Pub Date : 2024-01-01DOI: 10.33545/26649209.2024.v6.i1a.13
A. Antoine, Nakhoul Mary, S. Joyce
Objective: The introduction of direct-acting antivirals (DAAs) has the potential to make a substantial contribution to HCV eradication within dialysis centers. Our study seek assess effectiveness, safety of oral DAAs, both with and without ribavirin, in the Lebanese hemodialysis population afflicted with HCV. Methods: Patient on hemodialysis infected with hepatitis C virus having either genotype 1 or 4 were treated with DAAs. We conducted an analysis of various data points, including age, gender, year of HCV diagnosis, method of infection, comorbidities, previous treatment history, fibrosis stage, current DAAs treatment. We evaluated the virological response at the end of treatment, and12 weeks after stopping treatment Results: Twenty hemodialysis patients infected with HCV genotype 1 or 4 underwent DAA treatment. The gender ratio was 0.82, with an average age of 46.2 years. The mean duration between diagnosis and treatment was 5.7 years. Half of the patients contracted the virus in dialysis centers, 5% through blood transfusion, and in 45% of cases, the cause remained unknown. Comorbidities were present in 45% of cases, with 35% been treated with Ribavirin and Pegylated Interferon. Seventy percent of patients were genotype 1 (70% 1a, 15% 1b), while 25% had fibrosis
{"title":"Real-world experience of the Lebanese haemodialysis patient infected with the hepatitis C virus and treated with direct-acting antiviral drugs","authors":"A. Antoine, Nakhoul Mary, S. Joyce","doi":"10.33545/26649209.2024.v6.i1a.13","DOIUrl":"https://doi.org/10.33545/26649209.2024.v6.i1a.13","url":null,"abstract":"Objective: The introduction of direct-acting antivirals (DAAs) has the potential to make a substantial contribution to HCV eradication within dialysis centers. Our study seek assess effectiveness, safety of oral DAAs, both with and without ribavirin, in the Lebanese hemodialysis population afflicted with HCV. Methods: Patient on hemodialysis infected with hepatitis C virus having either genotype 1 or 4 were treated with DAAs. We conducted an analysis of various data points, including age, gender, year of HCV diagnosis, method of infection, comorbidities, previous treatment history, fibrosis stage, current DAAs treatment. We evaluated the virological response at the end of treatment, and12 weeks after stopping treatment Results: Twenty hemodialysis patients infected with HCV genotype 1 or 4 underwent DAA treatment. The gender ratio was 0.82, with an average age of 46.2 years. The mean duration between diagnosis and treatment was 5.7 years. Half of the patients contracted the virus in dialysis centers, 5% through blood transfusion, and in 45% of cases, the cause remained unknown. Comorbidities were present in 45% of cases, with 35% been treated with Ribavirin and Pegylated Interferon. Seventy percent of patients were genotype 1 (70% 1a, 15% 1b), while 25% had fibrosis <F2, 40% F2-F3, and 20% F4. Patients received Ombitasvir/Paritaprevir/Ritonavir +/- Ribavirin for genotype 4, and Ombitasvir/Paritaprevir/Ritonavir-Dasabuvir +/- Ribavirin for genotype 1. The sustained virological response (SVR) at 12 weeks was 95%, with one patient (5%) discontinuing treatment after 2 weeks due to poor tolerance. No significant differences in treatment response observed in the two genotypes, various fibrosis stages, or prior treatment history. Conclusion: These findings represent the first Lebanese data on HCV treatment using DAAs in hemodialysis patients. The study demonstrates an impressive SVR12 rate of 95%, with only 5% of patients experiencing treatment intolerance. These results in real-life settings show the potential for the eradication of HCV in hemodialysis centers.","PeriodicalId":204371,"journal":{"name":"International Journal of Gastroenterology Sciences","volume":"165 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140521400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.33545/26649209.2022.v4.i1a.10
Zyad Alali
{"title":"Upper limit of normal serum alanine transaminase ALT and correlation with gender and BMI","authors":"Zyad Alali","doi":"10.33545/26649209.2022.v4.i1a.10","DOIUrl":"https://doi.org/10.33545/26649209.2022.v4.i1a.10","url":null,"abstract":"","PeriodicalId":204371,"journal":{"name":"International Journal of Gastroenterology Sciences","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123319424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.33545/26649209.2021.v3.i1a.7
D. Monica
{"title":"Infectious diarrhea, as a current medical and public health problematic","authors":"D. Monica","doi":"10.33545/26649209.2021.v3.i1a.7","DOIUrl":"https://doi.org/10.33545/26649209.2021.v3.i1a.7","url":null,"abstract":"","PeriodicalId":204371,"journal":{"name":"International Journal of Gastroenterology Sciences","volume":"65 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114499358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.33545/26649209.2021.v3.i1a.8
Alkhatib Amani M D, Hallal Marwa B S, Awada Batoul M D, Danach Batoul M D, Hallal Mahmoud M D
{"title":"Prevalence of anti HBC antibodies in blood donors from different centers in Lebanon","authors":"Alkhatib Amani M D, Hallal Marwa B S, Awada Batoul M D, Danach Batoul M D, Hallal Mahmoud M D","doi":"10.33545/26649209.2021.v3.i1a.8","DOIUrl":"https://doi.org/10.33545/26649209.2021.v3.i1a.8","url":null,"abstract":"","PeriodicalId":204371,"journal":{"name":"International Journal of Gastroenterology Sciences","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115326254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-01-01DOI: 10.33545/26649209.2019.v1.i1a.4
Mirpouya Mirmozaffari
{"title":"Presenting an expert system for early diagnosis of gastrointestinal diseases","authors":"Mirpouya Mirmozaffari","doi":"10.33545/26649209.2019.v1.i1a.4","DOIUrl":"https://doi.org/10.33545/26649209.2019.v1.i1a.4","url":null,"abstract":"","PeriodicalId":204371,"journal":{"name":"International Journal of Gastroenterology Sciences","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129838267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-01-01DOI: 10.33545/26649209.2019.v1.i1a.11
Dr. Aniket Zarkar, B. Kalambe
{"title":"Post-cholecystectomy vascular and biliary injury resulting in hepatic artery pseudoaneurysm presenting with hemobilia and bile leak- a rare complication and surgical management ","authors":"Dr. Aniket Zarkar, B. Kalambe","doi":"10.33545/26649209.2019.v1.i1a.11","DOIUrl":"https://doi.org/10.33545/26649209.2019.v1.i1a.11","url":null,"abstract":"","PeriodicalId":204371,"journal":{"name":"International Journal of Gastroenterology Sciences","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115344373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-01-01DOI: 10.33545/26649209.2019.v1.i1a.3
Debbagh A, Slimani K, Sbitti Y, M. M, Tanz R, Errihani ., Ichou M
{"title":"Targeted therapy in gastric cancer: Review of literature","authors":"Debbagh A, Slimani K, Sbitti Y, M. M, Tanz R, Errihani ., Ichou M","doi":"10.33545/26649209.2019.v1.i1a.3","DOIUrl":"https://doi.org/10.33545/26649209.2019.v1.i1a.3","url":null,"abstract":"","PeriodicalId":204371,"journal":{"name":"International Journal of Gastroenterology Sciences","volume":"319 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126025512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-01-01DOI: 10.33545/26649209.2019.v1.i1a.2
Sanjita Das, Naveen Kumar
{"title":"Nipah virus: A Major threat to human","authors":"Sanjita Das, Naveen Kumar","doi":"10.33545/26649209.2019.v1.i1a.2","DOIUrl":"https://doi.org/10.33545/26649209.2019.v1.i1a.2","url":null,"abstract":"","PeriodicalId":204371,"journal":{"name":"International Journal of Gastroenterology Sciences","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128571773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-01-01DOI: 10.33545/26649209.2019.v1.i1a.6
Elena Santori, L. Pettine, P. Adamoli, G. Baratelli
{"title":"Henoch-Schouml;nlein purpura presenting as organic gastric outlet obstruction case report","authors":"Elena Santori, L. Pettine, P. Adamoli, G. Baratelli","doi":"10.33545/26649209.2019.v1.i1a.6","DOIUrl":"https://doi.org/10.33545/26649209.2019.v1.i1a.6","url":null,"abstract":"","PeriodicalId":204371,"journal":{"name":"International Journal of Gastroenterology Sciences","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125615948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-01-01DOI: 10.33545/26649209.2019.v1.i1a.5
Daminova Lt, Kodirov Sh S, Sheck Ab
{"title":"Varieties of gastrointestinal bleeding in patients with coronary heart disease","authors":"Daminova Lt, Kodirov Sh S, Sheck Ab","doi":"10.33545/26649209.2019.v1.i1a.5","DOIUrl":"https://doi.org/10.33545/26649209.2019.v1.i1a.5","url":null,"abstract":"","PeriodicalId":204371,"journal":{"name":"International Journal of Gastroenterology Sciences","volume":"SE-11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126576156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：