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Letter to the editor on "The effect of ketamine on acute and chronic wound pain in patients undergoing breast surgery: A meta-analysis and systematic review". 致编辑的信,主题为 "氯胺酮对乳房手术患者急性和慢性伤口疼痛的影响:荟萃分析和系统综述"。
IF 2.5 3区 医学 Q2 ANESTHESIOLOGY Pub Date : 2024-09-01 Epub Date: 2024-03-28 DOI: 10.1111/papr.13374
Umar Akram, Zain Ali Nadeem
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引用次数: 0
11. Cervicogenic headache and occipital neuralgia. 11.颈源性头痛和枕神经痛。
IF 2.5 3区 医学 Q2 ANESTHESIOLOGY Pub Date : 2024-09-01 DOI: 10.1111/papr.13405
Nicole Lefel, Hans van Suijlekom, Steven P C Cohen, Jan Willem Kallewaard, Jan Van Zundert

Introduction: Cervicogenic headache (CEH) and occipital neuralgia (ON) are headaches originating in the occiput and that radiate to the vertex. Because of the intimate relationship between structures based in the occiput and those in the upper cervical region, there is significant overlap between the presentation of CEH and ON. Diagnosis starts with a headache history to assess for diagnostic criteria formulated by the International Headache Society. Physical examination evaluates range of motion of the neck and the presence of tender areas or pressure points.

Methods: The literature for the diagnosis and treatment of CEH and ON was searched from 2015 through August 2022, retrieved, and summarized.

Results: Conservative treatment includes pain education and self-care, analgesic medication, physical therapy (such as reducing secondary muscle tension and improving posture), the use of TENS (transcutaneous electrical nerve stimulation), or a combination of the aforementioned treatments. Injection at various anatomical locations with local anesthetic with or without corticosteroids can provide pain relief for a short period. Deep cervical plexus block can result in improved pain for less than 6 months. In both CEH and ON, an occipital nerve block can provide important diagnostic information and improve pain in some patients, with PRF providing greater long-term pain control. Radiofrequency ablation of the cervical facet joints can result in improvement for over 1 year. Occipital nerve stimulation (ONS) should be considered for the treatment of refractory ON.

Conclusion: The treatment of CEH preferentially consists of radiofrequency treatment of the facet joints, while for ON, pulsed radiofrequency of the occipital nerves is indicated. For refractory cases, ONS may be considered.

导言:颈源性头痛(CEH)和枕神经痛(ON)是源于枕部并放射至顶点的头痛。由于枕部结构与上颈部结构之间的密切关系,颈源性头痛和枕神经痛的表现形式有很大的重叠。诊断首先要了解头痛病史,评估是否符合国际头痛协会制定的诊断标准。体格检查主要评估颈部的活动范围以及是否存在压痛区或压痛点:方法:检索了2015年至2022年8月有关CEH和ON诊断和治疗的文献,并进行了检索和总结:保守治疗包括疼痛教育和自我护理、镇痛药物、物理治疗(如减轻继发性肌肉紧张和改善姿势)、使用TENS(经皮神经电刺激)或上述治疗方法的组合。在不同的解剖位置注射局部麻醉剂,同时使用或不使用皮质类固醇,可在短期内缓解疼痛。深部颈丛神经阻滞可使疼痛在 6 个月内得到改善。在 CEH 和 ON 中,枕神经阻滞可提供重要的诊断信息,并改善部分患者的疼痛,而 PRF 可提供更好的长期疼痛控制。颈椎面关节射频消融术可使疼痛改善超过 1 年。在治疗难治性颈椎病时,应考虑使用枕神经刺激疗法(ONS):结论:治疗颈椎病的首选方法是对关节面进行射频治疗,而治疗颈椎病的方法则是对枕神经进行脉冲射频治疗。对于难治性病例,可考虑使用 ONS。
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引用次数: 0
Triptan treatment is associated with a higher number of red wine-induced migraine episodes: An exploratory questionnaire-based survey. 服用阿普唑仑与红葡萄酒诱发偏头痛发作次数增加有关:一项基于问卷的探索性调查。
IF 2.5 3区 医学 Q2 ANESTHESIOLOGY Pub Date : 2024-09-01 DOI: 10.1111/papr.13412
Saad Masood, Muhammad Ahrar Bin Naeem, Muhammad Qasim, Javeeria Arshad
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引用次数: 0
The current state of training in pain medicine fellowships: An Association of Pain Program Directors (APPD) survey of program directors. 疼痛医学研究员培训的现状:疼痛项目主任协会 (APPD) 对项目主任的调查。
IF 2.5 3区 医学 Q2 ANESTHESIOLOGY Pub Date : 2024-09-01 Epub Date: 2024-03-30 DOI: 10.1111/papr.13373
Sayed Emal Wahezi, Trent D Emerick, Moorice Caparó, Heejung Choi, Yashar Eshraghi, Tahereh Naeimi, Lynn Kohan, Magdalena Anitescu, Thelma Wright, Rene Przkora, Kiran Patel, Tim J Lamer, Susan Moeschler, Ugur Yener, Jonathan Alerte, Radhika Grandhe, Alexander Bautista, Boris Spektor, Kristen Noon, Rajiv Reddy, Uzondu C Osuagwu, Anna Carpenter, Frederic J Gerges, Danielle B Horn, Casey A Murphy, Chong Kim, Scott G Pritzlaff, Cameron Marshall, Gwynne Kirchen, Christine Oryhan, Tejinder S Swaran Singh, Dawood Sayed, Timothy R Lubenow, Nalini Sehgal, Charles E Argoff, Amit Gulati, Miles R Day, Naum Shaparin, Nabil Sibai, Anterpreet Dua, Meredith Barad

Introduction: The Accreditation Council for Graduate Medical Education (ACGME) approved the first pain medicine fellowship programs over three decades ago, designed around a pharmacological philosophy. Following that, there has been a rise in the transition of pain medicine education toward a multidisciplinary interventional model based on a tremendous surge of contemporaneous literature in these areas. This trend has created variability in clinical experience and education amongst accredited pain medicine programs with minimal literature evaluating the differences and commonalities in education and experience of different pain medicine fellowships through Program Director (PD) experiences. This study aims to gather insight from pain medicine fellowship program directors across the country to assess clinical and interventional training, providing valuable perspectives on the future of pain medicine education.

Methods: This study involved 56 PDs of ACGME-accredited pain fellowship programs in the United States. The recruitment process included three phases: advanced notification, invitation, and follow-up to maximize response rate. Participants completed a standard online questionnaire, covering various topics such as subcategory fields, online platforms for supplemental education, clinical experience, postgraduate practice success, and training adequacy.

Results: Surveys were completed by 39/56 (69%) standing members of the Association of Pain Program Directors (APPD). All PDs allowed fellows to participate in industry-related and professional society-related procedural workshops, with 59% encouraging these workshops. PDs emphasized the importance of integrity, professionalism, and diligence for long-term success. Fifty-four percent of PDs expressed the need for extension of fellowship training to avoid supplemental education by industry or pain/spine societies.

Conclusion: This study highlights the challenge of providing adequate training in all Pain Medicine subtopics within a 12-month pain medicine fellowship. PDs suggest the need for additional training for fellows and discuss the importance of curriculum standardization.

简介:三十多年前,美国毕业医学教育认证委员会(ACGME)批准了第一批疼痛医学奖学金项目,这些项目是围绕药理学理念设计的。此后,基于这些领域大量同期文献的涌现,疼痛医学教育开始向多学科介入模式过渡。这一趋势造成了经认证的疼痛医学项目在临床经验和教育方面的差异,而通过项目主任(PD)的经验来评估不同疼痛医学奖学金在教育和经验方面的差异和共性的文献却少之又少。本研究旨在收集全国各地疼痛医学奖学金项目主任的见解,以评估临床和介入培训,为疼痛医学教育的未来提供有价值的观点:本研究涉及美国经 ACGME 认证的疼痛研究项目的 56 名项目主任。招募过程包括三个阶段:提前通知、邀请和后续跟踪,以最大限度地提高回复率。参与者填写了一份标准的在线问卷,内容涉及子类别领域、补充教育在线平台、临床经验、研究生实践成功率和培训充分性等多个主题:疼痛项目主任协会(APPD)的39/56(69%)名长期会员完成了调查。所有项目主任都允许学员参加行业相关和专业协会相关的程序研讨会,其中59%的项目主任鼓励学员参加这些研讨会。项目主任强调了诚信、专业和勤奋对长期成功的重要性。54%的专业医师表示有必要扩大研究员培训,以避免行业或疼痛/脊柱学会的补充教育:本研究强调了在为期 12 个月的疼痛医学研究金中提供所有疼痛医学子课题的充分培训所面临的挑战。专业医师建议需要对研究员进行额外培训,并讨论了课程标准化的重要性。
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引用次数: 0
Lacertus notch as a sign of lacertus syndrome. 作为拉克特综合征标志的拉克特凹痕。
IF 2.5 3区 医学 Q2 ANESTHESIOLOGY Pub Date : 2024-09-01 Epub Date: 2024-03-29 DOI: 10.1111/papr.13372
Jean-Paul Brutus, Thiên-Trang Vo, Min Cheol Chang

Objective: Many clinicians are unfamiliar with a diagnosis of lacertus syndrome (LS). We investigated the value of the lacertus notch sign in diagnosing LS.

Methods: We included 56 consecutive patients (112 upper extremities) who had neuropathic pain and neurological symptoms of the hand. The presence of LS and the lacertus notch sign in each upper extremity was assessed.

Results: Of the 83 upper extremities with LS, 54 (65.1%) had a lacertus notch sign, whereas 29 (34.9%) did not. Of the 29 upper extremities without LS, 9 (31.0%) and 20 (69.0%) had and did not have a lacertus notch sign, respectively. The rates of lacertus notch presence in upper extremities with and without LS were significantly different. Of the 63 upper extremities with a lacertus notch sign, 54 (85.7%) were diagnosed with LS, whereas 9 (14.3%) were not. Of the 49 upper extremities without a lacertus notch sign, 20 (40.8%) were diagnosed with LS, and 29 (59.2%) were not. We observed significant differences in the rates of LS in upper extremities with and without lacertus notch.

Conclusions: The presence of the lacertus notch sign is useful for diagnosing LS. When patients with neuropathic pain and neurological symptoms present with a lacertus notch sign, clinicians should consider the possibility of LS.

目的:许多临床医生对腔隙综合征(LS)的诊断并不熟悉。我们研究了拉克图斯切迹征在诊断拉克图斯综合征中的价值:我们连续收治了 56 名手部有神经病理性疼痛和神经症状的患者(112 名上肢患者)。方法:我们连续纳入了 56 例(112 只上肢)手部神经痛和神经症状患者,评估了每只上肢是否存在 LS 和裂隙征:结果:在 83 个有 LS 的上肢中,54 个(65.1%)有拉克尔特切迹,29 个(34.9%)没有。在 29 例未出现 LS 的上肢中,分别有 9 例(31.0%)和 20 例(69.0%)出现和未出现裂隙切迹。有LS和没有LS的上肢中,出现裂隙切迹的比例有显著差异。在63例有裂隙切迹的上肢中,54例(85.7%)被诊断为LS,9例(14.3%)未被诊断为LS。在 49 例无腔隙切迹的上肢中,20 例(40.8%)被诊断为 LS,29 例(59.2%)未被诊断为 LS。我们观察到,在有和无腔隙切迹的上肢中,LS的发病率存在明显差异:结论:腔隙切迹的存在有助于诊断 LS。当神经病理性疼痛和神经症状患者出现裂隙切迹时,临床医生应考虑 LS 的可能性。
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引用次数: 0
9. Chronic knee pain. 9.慢性膝关节疼痛
IF 2.5 3区 医学 Q2 ANESTHESIOLOGY Pub Date : 2024-09-01 DOI: 10.1111/papr.13408
Thibaut Vanneste, Amy Belba, Gezina T M L Oei, Pieter Emans, Loic Fonkoue, Jan Willem Kallewaard, Leonardo Kapural, Philip Peng, Michael Sommer, Bert Vanneste, Steven P Cohen, Jan Van Zundert

Introduction: Chronic knee pain is defined as pain that persists or recurs over 3 months. The most common is degenerative osteoarthritis (OA). This review represents a comprehensive description of the pathology, diagnosis, and treatment of OA of the knee.

Methods: The literature on the diagnosis and treatment of chronic knee pain was retrieved and summarized. A modified Delphi approach was used to formulate recommendations on interventional treatments.

Results: Patients with knee OA commonly present with insidious, chronic knee pain that gradually worsens. Pain caused by knee OA is predominantly nociceptive pain, with occasional nociplastic and infrequent neuropathic characteristics occurring in a diseased knee. A standard musculoskeletal and neurological examination is required for the diagnosis of knee OA. Although typical clinical OA findings are sufficient for diagnosis, medical imaging may be performed to improve specificity. The differential diagnosis should exclude other causes of knee pain including bone and joint disorders such as rheumatoid arthritis, spondylo- and other arthropathies, and infections. When conservative treatment fails, intra-articular injections of corticosteroids and radiofrequency (conventional and cooled) of the genicular nerves have been shown to be effective. Hyaluronic acid infiltrations are conditionally recommended. Platelet-rich plasma infiltrations, chemical ablation of genicular nerves, and neurostimulation have, at the moment, not enough evidence and can be considered in a study setting. The decision to perform joint-preserving and joint-replacement options should be made multidisciplinary.

Conclusions: When conservative measures fail to provide satisfactory pain relief, a multidisciplinary approach is recommended including psychological therapy, integrative treatments, and procedural options such as intra-articular injections, radiofrequency ablation, and surgery.

简介慢性膝关节疼痛是指持续或复发超过 3 个月的疼痛。最常见的是退行性骨关节炎(OA)。本综述全面描述了膝关节 OA 的病理、诊断和治疗:方法:检索并总结了有关慢性膝关节疼痛诊断和治疗的文献。结果:膝关节OA患者通常表现为膝关节内侧疼痛:结果:膝关节 OA 患者通常表现为隐匿性慢性膝关节疼痛,并逐渐加重。膝关节 OA 引起的疼痛主要是痛觉性疼痛,病变膝关节偶尔会出现神经痉挛性疼痛,神经病理性疼痛并不常见。诊断膝关节 OA 需要进行标准的肌肉骨骼和神经系统检查。虽然典型的临床 OA 检查结果足以确诊,但仍可进行医学影像检查以提高特异性。鉴别诊断应排除引起膝关节疼痛的其他原因,包括类风湿性关节炎、脊柱关节病和其他关节病等骨关节疾病以及感染。当保守治疗无效时,关节内注射皮质类固醇和对膝关节神经进行射频(传统和冷却)治疗已被证明有效。有条件地推荐使用透明质酸浸润疗法。富血小板血浆浸润、膝关节神经化学消融和神经刺激目前还没有足够的证据,可在研究环境中考虑。结论:当保守疗法无法提供满意的止痛效果时,可以考虑使用关节置换术:结论:当保守治疗无法提供满意的疼痛缓解效果时,建议采用多学科方法,包括心理治疗、综合治疗以及关节内注射、射频消融和手术等程序性选择。
{"title":"9. Chronic knee pain.","authors":"Thibaut Vanneste, Amy Belba, Gezina T M L Oei, Pieter Emans, Loic Fonkoue, Jan Willem Kallewaard, Leonardo Kapural, Philip Peng, Michael Sommer, Bert Vanneste, Steven P Cohen, Jan Van Zundert","doi":"10.1111/papr.13408","DOIUrl":"https://doi.org/10.1111/papr.13408","url":null,"abstract":"<p><strong>Introduction: </strong>Chronic knee pain is defined as pain that persists or recurs over 3 months. The most common is degenerative osteoarthritis (OA). This review represents a comprehensive description of the pathology, diagnosis, and treatment of OA of the knee.</p><p><strong>Methods: </strong>The literature on the diagnosis and treatment of chronic knee pain was retrieved and summarized. A modified Delphi approach was used to formulate recommendations on interventional treatments.</p><p><strong>Results: </strong>Patients with knee OA commonly present with insidious, chronic knee pain that gradually worsens. Pain caused by knee OA is predominantly nociceptive pain, with occasional nociplastic and infrequent neuropathic characteristics occurring in a diseased knee. A standard musculoskeletal and neurological examination is required for the diagnosis of knee OA. Although typical clinical OA findings are sufficient for diagnosis, medical imaging may be performed to improve specificity. The differential diagnosis should exclude other causes of knee pain including bone and joint disorders such as rheumatoid arthritis, spondylo- and other arthropathies, and infections. When conservative treatment fails, intra-articular injections of corticosteroids and radiofrequency (conventional and cooled) of the genicular nerves have been shown to be effective. Hyaluronic acid infiltrations are conditionally recommended. Platelet-rich plasma infiltrations, chemical ablation of genicular nerves, and neurostimulation have, at the moment, not enough evidence and can be considered in a study setting. The decision to perform joint-preserving and joint-replacement options should be made multidisciplinary.</p><p><strong>Conclusions: </strong>When conservative measures fail to provide satisfactory pain relief, a multidisciplinary approach is recommended including psychological therapy, integrative treatments, and procedural options such as intra-articular injections, radiofrequency ablation, and surgery.</p>","PeriodicalId":19974,"journal":{"name":"Pain Practice","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142110805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Corrigendum. 更正。
IF 2.5 3区 医学 Q2 ANESTHESIOLOGY Pub Date : 2024-09-01 Epub Date: 2024-04-21 DOI: 10.1111/papr.13376
Eugene R Viscusi
{"title":"Corrigendum.","authors":"Eugene R Viscusi","doi":"10.1111/papr.13376","DOIUrl":"10.1111/papr.13376","url":null,"abstract":"","PeriodicalId":19974,"journal":{"name":"Pain Practice","volume":" ","pages":"969-970"},"PeriodicalIF":2.5,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140865099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Determinants of successful opioid deprescribing: Insights from French pain physicians-A qualitative study. 成功取消阿片类药物处方的决定因素:法国疼痛科医生的见解--一项定性研究。
IF 2.5 3区 医学 Q2 ANESTHESIOLOGY Pub Date : 2024-08-28 DOI: 10.1111/papr.13409
Pierre Nizet, Laure Deme, Adrien Evin, Emmanuelle Kuhn, Julien Nizard, Caroline Victorri Vigneau, Jean-François Huon

Background: Long-term use of opioids does not result in significant clinical improvement and has shown more adverse than beneficial effects in chronic pain conditions. When opioids cause more adverse effects than benefits for the patient, it may be necessary to initiate a process of deprescribing.

Aim: To explore the perceptions of French pain physicians regarding the process of opioid deprescribing in patients experiencing chronic non-cancer and to generate an understanding of the barriers and levers to the deprescribing process.

Methods: We conducted a multicentric observational study with qualitative approach. Individual semi-structured interviews exploring pain physicians' perceptions, beliefs, and representations to assess the determinants of opioid deprescribing with an interview guide were used. After checking the transcripts, an inductive and independent thematic analysis of the interviews was to extract meaningful themes from the dataset.

Results: Twelve pain physicians were interviewed. The main obstacles to deprescribing revolved around patient-specific attributes, characteristics of the opioids themselves, and limitations within the current healthcare system, that hinder optimal patient management. Conversely, patient motivation and education, recourse to hospitalization in a Pain Department with multidisciplinary care, follow-up by the general practitioner, and training and information dissemination among patients and clinicians emerged as facilitative elements for opioid deprescribing.

Conclusion: This study underscores the needs to improve the training of healthcare professionals, the effective communication of pertinent information to patients, and the establishment of a therapeutic partnership with the patient. It is therefore essential to carry out the deprescribing process in a collaborative and interprofessional manner, encompassing both pharmaceutical and non-pharmaceutical strategies.

背景:长期使用阿片类药物并不能明显改善临床症状,而且对慢性疼痛患者的不利影响大于有利影响。目的:探讨法国疼痛科医生对慢性非癌症患者阿片类药物停药过程的看法,并了解停药过程中的障碍和杠杆作用:我们采用定性方法开展了一项多中心观察研究。我们采用了半结构式访谈法,通过访谈指南探讨疼痛科医生的看法、信念和表述,以评估阿片类药物去处方化的决定因素。在核对访谈记录后,对访谈进行了归纳和独立的主题分析,以便从数据集中提取有意义的主题:结果:12 位疼痛科医生接受了访谈。去处方化的主要障碍围绕患者的特定属性、阿片类药物本身的特点以及当前医疗保健系统的局限性,这些因素阻碍了对患者的最佳管理。相反,患者的动机和教育、在疼痛科住院并接受多学科治疗、全科医生的随访以及在患者和临床医生中开展培训和信息传播则是促进阿片类药物停药的因素:本研究强调,需要加强对医护人员的培训,向患者有效传达相关信息,并与患者建立治疗伙伴关系。因此,必须以协作和跨专业的方式执行停药程序,其中包括药物和非药物策略。
{"title":"Determinants of successful opioid deprescribing: Insights from French pain physicians-A qualitative study.","authors":"Pierre Nizet, Laure Deme, Adrien Evin, Emmanuelle Kuhn, Julien Nizard, Caroline Victorri Vigneau, Jean-François Huon","doi":"10.1111/papr.13409","DOIUrl":"https://doi.org/10.1111/papr.13409","url":null,"abstract":"<p><strong>Background: </strong>Long-term use of opioids does not result in significant clinical improvement and has shown more adverse than beneficial effects in chronic pain conditions. When opioids cause more adverse effects than benefits for the patient, it may be necessary to initiate a process of deprescribing.</p><p><strong>Aim: </strong>To explore the perceptions of French pain physicians regarding the process of opioid deprescribing in patients experiencing chronic non-cancer and to generate an understanding of the barriers and levers to the deprescribing process.</p><p><strong>Methods: </strong>We conducted a multicentric observational study with qualitative approach. Individual semi-structured interviews exploring pain physicians' perceptions, beliefs, and representations to assess the determinants of opioid deprescribing with an interview guide were used. After checking the transcripts, an inductive and independent thematic analysis of the interviews was to extract meaningful themes from the dataset.</p><p><strong>Results: </strong>Twelve pain physicians were interviewed. The main obstacles to deprescribing revolved around patient-specific attributes, characteristics of the opioids themselves, and limitations within the current healthcare system, that hinder optimal patient management. Conversely, patient motivation and education, recourse to hospitalization in a Pain Department with multidisciplinary care, follow-up by the general practitioner, and training and information dissemination among patients and clinicians emerged as facilitative elements for opioid deprescribing.</p><p><strong>Conclusion: </strong>This study underscores the needs to improve the training of healthcare professionals, the effective communication of pertinent information to patients, and the establishment of a therapeutic partnership with the patient. It is therefore essential to carry out the deprescribing process in a collaborative and interprofessional manner, encompassing both pharmaceutical and non-pharmaceutical strategies.</p>","PeriodicalId":19974,"journal":{"name":"Pain Practice","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142081194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evidence for central sensitization as classified by the central sensitization inventory in patients with pain and hypermobility. 疼痛和活动过度患者中枢敏感性清单分类的证据。
IF 2.5 3区 医学 Q2 ANESTHESIOLOGY Pub Date : 2024-08-27 DOI: 10.1111/papr.13411
Mehul J Desai, Mason Brestle, Holly Jonely

Introduction: Pain is a very common complaint among patients with hypermobile Ehlers-Danlos Syndrome (hEDS) and Hypermobility Spectrum Disorders (HSDs). Often challenging to treat, insights into the underpinnings of pain in this population have been fleeting. Central sensitization (CS) has been postulated as a potential etiological factor.

Methods: In this retrospective study, 82 consecutive patients with hEDS/HSDs were reviewed. Demographic information and Central Sensitization Inventory (CSI) results were collected.

Results: 71 of 82 (86.5%) patients demonstrated CS. Scores ranged from 12 to 94 with a median of 56. Pain scores as measured on the numerical rating scale (NRS) ranged from 2 to 10 with a mean and median of 6.

Conclusion: A large percentage of patients with pain and a diagnosis of hEDS/HSDs demonstrated evidence of central sensitization as measured using the CSI. The CSI is simple to administer. The CSI may provide clinical insights that are key to successfully managing patients with hEDS/HSDs. Further research is needed to explore the ability to classify pain phenotypes in this patient population and the impact on precision medicine.

导言:疼痛是活动过度埃勒斯-丹洛斯综合征(hEDS)和活动过度频谱障碍(HSDs)患者的常见主诉。这类患者的疼痛往往难以治疗,对其疼痛根源的研究也是昙花一现。中枢敏化(CS)被认为是一个潜在的致病因素:在这项回顾性研究中,我们回顾了 82 名连续的 hEDS/HSD 患者。结果:82 名患者中有 71 人(86.5%)患有中枢性过敏反应:结果:82 位患者中有 71 位(86.5%)表现为 CS。评分范围为 12 到 94 分,中位数为 56 分。数字评分量表(NRS)显示的疼痛评分从 2 到 10 不等,平均值和中位数均为 6.Conclusion:结论:使用 CSI 测量,很大一部分被诊断为 hEDS/HSDs 的疼痛患者都有中枢敏化的证据。CSI 操作简单。CSI 可提供临床见解,是成功管理 hEDS/HSDs 患者的关键。还需要进一步的研究来探索对这类患者的疼痛表型进行分类的能力以及对精准医疗的影响。
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引用次数: 0
Clinical outcomes for minimally invasive sacroiliac joint fusion with allograft using a posterior approach. 后路微创骶髂关节同种异体移植融合术的临床疗效。
IF 2.5 3区 医学 Q2 ANESTHESIOLOGY Pub Date : 2024-08-23 DOI: 10.1111/papr.13406
Robert Moghim, Chris Bovinet, Max Y Jin, Katie Edwards, Alaa Abd-Elsayed

Background: Sacroiliac joint (SIJ) dysfunction can occur as a result of injury, degeneration, or inflammation. This dysfunction presents symptoms of pain at various locations, including the low back, hips, buttocks, and legs. The diagnosis of SIJ dysfunction is challenging and cannot be achieved solely with imaging studies such as X-rays, MRI, or CT. The current gold standard diagnostic modality is intra-articular SIJ blocks using two differing local anesthetics. Current treatments for SIJ dysfunction may be beneficial for short-term relief but lack long-term efficacy. The purpose of our study was to examine the outcomes of patients who underwent minimally invasive, posterior SIJ fusion using allograft at a single center.

Methods: This was a retrospective study which received exemption from the WCG IRB. Data regarding preoperative and postoperative pain levels, surgical time, complications, and medication usage were obtained retrospectively from patient electronic medical records and prescription drug monitoring program reports. No mapping was completed prior to the procedure. Pain was assessed with the 11-point (0-10) Visual Analogue Scale (VAS) and medication usage was assessed using Morphine Milligram Equivalents (MME). Patients were included if they had been diagnosed with SIJ dysfunction using two intra-articular diagnostic blocks that resulted in at least an 80% decrease in pain and had failed conservative management. Patients with sacral insufficiency fractures were excluded.

Results: VAS scores reduced from 8.26 (SD = 1.09) at baseline to 2.59 (SD = 2.57), 2.55 (SD = 2.56), 2.71 (SD = 2.88), and 2.71 (SD = 2.88) at 3, 6, 9, and 12 months, respectively. MME reduced from 78.21 mg (SD = 51.33) to 58.95 mg (SD = 48.64), 57.61 mg (SD = 47.92), 61.71 mg (SD = 45.64), and 66.29 mg (SD = 51.65) at 3, 6, 9, and 12 months, respectively. All reductions in VAS scores and MME were statistically significant. No adverse events occurred, and the average operating room time was 40.16 min (SD = 6.27).

Conclusion: Minimally invasive, posterior SIJ fusion using allograft is a safe and efficacious method for managing SIJ dysfunction.

背景:骶髂关节(SIJ)功能障碍可因损伤、退化或炎症而发生。这种功能障碍会导致不同部位的疼痛症状,包括腰部、臀部、臀部和腿部。SIJ 功能障碍的诊断具有挑战性,不能仅通过 X 光、核磁共振成像或 CT 等影像学检查来实现。目前的金标准诊断方法是使用两种不同的局部麻醉剂进行关节内 SIJ 阻滞。目前治疗 SIJ 功能障碍的方法可能有利于短期缓解症状,但缺乏长期疗效。我们的研究旨在考察在一个中心使用同种异体移植进行微创、后路 SIJ 融合术的患者的疗效:这是一项回顾性研究,获得了 WCG IRB 的豁免。有关术前和术后疼痛程度、手术时间、并发症和药物使用情况的数据是从患者电子病历和处方药监控计划报告中回顾性获得的。术前未完成绘图。疼痛采用11点(0-10)视觉模拟量表(VAS)进行评估,用药量采用吗啡毫克当量(MME)进行评估。如果患者通过两次关节内诊断性阻滞确诊为 SIJ 功能障碍,疼痛至少减轻了 80%,且保守治疗无效,则将其纳入治疗范围。骶骨功能不全骨折患者除外:VAS评分从基线时的8.26(SD = 1.09)分别降至3、6、9和12个月时的2.59(SD = 2.57)、2.55(SD = 2.56)、2.71(SD = 2.88)和2.71(SD = 2.88)。在 3、6、9 和 12 个月时,MME 分别从 78.21 毫克(标清 = 51.33)降至 58.95 毫克(标清 = 48.64)、57.61 毫克(标清 = 47.92)、61.71 毫克(标清 = 45.64)和 66.29 毫克(标清 = 51.65)。VAS评分和MME的降低幅度均具有统计学意义。无不良事件发生,手术室平均用时 40.16 分钟(标准差 = 6.27):结论:使用同种异体移植的微创后路 SIJ 融合术是治疗 SIJ 功能障碍的一种安全有效的方法。
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引用次数: 0
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Pain Practice
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