{"title":"Reciprocity of ultraviolet erythema in human skin.","authors":"E F Meanwell, B L Diffey","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":20061,"journal":{"name":"Photo-dermatology","volume":"6 3","pages":"146-8"},"PeriodicalIF":0.0,"publicationDate":"1989-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13902225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The relationship between ultraviolet (UV) light-induced sister chromatid exchanges (SCE) and UV cytotoxicity was compared among fibroblast strains from 18 patients with xeroderma pigmentosum (XP) (6 group A, 1 group C, 3 group D, 5 group E, 3 variant), 2 patients with Bloom's syndrome (BS) and 3 normal subjects. Spontaneous SCE frequencies in all of the XP strains were indistinguishable from those in normal cells, while BS cells exhibited about 10 times more spontaneous SCE than did normal cells. SCE were induced dose-dependently by UV at doses of 0-4.0 J/m2 in all the strains. The mean frequencies of UV-induced SCE were much higher in XP-A and -C cells than in normal cells. XP-D and -E cells were slightly more sensitive to UV-induced SCE formation than normal cells. XP-variant cells were almost as sensitive as normal cells. The induced SCE frequencies plotted as a function of surviving fraction were relatively lower in XP-A and -D cells than those in normal cells, though in XP-C, -E, and -variant cells they were almost the same as those in normal cells, suggesting that, in XP-A and -D groups, UV damage is more lethal than producing SCE in surviving cells. By contrast, 2 BS strains exhibited significantly higher frequencies of UV-induced SCE than the other strains as a function of not only UV dose but also surviving fraction. These results reflect the essential differences between XP and BS cells in UV induction of SCE.
{"title":"Different sensitivities to ultraviolet light-induced cytotoxicity and sister chromatid exchanges in xeroderma pigmentosum and Bloom's syndrome fibroblasts.","authors":"A Mamada, S Kondo, Y Satoh","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The relationship between ultraviolet (UV) light-induced sister chromatid exchanges (SCE) and UV cytotoxicity was compared among fibroblast strains from 18 patients with xeroderma pigmentosum (XP) (6 group A, 1 group C, 3 group D, 5 group E, 3 variant), 2 patients with Bloom's syndrome (BS) and 3 normal subjects. Spontaneous SCE frequencies in all of the XP strains were indistinguishable from those in normal cells, while BS cells exhibited about 10 times more spontaneous SCE than did normal cells. SCE were induced dose-dependently by UV at doses of 0-4.0 J/m2 in all the strains. The mean frequencies of UV-induced SCE were much higher in XP-A and -C cells than in normal cells. XP-D and -E cells were slightly more sensitive to UV-induced SCE formation than normal cells. XP-variant cells were almost as sensitive as normal cells. The induced SCE frequencies plotted as a function of surviving fraction were relatively lower in XP-A and -D cells than those in normal cells, though in XP-C, -E, and -variant cells they were almost the same as those in normal cells, suggesting that, in XP-A and -D groups, UV damage is more lethal than producing SCE in surviving cells. By contrast, 2 BS strains exhibited significantly higher frequencies of UV-induced SCE than the other strains as a function of not only UV dose but also surviving fraction. These results reflect the essential differences between XP and BS cells in UV induction of SCE.</p>","PeriodicalId":20061,"journal":{"name":"Photo-dermatology","volume":"6 3","pages":"124-30"},"PeriodicalIF":0.0,"publicationDate":"1989-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13902218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
F Aubin, M Zultak, D Blanc, F Terrasse, E Quencez, P Agache
The effects of an irradiation 6 times the minimal erythemal dose of UVB were studied using a visual scale from 1 to 4+ in 12 patients aged under 45 years with a past medical history of basal cell carcinoma, and in 12 sex-, age- and skin-type-matched controls. Erythema was significantly more intense at days 15 (p less than 0.01) and 22 (p less than 0.001) in patients than in controls. Pigmentation was significantly weaker at day 22 than in controls (p less than 0.005).
{"title":"Reaction to UV-induced erythema in young patients with basal cell carcinoma.","authors":"F Aubin, M Zultak, D Blanc, F Terrasse, E Quencez, P Agache","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The effects of an irradiation 6 times the minimal erythemal dose of UVB were studied using a visual scale from 1 to 4+ in 12 patients aged under 45 years with a past medical history of basal cell carcinoma, and in 12 sex-, age- and skin-type-matched controls. Erythema was significantly more intense at days 15 (p less than 0.01) and 22 (p less than 0.001) in patients than in controls. Pigmentation was significantly weaker at day 22 than in controls (p less than 0.005).</p>","PeriodicalId":20061,"journal":{"name":"Photo-dermatology","volume":"6 3","pages":"118-23"},"PeriodicalIF":0.0,"publicationDate":"1989-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13902217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
We examined and interviewed 809 randomly selected individuals (56% women and 44% men, mean age 44 years) from 4 Swedish cities; 1.7% had the sun-reactive skin type I, 26.2% type II, 61.3% type III and 10.7% type IV. Some variations in the distribution of skin types were found between the cities. One hundred subjects (12.4%), mostly women (p less than 0.001), had a history of polymorphous light eruption. People with skin type IV had significantly fewer facial skin problems than the rest of the subjects (p less than 0.05). The majority of subjects with atopic eczema, acne vulgaris or seborrheic dermatitis experienced improvement after exposure to sunlight. Individuals with rosacea also experienced improvement more often than impairment from exposure to sunlight. Facial telangiectases occurred in 57% of the subjects, unilaterally in 8.5% of the cases. The occurrence of telangiectases increased with increasing age (p less than 0.001), increasing sunbathing (p less than 0.01) and poor pigmentation ability (p less than 0.05).
{"title":"Epidemiological studies of the influence of sunlight on the skin.","authors":"M Berg","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>We examined and interviewed 809 randomly selected individuals (56% women and 44% men, mean age 44 years) from 4 Swedish cities; 1.7% had the sun-reactive skin type I, 26.2% type II, 61.3% type III and 10.7% type IV. Some variations in the distribution of skin types were found between the cities. One hundred subjects (12.4%), mostly women (p less than 0.001), had a history of polymorphous light eruption. People with skin type IV had significantly fewer facial skin problems than the rest of the subjects (p less than 0.05). The majority of subjects with atopic eczema, acne vulgaris or seborrheic dermatitis experienced improvement after exposure to sunlight. Individuals with rosacea also experienced improvement more often than impairment from exposure to sunlight. Facial telangiectases occurred in 57% of the subjects, unilaterally in 8.5% of the cases. The occurrence of telangiectases increased with increasing age (p less than 0.001), increasing sunbathing (p less than 0.01) and poor pigmentation ability (p less than 0.05).</p>","PeriodicalId":20061,"journal":{"name":"Photo-dermatology","volume":"6 2","pages":"80-4"},"PeriodicalIF":0.0,"publicationDate":"1989-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13888583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Cutaneous drug eruption caused by 8-methoxypsoralen.","authors":"N H Cox, S Rogers","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":20061,"journal":{"name":"Photo-dermatology","volume":"6 2","pages":"96-7"},"PeriodicalIF":0.0,"publicationDate":"1989-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13670681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Thirty patients suffering from polymorphous light eruption (PLE), selected by criteria pointing to UVB sensitivity, were phototested for reproduction of skin lesions. Twenty-seven patients (90.0%) had symptoms compatible with or very similar to papulovesicular light eruption (PVLE). Of the 30 patients, 56.7% developed typical lesion of PLE at the test site by provocative phototesting with UVB. Eruptions of the immediate onset type were apt to be reproduced by multiple repeated irradiation, but those of the delayed onset type were reproduced by a single high-dose exposure. In addition, pruritus at the test site seen in all patients was thought to be an important diagnostic symptom. It was obvious that UVB played an etiological role in PLE, including PVLE.
{"title":"Polymorphous light eruption: successful reproduction of skin lesions, including papulovesicular light eruption, with ultraviolet B.","authors":"宮元 千寿","doi":"10.11501/3084942","DOIUrl":"https://doi.org/10.11501/3084942","url":null,"abstract":"Thirty patients suffering from polymorphous light eruption (PLE), selected by criteria pointing to UVB sensitivity, were phototested for reproduction of skin lesions. Twenty-seven patients (90.0%) had symptoms compatible with or very similar to papulovesicular light eruption (PVLE). Of the 30 patients, 56.7% developed typical lesion of PLE at the test site by provocative phototesting with UVB. Eruptions of the immediate onset type were apt to be reproduced by multiple repeated irradiation, but those of the delayed onset type were reproduced by a single high-dose exposure. In addition, pruritus at the test site seen in all patients was thought to be an important diagnostic symptom. It was obvious that UVB played an etiological role in PLE, including PVLE.","PeriodicalId":20061,"journal":{"name":"Photo-dermatology","volume":"9 1","pages":"69-79"},"PeriodicalIF":0.0,"publicationDate":"1989-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88656895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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