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Case Report: Transorbital Neuroendoscopic Surgery (TONES) for a Case of Cavernoma-Associated Epilepsy Within the Mesial Temporal Lobe 病例报告:经眼眶神经内窥镜手术治疗一例颞叶内侧海绵状瘤相关癫痫
Pub Date : 2023-01-06 DOI: 10.35702/nrj.10015
Maa Salek, N. Jahan, A. Manik, Aum Chowdhurty, R. Chowdhury
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引用次数: 0
Brain CT-Scan Features in Methanol Toxicity and Their Association with Clinical Manifestations and Outcome; a Cross-Sectional Study 甲醇中毒的脑ct扫描特征及其与临床表现和预后的关系横断面研究
Pub Date : 2023-01-06 DOI: 10.35702/nrj.10013
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引用次数: 0
Blink Reflex Value in the Early Diagnosis of Guillain-Barre Syndrome 眨眼反射在格林-巴利综合征早期诊断中的价值
Pub Date : 2023-01-06 DOI: 10.35702/nrj.10014
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引用次数: 0
Asymptomatic Isolated Congenital Cervical Dermal Sinus 无症状孤立性先天性颈部真皮窦
Pub Date : 2022-10-13 DOI: 10.35702/nrj.10012
Saeid Esmaeilian, E. Mohajeri, Behnam Kian, Mehrdad Kayedi, M. Izadi
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引用次数: 0
Are Human Needs Fulfilled In Treatment Adherence In Hemodialysis? A Crossover between Social Work and Neurology 血液透析治疗依从性是否满足了人的需求?社会工作与神经学的交叉
Pub Date : 2022-06-10 DOI: 10.35702/nrj.10011
M. J. C. Sacadura, H. N. Almeida
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引用次数: 0
An Attempt to Assess Nurses’ Competence in Field of Sexual Counseling and Education 护士性咨询教育能力评估的尝试
Pub Date : 2021-04-24 DOI: 10.35702/nrj.10010
A. Różyk-Myrta, A. Brodziak, E. Kołat
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引用次数: 0
Stroke Treatment: Focus on Neuroprotection and EPO 脑卒中治疗:以神经保护和EPO为主
Pub Date : 2021-02-18 DOI: 10.35702/nrj.10008
Victoria A. Hamilton BHScc, A. Hebb
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引用次数: 0
IsoMov-CG: A New Effective Therapy Programme Utilizing Isometric and Movement Exercises for Children with ADHD IsoMov-CG:一种新的有效的治疗方案,利用等长和运动练习治疗多动症儿童
Pub Date : 2021-01-29 DOI: 10.35702/nrj.10007
C. Grzywniak
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引用次数: 0
Paraphilic Disorder: Definition, Contexts And Clinical Strategies 反性恋障碍:定义、背景和临床策略
Pub Date : 2019-09-24 DOI: 10.35702/nrj.10004
G. Perrotta
The evolution of the definition of perverted or paraphilic sexual activity reveals how psychiatric nosography reflects the society that expresses it. In the context of a culture that considered sexuality in relatively narrow terms, Freud (1905) first, in a closed socio-cultural context but eager to open up, defined perverse sexual activity according to various criteria, such as: focusing of body regions not necessarily genitals (eg: neck, back, ...); the replacement of the usual sexual practice exclusively focused on genital contacts with a partner of the other sex, often for procreative purposes, according to the religious direction; the tendency to be the exclusive practice of the individual. From his first paper, however, cultural attitudes relating to sexuality have changed radically, thanks to globalization and the spread of telematics and social networks capable of connecting individuals separated by oceans and continents. Over the decades, from the first theorizations of the beginning of the last century, not surprisingly, couples (in their intimacy) have cleared a variety of sexual behaviours so to speak “bizarre”, up to the removal of perverse behaviours like anal penetration and homosexual orientation [1].
变态或性反常行为定义的演变揭示了精神病学是如何反映表达它的社会的。弗洛伊德(1905)首先,在一个封闭的社会文化背景下,但渴望开放,根据各种标准定义了反常的性活动,例如:关注身体区域不一定是生殖器(例如:脖子,背部,……);取代通常的性行为,只专注于与异性伴侣的生殖器接触,通常是出于生殖目的,根据宗教方向;趋向于成为个人的专属实践。然而,从他的第一篇论文开始,与性有关的文化态度发生了根本性的变化,这要归功于全球化和远程信息处理技术的普及,以及能够将相隔大洋和大陆的个人联系起来的社交网络。在过去的几十年里,从上世纪初的第一个理论开始,毫不奇怪,夫妻(在他们的亲密关系中)已经清除了各种各样的性行为,可以说是“怪异的”,直到消除了像肛门插入和同性恋取向这样的反常行为[1]。
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引用次数: 40
High Throughput Sequencing Detect Gingivitis And Periodontal Oral Bacteria In Alzheimer’s Disease Autopsy Brains 高通量测序检测阿尔茨海默病尸检大脑中的牙龈炎和牙周口腔细菌
Pub Date : 2019-09-10 DOI: 10.35702/NRJ.10003
H. Siddiqui, Emenike R. K. Eribe, S. Singhrao, I. Olsen
The sporadic form of Alzheimer’s disease (AD) is the most common form of dementia characterized microscopically by the presence of amyloid-beta (Aβ) plaques and tau-neurofibrillary tangles with clinical presentation of cognitive deficit. Its etiology remains obscure. The cited literature from epidemiological studies suggests the presence of gingivitis and periodontitis almost double the risk for AD over a 10-year period. This feasibility study used 16S rDNA high throughput sequencing to evaluate the bacterial components of the oral microbiome in snap frozen human AD and non-AD control brains. Specimens (n = 20), 10 from AD brains and 10 from non-AD age-matched brains were subjected to molecular barcoding “blindly” with high throughput sequencing. Initial PCR treatment, using 14 different primer sets separately and in combination, identified 4 (40%) positive samples in the AD-group and 6 (60%) positive samples in the non-AD-group with bacterial species associated with the oral and the gastrointestinal tract. Brain cell lysates were validated for the presence of bacterial peptidoglycan and showed 8 out of 10 brains to be positive for this universal bacterial protein in both the AD and non-AD groups. Actinomycetales and Prevotella (bacterial marker for gingivitis) and Treponema and Veillonella, (periodontitis) were present exclusively in the AD group. This study confirmed Actinomycetales and Bacteroidales (Treponema and Veillonella species) were exclusively isolated from AD brain tissue, and supports other epidemiological which demonstrate gingivitis and periodontal disease to be associated with AD.
散发性阿尔茨海默病(AD)是最常见的痴呆症形式,其显微特征是存在淀粉样蛋白(Aβ)斑块和tau-神经原纤维缠结,临床表现为认知障碍。其病因尚不清楚。从流行病学研究中引用的文献表明,牙龈炎和牙周炎的存在使阿尔茨海默病的风险在10年内几乎增加了一倍。本可行性研究采用16S rDNA高通量测序技术,对快速冷冻的阿尔茨海默病患者和非阿尔茨海默病患者大脑中口腔微生物组的细菌组成进行了评估。采用高通量测序的“盲目”分子条形码技术,对20个样本(n = 20),其中10个来自AD大脑,10个来自非AD年龄匹配的大脑。在最初的PCR处理中,分别或联合使用14种不同的引物,在ad组中鉴定出4个(40%)阳性样本,在非ad组中鉴定出6个(60%)阳性样本,其细菌种类与口腔和胃肠道相关。脑细胞裂解物被证实存在细菌肽聚糖,结果显示,在阿尔茨海默病和非阿尔茨海默病组中,10个大脑中有8个对这种通用细菌蛋白呈阳性。放线菌和普雷沃氏菌(牙龈炎的细菌标志物)以及密螺旋体和细孔菌(牙周炎)仅存在于AD组。本研究证实放线菌和拟杆菌属(密螺旋体和细孔菌)完全从阿尔茨海默病脑组织中分离出来,并支持其他流行病学证据,证明牙龈炎和牙周病与阿尔茨海默病有关。
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引用次数: 23
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