neuralgia manifest similarly to those of other conditions, such as radiculopathy and sacroiliac joint pain. Peripheral nerve stimulation (PNS) is an emerging pain management modality used to treat various chronic pain conditions. This retrospective study will examine the outcomes of patients who have back pain caused by neuralgia and are treated with the permanent Freedom® PNS System (Curonix LLC) at the superior cluneal nerve.

Objectives: The primary objective was to examine the responder rate (proportion of patients who experienced greater than 50% relief) and changes in pain scores after the trial procedure. Secondary objectives included changes in pain scores from at least one month after permanent implantation, adverse event occurrences, changes in function and quality of life, and reductions in medication usage.

Setting: This was a retrospective single-site study. All procedures were performed by the same interventional pain physician.

Methods: A retrospective chart review was conducted to assess baseline and follow-up parameters. Inclusion criteria consisted of requirements that patients be 18 years or older and have a confirmed superior cluneal neuralgia diagnosis responsible for their pain presentation. Exclusion criteria included the presence of another active implanted device for pain management. The 11-point verbal rating scale (VRS) was used to assess pain scores.

Results: Twenty-one patients were included in this study. All 21 responded to the trial procedure with a 77% average reduction in VRS scores. At the follow-up (mean = 11 months), 20 patients reported an average 57% reduction in pain scores with the verbal rating scale. The same proportion of patients reported improved function and quality of life. Five patients reported reduced medication usage, including one who stopped taking pain medication altogether. No complications were reported.

Limitations: We were limited to the data available in the patient charts since this was a retrospective study investigating the efficacy and safety of the Freedom® PNS System for patients with refractory chronic back pain.

Conclusion: When used to target the superior cluneal nerve, the Curonix Freedom® PNS System is an effective and safe treatment for neuralgia-caused chronic lower back pain resistant to conservative therapy.

背景:腰痛是一种非常普遍的疾病,成本很高。臀上神经痛出现在高达14%的腰痛病例中。这种背痛的病因常常被忽视,因为上腱鞘神经痛的症状与其他疾病(如神经根病和骶髂关节痛)的症状相似。外周神经刺激(PNS)是一种新兴的疼痛管理方式,用于治疗各种慢性疼痛状况。这项回顾性研究将检查由神经痛引起的腰痛患者的预后,并在上胫腓神经处使用永久Freedom®PNS系统(Curonix LLC)进行治疗。目的:主要目的是检查试验过程后的应答率(缓解超过50%的患者比例)和疼痛评分的变化。次要目标包括永久性植入后至少一个月疼痛评分的变化,不良事件的发生,功能和生活质量的变化,以及药物使用的减少。背景:这是一项回顾性单点研究。所有手术均由同一名介入性疼痛医生进行。方法:采用回顾性图表评价基线和随访参数。纳入标准包括要求患者年满18岁,并有确认的颞叶神经痛诊断负责他们的疼痛表现。排除标准包括存在另一种用于疼痛管理的活性植入装置。采用11分口头评定量表(VRS)评定疼痛评分。结果:21例患者纳入本研究。所有21名患者对试验程序均有反应,VRS评分平均降低77%。在随访期间(平均11个月),20名患者报告用言语评定量表的疼痛评分平均降低了57%。同样比例的患者报告功能和生活质量得到改善。五名患者报告减少了药物使用,其中一名患者完全停止服用止痛药。无并发症报道。局限性:我们仅限于患者图表中可用的数据,因为这是一项回顾性研究,调查Freedom®PNS系统对难治性慢性背痛患者的疗效和安全性。结论:Curonix Freedom®PNS系统应用于髌上神经时,对于保守治疗无效的神经痛引起的慢性腰痛是一种安全有效的治疗方法。
{"title":"Peripheral Nerve Stimulation Using High-Frequency Electromagnetic Coupling Technology to Power an Implanted Neurostimulator with a Separate Receiver at the Superior Cluneal Nerve for Treatment of Chronic Back Pain Due to Neuralgia: A Retrospective Study.","authors":"David Lindley, Adrianna Anders","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Low back pain is a highly prevalent condition with substantial costs. Superior cluneal neuralgia is present in up to 14% of low back pain cases. This etiology of back pain is often overlooked because the symptoms of superior cluneal neuralgia manifest similarly to those of other conditions, such as radiculopathy and sacroiliac joint pain. Peripheral nerve stimulation (PNS) is an emerging pain management modality used to treat various chronic pain conditions. This retrospective study will examine the outcomes of patients who have back pain caused by neuralgia and are treated with the permanent Freedom® PNS System (Curonix LLC) at the superior cluneal nerve.</p><p><strong>Objectives: </strong>The primary objective was to examine the responder rate (proportion of patients who experienced greater than 50% relief) and changes in pain scores after the trial procedure. Secondary objectives included changes in pain scores from at least one month after permanent implantation, adverse event occurrences, changes in function and quality of life, and reductions in medication usage.</p><p><strong>Setting: </strong>This was a retrospective single-site study. All procedures were performed by the same interventional pain physician.</p><p><strong>Methods: </strong>A retrospective chart review was conducted to assess baseline and follow-up parameters. Inclusion criteria consisted of requirements that patients be 18 years or older and have a confirmed superior cluneal neuralgia diagnosis responsible for their pain presentation. Exclusion criteria included the presence of another active implanted device for pain management. The 11-point verbal rating scale (VRS) was used to assess pain scores.</p><p><strong>Results: </strong>Twenty-one patients were included in this study. All 21 responded to the trial procedure with a 77% average reduction in VRS scores. At the follow-up (mean = 11 months), 20 patients reported an average 57% reduction in pain scores with the verbal rating scale. The same proportion of patients reported improved function and quality of life. Five patients reported reduced medication usage, including one who stopped taking pain medication altogether. No complications were reported.</p><p><strong>Limitations: </strong>We were limited to the data available in the patient charts since this was a retrospective study investigating the efficacy and safety of the Freedom® PNS System for patients with refractory chronic back pain.</p><p><strong>Conclusion: </strong>When used to target the superior cluneal nerve, the Curonix Freedom® PNS System is an effective and safe treatment for neuralgia-caused chronic lower back pain resistant to conservative therapy.</p>","PeriodicalId":19841,"journal":{"name":"Pain physician","volume":"27 8","pages":"E937-E942"},"PeriodicalIF":2.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142771309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Novel Ultrasonographic Method to Quickly and Accurately Access the C2 Dorsal Root Ganglion. 一种快速准确进入C2背根神经节的新型超声检查方法。
IF 2.6 2区 医学 Q2 ANESTHESIOLOGY Pub Date : 2024-11-01
Liangliang He, Wenxing Zhao, Po-Yi Paul Su, Xu Liao, Jie Zhao, Zhi Dou, Hongyan Wang, Liqiang Yang, Zhonghui Guan

Background: Occipital neuralgia manifests as pain in the cutaneous distribution of occipital nerves, with the greater occipital nerve stemming from the C2 spinal nerve and the lesser occipital nerve originating from the C2 and C3 spinal nerves. While pulsed radiofrequency ablation of the C2 dorsal root ganglion (DRG) is an effective treatment for refractory occipital neuralgia, accessing the C2 DRG remains a clinical challenge even under fluoroscopic guidance.

Objective: We aimed to develop an ultrasonographic method for quickly and accurately accessing the C2 DRG.

Study design: This is a prospective, observational cohort study.

Setting: Our study was conducted in the Department of Pain Management, Xuanwu Hospital, Capital Medical University, Beijing, China.

Methods: Unlike the C3-C8 foramina, which are ventral to the corresponding facet joints, the C2 foramen is positioned more posteriorly, dorsal to the C1-C2 atlantoaxial joint and longitudinally aligns with the cervical facet joints of C2-C3 and C3-C4. This unique anatomical feature allowed us to rapidly identify the C2 foramen in the sonographic longitudinal-axis view, what we call the "Stage-light Sign." Further exposure of the C2 DRG in the oblique-axis view we call the "Turtle Sign." The following procedural parameters were prospectively obtained: the time required to identify the C2 DRG target, the time needed to reach the target from the point of skin puncture, the number of puncture attempts required to reach the target, and the minimum sensory testing voltage to evoke paresthesia responses in the cutaneous occipital nerve distributions. Clinical outcomes were assessed by serial pain severity using the Numeric Rating Scale at baseline and up to 3 months post the C2 DRG pulsed radiofrequency ablation procedure.

Results: The correct placement of the needle tip was initially confirmed with fluoroscopy, with the injected contrast medium distributed along the C2 spinal nerve. Importantly, electrical sensory stimulation elicited paresthesia in the headache area in all patients, with the required voltage being 0.35 ± 0.02 V. Furthermore, treatment outcomes supported the correct needle tip position, as pulsed radiofrequency ablation treatment led to sustained pain reduction. It took 36.2 ± 2.2 seconds to obtain the final "TurtleSign" view of the C2 DRG. Once the target was identified, it required a single puncture attempt to reach it, with a duration of 36.3 ± 2.5 seconds from puncturing the skin to reaching the target.

Limitation: We only followed patients for up to 3 months postprocedure.

Conclusion: We have developed an ultrasonographic method to quickly and accurately access the C2 DRG, which has the potential to greatly facilitate treating the C2 DRG for managing occipital neuralgia.

背景:枕神经痛表现为枕神经皮肤分布的疼痛,其中源自C2脊神经的枕大神经和源自C2和C3脊神经的枕小神经。虽然脉冲射频消融C2背根神经节(DRG)是治疗难治性枕神经痛的有效方法,但即使在x线镜指导下,进入C2背根神经节仍然是一个临床挑战。目的:建立一种快速、准确进入C2 DRG的超声检查方法。研究设计:这是一项前瞻性、观察性队列研究。地点:我们的研究在首都医科大学宣武医院疼痛管理科进行。方法:与C3-C8椎间孔位于相应小关节的腹侧不同,C2椎间孔位于C1-C2寰枢关节的后部,并纵向与C2- c3和C3-C4的颈椎小关节对齐。这种独特的解剖特征使我们能够在超声纵轴视图中快速识别C2孔,我们称之为“舞台灯光标志”。在斜轴视图中进一步暴露C2 DRG,我们称之为“海龟征”。前瞻性获得以下程序参数:识别C2 DRG靶点所需的时间,从皮肤穿刺点到达靶点所需的时间,到达靶点所需的穿刺次数,以及引起皮枕神经分布感觉异常反应的最小感觉测试电压。临床结果是在基线和C2 DRG脉冲射频消融手术后3个月,使用数值评定量表对连续疼痛严重程度进行评估。结果:透视初步确认针尖位置正确,注射造影剂沿C2脊神经分布。重要的是,电刺激在所有患者的头痛区域引起感觉异常,所需电压为0.35±0.02 V。此外,治疗结果支持正确的针尖位置,因为脉冲射频消融治疗导致持续的疼痛减轻。获得C2 DRG的最终“TurtleSign”视图需要36.2±2.2秒。一旦确定了目标,就需要一次穿刺尝试才能到达目标,从穿刺皮肤到到达目标的持续时间为36.3±2.5秒。局限性:我们只对患者进行了术后3个月的随访。结论:我们开发了一种快速准确进入C2 DRG的超声方法,为治疗枕神经痛的C2 DRG的治疗提供了极大的便利。
{"title":"A Novel Ultrasonographic Method to Quickly and Accurately Access the C2 Dorsal Root Ganglion.","authors":"Liangliang He, Wenxing Zhao, Po-Yi Paul Su, Xu Liao, Jie Zhao, Zhi Dou, Hongyan Wang, Liqiang Yang, Zhonghui Guan","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Occipital neuralgia manifests as pain in the cutaneous distribution of occipital nerves, with the greater occipital nerve stemming from the C2 spinal nerve and the lesser occipital nerve originating from the C2 and C3 spinal nerves. While pulsed radiofrequency ablation of the C2 dorsal root ganglion (DRG) is an effective treatment for refractory occipital neuralgia, accessing the C2 DRG remains a clinical challenge even under fluoroscopic guidance.</p><p><strong>Objective: </strong>We aimed to develop an ultrasonographic method for quickly and accurately accessing the C2 DRG.</p><p><strong>Study design: </strong>This is a prospective, observational cohort study.</p><p><strong>Setting: </strong>Our study was conducted in the Department of Pain Management, Xuanwu Hospital, Capital Medical University, Beijing, China.</p><p><strong>Methods: </strong>Unlike the C3-C8 foramina, which are ventral to the corresponding facet joints, the C2 foramen is positioned more posteriorly, dorsal to the C1-C2 atlantoaxial joint and longitudinally aligns with the cervical facet joints of C2-C3 and C3-C4. This unique anatomical feature allowed us to rapidly identify the C2 foramen in the sonographic longitudinal-axis view, what we call the \"Stage-light Sign.\" Further exposure of the C2 DRG in the oblique-axis view we call the \"Turtle Sign.\" The following procedural parameters were prospectively obtained: the time required to identify the C2 DRG target, the time needed to reach the target from the point of skin puncture, the number of puncture attempts required to reach the target, and the minimum sensory testing voltage to evoke paresthesia responses in the cutaneous occipital nerve distributions. Clinical outcomes were assessed by serial pain severity using the Numeric Rating Scale at baseline and up to 3 months post the C2 DRG pulsed radiofrequency ablation procedure.</p><p><strong>Results: </strong>The correct placement of the needle tip was initially confirmed with fluoroscopy, with the injected contrast medium distributed along the C2 spinal nerve. Importantly, electrical sensory stimulation elicited paresthesia in the headache area in all patients, with the required voltage being 0.35 ± 0.02 V. Furthermore, treatment outcomes supported the correct needle tip position, as pulsed radiofrequency ablation treatment led to sustained pain reduction. It took 36.2 ± 2.2 seconds to obtain the final \"TurtleSign\" view of the C2 DRG. Once the target was identified, it required a single puncture attempt to reach it, with a duration of 36.3 ± 2.5 seconds from puncturing the skin to reaching the target.</p><p><strong>Limitation: </strong>We only followed patients for up to 3 months postprocedure.</p><p><strong>Conclusion: </strong>We have developed an ultrasonographic method to quickly and accurately access the C2 DRG, which has the potential to greatly facilitate treating the C2 DRG for managing occipital neuralgia.</p>","PeriodicalId":19841,"journal":{"name":"Pain physician","volume":"27 8","pages":"E927-E935"},"PeriodicalIF":2.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142770996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Computed Tomography-guided Percutaneous Bilateral Neurolytic Celiac Plexus Block with Alcohol for Upper Abdominal Visceral Cancer Pain. ct引导下经皮酒精双侧腹腔神经丛阻滞治疗上腹部内脏癌性疼痛。
IF 2.6 2区 医学 Q2 ANESTHESIOLOGY Pub Date : 2024-11-01
Bing Huang, Dan Wu, YaJing Chen, Yingjie Hua, Zhongwei Zhao, Xufang Huang, Qiaoying Rao, Lu Liu, Jianliang Sun
<p><strong>Background: </strong>The neurolytic celiac plexus block (NCPB) can be introduced through the posterior para-aortic, anterior para-aortic, posterior transaortic, or endoscopic anterior para-aortic puncture approach, as well as the posterior approach via the intervertebral disc. To reduce the complications of puncture, this block's original manual blind puncture technique can be improved upon by using a C-arm fluoroscope, computed tomography (CT), or an ultrasound, the last of which may be endoscopic.</p><p><strong>Objective: </strong>To observe the distribution of absolute alcohol and its analgesic effect on cancer-induced upper abdominal visceral pain during percutaneous NCPB through the anterior and posterior diaphragmatic crura under CT guidance.</p><p><strong>Study design: </strong>Clinical research study.</p><p><strong>Setting: </strong>Department of Anesthesiology and Pain Medical Center, Jiaxing, People's Republic of China.</p><p><strong>Methods: </strong>Thirty-eight patients (19 men and 19 women) with advanced carcinomatous epigastric pain were enrolled in this study. The patients were 47-88 (mean, SD: 64.9 ± 8.8) years old, weighed 37-62 kg (mean, SD: 51.6 ± 12.3), and had a grade III or IV physical status on the classification system established by the American Society of Anesthesiologists. The left and right punctures were made through the T12-L1 intervertebral space under CT guidance. The left side was punctured through the paravertebral and diaphragmatic crura to the anterolateral side of the anterior abdominal aorta of the diaphragmatic crus; and the right side was punctured via the posterior approach through the intervertebral disc to the posterior abdominal aorta of the diaphragmatic crus and then to the exterior. A solution consisting of 8 mL of 1% lidocaine and 1 mL of 30% iohexol was injected. If this injectate wholly or partly surrounded the abdominal aorta, then injecting anhydrous alcohol was deemed practicable. Fifteen mL of absolute alcohol containing 10 mL iohexol were injected into the left and right sides 15 minutes later. The alcohol diffusion was observed by CT. The pain Visual Analog Scale was used to evaluate the analgesic effect before NCPB and one hour, one week, one month, 3 months, and 6 months after the treatment. Any treatment-related complications were recorded.</p><p><strong>Results: </strong>All patients were punctured at the predetermined position under CT guidance. Among the 23 patients whose injection of absolute alcohol surrounded the abdominal aorta completely, 19 (82.6%) stopped taking analgesic drugs altogether; of the 8 patients whose injection of absolute alcohol surrounded 75% of the abdominal aorta, 6 (75%) stopped taking oxycodone. In the 7 patients whose injection of absolute alcohol surrounded only 50% of the abdominal aorta, the pain was alleviated to varying degrees, but only 2 (28.6%) stopped taking oxycodone completely, and the other 5 patients still needed oral oxycodone. No ab
背景:神经溶解性腹腔丛阻滞(NCPB)可以通过后主动脉旁、前主动脉旁、后经主动脉或内镜前主动脉旁穿刺入路以及经椎间盘的后入路引入。为了减少穿刺的并发症,该区块原有的手动盲穿刺技术可以通过使用c臂透视、计算机断层扫描(CT)或超声(最后一种可能是内窥镜)来改进。目的:观察CT引导下经膈前后脚经皮NCPB术中无水酒精的分布及对肿瘤性上腹部内脏痛的镇痛作用。研究设计:临床研究。单位:中华人民共和国嘉兴市麻醉与疼痛医学中心麻醉科。方法:38例晚期癌性胃脘痛患者(男19例,女19例)入选本研究。患者年龄47 ~ 88岁(平均,SD: 64.9±8.8),体重37 ~ 62 kg(平均,SD: 51.6±12.3),按照美国麻醉医师学会制定的分类系统,身体状况为III级或IV级。在CT引导下通过T12-L1椎间隙进行左右穿刺。左侧经椎旁及膈脚穿刺至膈脚腹前主动脉前外侧;右侧通过后入路刺穿穿过椎间盘到达膈脚的腹后主动脉然后到达外部。注射1%利多卡因8ml和30%碘己醇1ml的溶液。如果这种注射全部或部分包围腹主动脉,则认为注射无水酒精是可行的。15分钟后,向左右两侧注射含10 mL碘己醇的无水酒精15 mL。CT观察酒精扩散。采用疼痛视觉模拟评分法评价NCPB治疗前及治疗后1小时、1周、1个月、3个月、6个月的镇痛效果。记录所有与治疗相关的并发症。结果:所有患者均在CT引导下在预定位置穿刺。在注射无水酒精完全包围腹主动脉的23例患者中,19例(82.6%)完全停止使用镇痛药物;在注射无水酒精包围75%腹主动脉的8例患者中,有6例(75%)停止服用羟考酮。7例注射无水酒精仅包围腹主动脉50%的患者疼痛均有不同程度缓解,但仅有2例(28.6%)完全停用羟考酮,其余5例仍需口服羟考酮。无腹部出血、腹部感染、截瘫发生。局限性:本研究的结果需要进一步的研究和更多的临床数据来证实。主要的限制是样本量小,缺乏对胃内和胃外注射给药方法的双盲对照比较。结论:采用ct引导下双针穿刺横膈膜前后脚的NCPB,可提高无水酒精对腹主动脉相应段的包围能力,并在注射时阻断大、小膈神经和腹腔丛。这种NCPB入路对上腹部难治性内脏癌性疼痛患者有较好的镇痛效果。
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引用次数: 0
L5-S3 Compared to L5-S2 Full-Endoscopic Rhizotomy and Ablation Under a Navigation System for Sacroiliac Joint Pain: A Comparative Study. 导航系统下L5-S3与L5-S2全内镜下根切断术和消融治疗骶髂关节疼痛的比较研究。
IF 2.6 2区 医学 Q2 ANESTHESIOLOGY Pub Date : 2024-11-01
Jae Hwan Lee, Kuo-Tai Chen, Ying-Chieh Chen, Chien-Min Chen

Background: Chronic low back pain (CLBP) with sacroiliac joint (SIJ) involvement is a prevalent issue in health care. Surgical intervention, employing an endoscopic technique with a navigation system, targets and ablates nociceptive nerve fibers associated with SIJ pain, although the clinical effect of omitting rhizotomy of the lateral sacral branch of S3 remains uncertain.

Objectives: This study aimed to compare the clinical outcomes of 2 full-endoscopic rhizotomy and ablation (FERA) techniques for SIJ pain and to determine the effect of omitting rhizotomy of the lateral sacral branch of S3 on patient outcomes.

Study design: This study adopted a retrospective cohort study design.

Setting: This study was conducted at a single medical institution by a neurosurgeon.

Methods: From January 2018 through March 2021, the records of 73 patients undergoing L5-S3 or L5-S2 FERA for SIJ pain associated with CLBP were retrospectively reviewed. The patients were evaluated using the Visual Analog Scale (VAS) for pain, Oswestry Disability Index (ODI) for functional disability, and MacNab criteria for satisfaction. The procedures were guided by 3-D robotic C-arm navigation. The L5-S3 FERA group underwent rhizotomy and ablation of the L5-S3 lateral branches, whereas the L5-S2 FERA group did not undergo rhizotomy of the S3 lateral sacral branch.

Results: Both groups showed significant  improvements at one year in VAS and ODI scores with similar trends. The L5-S2 FERA group had a shorter operative time, particularly bilaterally, without complications. Although the L5-S3 FERA group initially presented a slightly higher recurrence rate at 6 months, their recurrence rate was equal with that of the L5-S2 FERA group at one year. Furthermore, the MacNab criteria showed comparable satisfaction rates in both groups.

Limitation: This was a small retrospective study.

Conclusion: L5-S2 FERA demonstrated clinical outcomes similar to those of L5-S3 FERA for pain relief, functional improvement, and satisfaction. Omitting S3 lateral branch rhizotomy did not adversely affect the outcomes. Surgeons may consider omitting S3 lateral branch rhizotomy for SIJ pain treatment, thereby reducing operative time while maintaining patient benefits.

背景:慢性腰痛(CLBP)伴骶髂关节(SIJ)累及是医疗保健中的一个普遍问题。手术干预,采用带导航系统的内镜技术,靶向并切除与SIJ疼痛相关的伤害性神经纤维,尽管省略S3骶外侧支根切断术的临床效果仍不确定。目的:本研究旨在比较两种全内镜下根切断术和消融(FERA)技术治疗SIJ疼痛的临床结果,并确定省略S3骶外侧支根切断术对患者预后的影响。研究设计:本研究采用回顾性队列研究设计。环境:本研究由一名神经外科医生在一家医疗机构进行。方法:回顾性分析2018年1月至2021年3月73例L5-S3或L5-S2 FERA治疗CLBP相关SIJ疼痛的患者的记录。采用视觉模拟量表(VAS)评估疼痛,Oswestry残疾指数(ODI)评估功能残疾,MacNab标准评估满意度。该过程由三维机器人c臂导航引导。L5-S3 FERA组进行了L5-S3侧支的根切断术和消融,而L5-S2 FERA组没有进行S3骶侧支的根切断术。结果:两组在一年内VAS和ODI评分均有显著改善,趋势相似。L5-S2 FERA组手术时间较短,特别是双侧,无并发症。虽然L5-S3 FERA组最初6个月的复发率略高,但1年的复发率与L5-S2 FERA组相当。此外,MacNab标准显示两组的满意率相当。局限性:这是一项小型回顾性研究。结论:L5-S2 FERA在疼痛缓解、功能改善和满意度方面的临床效果与L5-S3 FERA相似。忽略S3侧支根切断术对结果没有不利影响。外科医生可能会考虑在SIJ疼痛治疗中省略S3侧支根切断术,从而在保持患者利益的同时减少手术时间。
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引用次数: 0
Mindfulness Meditation for Fibromyalgia Syndrome: A Systematic Review and Meta-analysis. 正念冥想治疗纤维肌痛综合征:系统回顾和荟萃分析。
IF 2.6 2区 医学 Q2 ANESTHESIOLOGY Pub Date : 2024-11-01
Shuo Meng, Chunfeng Cao, Minghua Zhang, Jing Dong, Minpeng Lu
<p><strong>Background: </strong>The effectiveness of mindfulness meditation (MM) for the treatment of fibromyalgia syndrome (FMS) is unknown and needs to be updated.</p><p><strong>Objective: </strong>This study aimed at investigating the effectiveness of MM for the treatment of FMS.</p><p><strong>Study design: </strong>A systematic review and meta-analysis.</p><p><strong>Methods: </strong>A comprehensive search of relevant studies published from the databases' inception through April 12, 2023 was conducted within the following databases: Cochrane Library, Embase, MEDLINE, PubMed, Clinicaltrials.gov, and PsycINFO. We included randomized controlled trials that reported at least one of the following outcome indicators: the Fibromyalgia Impact Questionnaire (FIQ), the Pittsburg Sleep Quality Index (PSQI), the Beck Depression Inventory (BDI), and the Perceived Stress Scale (PSS). Results are presented in terms of mean difference (MD), supplemented by 95% CIs The I2 statistic assessed heterogeneity across 3 distinct observational time frames. We used the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) framework to appraise the robustness of the evidence.</p><p><strong>Results: </strong>Ten randomized controlled trials were selected from 1,377 citations (n = 818). Various MM regimens were reported (type of mindfulness, duration, schemes, and ingredients). Among 818 patients, very low to moderate evidence indicated that MM could reduce FIQ in the short-term (MD = -6.20; 95% CI,-8.51 to -3.89; P < 0.05; GRADE: moderate); a lower PSQI score (MD = -1.84; 95% CI, -3.35 to -0.33; P < 0.05; GRADE: very low); a reduce BDI score (MD = -3.26; 95% CI, -5.77 to -0.76; P < 0.05; GRADE: moderate); and a decreased PSS score (MD = -4.85; 95% CI, -8.22 to -1.49; P < 0.05; GRADE: very low). At medium-term follow-up, MM consistently reduced the BDI score (MD = -2.88; 95% CI, -4.98 to -0.79; P < 0.05; GRADE: moderate) and decreased the PSS score (MD = -2.76; 95% CI, -4.82 to -0.70; P < 0.05; GRADE: moderate) but there was no significant difference in FIQ scores (MD = -2.78; 95% CI, -6.32 to 0.76; P > 0.05; GRADE: low) and PSQI scores (MD = -1.28; 95% CI, -3.35 to -0.80; P > 0.05; GRADE: very low). However, at long-term follow-up, MM still reduced FIQ scores (MD = -6.09; 95% CI, -9.01 to -3.16; P < 0.05; GRADE: moderate).</p><p><strong>Limitations: </strong>The relatively small sample size and the average quality of the included studies may have introduced biases. The time and method of meditation in the included studies were not completely unified, and there were confounding factors. Additionally, the limited amount of available literature is a challenge. Despite focusing on randomized controlled trials, there is heterogeneity among these studies. Future research should aim for larger, higher-quality studies to address these limitations and provide a more comprehensive understanding of MM's effectiveness in fibromyalgia management.</p><p><strong>
背景:正念冥想(MM)治疗纤维肌痛综合征(FMS)的有效性尚不清楚,需要更新。目的:探讨MM对FMS的治疗作用。研究设计:系统回顾和荟萃分析。方法:在以下数据库中全面检索从数据库建立到2023年4月12日发表的相关研究:Cochrane Library、Embase、MEDLINE、PubMed、Clinicaltrials.gov和PsycINFO。我们纳入了至少报告以下结果指标之一的随机对照试验:纤维肌痛影响问卷(FIQ)、匹兹堡睡眠质量指数(PSQI)、贝克抑郁量表(BDI)和感知压力量表(PSS)。结果以平均差异(MD)表示,补充95% ci。I2统计量评估了3个不同观察时间框架的异质性。我们使用分级建议评估、发展和评价(GRADE)框架来评估证据的稳健性。结果:从1377篇文献中选取10项随机对照试验(n = 818)。报告了各种MM方案(正念类型,持续时间,方案和成分)。在818例患者中,极低至中度证据表明MM可在短期内降低FIQ (MD = -6.20;95% CI,-8.51 ~ -3.89;P < 0.05;成绩:中等);PSQI评分较低(MD = -1.84;95% CI, -3.35 ~ -0.33;P < 0.05;等级:极低);BDI评分降低(MD = -3.26);95% CI, -5.77 ~ -0.76;P < 0.05;成绩:中等);PSS评分降低(MD = -4.85;95% CI, -8.22 ~ -1.49;P < 0.05;等级:非常低)。中期随访时,MM持续降低BDI评分(MD = -2.88;95% CI, -4.98 ~ -0.79;P < 0.05;GRADE:中度),PSS评分降低(MD = -2.76;95% CI, -4.82 ~ -0.70;P < 0.05;GRADE:中度),但FIQ评分无显著差异(MD = -2.78;95% CI, -6.32 ~ 0.76;P < 0.05;GRADE: low)和PSQI评分(MD = -1.28;95% CI, -3.35 ~ -0.80;P < 0.05;等级:非常低)。然而,在长期随访中,MM仍然降低FIQ评分(MD = -6.09;95% CI, -9.01 ~ -3.16;P < 0.05;成绩:中等)。局限性:相对较小的样本量和纳入研究的平均质量可能会引入偏倚。在纳入的研究中,冥想的时间和方法并不完全统一,并且存在混淆因素。此外,可用文献的数量有限也是一个挑战。尽管关注的是随机对照试验,但这些研究之间存在异质性。未来的研究应着眼于更大规模、更高质量的研究,以解决这些局限性,并提供更全面的了解MM在纤维肌痛治疗中的有效性。结论:极低至中度证据表明,MM在短期内改善了FMS患者的生活质量,缓解了压力,缓解了失眠和抑郁。值得注意的是,抑郁和压力水平的改善一直持续到中期。此外,在长期随访中可以看出生活质量的改善。这表明MM可以作为FMS的辅助治疗。国际前瞻性系统评价注册(PROSPERO)注册号:CRD42023442356。
{"title":"Mindfulness Meditation for Fibromyalgia Syndrome: A Systematic Review and Meta-analysis.","authors":"Shuo Meng, Chunfeng Cao, Minghua Zhang, Jing Dong, Minpeng Lu","doi":"","DOIUrl":"","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;The effectiveness of mindfulness meditation (MM) for the treatment of fibromyalgia syndrome (FMS) is unknown and needs to be updated.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;This study aimed at investigating the effectiveness of MM for the treatment of FMS.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Study design: &lt;/strong&gt;A systematic review and meta-analysis.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;A comprehensive search of relevant studies published from the databases' inception through April 12, 2023 was conducted within the following databases: Cochrane Library, Embase, MEDLINE, PubMed, Clinicaltrials.gov, and PsycINFO. We included randomized controlled trials that reported at least one of the following outcome indicators: the Fibromyalgia Impact Questionnaire (FIQ), the Pittsburg Sleep Quality Index (PSQI), the Beck Depression Inventory (BDI), and the Perceived Stress Scale (PSS). Results are presented in terms of mean difference (MD), supplemented by 95% CIs The I2 statistic assessed heterogeneity across 3 distinct observational time frames. We used the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) framework to appraise the robustness of the evidence.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Ten randomized controlled trials were selected from 1,377 citations (n = 818). Various MM regimens were reported (type of mindfulness, duration, schemes, and ingredients). Among 818 patients, very low to moderate evidence indicated that MM could reduce FIQ in the short-term (MD = -6.20; 95% CI,-8.51 to -3.89; P &lt; 0.05; GRADE: moderate); a lower PSQI score (MD = -1.84; 95% CI, -3.35 to -0.33; P &lt; 0.05; GRADE: very low); a reduce BDI score (MD = -3.26; 95% CI, -5.77 to -0.76; P &lt; 0.05; GRADE: moderate); and a decreased PSS score (MD = -4.85; 95% CI, -8.22 to -1.49; P &lt; 0.05; GRADE: very low). At medium-term follow-up, MM consistently reduced the BDI score (MD = -2.88; 95% CI, -4.98 to -0.79; P &lt; 0.05; GRADE: moderate) and decreased the PSS score (MD = -2.76; 95% CI, -4.82 to -0.70; P &lt; 0.05; GRADE: moderate) but there was no significant difference in FIQ scores (MD = -2.78; 95% CI, -6.32 to 0.76; P &gt; 0.05; GRADE: low) and PSQI scores (MD = -1.28; 95% CI, -3.35 to -0.80; P &gt; 0.05; GRADE: very low). However, at long-term follow-up, MM still reduced FIQ scores (MD = -6.09; 95% CI, -9.01 to -3.16; P &lt; 0.05; GRADE: moderate).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Limitations: &lt;/strong&gt;The relatively small sample size and the average quality of the included studies may have introduced biases. The time and method of meditation in the included studies were not completely unified, and there were confounding factors. Additionally, the limited amount of available literature is a challenge. Despite focusing on randomized controlled trials, there is heterogeneity among these studies. Future research should aim for larger, higher-quality studies to address these limitations and provide a more comprehensive understanding of MM's effectiveness in fibromyalgia management.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;","PeriodicalId":19841,"journal":{"name":"Pain physician","volume":"27 8","pages":"479-494"},"PeriodicalIF":2.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142771249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Predicting Responses to Interventional Pain Management Techniques for Chronic Low Back Pain: A Single-Center Observational Study (PReTi-Back Study). 预测对慢性腰痛介入疼痛管理技术的反应:一项单中心观察研究(PReTi-Back研究)。
IF 2.6 2区 医学 Q2 ANESTHESIOLOGY Pub Date : 2024-11-01
Santiago Garcia-Hernandez, Fernando Higuero-Cantonero, Francisco de la Gala Garcia, Ángel Alonso Chico, Javier Blanco Aceituno, Sara Zapatero Garcia, José Laureano Aguilar Godoy, Javier Hortal Iglesias, Ana Esther Lopez Perez, Ignacio Garutti
<p><strong>Background: </strong>Exploring factors linked to the outcomes of certain interventional pain management techniques may optimize the selection of candidates for those procedures. Our hypothesis is that factors that influence responses to interventional therapies for chronic low back pain (CLBP) can be identified by analyzing a prospective cohort.</p><p><strong>Objectives: </strong>Our main aim is to identify the factors that may be associated with adult patients' responses to interventional therapies for the treatment of CLBP after 4 weeks of follow-up. Secondary objectives include the development of a predictive model and the establishment of a predictive score.</p><p><strong>Study design: </strong>The PReTi-Back (Predicting REsponse to interventional Therapies In chronic BACK pain) study is an observational prospective single-center study, employing a nonprobability-sampling method.</p><p><strong>Setting: </strong>Our population consists of adult outpatients with CLBP in a chronic pain unit of a tertiary hospital. The procedures we evaluated included epidural steroid injections, medial branch blocks and denervations, dorsal root ganglion blocks, and pulsed radiofrequency.</p><p><strong>Methods: </strong>Ratings on the Numeric Pain Rating Scale (NPRS) and Oswestry Disability Index (ODI) were measured at the baseline and after 4 weeks of follow-up. The primary outcome of the study was composite and was evaluated at 4 weeks. A positive response to an intervention was defined as the simultaneous occurrence of a decrease of at least 2 points in the NPRS score and a decrease of at least 20% in the ODI score. A predictive model was constructed using logistic regression analysis, which incorporated 14 variables selected in advance. A predictive score was developed based on the odds ratios of the model variables.</p><p><strong>Results: </strong>Four hundred patients were recruited. Of these patients, 368 completed follow-up, 49 were excluded, and 319 were included in the analysis. The interventional therapies provided a positive response to 85 patients (26.6%) at 4 weeks. Listhesis, radicular compression, and satisfaction with previous interventional therapies were positively associated with the positive response, and their ORs were close to 2. Meanwhile, obesity and persistent spinal pain syndrome type 2 (PSPS-2) had negative associations with the outcome, presenting ORs close to 0.5. The models were statistically significant and exhibited satisfactory goodness of fit. The area under the curve was 0.67 (95% CI, 0.60-0.74). Both models exhibited low sensitivity but high specificity. The synthesis of the prediction score had little impact on its discriminatory capacity.</p><p><strong>Limitations: </strong>The subgroup analysis revealed that both listhesis and radicular compression were associated with the response to epidural therapies but not with the response to medial branch therapies. The score was efficient in ruling out those who would no
背景:探索与某些介入性疼痛管理技术结果相关的因素可能会优化这些手术的候选人选择。我们的假设是,影响慢性腰痛(CLBP)介入治疗反应的因素可以通过分析前瞻性队列来确定。目的:我们的主要目的是在4周的随访后,确定可能与成年患者对CLBP介入治疗反应相关的因素。次要目标包括建立预测模型和建立预测评分。研究设计:PReTi-Back(预测对慢性背痛介入治疗的反应)研究是一项观察性前瞻性单中心研究,采用非概率抽样方法。环境:我们的人群由三级医院慢性疼痛科的CLBP成年门诊患者组成。我们评估的治疗方法包括硬膜外类固醇注射、内侧分支阻滞和去神经支配、背根神经节阻滞和脉冲射频。方法:在基线和随访4周后分别测量疼痛评定量表(NPRS)和Oswestry残疾指数(ODI)评分。该研究的主要结果为综合结果,并在4周时进行评估。对干预的积极反应被定义为NPRS评分同时下降至少2分,ODI评分同时下降至少20%。采用logistic回归分析方法,将事先选择的14个变量纳入预测模型。根据模型变量的比值比建立预测评分。结果:共纳入400例患者。在这些患者中,368例完成随访,49例被排除,319例纳入分析。介入治疗4周时85例(26.6%)患者出现阳性反应。滑脱、神经根受压、既往介入治疗满意度与阳性反应呈正相关,其or均接近2。同时,肥胖和持续性脊柱疼痛综合征2型(PSPS-2)与预后呈负相关,or接近0.5。模型具有统计学意义,拟合优度令人满意。曲线下面积为0.67 (95% CI, 0.60-0.74)。两种模型灵敏度低,特异度高。预测分值的综合对其判别能力影响不大。局限性:亚组分析显示,滑脱和神经根压迫与硬膜外治疗的反应有关,而与内侧分支治疗的反应无关。该评分在排除那些不会从干预中获益的患者(得分为0或1)方面是有效的,但其主要限制是在识别那些可能反应良好的患者(得分≥2)方面效果较差。对先前进行的介入治疗满意的患者,或在影像学上表现出神经根受压或脱位的患者,对短期IMPT产生积极反应的可能性大约是没有这些特征的患者的两倍。肥胖或患有PSPS-2的患者比没有这些疾病的患者表现出大约50%的短期反应可能性低。
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引用次数: 0
A Review of Etiological Biomarkers for Fibromyalgia and Their Therapeutic Implications. 纤维肌痛的病因生物标志物及其治疗意义综述。
IF 2.6 2区 医学 Q2 ANESTHESIOLOGY Pub Date : 2024-11-01
Marc Russo, Danielle Santarelli, Peter Georgius, Paul J Austin
<p><strong>Background: </strong>Fibromyalgia is a complex condition that has long puzzled the medical community. Hypotheses to explain the chronic widespread pain associated with the disease have evolved significantly over the years. However, research efforts to identify disease-specific biomarkers and develop effective treatments have been largely unsuccessful.</p><p><strong>Objectives: </strong>The goals of this study were to review potential etiological biomarkers for fibromyalgia, focusing on micro-inflammation and metabolic syndrome, and to discuss the clinical implications of the review findings.</p><p><strong>Study design: </strong>A narrative review.</p><p><strong>Methods: </strong>Relevant literature was obtained via Medline/PubMed, using the following search terms: fibromyalgia[ti] ("metabolic syndrome" OR "metabolic disease" OR biomarker*[ti] OR micro-inflammation OR sub-inflammation OR "low-level inflammation" OR "low-grade inflammation"). Results were filtered for the English language and screened for inclusion in the review.</p><p><strong>Results: </strong>Articles included in the review covered the topics of pain, immune response/inflammation, micro-inflammation, metabolic syndrome, gut dysbiosis, oxidative stress, and stress response. Various molecules have been proposed as pain biomarkers for fibromyalgia, including neurotransmitters, neuropeptides, growth factors, and cytokines with possible etiological relevance. Recent genome-wide expression profiling suggests connections among low-level inflammation, termed "micro-inflammation," and the upregulation of genes involved in antibacterial and innate immune system response as well as those involved in clinical features, including high body mass index (BMI) and comorbid depression, in a subgroup of fibromyalgia patients. A set of 5 differentially expressed inflammatory genes have been identified as potential biomarkers of a micro-inflammation fibromyalgia subtype. Proposed triggers of micro-inflammation include bacterial disease and gut dysbiosis. Metabolic syndrome may be causative or consequential, while comorbid depression may be associated with dysbiosis and/or micro-inflammation through the gut-immune-brain axis. A potential new treatment approach based on this information has been proposed.</p><p><strong>Limitations: </strong>External validation of potential etiological biomarkers is needed. Further investigations to ascertain the involvement of metabolic syndrome and gut dysbiosis and support the proposed treatment paradigm are warranted.</p><p><strong>Conclusion: </strong>Fibromyalgia is likely the result of multiple causative factors, genetic and environmental. To date, no clear, reliable etiological biomarker for fibromyalgia has been identified. The considerable variability among patients suggests the presence of multiple disease subtypes with different pathophysiological mechanisms. Effective treatment therefore requires a multimodal, multidisciplinary approach that targ
背景:纤维肌痛是一种长期困扰医学界的复杂疾病。多年来,解释与该疾病相关的慢性广泛性疼痛的假说已经发生了重大变化。然而,识别疾病特异性生物标志物和开发有效治疗方法的研究工作在很大程度上是不成功的。目的:本研究的目的是回顾纤维肌痛的潜在病因生物标志物,重点是微炎症和代谢综合征,并讨论综述结果的临床意义。研究设计:叙述性回顾。方法:通过Medline/PubMed检索相关文献,检索词为纤维肌痛[ti](“代谢综合征”或“代谢性疾病”或生物标志物*[ti]或微炎症或亚炎症或“低水平炎症”或“低度炎症”)。对英语语言的结果进行筛选,并筛选纳入本综述。结果:纳入综述的文章涵盖了疼痛、免疫反应/炎症、微炎症、代谢综合征、肠道生态失调、氧化应激和应激反应等主题。各种分子被认为是纤维肌痛的疼痛生物标志物,包括神经递质、神经肽、生长因子和可能与病因相关的细胞因子。最近的全基因组表达谱分析表明,在纤维肌痛患者亚组中,低水平炎症(称为“微炎症”)与参与抗菌和先天免疫系统反应的基因上调以及涉及临床特征(包括高体重指数(BMI)和共病抑郁症)的基因上调之间存在联系。一组5个差异表达的炎症基因已被确定为微炎症纤维肌痛亚型的潜在生物标志物。微炎症的触发因素包括细菌性疾病和肠道生态失调。代谢综合征可能是病因或结果,而共病性抑郁可能与生态失调和/或通过肠道-免疫-脑轴的微炎症有关。基于这一信息提出了一种潜在的新治疗方法。局限性:需要对潜在的病因生物标志物进行外部验证。进一步的调查以确定代谢综合征和肠道生态失调的参与,并支持所提出的治疗模式是必要的。结论:纤维肌痛可能是遗传、环境等多种因素共同作用的结果。到目前为止,还没有明确、可靠的纤维肌痛病因生物标志物。患者之间的相当大的差异表明存在多种具有不同病理生理机制的疾病亚型。因此,有效的治疗需要多模式、多学科的方法,针对每个患者的病理生理特征。提出的治疗模式试图解决最近在纤维肌痛的发展和维持中涉及的多种因素,如微炎症、代谢综合征和肠道生态失调。
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Pain physician
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