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The effects of hyperbaric treatment on perianal fistula activity in patients with Crohn's disease. 高压氧治疗对克罗恩病患者肛周瘘活动的影响。
IF 1.7 Q3 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2024-01-01 Epub Date: 2024-09-23 DOI: 10.5114/pg.2024.143439
Grażyna Piotrowicz, Jacek Kot, Andrzej Babicki, Piotr Banaszkiewicz, Adam Piotrowicz, Magdalena Rzeszutek, Agata Rudnik, Piotr Zientara, Joanna Adamska-Mieruszewska, Grażyna Rydzewska

Introduction: Crohn's disease is a chronic, complex inflammatory disorder of the gastrointestinal tract. Among its most challenging complications are perianal fistulas.

Aim: This study aims to explore the efficacy of hyperbaric oxygen therapy (HBOT) in reducing the activity of perianal fistulas in Crohn's disease patients.

Material and methods: This study enrolled patients diagnosed with Crohn's disease-associated perianal fistulas, with a disease duration of at least 3 years. Participants underwent HBOT in conjunction with standard medical therapy. The therapeutic effects were assessed at predetermined intervals using the Crohn's Disease Activity Index (CDAI), and laboratory parameters including faecal calprotectin levels, C-reactive protein (CRP) activity, serum iron concentration, and peripheral blood haemoglobin levels. Additionally, the Simple Endoscopic Score for Crohn's Disease (SESCD) and the Perianal Disease Activity Index (PDAI) were employed for evaluation.

Results: The adjunctive use of HBOT with conventional therapy yielded significant clinical improvements in patients with Crohn's disease complicated by perianal fistulas. This was shown by an 81.8% improvement in CDAI scores and a 54.5% clinical remission rate, as determined by SESCD and PDAI. Notably, the beneficial effects of HBOT on SESCD, PDAI, and faecal calprotectin levels were statistically significant and persisted for 6 weeks post-HBOT, with sustained improvements observed in a follow-up assessment approximately 9 months after treatment.

Conclusions: The findings of this study suggest that HBOT may be a viable therapeutic adjunct in the management of complex cases of Crohn's disease, particularly those with recurrent symptoms and limited responsiveness to conventional treatments. HBOT demonstrated potential in improving clinical outcomes and achieving remission rates exceeding 50%, indicating its promise as a treatment modality in this patient population.

克罗恩病是一种慢性、复杂的胃肠道炎症性疾病。其中最具挑战性的并发症是肛周瘘管。目的:探讨高压氧治疗(HBOT)对克罗恩病患者肛周瘘活动性的影响。材料和方法:本研究纳入诊断为克罗恩病相关肛周瘘的患者,病程至少为3年。参与者接受HBOT结合标准药物治疗。使用克罗恩病活动性指数(CDAI)和实验室参数(包括粪便钙保护蛋白水平、c反应蛋白(CRP)活性、血清铁浓度和外周血血红蛋白水平)在预定间隔内评估治疗效果。此外,采用简单内镜下克罗恩病评分(SESCD)和肛周疾病活动指数(PDAI)进行评估。结果:在常规治疗的基础上辅助应用HBOT对克罗恩病合并肛周瘘患者的临床疗效有显著改善。根据SESCD和PDAI的测定,CDAI评分改善了81.8%,临床缓解率为54.5%。值得注意的是,HBOT对SESCD、PDAI和粪便钙保护蛋白水平的有益影响具有统计学意义,并在HBOT后持续6周,在治疗后约9个月的随访评估中观察到持续改善。结论:本研究结果表明,HBOT可能是治疗复杂克罗恩病病例的一种可行的辅助治疗方法,特别是那些症状复发且对常规治疗反应有限的患者。HBOT在改善临床结果和达到超过50%的缓解率方面显示出潜力,表明它有望成为这类患者群体的一种治疗方式。
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引用次数: 0
The role of intestinal ultrasound with colour Doppler in predicting the response to biologic therapy in inflammatory bowel disease patients. 彩色多普勒肠超声在预测炎症性肠病患者对生物治疗反应中的作用。
IF 1.7 Q3 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2024-01-01 Epub Date: 2023-11-17 DOI: 10.5114/pg.2023.132932
Mohamed Ali El-Nady, Nour Eldeen El-Hefny, Hayam Fathy, Wageeh Ali, Ahmed Mohammed Ashmawy

Introduction: Inflammatory bowel disease patients are exposed to frequent procedures and hospital admissions as well as recurrent need for radiological examinations with a high risk of exposure to radiation and contrast.

Aim: Our objective was to evaluate the role of a combination of both intestinal ultrasound (IUS) and colour Doppler with different parameters for monitoring changes in inflammation over time and to reveal their potential role in the assessment of response to biologic therapy in inflammatory bowel disease (IBD) patients.

Material and methods: Before the induction of biological therapy, IUS together with colour Doppler of the intestine was conducted. Response to therapy was defined following the international guidelines.

Results: A total of 45 patients with histopathological diagnosis of IBD were enrolled in the study. All patients received biological therapy and were assessed for response after 3 months. Out of those patients, 34 (75.6%) had good response while 11 (24.4%) failed to respond to the treatment. Our findings point to a strong association between bowel wall thickening (BWT) and serum albumin, erythrocyte sedimentation rate (ESR), and c-reactive protein (CRP). The overall sensitivity of IUS varied from 54 to 93% when evaluating bowel affection, with a specificity of 97-100%, in comparison to our results, which showed a sensitivity of 64-74% and specificity of 79-82%. Doppler parameters could predict the response to the biologic therapy in IBD patients.

Conclusions: Intestinal ultrasound and colour Doppler provide a safe, non-invasive way to monitor changes in inflammation and blood flow in the digestive tract.

简介:炎症性肠病患者暴露于频繁的手术和住院,以及反复需要放射检查,暴露于辐射和造影剂的高风险。目的:我们的目的是评估不同参数的肠道超声(IUS)和彩色多普勒联合监测炎症随时间变化的作用,并揭示它们在评估炎症性肠病(IBD)患者对生物治疗的反应中的潜在作用。材料与方法:诱导生物治疗前,行IUS联合小肠彩色多普勒检查。对治疗的反应是按照国际准则定义的。结果:共纳入45例经组织病理学诊断为IBD的患者。所有患者均接受生物治疗,3个月后评估疗效。其中,34例(75.6%)患者反应良好,11例(24.4%)患者治疗无效。我们的研究结果表明,肠壁增厚(BWT)与血清白蛋白、红细胞沉降率(ESR)和c反应蛋白(CRP)有很强的相关性。在评估肠道影响时,IUS的总体敏感性为54 - 93%,特异性为97-100%,而我们的结果显示敏感性为64-74%,特异性为79-82%。多普勒参数可以预测IBD患者对生物治疗的反应。结论:肠道超声和彩色多普勒为监测消化道炎症和血流变化提供了一种安全、无创的方法。
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引用次数: 0
Prevention of obesity and carbohydrate metabolism disorders in the population at an industrial facility. 预防工业设施人群的肥胖症和碳水化合物代谢紊乱。
IF 1.3 Q3 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2024-01-01 Epub Date: 2024-03-14 DOI: 10.5114/pg.2024.136246
Maxim Tszyan

Introduction: One of the urgent tasks of modern healthcare is the development of measures aimed at preventing obesity in the able-bodied population, including in the Republic of Kazakhstan, which would reduce economic losses and increase the coefficient of life expectancy in the population.

Aim: To identify measures for the early prevention of excess weight, obesity, and carbohydrate metabolism disorders in the able-bodied population at an industrial facility in Kazakhstan.

Material and methods: The study involved 662 people (574 men and 88 women) aged 19 to 64 years. The subjects were divided into 2 groups: the main group - persons with obesity (242 people) and the control group - relatively healthy persons (422 people). The diagnosis of obesity was made based on the medical history of a patient, external examination, and physical, laboratory, and instrumental assessment.

Results: Three main factors influencing the development of obesity have been identified: a significant level of inactivity; serum glucose; the presence of comorbidities. Other factors (gender and age, smoking) do not have a significant effect on the increase in the body mass index of persons working at an industrial facility.

Conclusions: Accordingly, a priority in the prevention of obesity is a healthy lifestyle, involving regular physical activity and a healthy balanced diet.

导言:现代医疗保健的紧迫任务之一是制定旨在预防包括哈萨克斯坦共和国在内的健全人口肥胖症的措施,这将减少经济损失并提高人口预期寿命系数。目的:确定哈萨克斯坦工业设施中健全人口早期预防超重、肥胖和碳水化合物代谢紊乱的措施:研究涉及 662 人(574 名男性和 88 名女性),年龄在 19 至 64 岁之间。研究对象分为两组:主要组--肥胖症患者(242 人)和对照组--相对健康的人(422 人)。肥胖症的诊断是根据患者的病史、外部检查以及身体、实验室和仪器评估做出的:结果:已确定影响肥胖发生的三个主要因素:明显的缺乏活动;血清葡萄糖;合并症的存在。其他因素(性别和年龄、吸烟)对在工业设施工作的人员体重指数的增加没有明显影响:因此,预防肥胖的首要任务是养成健康的生活方式,包括定期进行体育锻炼和健康均衡的饮食。
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引用次数: 0
Recurrent tetany in a male patient with short bowel syndrome and Crohn's disease. 一名患有短肠综合征和克罗恩病的男性患者反复四肢抽搐。
IF 1.3 Q3 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2024-01-01 Epub Date: 2023-11-27 DOI: 10.5114/pg.2023.133222
Paweł Kurzelowski, Maciej Pluskiewicz, Aleksandra Pilśniak, Agnieszka Jarosińska, Michał Holecki
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引用次数: 0
Direct peroral cholangioscopy combined with argon plasma and radio-frequency ablation in restoring the patency of a self-expandable metal stent. 直接经口胆道镜联合氩等离子体和射频消融修复自膨胀金属支架的通畅。
IF 1.7 Q3 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2024-01-01 Epub Date: 2024-09-23 DOI: 10.5114/pg.2024.143165
Tomasz Klimczak, Jacek Śmigielski
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引用次数: 0
Resistance to death pathway induction as a potential targeted therapy in CRISPR/Cas-9 knock-out colorectal cancer cell lines. 在 CRISPR/Cas-9 基因敲除的结直肠癌细胞系中,死亡通路诱导作为一种潜在的靶向疗法具有抗药性。
IF 1.7 Q3 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2024-01-01 Epub Date: 2024-02-05 DOI: 10.5114/pg.2024.134872
Malgorzata Adamiec-Organisciok, Magdalena Wegrzyn, Lukasz Cienciala, Ngoni Magate, Magdalena Skonieczna, Joanna Nackiewicz

Regulated cell death is a fundamental biological process that plays a crucial role in maintaining tissue homeostasis and eliminating damaged or unnecessary cells. Ferroptosis is an iron-dependent process, characterized by the accumulation of oxidized and damaged lipids, which leads to programmed cell death. Among the ferroptotic pathway genes regulating this process, GPX4, TFRC, ACSL4, FSP1, SLC7A11, and PROM2 could be considered. There are many well-known ferroptotic pathway regulators, which are discussed in this compact review. Cells with tissues of different origin display sensitive or resistant phenotypes to such regulators. In some cases, unexpected changes during cell treatment occurred, suggesting the possibility of regulating the death pathway. We assumed that possible changing of ferro-sensitivity to ferro-resistance in cells, especially in colorectal cancer cell lines, is responded for induced chemoresistance. Using novel techniques, such as CRISPR/Cas-9 genome editing, an induced phenotype "switching" is possible.

调节细胞死亡是一个基本的生物过程,在维持组织平衡和清除受损或不必要的细胞方面发挥着至关重要的作用。铁变态反应是一个依赖铁的过程,其特点是氧化和受损脂质的积累,从而导致细胞的程序性死亡。在调控这一过程的铁氧化途径基因中,GPX4、TFRC、ACSL4、FSP1、SLC7A11 和 PROM2 可被考虑在内。本综述将讨论许多众所周知的铁氧化途径调控因子。不同来源组织的细胞对这些调节因子表现出敏感或抵抗的表型。在某些情况下,细胞处理过程中出现了意想不到的变化,这表明死亡途径可能受到调控。我们认为,细胞(尤其是结直肠癌细胞株)对铁的敏感性可能转变为对铁的耐受性,这是诱导化疗耐药性的原因。利用 CRISPR/Cas-9 基因组编辑等新技术,诱导表型 "转换 "是可能的。
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引用次数: 0
Impact of cefixime and probiotics on functional abdominal bloating: a pilot study. 头孢克肟和益生菌对功能性腹胀的影响:一项初步研究。
IF 1.7 Q3 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2024-01-01 Epub Date: 2024-12-02 DOI: 10.5114/pg.2024.142141
Rasha I Salama, Salwa Tawfik, Mohamed H Emara, Abeer H Abdelkader

Introduction: Abdominal bloating is a prevalent condition that affects up to 30% of the population.

Aim: Investigate the impact of cefixime and probiotics on the bloating sensation among patients with functional abdominal bloating (FAB).

Material and methods: Out of 763 patients with bloating, 122 patients were diagnosed with FAB. Group I (n = 40) were treated with a combination of non-activated herbal charcoal and silicone dioxide with dimethylpolysiloxane (conventional treatment group); group II (n = 41) were treated by the same lines as in group I with the addition of cefixime 400 mg once daily for 6 days; and group III (n = 41) were treated by the same lines given to group I with the addition of a probiotic formulation harbouring the probiotic strain Lactobacillus helveticus candisis for 2 weeks. All patients were evaluated by history taking, clinical examination, laboratory assessment, relevant imaging, and symptom questionnaire before and by the end of treatment.

Results: The prevalence of FAB was 15.9% (122/763). The majority were females (58.1%). Patients treated with probiotics and cefixime reported significant improvement in the sense of bloating and the visible abdominal distension in comparison to conventional treatment (p = 0.008 and < 0.001, respectively). Abdominal pain, belching, bowel habit change, and nausea improved and were comparable among the 3 groups by the end of treatment. No adverse events related to the used medications were observed.

Conclusions: Cefixime and probiotics exert significant improvement in the subjective sensation of bloating and objective abdominal distension among patients with FAB in comparison to conventional anti-flatulence therapy.

简介目的:研究头孢克肟和益生菌对功能性腹胀(FAB)患者腹胀感觉的影响:在763名腹胀患者中,122名患者被诊断为功能性腹胀。第一组(n = 40)采用非活性草炭和二氧化硅与二甲基聚硅氧烷的组合疗法(常规治疗组);第二组(n = 41)采用与第一组相同的疗法,同时添加头孢克肟 400 毫克,每日一次,连续 6 天;第三组(n = 41)采用与第一组相同的疗法,同时添加含有益生菌株 helveticus Lactobacillus candis 的益生菌配方,连续 2 周。所有患者在治疗前和治疗结束后都接受了病史采集、临床检查、实验室评估、相关影像学检查和症状问卷调查:结果:FAB的发病率为15.9%(122/763)。大多数患者为女性(58.1%)。与常规治疗相比,使用益生菌和头孢克肟治疗的患者腹胀感和明显腹胀症状均有明显改善(p = 0.008 和 < 0.001)。治疗结束时,腹痛、嗳气、排便习惯改变和恶心症状均有所改善,三组患者的改善程度相当。没有观察到与所用药物相关的不良反应:结论:与传统的消胀疗法相比,头孢克肟和益生菌能显著改善 FAB 患者的主观腹胀感和客观腹胀感。
{"title":"Impact of cefixime and probiotics on functional abdominal bloating: a pilot study.","authors":"Rasha I Salama, Salwa Tawfik, Mohamed H Emara, Abeer H Abdelkader","doi":"10.5114/pg.2024.142141","DOIUrl":"10.5114/pg.2024.142141","url":null,"abstract":"<p><strong>Introduction: </strong>Abdominal bloating is a prevalent condition that affects up to 30% of the population.</p><p><strong>Aim: </strong>Investigate the impact of cefixime and probiotics on the bloating sensation among patients with functional abdominal bloating (FAB).</p><p><strong>Material and methods: </strong>Out of 763 patients with bloating, 122 patients were diagnosed with FAB. Group I (<i>n</i> = 40) were treated with a combination of non-activated herbal charcoal and silicone dioxide with dimethylpolysiloxane (conventional treatment group); group II (<i>n</i> = 41) were treated by the same lines as in group I with the addition of cefixime 400 mg once daily for 6 days; and group III (<i>n</i> = 41) were treated by the same lines given to group I with the addition of a probiotic formulation harbouring the probiotic strain <i>Lactobacillus helveticus candisis</i> for 2 weeks. All patients were evaluated by history taking, clinical examination, laboratory assessment, relevant imaging, and symptom questionnaire before and by the end of treatment.</p><p><strong>Results: </strong>The prevalence of FAB was 15.9% (122/763). The majority were females (58.1%). Patients treated with probiotics and cefixime reported significant improvement in the sense of bloating and the visible abdominal distension in comparison to conventional treatment (<i>p</i> = 0.008 and < 0.001, respectively). Abdominal pain, belching, bowel habit change, and nausea improved and were comparable among the 3 groups by the end of treatment. No adverse events related to the used medications were observed.</p><p><strong>Conclusions: </strong>Cefixime and probiotics exert significant improvement in the subjective sensation of bloating and objective abdominal distension among patients with FAB in comparison to conventional anti-flatulence therapy.</p>","PeriodicalId":20719,"journal":{"name":"Przegla̜d Gastroenterologiczny","volume":"16 4","pages":"408-415"},"PeriodicalIF":1.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11726219/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142984590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Identification of ASF1B as a prognostic marker for liver cancer by meta-analysis and its immune value revealed by a comprehensive pan-cancer analysis of 33 human cancersrevealed by a comprehensive pan-cancer analysis of 33 human cancers 通过荟萃分析鉴定ASF1B作为肝癌预后标志物,并通过对33例人类癌症的综合泛癌分析揭示其免疫价值
IF 1.3 Q3 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2023-01-23 DOI: 10.5114/pg.2023.124423
Yiyang Chen, Wanbang Zhou, Yiju Gong, Xi Ou
Introduction As one of the most common malignant tumours, liver cancer is difficult to detect in the early stage, with strong metastasis and poor prognosis. Anti-silencing function protein 1 was originally discovered in yeast as a histone H3-H4 chaperone, and studies have shown that ASF1B may be a target for inhibiting the growth of hepatocellular carcinoma cells. Aim To evaluate the diagnostic and prognostic significance of ASF1B expression in human LIHC on the basis of TCGA data. Material and methods A meta-analysis revealed that high ASF1B expression was strongly associated with better overall survival. A comprehensive pan-cancer analysis of 33 human cancers revealed the immunotherapeutic value of ASF1B. Results In this study, we observed a significant upregulation of ASF1B expression in LIHC samples compared to non-cancer samples. Clinical analysis showed that high expression of ASF1B was associated with age, tumour status, and clinical stage. Survival analysis showed that patients with high ASF1B expression had worse overall survival and progression-free survival than patients with low ASF1B expression. The AUCs of the 1-year, 3-year, and 5-year survival-related ROC curves were 0.672, 0.590, and 0.591, respectively. Conclusions Our study shows that ASF1B may provide new ideas for the diagnosis and prognosis of liver cancer patients, as well as providing a new direction for the application of ASF1B in tumour immunotherapy.
{"title":"Identification of ASF1B as a prognostic marker for liver cancer by meta-analysis and its immune value revealed by a comprehensive pan-cancer analysis of 33 human cancersrevealed by a comprehensive pan-cancer analysis of 33 human cancers","authors":"Yiyang Chen, Wanbang Zhou, Yiju Gong, Xi Ou","doi":"10.5114/pg.2023.124423","DOIUrl":"https://doi.org/10.5114/pg.2023.124423","url":null,"abstract":"Introduction As one of the most common malignant tumours, liver cancer is difficult to detect in the early stage, with strong metastasis and poor prognosis. Anti-silencing function protein 1 was originally discovered in yeast as a histone H3-H4 chaperone, and studies have shown that ASF1B may be a target for inhibiting the growth of hepatocellular carcinoma cells. Aim To evaluate the diagnostic and prognostic significance of ASF1B expression in human LIHC on the basis of TCGA data. Material and methods A meta-analysis revealed that high ASF1B expression was strongly associated with better overall survival. A comprehensive pan-cancer analysis of 33 human cancers revealed the immunotherapeutic value of ASF1B. Results In this study, we observed a significant upregulation of ASF1B expression in LIHC samples compared to non-cancer samples. Clinical analysis showed that high expression of ASF1B was associated with age, tumour status, and clinical stage. Survival analysis showed that patients with high ASF1B expression had worse overall survival and progression-free survival than patients with low ASF1B expression. The AUCs of the 1-year, 3-year, and 5-year survival-related ROC curves were 0.672, 0.590, and 0.591, respectively. Conclusions Our study shows that ASF1B may provide new ideas for the diagnosis and prognosis of liver cancer patients, as well as providing a new direction for the application of ASF1B in tumour immunotherapy.","PeriodicalId":20719,"journal":{"name":"Przegla̜d Gastroenterologiczny","volume":"6 1","pages":"249 - 265"},"PeriodicalIF":1.3,"publicationDate":"2023-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70475058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Characteristics of the endoscopic procedures performed in a hybrid tertiary-level hospital during the first year of the COVID-19 pandemic. COVID-19大流行第一年在三级混合医院进行的内窥镜手术的特点
IF 1.3 Q3 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2023-01-01 DOI: 10.5114/pg.2022.118136
Héctor Adrián Díaz Hernández, José Elihú Cuevas Castillejos, Godolfino Miranda Zazueta, Adriana Fabiola Romano Munive, Francisco Valdovinos Andraca

Introduction: The COVID-19 pandemic caused many changes in gastrointestinal endoscopy units.

Aim: To describe the changes that occurred in a gastrointestinal endoscopy unit of a hybrid hospital during the COVID-19 pandemic.

Material and methods: We performed a retrospective study of endoscopies performed in the first year of the COVID-19 pandemic. We collected and described the data of interest to the study, which is presented with numbers and percentages or measures of central tendency and dispersion as appropriate. Fisher's exact test or the χ2 test were used as appropriate.

Results: A total of 507 procedures were performed. There was a 92.5% reduction in the performance of endoscopic procedures. In all, 77 (15%) procedures were performed on patients with COVID-19. The most frequent procedures were esophagogastroduodenoscopy (EGD), colonoscopy, and endoscopic retrograde cholangiopancreatography (ERCP). The main indications were gastrointestinal bleeding, placement of enteral accesses, and alterations in the biliary and pancreatic ducts. Of these, 37 (48%) were therapeutic. Patients with COVID-19 were more susceptible to the development of complications.

Conclusions: During the first year of the COVID-19 pandemic, the number of endoscopic procedures performed decreased significantly. The procedures most often required were EGD, colonoscopy, and ERCP, mainly indicated by gastrointestinal bleeding, placement of enteral accesses, and alterations of the bile and pancreatic ducts.

新冠肺炎大流行导致胃肠道内窥镜检查单位发生了许多变化。目的:描述2019冠状病毒病大流行期间混合医院胃肠内窥镜病房发生的变化。材料和方法:我们对COVID-19大流行第一年进行的内窥镜检查进行了回顾性研究。我们收集并描述了对研究感兴趣的数据,这些数据以适当的数字和百分比或集中趋势和分散的度量来呈现。适当使用Fisher精确检验或χ2检验。结果:共手术507例。内窥镜手术的效果降低了92.5%。总共有77例(15%)对COVID-19患者进行了手术。最常见的手术是食管胃十二指肠镜检查(EGD)、结肠镜检查和内窥镜逆行胆管造影(ERCP)。主要适应症为消化道出血,肠内通路的放置,胆管和胰管的改变。其中37例(48%)是治疗性的。COVID-19患者更容易出现并发症。结论:在2019冠状病毒病大流行的第一年,内窥镜手术的数量显著减少。最常需要的程序是EGD,结肠镜检查和ERCP,主要指胃肠道出血,肠内通路的放置,以及胆管和胰管的改变。
{"title":"Characteristics of the endoscopic procedures performed in a hybrid tertiary-level hospital during the first year of the COVID-19 pandemic.","authors":"Héctor Adrián Díaz Hernández,&nbsp;José Elihú Cuevas Castillejos,&nbsp;Godolfino Miranda Zazueta,&nbsp;Adriana Fabiola Romano Munive,&nbsp;Francisco Valdovinos Andraca","doi":"10.5114/pg.2022.118136","DOIUrl":"https://doi.org/10.5114/pg.2022.118136","url":null,"abstract":"<p><strong>Introduction: </strong>The COVID-19 pandemic caused many changes in gastrointestinal endoscopy units.</p><p><strong>Aim: </strong>To describe the changes that occurred in a gastrointestinal endoscopy unit of a hybrid hospital during the COVID-19 pandemic.</p><p><strong>Material and methods: </strong>We performed a retrospective study of endoscopies performed in the first year of the COVID-19 pandemic. We collected and described the data of interest to the study, which is presented with numbers and percentages or measures of central tendency and dispersion as appropriate. Fisher's exact test or the χ<sup>2</sup> test were used as appropriate.</p><p><strong>Results: </strong>A total of 507 procedures were performed. There was a 92.5% reduction in the performance of endoscopic procedures. In all, 77 (15%) procedures were performed on patients with COVID-19. The most frequent procedures were esophagogastroduodenoscopy (EGD), colonoscopy, and endoscopic retrograde cholangiopancreatography (ERCP). The main indications were gastrointestinal bleeding, placement of enteral accesses, and alterations in the biliary and pancreatic ducts. Of these, 37 (48%) were therapeutic. Patients with COVID-19 were more susceptible to the development of complications.</p><p><strong>Conclusions: </strong>During the first year of the COVID-19 pandemic, the number of endoscopic procedures performed decreased significantly. The procedures most often required were EGD, colonoscopy, and ERCP, mainly indicated by gastrointestinal bleeding, placement of enteral accesses, and alterations of the bile and pancreatic ducts.</p>","PeriodicalId":20719,"journal":{"name":"Przegla̜d Gastroenterologiczny","volume":"18 2","pages":"198-203"},"PeriodicalIF":1.3,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/dd/09/PG-18-47490.PMC10395057.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9935790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The role of deep learning in diagnosing colorectal cancer. 深度学习在癌症诊断中的作用。
IF 1.3 Q3 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2023-01-01 Epub Date: 2023-07-17 DOI: 10.5114/pg.2023.129494
Dimitrios Bousis, Georgios-Ioannis Verras, Konstantinos Bouchagier, Andreas Antzoulas, Ioannis Panagiotopoulos, Anastasia Katinioti, Dimitrios Kehagias, Charalampos Kaplanis, Konstantinos Kotis, Christos-Nikolaos Anagnostopoulos, Francesk Mulita

Colon cancer is a major public health issue, affecting a growing number of individuals worldwide. Proper and early diagnosis of colon cancer is the necessary first step toward effective treatment and/or prevention of future disease relapse. Artificial intelligence and its subtypes, deep learning in particular, tend nowadays to have an expanding role in all fields of medicine, and diagnosing colon cancer is no exception. This report aims to summarize the entire application spectrum of deep learning in all diagnostic tests regarding colon cancer, from endoscopy and histologic examination to medical imaging and screening serologic tests.

癌症是一个重大的公共卫生问题,影响着全世界越来越多的人。正确和早期诊断结肠癌是有效治疗和/或预防未来疾病复发的必要第一步。人工智能及其亚型,尤其是深度学习,如今在医学的各个领域都发挥着越来越大的作用,诊断结肠癌癌症也不例外。本报告旨在总结深度学习在癌症所有诊断测试中的整个应用范围,从内窥镜检查和组织学检查到医学成像和血清学筛查。
{"title":"The role of deep learning in diagnosing colorectal cancer.","authors":"Dimitrios Bousis, Georgios-Ioannis Verras, Konstantinos Bouchagier, Andreas Antzoulas, Ioannis Panagiotopoulos, Anastasia Katinioti, Dimitrios Kehagias, Charalampos Kaplanis, Konstantinos Kotis, Christos-Nikolaos Anagnostopoulos, Francesk Mulita","doi":"10.5114/pg.2023.129494","DOIUrl":"10.5114/pg.2023.129494","url":null,"abstract":"<p><p>Colon cancer is a major public health issue, affecting a growing number of individuals worldwide. Proper and early diagnosis of colon cancer is the necessary first step toward effective treatment and/or prevention of future disease relapse. Artificial intelligence and its subtypes, deep learning in particular, tend nowadays to have an expanding role in all fields of medicine, and diagnosing colon cancer is no exception. This report aims to summarize the entire application spectrum of deep learning in all diagnostic tests regarding colon cancer, from endoscopy and histologic examination to medical imaging and screening serologic tests.</p>","PeriodicalId":20719,"journal":{"name":"Przegla̜d Gastroenterologiczny","volume":"1 1","pages":"266-273"},"PeriodicalIF":1.3,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10626379/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70475065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
期刊
Przegla̜d Gastroenterologiczny
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