Pub Date : 2017-02-27DOI: 10.12974/2311-8792.2017.05.3
S. Khakpour, A. Shahidian, M. Ghassemi
Cardiovascular diseases takes many lives yearly, whereas atherosclerosis is on the top. Carotid atherosclerosis disease considered as a multi-aspects disease and only by considering all of its aspects, a comprehensive insight can be achieved. It seems that wall motion has great effects on arterial hemodynamics and Low Density Lipoprotein (LDL)mass transport and concentration while LDL concentration is believed to be highly associated with atherosclerosis plaque formation. The primary goal of this study is to investigate the wall elasticity effects on carotid hemodynamics and LDL mass transport through carotid artery bifurcation as a challenging case due to its geometry and location. The blood is modeled as Carreau fluid which is considered as a well-behavior model for blood. A pulsatile speed profile applied as the inlet boundary and two-ways Fluid Structure Interaction (FSI) transient analysis is performed to achieve more accurate. In order to investigate wall elasticity effects, the carotid bifurcation modeled as solid, linear elastic and hyperelastic (Mooney-Rivlin). As the high LDL concentration can be considered as atherogenes is region indicator, therefore, it is used as the criterion for assessing the different arterial wall assumption. The wall elasticity effects on the hemodynamics are presented in three-time steps; early systole, end systole and end diastole. Results show that linear elastic and hyperelastic models predict very alike flow pattern however wall deformation and behavior are totally different. Results indicatet hat solid wall assumption is not appropriate for large and complicated arteries such as carotid bifurcation. Hyperelastic model (Mooney-Rivlin) seems more relevant and one the second place, the linear wall elastic model may be a good choice.
{"title":"Wall Elasticity Effects on Carotid Hemodynamics and LDL Mass Transport; a Computational Approach","authors":"S. Khakpour, A. Shahidian, M. Ghassemi","doi":"10.12974/2311-8792.2017.05.3","DOIUrl":"https://doi.org/10.12974/2311-8792.2017.05.3","url":null,"abstract":"Cardiovascular diseases takes many lives yearly, whereas atherosclerosis is on the top. Carotid atherosclerosis disease considered as a multi-aspects disease and only by considering all of its aspects, a comprehensive insight can be achieved. It seems that wall motion has great effects on arterial hemodynamics and Low Density Lipoprotein (LDL)mass transport and concentration while LDL concentration is believed to be highly associated with atherosclerosis plaque formation. The primary goal of this study is to investigate the wall elasticity effects on carotid hemodynamics and LDL mass transport through carotid artery bifurcation as a challenging case due to its geometry and location. The blood is modeled as Carreau fluid which is considered as a well-behavior model for blood. A pulsatile speed profile applied as the inlet boundary and two-ways Fluid Structure Interaction (FSI) transient analysis is performed to achieve more accurate. In order to investigate wall elasticity effects, the carotid bifurcation modeled as solid, linear elastic and hyperelastic (Mooney-Rivlin). As the high LDL concentration can be considered as atherogenes is region indicator, therefore, it is used as the criterion for assessing the different arterial wall assumption. The wall elasticity effects on the hemodynamics are presented in three-time steps; early systole, end systole and end diastole. Results show that linear elastic and hyperelastic models predict very alike flow pattern however wall deformation and behavior are totally different. Results indicatet hat solid wall assumption is not appropriate for large and complicated arteries such as carotid bifurcation. Hyperelastic model (Mooney-Rivlin) seems more relevant and one the second place, the linear wall elastic model may be a good choice.","PeriodicalId":198717,"journal":{"name":"Journal of Nanotechnology in Diagnosis and Treatment","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121809265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-02-27DOI: 10.12974/2311-8792.2017.05.2
Sayyed Mohammad Ali Ne’mati, M. Ghassemi, A. Shahidian
Using the great magnetic drug carriers (MDCs) is proposed mechanism to reduce and increase the toxic drugs penetration within the healthy and cancerous tissues, respectively. The purpose of current study is to investigate the penetration of magnetic drug carriers within the cancerous tumor tissue under the influence of external magnet. In order to solve the coupled governing equations an in house finite volume based code is developed and utilized. Capillary wall and tumor tissue is modelled as a saturated porous media. Results show the penetration of MDCs into the tumor in the absence of magnetic field is minimal and is limited to the surface of the tumor. On the other hand, under the influence of external magnet the penetration of MDCs within the tumor increases exponentially.
{"title":"Numerical Analysis of Magnetic Nanoparticles Penetration within the Cancerous Tumor Tissue under Influence of External Magnet","authors":"Sayyed Mohammad Ali Ne’mati, M. Ghassemi, A. Shahidian","doi":"10.12974/2311-8792.2017.05.2","DOIUrl":"https://doi.org/10.12974/2311-8792.2017.05.2","url":null,"abstract":"Using the great magnetic drug carriers (MDCs) is proposed mechanism to reduce and increase the toxic drugs penetration within the healthy and cancerous tissues, respectively. The purpose of current study is to investigate the penetration of magnetic drug carriers within the cancerous tumor tissue under the influence of external magnet. In order to solve the coupled governing equations an in house finite volume based code is developed and utilized. Capillary wall and tumor tissue is modelled as a saturated porous media. Results show the penetration of MDCs into the tumor in the absence of magnetic field is minimal and is limited to the surface of the tumor. On the other hand, under the influence of external magnet the penetration of MDCs within the tumor increases exponentially.","PeriodicalId":198717,"journal":{"name":"Journal of Nanotechnology in Diagnosis and Treatment","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131116552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-02-27DOI: 10.12974/2311-8792.2017.05.4
Ramprakash Chauhan, Aneesh Dharmani
Cancer detection and treatment has been a challenge for medical science till the years. The ability of cancer cells to multiply quickly and invade other parts of the body by process of metastasis further complicates the situation. Hence prognosis of cancer and its proper treatment also becomes difficult, as invading cells are not easy to detect at initial stages of spreading of infection. This limitation of not being able to detect invading tumor cells can be overcome by applying nanotechnology based approaches. Nanomaterials being very small in size have remarkable properties which are absent in their bulk counterparts. These properties possessed by materials at the nanoscale make them very useful for cancer theranostics. Further nanomaterials are having large number of surface atoms, as well as high surface activity because of high surface area to volume ratio; therefore their surface functionalisation can be done so as to make them useful for diagnosis and treatment of cancer. This could prove to be very promising in the early detection and treatment of cancer.
{"title":"Applications of Magnetic Nanoparticles in Cancer Detection and Treatment","authors":"Ramprakash Chauhan, Aneesh Dharmani","doi":"10.12974/2311-8792.2017.05.4","DOIUrl":"https://doi.org/10.12974/2311-8792.2017.05.4","url":null,"abstract":"Cancer detection and treatment has been a challenge for medical science till the years. The ability of cancer cells to multiply quickly and invade other parts of the body by process of metastasis further complicates the situation. Hence prognosis of cancer and its proper treatment also becomes difficult, as invading cells are not easy to detect at initial stages of spreading of infection. This limitation of not being able to detect invading tumor cells can be overcome by applying nanotechnology based approaches. Nanomaterials being very small in size have remarkable properties which are absent in their bulk counterparts. These properties possessed by materials at the nanoscale make them very useful for cancer theranostics. Further nanomaterials are having large number of surface atoms, as well as high surface activity because of high surface area to volume ratio; therefore their surface functionalisation can be done so as to make them useful for diagnosis and treatment of cancer. This could prove to be very promising in the early detection and treatment of cancer. ","PeriodicalId":198717,"journal":{"name":"Journal of Nanotechnology in Diagnosis and Treatment","volume":"205 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127676588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-02-27DOI: 10.12974/2311-8792.2017.05.1
O. Fouad, F. Morsy, S. El-sherbiny, Diaa Abd Elshafy
This study investigates the synthesis of mono metallic (copper and silver) and bi-metallic (copper/silver core/shell) conductive nanopigments for inkjet printing. Polyethylene glycol (PEG) was used as a main reducing agent followed by polyvinylpyrrolidone (PVP) as a capping and dispersing agent. From the XRD, TEM, and SEM analyses, the synthesized mono and bi metallic particles were con?rmed to be in a nano scale with particle size 7, 8.5 and 15.5 nm for copper, silver and copper/silver core/shell, respectively. The prepared nanopigments were included in inkjet ink formulation and printed on flexible polyethylene terephthalate (PET) films. The printed ink films were sintered at various temperatures (110, 150, 200). The results revealed that the resistivity of these particles was reduced by sintering and the resistivity of Cu, Ag and Cu/Ag patterns sintered in air at 200 ºC for 30 min were 3.1, 2.99 and 4.14 µ?-cm, respectively. The obtained results were in a good agreement with the published ones and insured the promising using of our products in metal-based inkjet printed circuit boards (PCB).
{"title":"Metal Nanoparticles Based Inkjet Ink for Advanced Circuit Board Application","authors":"O. Fouad, F. Morsy, S. El-sherbiny, Diaa Abd Elshafy","doi":"10.12974/2311-8792.2017.05.1","DOIUrl":"https://doi.org/10.12974/2311-8792.2017.05.1","url":null,"abstract":"This study investigates the synthesis of mono metallic (copper and silver) and bi-metallic (copper/silver core/shell) conductive nanopigments for inkjet printing. Polyethylene glycol (PEG) was used as a main reducing agent followed by polyvinylpyrrolidone (PVP) as a capping and dispersing agent. From the XRD, TEM, and SEM analyses, the synthesized mono and bi metallic particles were con?rmed to be in a nano scale with particle size 7, 8.5 and 15.5 nm for copper, silver and copper/silver core/shell, respectively. The prepared nanopigments were included in inkjet ink formulation and printed on flexible polyethylene terephthalate (PET) films. The printed ink films were sintered at various temperatures (110, 150, 200). The results revealed that the resistivity of these particles was reduced by sintering and the resistivity of Cu, Ag and Cu/Ag patterns sintered in air at 200 ºC for 30 min were 3.1, 2.99 and 4.14 µ?-cm, respectively. The obtained results were in a good agreement with the published ones and insured the promising using of our products in metal-based inkjet printed circuit boards (PCB). ","PeriodicalId":198717,"journal":{"name":"Journal of Nanotechnology in Diagnosis and Treatment","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124443879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-06-15DOI: 10.12974/2311-8792.2016.04.2
H. A. Al Husseini
We examine the nonlinear dynamics of a semiconductor quantum-dot (QD) laser subject to external optical feedback by using dimensionless equations numerical model. In our QD laser model we employ dynamic for ground and excited state processes, additionally between the QDs and the wetting layer (WL). This enables us to tune the output of external cavity modes QDs by changing the bias current, delayed time and feedback strength to investigate how they affect the stability properties of the QD laser. Our results show that high bias current and small ?-factor value lead to lower sensitivity of the laser towards optical feedback.
{"title":"Control of Nonlinear Dynamics of Quantum Dot Laser with External Optical Feedback","authors":"H. A. Al Husseini","doi":"10.12974/2311-8792.2016.04.2","DOIUrl":"https://doi.org/10.12974/2311-8792.2016.04.2","url":null,"abstract":"We examine the nonlinear dynamics of a semiconductor quantum-dot (QD) laser subject to external optical feedback by using dimensionless equations numerical model. In our QD laser model we employ dynamic for ground and excited state processes, additionally between the QDs and the wetting layer (WL). This enables us to tune the output of external cavity modes QDs by changing the bias current, delayed time and feedback strength to investigate how they affect the stability properties of the QD laser. Our results show that high bias current and small ?-factor value lead to lower sensitivity of the laser towards optical feedback. ","PeriodicalId":198717,"journal":{"name":"Journal of Nanotechnology in Diagnosis and Treatment","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123359730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-06-15DOI: 10.12974/2311-8792.2016.04.1
N. Kamanina, S. Likhomanova, V. I. Studeonov, I. Rău, Anca Dibla, A. Pawlicka
It is well known that in the biomedicine the people use sugar meter instruments to test the level of the sugar in the blood. The physical effect activated in these types of the devices is coincided with the mechanism of the rotation of the polarization plane of the light. Generally, in order to operate with an active media responsible for the rotation of the light polarization plane one can use classical ~10% sugar-water solution. In the current paper the innovative approach has been shown to apply the DNA-based structures in order to activate the optical effect regarding the rotation of the polarization plane of the light.
{"title":"Rotation of the Polarization Plane of Light Via Use of the DNA-Based Structures for Innovative Medical Devices","authors":"N. Kamanina, S. Likhomanova, V. I. Studeonov, I. Rău, Anca Dibla, A. Pawlicka","doi":"10.12974/2311-8792.2016.04.1","DOIUrl":"https://doi.org/10.12974/2311-8792.2016.04.1","url":null,"abstract":"It is well known that in the biomedicine the people use sugar meter instruments to test the level of the sugar in the blood. The physical effect activated in these types of the devices is coincided with the mechanism of the rotation of the polarization plane of the light. Generally, in order to operate with an active media responsible for the rotation of the light polarization plane one can use classical ~10% sugar-water solution. In the current paper the innovative approach has been shown to apply the DNA-based structures in order to activate the optical effect regarding the rotation of the polarization plane of the light. ","PeriodicalId":198717,"journal":{"name":"Journal of Nanotechnology in Diagnosis and Treatment","volume":"54 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132923945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-02-05DOI: 10.12974/2311-8792.2014.02.01.2
P. Sia
In recent years diagnosis and treatment in medicine have important advantages by the use of nanoparticles. Of great interest results the modality, with which they diffuse into the human body, and/or in specific human organs; the diffusion is indeed one of the three most important parameters for transport processes in solid state physics and soft condensed matter, also at nanolevel. A new appeared analytical “time-domain” Drude-Lorentz-like model for classical, quantum and relativistic transport in nano-systems is demonstrating high generality and good fitting with available experimental literature data. The range of application is very large, due to a gauge factor inside the model, comprehending all sectors of medicine. An interesting analysis related to the diffusion of nano-substances in the human body through nanoparticles indicated in nanomedicine is considered in this paper.
{"title":"Interesting Details about Diffusion of Nanoparticles for Diagnosis and Treatment in Medicine by a New Analytical Theoretical Model ","authors":"P. Sia","doi":"10.12974/2311-8792.2014.02.01.2","DOIUrl":"https://doi.org/10.12974/2311-8792.2014.02.01.2","url":null,"abstract":"In recent years diagnosis and treatment in medicine have important advantages by the use of nanoparticles. Of great interest results the modality, with which they diffuse into the human body, and/or in specific human organs; the diffusion is indeed one of the three most important parameters for transport processes in solid state physics and soft condensed matter, also at nanolevel. A new appeared analytical “time-domain” Drude-Lorentz-like model for classical, quantum and relativistic transport in nano-systems is demonstrating high generality and good fitting with available experimental literature data. The range of application is very large, due to a gauge factor inside the model, comprehending all sectors of medicine. An interesting analysis related to the diffusion of nano-substances in the human body through nanoparticles indicated in nanomedicine is considered in this paper. ","PeriodicalId":198717,"journal":{"name":"Journal of Nanotechnology in Diagnosis and Treatment","volume":"93 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116796196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-02-05DOI: 10.12974/2311-8792.2014.02.01.3
A. Mochalova, A. S. Koryagin, E. Salomatina, V. N. Dydykina, L. Smirnova, N. Lobachevsky
The anticancer activity of the multicomponent nanostructured drug “gold nanoparticles – apitoxin - chitosan” was revealed on white rats with implanted carcinoma under injecting encompassing of neoplasms. Drug at therapeutic doses when the apitoxin containing in it one degree lower than toxic (DL 50) effectively inhibits the growth of implanted tumor. On the 28th day after the course administration the external surface area of the tumor decreases in 5 times compared to control animals. Antitumor effect is also reflected as the normalization of free-radical processes. Indicators of biochemiluminescence (Imax) of animals reduces from 250 mV with implanted tumor in the control group to 150 mV of animals with implanted tumor which injected the drug. The value of leukocyte coefficient which characterizes the status of the animals organism (normal or stress), in experiments with the drug do not significantly differ from the normal values (5.36 ± 0.72; 6.73 ± 1.09 respectively) and appreciably higher than in control group of animals with implanted tumor that the drug is not administered (1.91 ± 0.15). Leukocyte ratio 1.91 shows that control animals are under stress.
{"title":"Anticancer Activity of Multicomponent Nanostructured System «Gold Nanoparticles-Apitoxin-Chitosan» ","authors":"A. Mochalova, A. S. Koryagin, E. Salomatina, V. N. Dydykina, L. Smirnova, N. Lobachevsky","doi":"10.12974/2311-8792.2014.02.01.3","DOIUrl":"https://doi.org/10.12974/2311-8792.2014.02.01.3","url":null,"abstract":"The anticancer activity of the multicomponent nanostructured drug “gold nanoparticles – apitoxin - chitosan” was revealed on white rats with implanted carcinoma under injecting encompassing of neoplasms. Drug at therapeutic doses when the apitoxin containing in it one degree lower than toxic (DL 50) effectively inhibits the growth of implanted tumor. On the 28th day after the course administration the external surface area of the tumor decreases in 5 times compared to control animals. Antitumor effect is also reflected as the normalization of free-radical processes. Indicators of biochemiluminescence (Imax) of animals reduces from 250 mV with implanted tumor in the control group to 150 mV of animals with implanted tumor which injected the drug. The value of leukocyte coefficient which characterizes the status of the animals organism (normal or stress), in experiments with the drug do not significantly differ from the normal values (5.36 ± 0.72; 6.73 ± 1.09 respectively) and appreciably higher than in control group of animals with implanted tumor that the drug is not administered (1.91 ± 0.15). Leukocyte ratio 1.91 shows that control animals are under stress. ","PeriodicalId":198717,"journal":{"name":"Journal of Nanotechnology in Diagnosis and Treatment","volume":"56 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129046113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-02-05DOI: 10.12974/2311-8792.2014.02.01.1
N. Kamanina, S. V. Serov, Yu. A. Zubtsova, Y. Bretonnière, C. Andraud, P. Baldeck, F. Kajzar
Based on using the holographic recording technique the photorefractive parameters of some organic materials doped with nano- and bio-objects have been studied. Some spectral and structural features have been established. The area of application of the materials has been discussed in order to use them in the optoelectronics and biomedicine.
{"title":"Photorefractive Properties of Some Nano- and Bio-Structured Organic Materials ","authors":"N. Kamanina, S. V. Serov, Yu. A. Zubtsova, Y. Bretonnière, C. Andraud, P. Baldeck, F. Kajzar","doi":"10.12974/2311-8792.2014.02.01.1","DOIUrl":"https://doi.org/10.12974/2311-8792.2014.02.01.1","url":null,"abstract":"Based on using the holographic recording technique the photorefractive parameters of some organic materials doped with nano- and bio-objects have been studied. Some spectral and structural features have been established. The area of application of the materials has been discussed in order to use them in the optoelectronics and biomedicine. ","PeriodicalId":198717,"journal":{"name":"Journal of Nanotechnology in Diagnosis and Treatment","volume":"52 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132651961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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