首页 > 最新文献

Problemy endokrinologii最新文献

英文 中文
[Features of steroidogenesis in men with hypogonadism and type 2 diabetes]. [男性性腺功能减退症和 2 型糖尿病患者的类固醇生成特征]。
Q4 Medicine Pub Date : 2022-06-16 DOI: 10.14341/probl13129
R V Rozhivanov, M O Chernova, V A Ioutsi, G A Mel'nichenko, M V Shestakova, N G Mokrysheva

Background: Type 2 diabetes mellitus (DM2) in men is associated with a high incidence of hypogonadism. Testosterone is a steroid hormone and one of the final metabolites of steroidogenesis, which causes interest in assessing the content of key steroid hormones, their precursors and metabolites in hypogonadal and eugonadal men with T2DM.

Aims: Assessment of the features of steroidogenesis in men with hypogonadism in T2DM using tandem mass spectrometry.

Materials and methods: A full-design, cross-sectional, screening, single-center, non-interventional study included men with T2DM, who were he was treated in Endocrinology Research Centre, Moscow. The study was conducted from October 2021 to January 2022. Medical history assessment, physical examination with determination of body mass index (BMI), measurement of key steroid hormones, their precursors and metabolites by isotope dilution liquid chromatography/tandem mass spectrometry, glycated hemoglobin (HbA1c) were performed. The groups were compared using the Mann-Whitney U-test for quantitative indicators and χ² with Yates' correction for qualitative ones. Correlation analysis was performed by the Spearman correlation method. When determining the criterion of statistical significance, the Bonferroni correction was applied.

Results: Patients with hypogonadism had statistically significantly more pronounced obesity compared with eugonadal men. In a comparative analysis of patients, depending on the presence of hypogonadism, there were statistically significantly lower levels of androgen precursors 17-hydroxypregnenolone and 17-hydroxyprogesterone in hypogonadal men. At the same time, a positive statistically significant correlation was found between total testosterone and 17-hydroxyprogesterone. In addition, 17-hydroxyprogesterone, although to a lesser extent, but positively correlated with other androgens - androstenedione (r=0,328; p<0,001) and dehydroepiandrosterone (r=0,183; p=0,004). >< 0,001) and dehydroepiandrosterone (r=0,183; p=0,004).

Conclusions: In this investigation the prevalence of male hypogonadism in type 2 diabetes, determined by high-precision tandem mass spectrometry, was 69,5%. There was no effect of the disease on the mineralocorticoid and glucocorticoid links of adrenal steroidogenesis. Hypogonadism was associated with decreased levels of a number of testosterone precursors. The most significant of them was 17-hydroxyprogesterone, which can be considered as a marker of testicular steroidogenesis.

背景:男性2型糖尿病(DM2)与性腺功能减退症的高发病率有关。睾酮是一种类固醇激素,也是类固醇生成的最终代谢产物之一,这引起了人们对评估T2DM男性性腺功能减退者和优生优育者体内关键类固醇激素、其前体和代谢产物含量的兴趣:这是一项全设计、横断面、筛查、单中心、非干预性研究,研究对象包括在莫斯科内分泌学研究中心接受治疗的T2DM男性患者。研究时间为 2021 年 10 月至 2022 年 1 月。研究人员进行了病史评估、体格检查和体重指数(BMI)测定,并通过同位素稀释液相色谱法/串联质谱法测量了主要类固醇激素及其前体和代谢物、糖化血红蛋白(HbA1c)。对定量指标采用 Mann-Whitney U 检验进行组间比较,对定性指标采用χ²加 Yates 校正进行组间比较。相关分析采用斯皮尔曼相关法。在确定统计学意义标准时,采用了Bonferroni校正法:结果:从统计学角度看,性腺功能减退症患者的肥胖程度明显高于性腺功能正常的男性。在对患者进行的比较分析中,根据是否存在性腺功能减退症,性腺功能减退男性的雄激素前体 17- 羟基孕烯醇酮和 17- 羟基孕酮的水平在统计学上明显较低。与此同时,总睾酮和 17- 羟孕酮之间在统计学上存在显著的正相关。此外,17-羟孕酮与其他雄激素--雄烯二酮(r=0,328;p<0,001)和脱氢表雄酮(r=0,183;p=0,004)也呈正相关,但程度较小:在这项调查中,通过高精度串联质谱测定,2 型糖尿病男性性腺功能减退症的发病率为 69.5%。该病对肾上腺类固醇生成的矿皮质激素和糖皮质激素环节没有影响。性腺功能减退与多种睾酮前体水平下降有关。其中最重要的是17-羟孕酮,它可被视为睾丸类固醇生成的标志物。
{"title":"[Features of steroidogenesis in men with hypogonadism and type 2 diabetes].","authors":"R V Rozhivanov, M O Chernova, V A Ioutsi, G A Mel'nichenko, M V Shestakova, N G Mokrysheva","doi":"10.14341/probl13129","DOIUrl":"10.14341/probl13129","url":null,"abstract":"<p><strong>Background: </strong>Type 2 diabetes mellitus (DM2) in men is associated with a high incidence of hypogonadism. Testosterone is a steroid hormone and one of the final metabolites of steroidogenesis, which causes interest in assessing the content of key steroid hormones, their precursors and metabolites in hypogonadal and eugonadal men with T2DM.</p><p><strong>Aims: </strong>Assessment of the features of steroidogenesis in men with hypogonadism in T2DM using tandem mass spectrometry.</p><p><strong>Materials and methods: </strong>A full-design, cross-sectional, screening, single-center, non-interventional study included men with T2DM, who were he was treated in Endocrinology Research Centre, Moscow. The study was conducted from October 2021 to January 2022. Medical history assessment, physical examination with determination of body mass index (BMI), measurement of key steroid hormones, their precursors and metabolites by isotope dilution liquid chromatography/tandem mass spectrometry, glycated hemoglobin (HbA1c) were performed. The groups were compared using the Mann-Whitney U-test for quantitative indicators and χ² with Yates' correction for qualitative ones. Correlation analysis was performed by the Spearman correlation method. When determining the criterion of statistical significance, the Bonferroni correction was applied.</p><p><strong>Results: </strong>Patients with hypogonadism had statistically significantly more pronounced obesity compared with eugonadal men. In a comparative analysis of patients, depending on the presence of hypogonadism, there were statistically significantly lower levels of androgen precursors 17-hydroxypregnenolone and 17-hydroxyprogesterone in hypogonadal men. At the same time, a positive statistically significant correlation was found between total testosterone and 17-hydroxyprogesterone. In addition, 17-hydroxyprogesterone, although to a lesser extent, but positively correlated with other androgens - androstenedione (r=0,328; p&lt;0,001) and dehydroepiandrosterone (r=0,183; p=0,004). &gt;&lt; 0,001) and dehydroepiandrosterone (r=0,183; p=0,004).</p><p><strong>Conclusions: </strong>In this investigation the prevalence of male hypogonadism in type 2 diabetes, determined by high-precision tandem mass spectrometry, was 69,5%. There was no effect of the disease on the mineralocorticoid and glucocorticoid links of adrenal steroidogenesis. Hypogonadism was associated with decreased levels of a number of testosterone precursors. The most significant of them was 17-hydroxyprogesterone, which can be considered as a marker of testicular steroidogenesis.</p>","PeriodicalId":20433,"journal":{"name":"Problemy endokrinologii","volume":" ","pages":"113-120"},"PeriodicalIF":0.0,"publicationDate":"2022-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40527256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Panhypopituitarism as the first manifestation of sarcoidosis: case report]. [结节病首发表现为全垂体功能减退1例]。
Q4 Medicine Pub Date : 2022-06-15 DOI: 10.14341/probl13115
Yu A Ukhanova, I A Ilovayskaya, S A Terpigorev

Sarcoidosis is a systemic inflammatory disease of unknown etiology characterized by the formation of noncaseating granulomas in various organs and tissues and the activation of T-cells at the site of granulomatous inflammation with the release of various chemokines and cytokines [1]. The incidence on average ranges from 10 to 20 per 100,000 population [2]. Most often in patients with sarcoidosis, lesions of the lungs and intrathoracic lymph nodes are detected. Significantly less often (in about 5-20% of patients) damage to the nervous system is noted [6,7,9]. In 9-18% of patients with neurosarcoidosis, involvement of the pituitary gland, pituitary infundibulum and hypothalamus is found, which is manifested by a variety of clinical symptoms [8,10]. We observed a patient with sarcoidosis whose disease debuted with clinical symptoms of hypogonadism, followed by the development of signs of secondary hypothyroidism, adrenal insufficiency, and diabetes insipidus, which was initially regarded as panhypopituitarism against the background of a hypothalamic lesion of unknown origin. Later, additional examination revealed signs of intrathoracic lymphadenopathy and focal changes in the lung parenchyma on CT, as well as skin lesions. Despite the biochemical compensation of hypopituitarism, the clinical efficacy of hormonal therapy with cabergoline, testosterone, hydrocortisone and levothyroxine sodium was insufficient, and the patient's condition improved after the addition of immunosuppressive and anti-inflammatory therapy with methotrexate and methylprednisolone.

结节病是一种病因不明的全身性炎症性疾病,其特点是在各器官和组织中形成非干酪化肉芽肿,肉芽肿炎症部位t细胞活化,释放多种趋化因子和细胞因子[1]。发病率平均为10 - 20 / 10万人[2]。结节病患者最常发现肺和胸内淋巴结病变。神经系统损伤的发生率明显较低(约占患者的5-20%)[6,7,9]。9-18%的神经结节病患者可累及垂体、垂体底和下丘脑,表现为多种临床症状[8,10]。我们观察到一位结节病患者,其疾病首发临床症状为性腺功能减退,随后发展为继发性甲状腺功能减退、肾上腺功能不全和尿囊症的体征,最初被认为是起因不明的下丘脑病变的全垂体功能减退症。随后,进一步检查发现胸内淋巴结病变和CT肺实质局灶性改变,以及皮肤病变。尽管垂体功能低下具有生化代偿作用,但卡麦角林、睾酮、氢化可的松、左旋甲状腺素钠等激素治疗临床疗效不足,在加用甲氨蝶呤、甲泼尼龙进行免疫抑制和抗炎治疗后,患者病情有所改善。
{"title":"[Panhypopituitarism as the first manifestation of sarcoidosis: case report].","authors":"Yu A Ukhanova,&nbsp;I A Ilovayskaya,&nbsp;S A Terpigorev","doi":"10.14341/probl13115","DOIUrl":"https://doi.org/10.14341/probl13115","url":null,"abstract":"<p><p>Sarcoidosis is a systemic inflammatory disease of unknown etiology characterized by the formation of noncaseating granulomas in various organs and tissues and the activation of T-cells at the site of granulomatous inflammation with the release of various chemokines and cytokines [1]. The incidence on average ranges from 10 to 20 per 100,000 population [2]. Most often in patients with sarcoidosis, lesions of the lungs and intrathoracic lymph nodes are detected. Significantly less often (in about 5-20% of patients) damage to the nervous system is noted [6,7,9]. In 9-18% of patients with neurosarcoidosis, involvement of the pituitary gland, pituitary infundibulum and hypothalamus is found, which is manifested by a variety of clinical symptoms [8,10]. We observed a patient with sarcoidosis whose disease debuted with clinical symptoms of hypogonadism, followed by the development of signs of secondary hypothyroidism, adrenal insufficiency, and diabetes insipidus, which was initially regarded as panhypopituitarism against the background of a hypothalamic lesion of unknown origin. Later, additional examination revealed signs of intrathoracic lymphadenopathy and focal changes in the lung parenchyma on CT, as well as skin lesions. Despite the biochemical compensation of hypopituitarism, the clinical efficacy of hormonal therapy with cabergoline, testosterone, hydrocortisone and levothyroxine sodium was insufficient, and the patient's condition improved after the addition of immunosuppressive and anti-inflammatory therapy with methotrexate and methylprednisolone.</p>","PeriodicalId":20433,"journal":{"name":"Problemy endokrinologii","volume":"68 4","pages":"46-51"},"PeriodicalIF":0.0,"publicationDate":"2022-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9762432/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10483966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Dysfunctional high-density lipoproteins in diabetes mellitus]. [糖尿病高密度脂蛋白功能失调]。
Q4 Medicine Pub Date : 2022-06-10 DOI: 10.14341/probl13118
O N Poteryaeva, I F Usynin

The risk of cardiovascular disease (CVD) in persons with type 2 diabetes mellitus (DM2) increases two to four times. One of the main factors increasing cardiovascular risk is dyslipidemia, which includes abnormalities in all lipoproteins, including high-density lipoproteins (HDL). The development of DM2 is accompanied not only by a decrease in the level of HDL, but also by significant changes in their structure. This leads to the transformation of native HDL into so-called dysfunctional or diabetic HDL, which loses their antiatherogenic, cardioprotective, anti-inflammatory and anti-diabetic properties. In poorly controlled diabetes mellitus HDL can not only lose its beneficial functions, but also acquire proatherogenic, proinflammatory ones. Diabetic HDL can contribute to the accumulation of such unfavorable qualities as increased proliferation, migration, and invasion of cancer cells. Given that HDL, in addition to participation in cholesterol transport, performs important regulatory functions in the body, there is reason to assume that structural modifications of HDL (oxidation, glycation, triglyceride enrichment, loss of HDL-associated enzymes, etc.) are one of the causes of vascular complications of diabetes.

2型糖尿病(DM2)患者患心血管疾病(CVD)的风险增加2至4倍。增加心血管风险的主要因素之一是血脂异常,包括所有脂蛋白的异常,包括高密度脂蛋白(HDL)。DM2的发展不仅伴随着HDL水平的下降,而且伴随着其结构的显著变化。这导致天然HDL转化为所谓的功能失调或糖尿病性HDL,从而失去其抗动脉粥样硬化、心脏保护、抗炎和抗糖尿病的特性。在控制不良的糖尿病患者中,HDL不仅失去其有益功能,而且还获得了促动脉粥样硬化、促炎症的功能。糖尿病高密度脂蛋白可促进诸如癌细胞增殖、迁移和侵袭增加等不利特性的积累。鉴于HDL除了参与胆固醇转运外,在体内还具有重要的调节功能,我们有理由认为HDL的结构修饰(氧化、糖基化、甘油三酯富集、HDL相关酶丧失等)是糖尿病血管并发症的原因之一。
{"title":"[Dysfunctional high-density lipoproteins in diabetes mellitus].","authors":"O N Poteryaeva,&nbsp;I F Usynin","doi":"10.14341/probl13118","DOIUrl":"https://doi.org/10.14341/probl13118","url":null,"abstract":"<p><p>The risk of cardiovascular disease (CVD) in persons with type 2 diabetes mellitus (DM2) increases two to four times. One of the main factors increasing cardiovascular risk is dyslipidemia, which includes abnormalities in all lipoproteins, including high-density lipoproteins (HDL). The development of DM2 is accompanied not only by a decrease in the level of HDL, but also by significant changes in their structure. This leads to the transformation of native HDL into so-called dysfunctional or diabetic HDL, which loses their antiatherogenic, cardioprotective, anti-inflammatory and anti-diabetic properties. In poorly controlled diabetes mellitus HDL can not only lose its beneficial functions, but also acquire proatherogenic, proinflammatory ones. Diabetic HDL can contribute to the accumulation of such unfavorable qualities as increased proliferation, migration, and invasion of cancer cells. Given that HDL, in addition to participation in cholesterol transport, performs important regulatory functions in the body, there is reason to assume that structural modifications of HDL (oxidation, glycation, triglyceride enrichment, loss of HDL-associated enzymes, etc.) are one of the causes of vascular complications of diabetes.</p>","PeriodicalId":20433,"journal":{"name":"Problemy endokrinologii","volume":"68 4","pages":"69-77"},"PeriodicalIF":0.0,"publicationDate":"2022-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9762443/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10483965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
[Adipsic diabetes insipidus after transsphenoidal surgery for suprasellar intraventricular]. [鞍上脑室经蝶窦手术后尿崩症]。
Q4 Medicine Pub Date : 2022-06-06 DOI: 10.14341/probl13126
L I Astafyeva, I N Badmaeva, Yu G Sidneva, I S Klochkova, D V Fomichev, I V Chernov, P L Kalinin

Presented case demonstrates a rare diencephalic pathology - adipsic diabetes insipidus (ADI) with severe hypernatremia in a 58-year-old woman after ttranssphenoidal removal of stalk intraventricular craniopharyngioma. ADI was diagnosed because of hypernatremia (150-155 mmol/L), polyuria (up to 4 liters per day) and absence of thirst. Normalization of water-electrolyte balance occurred on the background of desmopressin therapy and sufficient hydration in postoperative period. After release from the hospital, the patient independently stopped desmopressin therapy and did not consume an adequate amount of fluid of the background of polyuria. This led to severe hypernatremia (155-160 mmol/L) and rough mental disorders.Patients with ADI need closely monitoring of medical condition and water-electrolyte parameters, appointment of fixed doses of desmopressin and adequate hydration.

本病例表现了一种罕见的间脑病理-脂肪性尿崩症(ADI)伴严重高钠血症,发生于一名58岁女性经蝶窦切除脑室内颅咽管瘤后。ADI的诊断是由于高钠血症(150-155 mmol/L)、多尿(每天高达4升)和不口渴。在去氨加压素治疗和术后充分补水的背景下,水电解质平衡恢复正常。出院后,患者自行停止去氨加压素治疗,并没有摄入足量的多尿背景液体。这导致严重的高钠血症(155-160 mmol/L)和严重的精神障碍。ADI患者需要密切监测医疗状况和水电解质参数,预约固定剂量的去氨加压素并充分补水。
{"title":"[Adipsic diabetes insipidus after transsphenoidal surgery for suprasellar intraventricular].","authors":"L I Astafyeva,&nbsp;I N Badmaeva,&nbsp;Yu G Sidneva,&nbsp;I S Klochkova,&nbsp;D V Fomichev,&nbsp;I V Chernov,&nbsp;P L Kalinin","doi":"10.14341/probl13126","DOIUrl":"https://doi.org/10.14341/probl13126","url":null,"abstract":"<p><p>Presented case demonstrates a rare diencephalic pathology - adipsic diabetes insipidus (ADI) with severe hypernatremia in a 58-year-old woman after ttranssphenoidal removal of stalk intraventricular craniopharyngioma. ADI was diagnosed because of hypernatremia (150-155 mmol/L), polyuria (up to 4 liters per day) and absence of thirst. Normalization of water-electrolyte balance occurred on the background of desmopressin therapy and sufficient hydration in postoperative period. After release from the hospital, the patient independently stopped desmopressin therapy and did not consume an adequate amount of fluid of the background of polyuria. This led to severe hypernatremia (155-160 mmol/L) and rough mental disorders.Patients with ADI need closely monitoring of medical condition and water-electrolyte parameters, appointment of fixed doses of desmopressin and adequate hydration.</p>","PeriodicalId":20433,"journal":{"name":"Problemy endokrinologii","volume":"68 4","pages":"40-45"},"PeriodicalIF":0.0,"publicationDate":"2022-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9762437/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10493042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
[Time-restricted eating as a novel strategy for treatment of obesity and it's comorbid conditions]. [限时饮食作为治疗肥胖及其并发症的新策略]。
Q4 Medicine Pub Date : 2022-06-01 DOI: 10.14341/probl13078
M A Berkovskaya, O Y Gurova, I A Khaykina, V V Fadeev

The article provides a review of the current literature about time-restricted eating (TRE) as a new tool for the treatment of obesity and comorbid conditions. The search for new nutritional strategies in obesity, one of which is TRE, is due to the weak adherence of patients to hypocaloric diets in the long term, as well as the available data on the importance of -desynchronization of food intake with natural circadian rhythms in the development and progression of obesity and cardio--metabolic complications. The article describes the main mechanisms that regulate the circadian rhythms of food intake and nutrient absorption, substantiates the importance of adhering to a physiological diet for maintaining metabolic health. The main part of the review is devoted to reviewing the currently available researches on the effectiveness of various strategies of intermittent energy restriction for weight loss and the correction of metabolic parameters. Potential mechanisms of  the -effect of TRE on health are discussed, including those mediated by an unintentional decrease in caloric intake and changes in eating behavior, and differences in the effectiveness of early and late TRE. The article contains a detailed discussion of the potential problems and contradictions associated with the use of time-restricted eating in clinical practice, namely: the limitations and inconsistencies of the available clinical trials, the lack of data on long-term efficacy and safety, social and psychological limitations that impede the widespread use of TRE.

本文综述了目前关于限时饮食(TRE)作为治疗肥胖和合并症的新工具的文献。寻找新的肥胖营养策略,其中之一是TRE,是由于患者长期坚持低热量饮食的能力较弱,以及现有数据表明食物摄入与自然昼夜节律不同步在肥胖和心脏代谢并发症的发生和进展中的重要性。本文描述了调节食物摄入和营养吸收昼夜节律的主要机制,证实了坚持生理饮食对维持代谢健康的重要性。综述的主要部分是对目前关于各种间歇性能量限制策略对减肥和代谢参数校正的有效性的研究进行综述。本文还讨论了三次营养刺激对健康影响的潜在机制,包括由热量摄入的无意减少和饮食行为的改变所介导的机制,以及早期和晚期三次营养刺激有效性的差异。这篇文章详细讨论了在临床实践中使用限时饮食相关的潜在问题和矛盾,即:现有临床试验的局限性和不一致性,缺乏长期疗效和安全性的数据,阻碍TRE广泛使用的社会和心理限制。
{"title":"[Time-restricted eating as a novel strategy for treatment of obesity and it's comorbid conditions].","authors":"M A Berkovskaya,&nbsp;O Y Gurova,&nbsp;I A Khaykina,&nbsp;V V Fadeev","doi":"10.14341/probl13078","DOIUrl":"https://doi.org/10.14341/probl13078","url":null,"abstract":"<p><p>The article provides a review of the current literature about time-restricted eating (TRE) as a new tool for the treatment of obesity and comorbid conditions. The search for new nutritional strategies in obesity, one of which is TRE, is due to the weak adherence of patients to hypocaloric diets in the long term, as well as the available data on the importance of -desynchronization of food intake with natural circadian rhythms in the development and progression of obesity and cardio--metabolic complications. The article describes the main mechanisms that regulate the circadian rhythms of food intake and nutrient absorption, substantiates the importance of adhering to a physiological diet for maintaining metabolic health. The main part of the review is devoted to reviewing the currently available researches on the effectiveness of various strategies of intermittent energy restriction for weight loss and the correction of metabolic parameters. Potential mechanisms of  the -effect of TRE on health are discussed, including those mediated by an unintentional decrease in caloric intake and changes in eating behavior, and differences in the effectiveness of early and late TRE. The article contains a detailed discussion of the potential problems and contradictions associated with the use of time-restricted eating in clinical practice, namely: the limitations and inconsistencies of the available clinical trials, the lack of data on long-term efficacy and safety, social and psychological limitations that impede the widespread use of TRE.</p>","PeriodicalId":20433,"journal":{"name":"Problemy endokrinologii","volume":"68 4","pages":"78-91"},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9762455/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10483968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Experience in using teriparatide for the treatment of postoperative hypoparathyroidism in hemodialysis patients]. 特立帕肽治疗血液透析患者术后甲状旁腺功能低下的体会
Q4 Medicine Pub Date : 2022-05-30 DOI: 10.14341/probl13075
A K Eremkina, A M Gorbacheva, V A Enenko, E E Litvinova, N G Mokrysheva

The frequency of chronic postoperative hypoparathyroidism after total parathyroidectomy for secondary and tertiary hyperparathyroidism in patients with end-stage renal failure, according to various authors, can reach 20% or more. Prescribing active metabolites of vitamin D and calcium it is not always sufficient for achievement of target goals. This dictates the need for replacement therapy with recombinant parathyroid hormone. Teriparatide is the only drug of this series approved by the American Food and Drug Administration (FDA) and registered in the Russian Federation. However, it is registered as an anabolic anti-osteoporotic drug and is not indicated for the treatment of chronic hypoparathyroidism. The use of teriparatide in postoperative hypoparathyroidism in patients receiving renal replacement therapy with programmed hemodialysis in the Russian Federation has not been previously studied. Data on this issue is also limited in foreign literature. However, it is a potential treatment option for hemodialysis patients with chronic hypoparathyroidism and severe bone disorders. In this article, we present 2 clinical cases of substitution and anabolic therapy with teriparatide in this cohort of patients.

终末期肾功能衰竭患者继发性和三期甲状旁腺功能亢进患者全甲状旁腺切除术后发生慢性甲状旁腺功能减退的频率,据多位作者报道,可达20%以上。处方维生素D和钙的活性代谢物并不总是足以达到目标目标。这表明需要用重组甲状旁腺激素替代治疗。特立帕肽是该系列中唯一获得美国食品和药物管理局(FDA)批准并在俄罗斯联邦注册的药物。然而,它被注册为一种合成代谢抗骨质疏松药物,不用于治疗慢性甲状旁腺功能低下。特利帕肽在俄罗斯联邦接受肾替代治疗的程序性血液透析患者术后甲状旁腺功能低下中的应用尚未进行过研究。关于这一问题的资料在国外文献中也很有限。然而,对于患有慢性甲状旁腺功能低下和严重骨骼疾病的血液透析患者,它是一种潜在的治疗选择。在这篇文章中,我们报告了2例用特立帕肽替代和合成代谢治疗的临床病例。
{"title":"[Experience in using teriparatide for the treatment of postoperative hypoparathyroidism in hemodialysis patients].","authors":"A K Eremkina,&nbsp;A M Gorbacheva,&nbsp;V A Enenko,&nbsp;E E Litvinova,&nbsp;N G Mokrysheva","doi":"10.14341/probl13075","DOIUrl":"https://doi.org/10.14341/probl13075","url":null,"abstract":"<p><p>The frequency of chronic postoperative hypoparathyroidism after total parathyroidectomy for secondary and tertiary hyperparathyroidism in patients with end-stage renal failure, according to various authors, can reach 20% or more. Prescribing active metabolites of vitamin D and calcium it is not always sufficient for achievement of target goals. This dictates the need for replacement therapy with recombinant parathyroid hormone. Teriparatide is the only drug of this series approved by the American Food and Drug Administration (FDA) and registered in the Russian Federation. However, it is registered as an anabolic anti-osteoporotic drug and is not indicated for the treatment of chronic hypoparathyroidism. The use of teriparatide in postoperative hypoparathyroidism in patients receiving renal replacement therapy with programmed hemodialysis in the Russian Federation has not been previously studied. Data on this issue is also limited in foreign literature. However, it is a potential treatment option for hemodialysis patients with chronic hypoparathyroidism and severe bone disorders. In this article, we present 2 clinical cases of substitution and anabolic therapy with teriparatide in this cohort of patients.</p>","PeriodicalId":20433,"journal":{"name":"Problemy endokrinologii","volume":"68 4","pages":"30-39"},"PeriodicalIF":0.0,"publicationDate":"2022-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10453195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
[Two models of insulin resistance development and the strategy to combat age-related diseases: literature review]. [胰岛素抵抗发展的两种模式和对抗年龄相关疾病的策略:文献综述]。
Q4 Medicine Pub Date : 2022-05-30 DOI: 10.14341/probl13090
A V Martyushev-Poklad, D S Yankevich, M V Petrova, N G Savitskaya

Background: Insulin resistance (IR) is the root cause of most age-related diseases (ARD), the major challenge for today's health systems. Therefore, adequate understanding of the mechanisms underlying IR is essential to build effective ARD prevention.

Objective: Analyze the existing models of IR causation and progression in order to justify the most effective ARD prevention strategy.

Methods: Search and analysis of publications on IR and hyperinsulinemia (HI) from databases elibrary.ru, PubMed, and Google Scholar.

Results: Two models of IR development are analyzed along with the relationship between IR, HI, and obesity. The prevailing model considers obesity (imbalance of caloric intake and energy expenditure) as the main factor in the development of IR; HI is seen as a consequence of IR, mostly insignificant for the outcomes of IR. The model contradicts many experimental and clinical findings. The strategy to combat ARDs that follows from the model (hypocaloric diet and pharmacotherapy of IR) has proven mostly ineffective.The alternative model (IR as a consequence of HI, and obesity as one of IR manifestations) is more consistent with the pool of experimental and clinical data. It more precisely predicts ARD development and allows more adequate correction of adverse lifestyle factors. It corresponds to a different strategy for combating ARD: emphasis on low-carb diet and longer fasting window combined with consideration of other factors of IR.

Conclusion: If the prevailing model of IR development is revised, this should open up opportunities for more effective early prevention of a wide range of chronic diseases in which the role of IR is significant.

背景:胰岛素抵抗(IR)是大多数年龄相关疾病(ARD)的根本原因,是当今卫生系统面临的主要挑战。因此,充分了解IR的潜在机制对于建立有效的ARD预防至关重要。目的:分析现有IR的病因和进展模型,以确定最有效的ARD预防策略。方法:从数据库elibrar .ru、PubMed和Google Scholar中检索和分析有关IR和高胰岛素血症(HI)的出版物。结果:分析了IR发展的两种模式以及IR、HI和肥胖之间的关系。流行的模型认为肥胖(热量摄入和能量消耗不平衡)是IR发展的主要因素;HI被视为IR的结果,对IR的结果几乎无关紧要。该模型与许多实验和临床发现相矛盾。根据该模式(低热量饮食和IR药物治疗),对抗ARDs的策略已被证明大多无效。另一种模型(IR是HI的结果,肥胖是IR的表现之一)与实验和临床数据更加一致。它更准确地预测ARD的发展,并允许更充分地纠正不良生活方式因素。这对应于对抗ARD的不同策略:强调低碳水化合物饮食和更长的禁食窗口,并考虑IR的其他因素。结论:如果对IR发展的主流模式进行修订,这将为更有效地早期预防广泛的慢性疾病提供机会,其中IR的作用非常重要。
{"title":"[Two models of insulin resistance development and the strategy to combat age-related diseases: literature review].","authors":"A V Martyushev-Poklad,&nbsp;D S Yankevich,&nbsp;M V Petrova,&nbsp;N G Savitskaya","doi":"10.14341/probl13090","DOIUrl":"https://doi.org/10.14341/probl13090","url":null,"abstract":"<p><strong>Background: </strong>Insulin resistance (IR) is the root cause of most age-related diseases (ARD), the major challenge for today's health systems. Therefore, adequate understanding of the mechanisms underlying IR is essential to build effective ARD prevention.</p><p><strong>Objective: </strong>Analyze the existing models of IR causation and progression in order to justify the most effective ARD prevention strategy.</p><p><strong>Methods: </strong>Search and analysis of publications on IR and hyperinsulinemia (HI) from databases elibrary.ru, PubMed, and Google Scholar.</p><p><strong>Results: </strong>Two models of IR development are analyzed along with the relationship between IR, HI, and obesity. The prevailing model considers obesity (imbalance of caloric intake and energy expenditure) as the main factor in the development of IR; HI is seen as a consequence of IR, mostly insignificant for the outcomes of IR. The model contradicts many experimental and clinical findings. The strategy to combat ARDs that follows from the model (hypocaloric diet and pharmacotherapy of IR) has proven mostly ineffective.The alternative model (IR as a consequence of HI, and obesity as one of IR manifestations) is more consistent with the pool of experimental and clinical data. It more precisely predicts ARD development and allows more adequate correction of adverse lifestyle factors. It corresponds to a different strategy for combating ARD: emphasis on low-carb diet and longer fasting window combined with consideration of other factors of IR.</p><p><strong>Conclusion: </strong>If the prevailing model of IR development is revised, this should open up opportunities for more effective early prevention of a wide range of chronic diseases in which the role of IR is significant.</p>","PeriodicalId":20433,"journal":{"name":"Problemy endokrinologii","volume":"68 4","pages":"59-68"},"PeriodicalIF":0.0,"publicationDate":"2022-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10801740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
[A clinical Case and brief literature review of Icenko-Cushing's Disease in a pediatric patient with atypical onset of the disease]. 【小儿Icenko-Cushing病发病不典型的临床病例及简要文献回顾】。
Q4 Medicine Pub Date : 2022-05-14 DOI: 10.14341/probl13102
M A Tiulpakov, O B Bezlepkina, E V Nagaeva, V N Azizian, A M Lapshina

Itsenko-Cushing's disease is a rare, multisystem disease characterized by the presence of endogenous central hypercortisolism due to an ACTH-secreting brain tumor. The frequency of Itsenko-Cushing's disease in adulthood is 0.7-2.4 per 1 million population, and only 10% of all cases occur in childhood. The age of onset of the disease in children is on average 12.0-14.8 years. A typical manifestation of the disease in children, along with obesity and arterial hypertension, is a decrease in growth rates. The gold standard for diagnosing central hypercortisolism is MRI of the brain, however, the effectiveness of this method in children is only 50%. The main method of treatment is neurosurgical transnasal transsphenoidal removal of endosellar pituitary adenoma, which makes it possible to achieve remission in more than 65% of cases. This article describes a clinical case of Itsenko-Cushing's disease in a 6.5-year-old child with obesity, arterial hypertension, atypically «high» stature, average velocity and non-visualizable corticotropinoma. The article presents the stages of diagnostic search, the complexity of differential diagnosis and surgical treatment, the results of follow-up after the treatment and a brief review of the literature.

Itsenko-Cushing病是一种罕见的多系统疾病,其特征是由分泌acth的脑肿瘤引起内源性中枢高皮质醇血症。成人期Itsenko-Cushing病的发病率为每100万人中0.7-2.4例,所有病例中只有10%发生在儿童期。儿童发病年龄平均为12.0-14.8岁。该疾病在儿童中的典型表现,连同肥胖和动脉高血压,是生长速度下降。诊断中枢性高皮质醇症的金标准是脑MRI,然而,该方法在儿童中的有效性仅为50%。主要的治疗方法是神经外科经鼻经蝶窦切除垂体鞍内腺瘤,这使得超过65%的病例有可能达到缓解。本文描述了一个6.5岁儿童Itsenko-Cushing病的临床病例,伴有肥胖、动脉高血压、非典型“高”身材、平均速度和看不到的皮质瘤。本文介绍了诊断搜索的阶段,鉴别诊断和手术治疗的复杂性,治疗后随访的结果,并简要回顾了文献。
{"title":"[A clinical Case and brief literature review of Icenko-Cushing's Disease in a pediatric patient with atypical onset of the disease].","authors":"M A Tiulpakov,&nbsp;O B Bezlepkina,&nbsp;E V Nagaeva,&nbsp;V N Azizian,&nbsp;A M Lapshina","doi":"10.14341/probl13102","DOIUrl":"https://doi.org/10.14341/probl13102","url":null,"abstract":"<p><p>Itsenko-Cushing's disease is a rare, multisystem disease characterized by the presence of endogenous central hypercortisolism due to an ACTH-secreting brain tumor. The frequency of Itsenko-Cushing's disease in adulthood is 0.7-2.4 per 1 million population, and only 10% of all cases occur in childhood. The age of onset of the disease in children is on average 12.0-14.8 years. A typical manifestation of the disease in children, along with obesity and arterial hypertension, is a decrease in growth rates. The gold standard for diagnosing central hypercortisolism is MRI of the brain, however, the effectiveness of this method in children is only 50%. The main method of treatment is neurosurgical transnasal transsphenoidal removal of endosellar pituitary adenoma, which makes it possible to achieve remission in more than 65% of cases. This article describes a clinical case of Itsenko-Cushing's disease in a 6.5-year-old child with obesity, arterial hypertension, atypically «high» stature, average velocity and non-visualizable corticotropinoma. The article presents the stages of diagnostic search, the complexity of differential diagnosis and surgical treatment, the results of follow-up after the treatment and a brief review of the literature.</p>","PeriodicalId":20433,"journal":{"name":"Problemy endokrinologii","volume":"68 4","pages":"92-101"},"PeriodicalIF":0.0,"publicationDate":"2022-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10801741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
[Prevention of iodine deficiency diseases: focus on regional targeted programs]. [预防碘缺乏病:关注有针对性的地区计划]。
Q4 Medicine Pub Date : 2022-04-27 DOI: 10.14341/probl13119
I I Dedov, N M Platonova, E A Troshina, N P Makolina, I M Belovalova, E S Senyushkina, G A Melnichenko

The strategy for the elimination of diseases associated with iodine deficiency throughout the Russian Federation is based on the adoption of a federal law providing for the use of iodized salt as a means of mass (population) iodine prophylaxis. Chronic iodine deficiency that exists in Russia leads to dramatic consequences: the development of mental and physical retardation in children, cretinism, thyroid diseases, and infertility. Under conditions of iodine deficiency, the risk of radiation-induced thyroid cancer in children in the event of nuclear disasters increases hundreds of times. By definition, all iodine deficiency diseases (IDDs) can be prevented, while changes caused by iodine deficiency during fetal development and in early childhood are irreversible and practically defy treatment and rehabilitation. The actual average consumption of iodine by a resident of Russia is only 40-80 mcg per day, which is 3 times less than the established norm (150-250 mcg). Every year, more than 1.5 million adults and 650 thousand children with various thyroid diseases turn to medical institutions. The cause of 65% of cases of thyroid disease in adults and 95% in children is insufficient intake of iodine from the diet. At the stage of preparing the relevant legislative act, the development and implementation of regional programs for the prevention of IDD is of utmost importance. A typical draft of such a program is proposed in this article for its adaptation and use at the regional level.

在俄罗斯联邦全国范围内消除与缺碘有关的疾病的战略是以通过一项联邦法律为基础的,该法律规定使用加碘盐作为大规模(人口)碘预防手段。俄罗斯存在的长期缺碘现象会导致严重后果:儿童智力和身体发育迟缓、克汀病、甲状腺疾病和不育症。在缺碘的情况下,一旦发生核灾难,儿童因辐射诱发甲状腺癌的风险会增加数百倍。根据定义,所有碘缺乏病(IDDs)都是可以预防的,而在胎儿发育期和幼儿期缺碘引起的变化是不可逆的,几乎无法治疗和康复。俄罗斯居民的实际平均碘摄入量仅为每天 40-80 微克,比规定标准(150-250 微克)低 3 倍。每年有 150 多万成年人和 65 万儿童因患有各种甲状腺疾病而求助于医疗机构。65% 的成人甲状腺疾病和 95% 的儿童甲状腺疾病的病因都是从饮食中摄入的碘不足。在制定相关法案的阶段,制定和实施预防 IDD 的地区方案至关重要。本文提出了此类计划的典型草案,供地区一级调整和使用。
{"title":"[Prevention of iodine deficiency diseases: focus on regional targeted programs].","authors":"I I Dedov, N M Platonova, E A Troshina, N P Makolina, I M Belovalova, E S Senyushkina, G A Melnichenko","doi":"10.14341/probl13119","DOIUrl":"10.14341/probl13119","url":null,"abstract":"<p><p>The strategy for the elimination of diseases associated with iodine deficiency throughout the Russian Federation is based on the adoption of a federal law providing for the use of iodized salt as a means of mass (population) iodine prophylaxis. Chronic iodine deficiency that exists in Russia leads to dramatic consequences: the development of mental and physical retardation in children, cretinism, thyroid diseases, and infertility. Under conditions of iodine deficiency, the risk of radiation-induced thyroid cancer in children in the event of nuclear disasters increases hundreds of times. By definition, all iodine deficiency diseases (IDDs) can be prevented, while changes caused by iodine deficiency during fetal development and in early childhood are irreversible and practically defy treatment and rehabilitation. The actual average consumption of iodine by a resident of Russia is only 40-80 mcg per day, which is 3 times less than the established norm (150-250 mcg). Every year, more than 1.5 million adults and 650 thousand children with various thyroid diseases turn to medical institutions. The cause of 65% of cases of thyroid disease in adults and 95% in children is insufficient intake of iodine from the diet. At the stage of preparing the relevant legislative act, the development and implementation of regional programs for the prevention of IDD is of utmost importance. A typical draft of such a program is proposed in this article for its adaptation and use at the regional level.</p>","PeriodicalId":20433,"journal":{"name":"Problemy endokrinologii","volume":"68 3","pages":"16-20"},"PeriodicalIF":0.0,"publicationDate":"2022-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9762532/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10492066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Regional target program «Prevention of iodine deficiency diseases for 202X-202X»]. [区域目标方案" 2020 - 2020年预防缺碘病"]。
Q4 Medicine Pub Date : 2022-04-27 DOI: 10.14341/probl13120
E A Troshina, N M Platonova, N P Makolina, I M Belovalova, E S Senyushkina, G A Melnichenko, I I Dedov

.

{"title":"[Regional target program «Prevention of iodine deficiency diseases for 202X-202X»].","authors":"E A Troshina,&nbsp;N M Platonova,&nbsp;N P Makolina,&nbsp;I M Belovalova,&nbsp;E S Senyushkina,&nbsp;G A Melnichenko,&nbsp;I I Dedov","doi":"10.14341/probl13120","DOIUrl":"https://doi.org/10.14341/probl13120","url":null,"abstract":"<p><p>.</p>","PeriodicalId":20433,"journal":{"name":"Problemy endokrinologii","volume":"68 3","pages":"21-29"},"PeriodicalIF":0.0,"publicationDate":"2022-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9762531/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10492067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
期刊
Problemy endokrinologii
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1