Pub Date : 2022-05-07DOI: 10.1007/s00424-022-02699-3
A. Draguhn
{"title":"No single place for space: neuronal representation of location beyond the hippocampus","authors":"A. Draguhn","doi":"10.1007/s00424-022-02699-3","DOIUrl":"https://doi.org/10.1007/s00424-022-02699-3","url":null,"abstract":"","PeriodicalId":20032,"journal":{"name":"Pflugers Archiv","volume":"8 1","pages":"569 - 571"},"PeriodicalIF":0.0,"publicationDate":"2022-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88967174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-09DOI: 10.1007/s00424-022-02686-8
Vincenzo Costanzo, Luciano D’Apolito, Donato Sardella, A. Iervolino, G. La Manna, G. Capasso, S. Frische, F. Trepiccione
{"title":"Single nephron glomerular filtration rate measured by linescan multiphoton microscopy compared to conventional micropuncture","authors":"Vincenzo Costanzo, Luciano D’Apolito, Donato Sardella, A. Iervolino, G. La Manna, G. Capasso, S. Frische, F. Trepiccione","doi":"10.1007/s00424-022-02686-8","DOIUrl":"https://doi.org/10.1007/s00424-022-02686-8","url":null,"abstract":"","PeriodicalId":20032,"journal":{"name":"Pflugers Archiv","volume":"146 1","pages":"733 - 741"},"PeriodicalIF":0.0,"publicationDate":"2022-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77726990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-05DOI: 10.1007/s00424-022-02689-5
P. Reeh, M. Fischer
{"title":"Correction to: Nobel somatosensations and pain","authors":"P. Reeh, M. Fischer","doi":"10.1007/s00424-022-02689-5","DOIUrl":"https://doi.org/10.1007/s00424-022-02689-5","url":null,"abstract":"","PeriodicalId":20032,"journal":{"name":"Pflugers Archiv","volume":"24 1","pages":"647 - 647"},"PeriodicalIF":0.0,"publicationDate":"2022-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84729479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-07DOI: 10.1007/s00424-022-02676-w
R. Brandes, S. Gründer
{"title":"Europhysiology 2022: bringing together the physiologists of Europe and the World","authors":"R. Brandes, S. Gründer","doi":"10.1007/s00424-022-02676-w","DOIUrl":"https://doi.org/10.1007/s00424-022-02676-w","url":null,"abstract":"","PeriodicalId":20032,"journal":{"name":"Pflugers Archiv","volume":"165 1","pages":"481 - 482"},"PeriodicalIF":0.0,"publicationDate":"2022-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85250912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-11-14DOI: 10.1007/s00424-020-02493-z
M. Hecker, A. Kurtz
{"title":"Pflügers Archiv - European journal of physiology becomes the official journal of the German Physiological Society","authors":"M. Hecker, A. Kurtz","doi":"10.1007/s00424-020-02493-z","DOIUrl":"https://doi.org/10.1007/s00424-020-02493-z","url":null,"abstract":"","PeriodicalId":20032,"journal":{"name":"Pflugers Archiv","volume":"118 1","pages":"1657 - 1657"},"PeriodicalIF":0.0,"publicationDate":"2020-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87975336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-12-01Epub Date: 2019-11-15DOI: 10.1007/s00424-019-02327-7
David C-Y Lu, Anke Hannemann, Rasiqh Wadud, David C Rees, John N Brewin, Philip S Low, John S Gibson
Abnormal activity of red cell KCl cotransport (KCC) is involved in pathogenesis of sickle cell anaemia (SCA). KCC-mediated solute loss causes shrinkage, concentrates HbS, and promotes HbS polymerisation. Red cell KCC also responds to various stimuli including pH, volume, urea, and oxygen tension, and regulation involves protein phosphorylation. The main aim of this study was to investigate the role of the WNK/SPAK/OSR1 pathway in sickle cells. The pan WNK inhibitor WNK463 stimulated KCC with an EC50 of 10.9 ± 1.1 nM and 7.9 ± 1.2 nM in sickle and normal red cells, respectively. SPAK/OSR1 inhibitors had little effect. The action of WNK463 was not additive with other kinase inhibitors (staurosporine and N-ethylmaleimide). Its effects were largely abrogated by pre-treatment with the phosphatase inhibitor calyculin A. WNK463 also reduced the effects of physiological KCC stimuli (pH, volume, urea) and abolished any response of KCC to changes in oxygen tension. Finally, although protein kinases have been implicated in regulation of phosphatidylserine exposure, WNK463 had no effect. Findings indicate a predominant role for WNKs in control of KCC in sickle cells but an apparent absence of downstream involvement of SPAK/OSR1. A more complete understanding of the mechanisms will inform pathogenesis whilst manipulation of WNK activity represents a potential therapeutic approach.
{"title":"The role of WNK in modulation of KCl cotransport activity in red cells from normal individuals and patients with sickle cell anaemia.","authors":"David C-Y Lu, Anke Hannemann, Rasiqh Wadud, David C Rees, John N Brewin, Philip S Low, John S Gibson","doi":"10.1007/s00424-019-02327-7","DOIUrl":"10.1007/s00424-019-02327-7","url":null,"abstract":"<p><p>Abnormal activity of red cell KCl cotransport (KCC) is involved in pathogenesis of sickle cell anaemia (SCA). KCC-mediated solute loss causes shrinkage, concentrates HbS, and promotes HbS polymerisation. Red cell KCC also responds to various stimuli including pH, volume, urea, and oxygen tension, and regulation involves protein phosphorylation. The main aim of this study was to investigate the role of the WNK/SPAK/OSR1 pathway in sickle cells. The pan WNK inhibitor WNK463 stimulated KCC with an EC<sub>50</sub> of 10.9 ± 1.1 nM and 7.9 ± 1.2 nM in sickle and normal red cells, respectively. SPAK/OSR1 inhibitors had little effect. The action of WNK463 was not additive with other kinase inhibitors (staurosporine and N-ethylmaleimide). Its effects were largely abrogated by pre-treatment with the phosphatase inhibitor calyculin A. WNK463 also reduced the effects of physiological KCC stimuli (pH, volume, urea) and abolished any response of KCC to changes in oxygen tension. Finally, although protein kinases have been implicated in regulation of phosphatidylserine exposure, WNK463 had no effect. Findings indicate a predominant role for WNKs in control of KCC in sickle cells but an apparent absence of downstream involvement of SPAK/OSR1. A more complete understanding of the mechanisms will inform pathogenesis whilst manipulation of WNK activity represents a potential therapeutic approach.</p>","PeriodicalId":20032,"journal":{"name":"Pflugers Archiv","volume":"22 1","pages":"1539-1549"},"PeriodicalIF":0.0,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6892352/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72756635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-11-15DOI: 10.1007/s00424-019-02322-y
Maksymilian Onyszkiewicz, M. Gawryś-Kopczyńska, P. Konopelski, M. Aleksandrowicz, Aneta Sawicka, E. Kozniewska, E. Samborowska, M. Ufnal
{"title":"Butyric acid, a gut bacteria metabolite, lowers arterial blood pressure via colon-vagus nerve signaling and GPR41/43 receptors","authors":"Maksymilian Onyszkiewicz, M. Gawryś-Kopczyńska, P. Konopelski, M. Aleksandrowicz, Aneta Sawicka, E. Kozniewska, E. Samborowska, M. Ufnal","doi":"10.1007/s00424-019-02322-y","DOIUrl":"https://doi.org/10.1007/s00424-019-02322-y","url":null,"abstract":"","PeriodicalId":20032,"journal":{"name":"Pflugers Archiv","volume":"123 1","pages":"1441 - 1453"},"PeriodicalIF":0.0,"publicationDate":"2019-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72827949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-10-01DOI: 10.1007/s00424-019-02312-0
A. Kozłowska, P. Wojtacha, M. Majewski, M. Równiak
{"title":"The cytokine alterations/abnormalities and oxidative damage in the pancreas during hypertension development","authors":"A. Kozłowska, P. Wojtacha, M. Majewski, M. Równiak","doi":"10.1007/s00424-019-02312-0","DOIUrl":"https://doi.org/10.1007/s00424-019-02312-0","url":null,"abstract":"","PeriodicalId":20032,"journal":{"name":"Pflugers Archiv","volume":"4 1","pages":"1331 - 1340"},"PeriodicalIF":0.0,"publicationDate":"2019-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87583424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-08-21DOI: 10.1007/s00424-019-02304-0
S. Blackwood, A. Katz
{"title":"Isoproterenol enhances force production in mouse glycolytic and oxidative muscle via separate mechanisms","authors":"S. Blackwood, A. Katz","doi":"10.1007/s00424-019-02304-0","DOIUrl":"https://doi.org/10.1007/s00424-019-02304-0","url":null,"abstract":"","PeriodicalId":20032,"journal":{"name":"Pflugers Archiv","volume":"516 1","pages":"1305 - 1316"},"PeriodicalIF":0.0,"publicationDate":"2019-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77109998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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