Pub Date : 2022-10-17DOI: 10.48550/arXiv.2210.09440
Omid Rohanian, Hannah Jauncey, Mohammadmahdi Nouriborji, Bronner P. Gonccalves, C. Kartsonaki, Isaric Clinical Characterisation Group, L. Merson, D. Clifton
Processing information locked within clinical health records is a challenging task that remains an active area of research in biomedical NLP. In this work, we evaluate a broad set of machine learning techniques ranging from simple RNNs to specialised transformers such as BioBERT on a dataset containing clinical notes along with a set of annotations indicating whether a sample is cancer-related or not. Furthermore, we specifically employ efficient fine-tuning methods from NLP, namely, bottleneck adapters and prompt tuning, to adapt the models to our specialised task. Our evaluations suggest that fine-tuning a frozen BERT model pre-trained on natural language and with bottleneck adapters outperforms all other strategies, including full fine-tuning of the specialised BioBERT model. Based on our findings, we suggest that using bottleneck adapters in low-resource situations with limited access to labelled data or processing capacity could be a viable strategy in biomedical text mining.
{"title":"Using Bottleneck Adapters to Identify Cancer in Clinical Notes under Low-Resource Constraints","authors":"Omid Rohanian, Hannah Jauncey, Mohammadmahdi Nouriborji, Bronner P. Gonccalves, C. Kartsonaki, Isaric Clinical Characterisation Group, L. Merson, D. Clifton","doi":"10.48550/arXiv.2210.09440","DOIUrl":"https://doi.org/10.48550/arXiv.2210.09440","url":null,"abstract":"Processing information locked within clinical health records is a challenging task that remains an active area of research in biomedical NLP. In this work, we evaluate a broad set of machine learning techniques ranging from simple RNNs to specialised transformers such as BioBERT on a dataset containing clinical notes along with a set of annotations indicating whether a sample is cancer-related or not. Furthermore, we specifically employ efficient fine-tuning methods from NLP, namely, bottleneck adapters and prompt tuning, to adapt the models to our specialised task. Our evaluations suggest that fine-tuning a frozen BERT model pre-trained on natural language and with bottleneck adapters outperforms all other strategies, including full fine-tuning of the specialised BioBERT model. Based on our findings, we suggest that using bottleneck adapters in low-resource situations with limited access to labelled data or processing capacity could be a viable strategy in biomedical text mining.","PeriodicalId":200974,"journal":{"name":"Workshop on Biomedical Natural Language Processing","volume":"59 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124678993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-21DOI: 10.48550/arXiv.2204.10408
George Michalopoulos, Michal Malyska, Nicola Sahar, Alexander Wong, Helen H. Chen
The International Classification of Diseases (ICD) system is the international standard for classifying diseases and procedures during a healthcare encounter and is widely used for healthcare reporting and management purposes. Assigning correct codes for clinical procedures is important for clinical, operational and financial decision-making in healthcare. Contextual word embedding models have achieved state-of-the-art results in multiple NLP tasks. However, these models have yet to achieve state-of-the-art results in the ICD classification task since one of their main disadvantages is that they can only process documents that contain a small number of tokens which is rarely the case with real patient notes. In this paper, we introduce ICDBigBird a BigBird-based model which can integrate a Graph Convolutional Network (GCN), that takes advantage of the relations between ICD codes in order to create ‘enriched’ representations of their embeddings, with a BigBird contextual model that can process larger documents. Our experiments on a real-world clinical dataset demonstrate the effectiveness of our BigBird-based model on the ICD classification task as it outperforms the previous state-of-the-art models.
{"title":"ICDBigBird: A Contextual Embedding Model for ICD Code Classification","authors":"George Michalopoulos, Michal Malyska, Nicola Sahar, Alexander Wong, Helen H. Chen","doi":"10.48550/arXiv.2204.10408","DOIUrl":"https://doi.org/10.48550/arXiv.2204.10408","url":null,"abstract":"The International Classification of Diseases (ICD) system is the international standard for classifying diseases and procedures during a healthcare encounter and is widely used for healthcare reporting and management purposes. Assigning correct codes for clinical procedures is important for clinical, operational and financial decision-making in healthcare. Contextual word embedding models have achieved state-of-the-art results in multiple NLP tasks. However, these models have yet to achieve state-of-the-art results in the ICD classification task since one of their main disadvantages is that they can only process documents that contain a small number of tokens which is rarely the case with real patient notes. In this paper, we introduce ICDBigBird a BigBird-based model which can integrate a Graph Convolutional Network (GCN), that takes advantage of the relations between ICD codes in order to create ‘enriched’ representations of their embeddings, with a BigBird contextual model that can process larger documents. Our experiments on a real-world clinical dataset demonstrate the effectiveness of our BigBird-based model on the ICD classification task as it outperforms the previous state-of-the-art models.","PeriodicalId":200974,"journal":{"name":"Workshop on Biomedical Natural Language Processing","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129291982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-14DOI: 10.48550/arXiv.2204.06699
Samuel Cahyawijaya, Tiezheng Yu, Zihan Liu, Tiffany Mak, Xiaopu Zhou, N. Ip, Pascale Fung
Self-supervised pre-training methods have brought remarkable breakthroughs in the understanding of text, image, and speech. Recent developments in genomics has also adopted these pre-training methods for genome understanding. However, they focus only on understanding haploid sequences, which hinders their applicability towards understanding genetic variations, also known as single nucleotide polymorphisms (SNPs), which is crucial for genome-wide association study. In this paper, we introduce SNP2Vec, a scalable self-supervised pre-training approach for understanding SNP. We apply SNP2Vec to perform long-sequence genomics modeling, and we evaluate the effectiveness of our approach on predicting Alzheimer’s disease risk in a Chinese cohort. Our approach significantly outperforms existing polygenic risk score methods and all other baselines, including the model that is trained entirely with haploid sequences.
{"title":"SNP2Vec: Scalable Self-Supervised Pre-Training for Genome-Wide Association Study","authors":"Samuel Cahyawijaya, Tiezheng Yu, Zihan Liu, Tiffany Mak, Xiaopu Zhou, N. Ip, Pascale Fung","doi":"10.48550/arXiv.2204.06699","DOIUrl":"https://doi.org/10.48550/arXiv.2204.06699","url":null,"abstract":"Self-supervised pre-training methods have brought remarkable breakthroughs in the understanding of text, image, and speech. Recent developments in genomics has also adopted these pre-training methods for genome understanding. However, they focus only on understanding haploid sequences, which hinders their applicability towards understanding genetic variations, also known as single nucleotide polymorphisms (SNPs), which is crucial for genome-wide association study. In this paper, we introduce SNP2Vec, a scalable self-supervised pre-training approach for understanding SNP. We apply SNP2Vec to perform long-sequence genomics modeling, and we evaluate the effectiveness of our approach on predicting Alzheimer’s disease risk in a Chinese cohort. Our approach significantly outperforms existing polygenic risk score methods and all other baselines, including the model that is trained entirely with haploid sequences.","PeriodicalId":200974,"journal":{"name":"Workshop on Biomedical Natural Language Processing","volume":"59 8","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"120907677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-11DOI: 10.48550/arXiv.2204.10178
Hillary Ngai, Frank Rudzicz
We introduce Doctor XAvIer — a BERT-based diagnostic system that extracts relevant clinical data from transcribed patient-doctor dialogues and explains predictions using feature attribution methods. We present a novel performance plot and evaluation metric for feature attribution methods — Feature Attribution Dropping (FAD) curve and its Normalized Area Under the Curve (N-AUC). FAD curve analysis shows that integrated gradients outperforms Shapley values in explaining diagnosis classification. Doctor XAvIer outperforms the baseline with 0.97 F1-score in named entity recognition and symptom pertinence classification and 0.91 F1-score in diagnosis classification.
{"title":"Doctor XAvIer: Explainable Diagnosis on Physician-Patient Dialogues and XAI Evaluation","authors":"Hillary Ngai, Frank Rudzicz","doi":"10.48550/arXiv.2204.10178","DOIUrl":"https://doi.org/10.48550/arXiv.2204.10178","url":null,"abstract":"We introduce Doctor XAvIer — a BERT-based diagnostic system that extracts relevant clinical data from transcribed patient-doctor dialogues and explains predictions using feature attribution methods. We present a novel performance plot and evaluation metric for feature attribution methods — Feature Attribution Dropping (FAD) curve and its Normalized Area Under the Curve (N-AUC). FAD curve analysis shows that integrated gradients outperforms Shapley values in explaining diagnosis classification. Doctor XAvIer outperforms the baseline with 0.97 F1-score in named entity recognition and symptom pertinence classification and 0.91 F1-score in diagnosis classification.","PeriodicalId":200974,"journal":{"name":"Workshop on Biomedical Natural Language Processing","volume":"163 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133453764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-10DOI: 10.48550/arXiv.2204.04775
Saadullah Amin, Noon Pokaratsiri Goldstein, M. Wixted, Alejandro Garc'ia-Rudolph, Catalina Mart'inez-Costa, G. Neumann
Despite the advances in digital healthcare systems offering curated structured knowledge, much of the critical information still lies in large volumes of unlabeled and unstructured clinical texts. These texts, which often contain protected health information (PHI), are exposed to information extraction tools for downstream applications, risking patient identification. Existing works in de-identification rely on using large-scale annotated corpora in English, which often are not suitable in real-world multilingual settings. Pre-trained language models (LM) have shown great potential for cross-lingual transfer in low-resource settings. In this work, we empirically show the few-shot cross-lingual transfer property of LMs for named entity recognition (NER) and apply it to solve a low-resource and real-world challenge of code-mixed (Spanish-Catalan) clinical notes de-identification in the stroke domain. We annotate a gold evaluation dataset to assess few-shot setting performance where we only use a few hundred labeled examples for training. Our model improves the zero-shot F1-score from 73.7% to 91.2% on the gold evaluation set when adapting Multilingual BERT (mBERT) (CITATION) from the MEDDOCAN (CITATION) corpus with our few-shot cross-lingual target corpus. When generalized to an out-of-sample test set, the best model achieves a human-evaluation F1-score of 97.2%.
{"title":"Few-Shot Cross-lingual Transfer for Coarse-grained De-identification of Code-Mixed Clinical Texts","authors":"Saadullah Amin, Noon Pokaratsiri Goldstein, M. Wixted, Alejandro Garc'ia-Rudolph, Catalina Mart'inez-Costa, G. Neumann","doi":"10.48550/arXiv.2204.04775","DOIUrl":"https://doi.org/10.48550/arXiv.2204.04775","url":null,"abstract":"Despite the advances in digital healthcare systems offering curated structured knowledge, much of the critical information still lies in large volumes of unlabeled and unstructured clinical texts. These texts, which often contain protected health information (PHI), are exposed to information extraction tools for downstream applications, risking patient identification. Existing works in de-identification rely on using large-scale annotated corpora in English, which often are not suitable in real-world multilingual settings. Pre-trained language models (LM) have shown great potential for cross-lingual transfer in low-resource settings. In this work, we empirically show the few-shot cross-lingual transfer property of LMs for named entity recognition (NER) and apply it to solve a low-resource and real-world challenge of code-mixed (Spanish-Catalan) clinical notes de-identification in the stroke domain. We annotate a gold evaluation dataset to assess few-shot setting performance where we only use a few hundred labeled examples for training. Our model improves the zero-shot F1-score from 73.7% to 91.2% on the gold evaluation set when adapting Multilingual BERT (mBERT) (CITATION) from the MEDDOCAN (CITATION) corpus with our few-shot cross-lingual target corpus. When generalized to an out-of-sample test set, the best model achieves a human-evaluation F1-score of 97.2%.","PeriodicalId":200974,"journal":{"name":"Workshop on Biomedical Natural Language Processing","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122994600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pretrained language models have served as important backbones for natural language processing. Recently, in-domain pretraining has been shown to benefit various domain-specific downstream tasks. In the biomedical domain, natural language generation (NLG) tasks are of critical importance, while understudied. Approaching natural language understanding (NLU) tasks as NLG achieves satisfying performance in the general domain through constrained language generation or language prompting. We emphasize the lack of in-domain generative language models and the unsystematic generative downstream benchmarks in the biomedical domain, hindering the development of the research community. In this work, we introduce the generative language model BioBART that adapts BART to the biomedical domain. We collate various biomedical language generation tasks including dialogue, summarization, entity linking, and named entity recognition. BioBART pretrained on PubMed abstracts has enhanced performance compared to BART and set strong baselines on several tasks. Furthermore, we conduct ablation studies on the pretraining tasks for BioBART and find that sentence permutation has negative effects on downstream tasks.
{"title":"BioBART: Pretraining and Evaluation of A Biomedical Generative Language Model","authors":"Hongyi Yuan, Zheng Yuan, Ruyi Gan, Jiaxing Zhang, Yutao Xie, Sheng Yu","doi":"10.48550/arXiv.2204.03905","DOIUrl":"https://doi.org/10.48550/arXiv.2204.03905","url":null,"abstract":"Pretrained language models have served as important backbones for natural language processing. Recently, in-domain pretraining has been shown to benefit various domain-specific downstream tasks. In the biomedical domain, natural language generation (NLG) tasks are of critical importance, while understudied. Approaching natural language understanding (NLU) tasks as NLG achieves satisfying performance in the general domain through constrained language generation or language prompting. We emphasize the lack of in-domain generative language models and the unsystematic generative downstream benchmarks in the biomedical domain, hindering the development of the research community. In this work, we introduce the generative language model BioBART that adapts BART to the biomedical domain. We collate various biomedical language generation tasks including dialogue, summarization, entity linking, and named entity recognition. BioBART pretrained on PubMed abstracts has enhanced performance compared to BART and set strong baselines on several tasks. Furthermore, we conduct ablation studies on the pretraining tasks for BioBART and find that sentence permutation has negative effects on downstream tasks.","PeriodicalId":200974,"journal":{"name":"Workshop on Biomedical Natural Language Processing","volume":"85 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122475303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-03DOI: 10.48550/arXiv.2204.01098
John Giorgi, Gary D Bader, Bo Wang
Motivated by the fact that many relations cross the sentence boundary, there has been increasing interest in document-level relation extraction (DocRE). DocRE requires integrating information within and across sentences, capturing complex interactions between mentions of entities. Most existing methods are pipeline-based, requiring entities as input. However, jointly learning to extract entities and relations can improve performance and be more efficient due to shared parameters and training steps. In this paper, we develop a sequence-to-sequence approach, seq2rel, that can learn the subtasks of DocRE (entity extraction, coreference resolution and relation extraction) end-to-end, replacing a pipeline of task-specific components. Using a simple strategy we call entity hinting, we compare our approach to existing pipeline-based methods on several popular biomedical datasets, in some cases exceeding their performance. We also report the first end-to-end results on these datasets for future comparison. Finally, we demonstrate that, under our model, an end-to-end approach outperforms a pipeline-based approach. Our code, data and trained models are available at https://github.com/johngiorgi/seq2rel. An online demo is available at https://share.streamlit.io/johngiorgi/seq2rel/main/demo.py.
{"title":"A sequence-to-sequence approach for document-level relation extraction","authors":"John Giorgi, Gary D Bader, Bo Wang","doi":"10.48550/arXiv.2204.01098","DOIUrl":"https://doi.org/10.48550/arXiv.2204.01098","url":null,"abstract":"Motivated by the fact that many relations cross the sentence boundary, there has been increasing interest in document-level relation extraction (DocRE). DocRE requires integrating information within and across sentences, capturing complex interactions between mentions of entities. Most existing methods are pipeline-based, requiring entities as input. However, jointly learning to extract entities and relations can improve performance and be more efficient due to shared parameters and training steps. In this paper, we develop a sequence-to-sequence approach, seq2rel, that can learn the subtasks of DocRE (entity extraction, coreference resolution and relation extraction) end-to-end, replacing a pipeline of task-specific components. Using a simple strategy we call entity hinting, we compare our approach to existing pipeline-based methods on several popular biomedical datasets, in some cases exceeding their performance. We also report the first end-to-end results on these datasets for future comparison. Finally, we demonstrate that, under our model, an end-to-end approach outperforms a pipeline-based approach. Our code, data and trained models are available at https://github.com/johngiorgi/seq2rel. An online demo is available at https://share.streamlit.io/johngiorgi/seq2rel/main/demo.py.","PeriodicalId":200974,"journal":{"name":"Workshop on Biomedical Natural Language Processing","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126307883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-01DOI: 10.48550/arXiv.2204.00391
Sihang Zeng, Zheng Yuan, Sheng Yu
Term clustering is important in biomedical knowledge graph construction. Using similarities between terms embedding is helpful for term clustering. State-of-the-art term embeddings leverage pretrained language models to encode terms, and use synonyms and relation knowledge from knowledge graphs to guide contrastive learning. These embeddings provide close embeddings for terms belonging to the same concept. However, from our probing experiments, these embeddings are not sensitive to minor textual differences which leads to failure for biomedical term clustering. To alleviate this problem, we adjust the sampling strategy in pretraining term embeddings by providing dynamic hard positive and negative samples during contrastive learning to learn fine-grained representations which result in better biomedical term clustering. We name our proposed method as CODER++, and it has been applied in clustering biomedical concepts in the newly released Biomedical Knowledge Graph named BIOS.
{"title":"Automatic Biomedical Term Clustering by Learning Fine-grained Term Representations","authors":"Sihang Zeng, Zheng Yuan, Sheng Yu","doi":"10.48550/arXiv.2204.00391","DOIUrl":"https://doi.org/10.48550/arXiv.2204.00391","url":null,"abstract":"Term clustering is important in biomedical knowledge graph construction. Using similarities between terms embedding is helpful for term clustering. State-of-the-art term embeddings leverage pretrained language models to encode terms, and use synonyms and relation knowledge from knowledge graphs to guide contrastive learning. These embeddings provide close embeddings for terms belonging to the same concept. However, from our probing experiments, these embeddings are not sensitive to minor textual differences which leads to failure for biomedical term clustering. To alleviate this problem, we adjust the sampling strategy in pretraining term embeddings by providing dynamic hard positive and negative samples during contrastive learning to learn fine-grained representations which result in better biomedical term clustering. We name our proposed method as CODER++, and it has been applied in clustering biomedical concepts in the newly released Biomedical Knowledge Graph named BIOS.","PeriodicalId":200974,"journal":{"name":"Workshop on Biomedical Natural Language Processing","volume":"51 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127089437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-30DOI: 10.48550/arXiv.2204.03489
Micheal Abaho, D. Bollegala, P. Williamson, S. Dodd
Probing factual knowledge in Pre-trained Language Models (PLMs) using prompts has indirectly implied that language models (LMs) can be treated as knowledge bases. To this end, this phenomenon has been effective, especially when these LMs are fine-tuned towards not just data, but also to the style or linguistic pattern of the prompts themselves. We observe that satisfying a particular linguistic pattern in prompts is an unsustainable, time-consuming constraint in the probing task, especially because they are often manually designed and the range of possible prompt template patterns can vary depending on the prompting task. To alleviate this constraint, we propose using a position-attention mechanism to capture positional information of each word in a prompt relative to the mask to be filled, hence avoiding the need to re-construct prompts when the prompts’ linguistic pattern changes. Using our approach, we demonstrate the ability of eliciting answers (in a case study on health outcome generation) to not only common prompt templates like Cloze and Prefix but also rare ones too, such as Postfix and Mixed patterns whose masks are respectively at the start and in multiple random places of the prompt. More so, using various biomedical PLMs, our approach consistently outperforms a baseline in which the default PLMs representation is used to predict masked tokens.
{"title":"Position-based Prompting for Health Outcome Generation","authors":"Micheal Abaho, D. Bollegala, P. Williamson, S. Dodd","doi":"10.48550/arXiv.2204.03489","DOIUrl":"https://doi.org/10.48550/arXiv.2204.03489","url":null,"abstract":"Probing factual knowledge in Pre-trained Language Models (PLMs) using prompts has indirectly implied that language models (LMs) can be treated as knowledge bases. To this end, this phenomenon has been effective, especially when these LMs are fine-tuned towards not just data, but also to the style or linguistic pattern of the prompts themselves. We observe that satisfying a particular linguistic pattern in prompts is an unsustainable, time-consuming constraint in the probing task, especially because they are often manually designed and the range of possible prompt template patterns can vary depending on the prompting task. To alleviate this constraint, we propose using a position-attention mechanism to capture positional information of each word in a prompt relative to the mask to be filled, hence avoiding the need to re-construct prompts when the prompts’ linguistic pattern changes. Using our approach, we demonstrate the ability of eliciting answers (in a case study on health outcome generation) to not only common prompt templates like Cloze and Prefix but also rare ones too, such as Postfix and Mixed patterns whose masks are respectively at the start and in multiple random places of the prompt. More so, using various biomedical PLMs, our approach consistently outperforms a baseline in which the default PLMs representation is used to predict masked tokens.","PeriodicalId":200974,"journal":{"name":"Workshop on Biomedical Natural Language Processing","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127290848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-09-17DOI: 10.18653/v1/2022.bionlp-1.7
Yannis Papanikolaou, Francine Bennett
Information Extraction (IE) from text refers to the task of extracting structured knowledge from unstructured text. The task typically consists of a series of sub-tasks such as Named Entity Recognition and Relation Extraction. Sourcing entity and relation type specific training data is a major bottleneck in domains with limited resources such as biomedicine. In this work we present a slot filling approach to the task of biomedical IE, effectively replacing the need for entity and relation-specific training data, allowing us to deal with zero-shot settings. We follow the recently proposed paradigm of coupling a Tranformer-based bi-encoder, Dense Passage Retrieval, with a Transformer-based reading comprehension model to extract relations from biomedical text. We assemble a biomedical slot filling dataset for both retrieval and reading comprehension and conduct a series of experiments demonstrating that our approach outperforms a number of simpler baselines. We also evaluate our approach end-to-end for standard as well as zero-shot settings. Our work provides a fresh perspective on how to solve biomedical IE tasks, in the absence of relevant training data. Our code, models and datasets are available at https://github.com/tba.
{"title":"Slot Filling for Biomedical Information Extraction","authors":"Yannis Papanikolaou, Francine Bennett","doi":"10.18653/v1/2022.bionlp-1.7","DOIUrl":"https://doi.org/10.18653/v1/2022.bionlp-1.7","url":null,"abstract":"Information Extraction (IE) from text refers to the task of extracting structured knowledge from unstructured text. The task typically consists of a series of sub-tasks such as Named Entity Recognition and Relation Extraction. Sourcing entity and relation type specific training data is a major bottleneck in domains with limited resources such as biomedicine. In this work we present a slot filling approach to the task of biomedical IE, effectively replacing the need for entity and relation-specific training data, allowing us to deal with zero-shot settings. We follow the recently proposed paradigm of coupling a Tranformer-based bi-encoder, Dense Passage Retrieval, with a Transformer-based reading comprehension model to extract relations from biomedical text. We assemble a biomedical slot filling dataset for both retrieval and reading comprehension and conduct a series of experiments demonstrating that our approach outperforms a number of simpler baselines. We also evaluate our approach end-to-end for standard as well as zero-shot settings. Our work provides a fresh perspective on how to solve biomedical IE tasks, in the absence of relevant training data. Our code, models and datasets are available at https://github.com/tba.","PeriodicalId":200974,"journal":{"name":"Workshop on Biomedical Natural Language Processing","volume":"61 10","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132694517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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