Pub Date : 2023-05-01DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a6253
Y. Wang, J. Liu, C. Leng, L. Afrose, T. Dao, R. Sakurai, O. Naveed, S. Umar, V. Rehan
{"title":"Small Molecule Readthrough Compound GJ103 Effectively Blocks the Development of Heritable Pulmonary Arterial Hypertension in a Mouse Model","authors":"Y. Wang, J. Liu, C. Leng, L. Afrose, T. Dao, R. Sakurai, O. Naveed, S. Umar, V. Rehan","doi":"10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a6253","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a6253","url":null,"abstract":"","PeriodicalId":206893,"journal":{"name":"D18. MOLECULAR TRAFFIC HUBS IN PULMONARY VASCULAR DISEASE","volume":"84 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122834044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-01DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a6257
S. Balachandar, T. O’Connell, M. Aldred
{"title":"Cybrid Analysis Delineates Nuclear and Mitochondrial Contributions to Oxidative Stress in Pulmonary Arterial Hypertension","authors":"S. Balachandar, T. O’Connell, M. Aldred","doi":"10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a6257","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a6257","url":null,"abstract":"","PeriodicalId":206893,"journal":{"name":"D18. MOLECULAR TRAFFIC HUBS IN PULMONARY VASCULAR DISEASE","volume":"50 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134381061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-01DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a6256
J.-R. Jheng, Y. Bai, K. Noda, J. Huot, T. Cook, G. Halliday, M. Simon, D. Forman, A. Bonetto, R. Machado, M. Gladwin, Y. Lai
{"title":"Skeletal Muscle SIRT3 Deficiency Remotely Regulates Pulmonary Vascular Remodeling Via LOXL2-CNPY2-p53 Axis in Pulmonary Hypertension in Heart Failure With Preserved Ejection Fraction","authors":"J.-R. Jheng, Y. Bai, K. Noda, J. Huot, T. Cook, G. Halliday, M. Simon, D. Forman, A. Bonetto, R. Machado, M. Gladwin, Y. Lai","doi":"10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a6256","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a6256","url":null,"abstract":"","PeriodicalId":206893,"journal":{"name":"D18. MOLECULAR TRAFFIC HUBS IN PULMONARY VASCULAR DISEASE","volume":"100 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114581841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-01DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a6250
Y. Kim, H. Kim, Y. Liu, T. Klouda, V. Schumacher, R. Thompson, J.C. Wu, J.B. Li, B. Raby, K. Yuan
{"title":"ADAR1 Mediated RNA Editing Contributes to Vascular Remodeling in PAH","authors":"Y. Kim, H. Kim, Y. Liu, T. Klouda, V. Schumacher, R. Thompson, J.C. Wu, J.B. Li, B. Raby, K. Yuan","doi":"10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a6250","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a6250","url":null,"abstract":"","PeriodicalId":206893,"journal":{"name":"D18. MOLECULAR TRAFFIC HUBS IN PULMONARY VASCULAR DISEASE","volume":"410 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134003999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-01DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a6252
R. El-Kabbout, A. Abi-Sleimen, S. Breuils-bonnet, A. Bourgeois, S. Martineau, O. Boucherat, S. Provencher, S. Bonnet, F. Potus
{"title":"Hypomethylating Drugs Improve Pulmonary Vascular Remodelling and Alleviate Pulmonary Hypertension Development in a Preclinical Model of the Disease","authors":"R. El-Kabbout, A. Abi-Sleimen, S. Breuils-bonnet, A. Bourgeois, S. Martineau, O. Boucherat, S. Provencher, S. Bonnet, F. Potus","doi":"10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a6252","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a6252","url":null,"abstract":"","PeriodicalId":206893,"journal":{"name":"D18. MOLECULAR TRAFFIC HUBS IN PULMONARY VASCULAR DISEASE","volume":"198 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124706832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-01DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a6255
J. James, M. Valuparampil Varghese, M. Niihori, N. McClain, O. Rafikova, R. Rafikov
{"title":"Targeting the Signaling Domain of Aminopeptidase N Ameliorates Pulmonary Hypertension","authors":"J. James, M. Valuparampil Varghese, M. Niihori, N. McClain, O. Rafikova, R. Rafikov","doi":"10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a6255","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a6255","url":null,"abstract":"","PeriodicalId":206893,"journal":{"name":"D18. MOLECULAR TRAFFIC HUBS IN PULMONARY VASCULAR DISEASE","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122034230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-01DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a6251
L. Jiang, D. Goncharov, Y. Shen, L. Teos, D. Lin, A. Saiyed, I. Zhyvylo, E. Goncharova, T. Kudryashova
{"title":"HIPK2/YAP/CEP55 Crosstalk Regulates Pulmonary Vascular Smooth Muscle Cell Proliferation, Survival and Pulmonary Hypertension","authors":"L. Jiang, D. Goncharov, Y. Shen, L. Teos, D. Lin, A. Saiyed, I. Zhyvylo, E. Goncharova, T. Kudryashova","doi":"10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a6251","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a6251","url":null,"abstract":"","PeriodicalId":206893,"journal":{"name":"D18. MOLECULAR TRAFFIC HUBS IN PULMONARY VASCULAR DISEASE","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123608679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-01DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a6249
Sarah-Eve Lemay, Y. Grobs, S. Martineau, Mohammad Saad Zaghloul Salem, T. Shimauchi, S. Breuils-bonnet, A. Bourgeois, F. Potus, S. Provencher, S. Bonnet, O. Boucherat
{"title":"Deoxyhypusine Synthase-mediated Hypusination of eIF5A Drives PASMC Proliferation and Vascular Remodeling in Pulmonary Arterial Hypertension","authors":"Sarah-Eve Lemay, Y. Grobs, S. Martineau, Mohammad Saad Zaghloul Salem, T. Shimauchi, S. Breuils-bonnet, A. Bourgeois, F. Potus, S. Provencher, S. Bonnet, O. Boucherat","doi":"10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a6249","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a6249","url":null,"abstract":"","PeriodicalId":206893,"journal":{"name":"D18. MOLECULAR TRAFFIC HUBS IN PULMONARY VASCULAR DISEASE","volume":"1151 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122944915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-01DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a6254
Y. Shi, J. Zagorski, A. Gupta, X. Sun, G. Gupta, R. Machado, JG Garcia, D. Li, H. Tang, A. A. Desai
{"title":"GALNT1-mediated O-GalNAc Glycosylation Is a Novel Mediator of Pulmonary Arterial Hypertension","authors":"Y. Shi, J. Zagorski, A. Gupta, X. Sun, G. Gupta, R. Machado, JG Garcia, D. Li, H. Tang, A. A. Desai","doi":"10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a6254","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a6254","url":null,"abstract":"","PeriodicalId":206893,"journal":{"name":"D18. MOLECULAR TRAFFIC HUBS IN PULMONARY VASCULAR DISEASE","volume":"39 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124279621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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