Introduction Bone lymphoma is a very rare entity. It constitutes less than 2% of lymphomas and the sacrum is an unusual primary location. Only 11 cases have been described to date. Objective To describe a case of primary sacral lymphoma in a 46-year-old patient after reporting lumbar pain with radiculopathy of one month's evolution. Material and methods A 46-year-old female patient with lumbar pain of one month's evolution of mechanical characteristics with radiculopathy S1 of the right leg. No acute bone injury was observed in the X-rays performed. A CT scan was performed in a private center that reported a lytic lesion of 28 x 97 mm diameter in the right sacral wing with malignant characteristics. MRI is requested, which confirms the lesion with extension to soft tissues. Tumor markers and plasma proteins were not elevated. Biopsy with histopathological analysis reported a diffuse large B-cell lymphoma with positivity for cMYC, BCL2, BLC6, CD20, CD79a, PAX5, MUM1, with a Ki67 index of 75%. Results After diagnosis of primary diffuse large B-cell lymphoma without distant metastasis, chemotherapy treatment was started with 6 cycles of R-CHOP followed by radiotherapy. Conclusion Primary bone lymphoma is a very rare entity, and even more rare at the bone level, but knowledge of this entity is necessary to include it as a differential diagnosis of low back pain with radiculopathy.
骨淋巴瘤是一种非常罕见的疾病。它占不到2%的淋巴瘤,骶骨是一个不寻常的原发部位。迄今为止,仅报告了11例病例。目的报告1例46岁患者腰痛并发神经根病1个月后发生的原发性骶部淋巴瘤。材料与方法46岁女性患者,腰痛1个月,力学特征演变,右腿S1神经根病。x线检查未见急性骨损伤。在一家私人中心进行了CT扫描,报告了右侧骶骨翼28 x 97 mm直径的溶解性病变,具有恶性特征。要求行MRI检查,证实病变已扩展至软组织。肿瘤标志物和血浆蛋白均未升高。活检和组织病理学分析报告弥漫性大b细胞淋巴瘤,cMYC、BCL2、BLC6、CD20、CD79a、PAX5、MUM1阳性,Ki67指数为75%。结果原发性弥漫性大b细胞淋巴瘤无远处转移,经6个周期的R-CHOP化疗后开始放疗。结论原发性骨淋巴瘤是一种非常罕见的疾病,在骨水平上更为罕见,但有必要了解这种疾病,将其作为腰痛伴神经根病的鉴别诊断。
{"title":"Linfoma No-Hodgkin primario de sacro. Presentación de un caso clínico y revisión de la\u0000literatura.","authors":"DIEZ ALBERO, MORIL PEÑALVER, SEVILLA MONLLOR, FORNES GALLEGO, LAPEÑA MARTÍNEZ","doi":"10.37315/sotocav20222895716","DOIUrl":"https://doi.org/10.37315/sotocav20222895716","url":null,"abstract":"Introduction Bone lymphoma is a very rare entity. It constitutes less than 2% of lymphomas and the sacrum is an unusual primary location. Only 11 cases have been described to date. Objective To describe a case of primary sacral lymphoma in\u0000a 46-year-old patient after reporting lumbar pain with radiculopathy of one month's evolution. Material and methods A 46-year-old female patient with lumbar pain of one month's evolution of mechanical characteristics with radiculopathy S1 of the right leg. No acute bone injury was observed in the X-rays performed. A CT scan was performed in a private center that reported a lytic lesion of 28 x 97 mm diameter in the right sacral wing with malignant characteristics. MRI is requested, which confirms the lesion with extension to soft tissues. Tumor markers and plasma proteins were not elevated. Biopsy\u0000with histopathological analysis reported a diffuse large B-cell lymphoma with positivity for cMYC, BCL2, BLC6, CD20, CD79a, PAX5, MUM1, with a Ki67 index of 75%. Results After diagnosis of primary diffuse large B-cell lymphoma without distant metastasis, chemotherapy treatment was started with 6 cycles of R-CHOP followed by radiotherapy. Conclusion Primary bone lymphoma is a very rare entity, and even more rare at the bone level, but knowledge of this entity is necessary to include it as a differential diagnosis of low back pain with radiculopathy.","PeriodicalId":202353,"journal":{"name":"Revista Española de Cirugía Osteoarticular","volume":"126 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132000474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}