Pub Date : 1993-01-01DOI: 10.1007/978-3-642-78010-3_2
A D Strosberg
{"title":"Structure-function analysis of the three beta-adrenergic catecholamine receptors.","authors":"A D Strosberg","doi":"10.1007/978-3-642-78010-3_2","DOIUrl":"https://doi.org/10.1007/978-3-642-78010-3_2","url":null,"abstract":"","PeriodicalId":20892,"journal":{"name":"Psychopharmacology series","volume":"10 ","pages":"9-14"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19381447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1993-01-01DOI: 10.1007/978-3-642-78451-4_10
M W Emmett-Oglesby, D A Lytle, S A English
{"title":"Abecarnil used to treat benzodiazepine withdrawal.","authors":"M W Emmett-Oglesby, D A Lytle, S A English","doi":"10.1007/978-3-642-78451-4_10","DOIUrl":"https://doi.org/10.1007/978-3-642-78451-4_10","url":null,"abstract":"","PeriodicalId":20892,"journal":{"name":"Psychopharmacology series","volume":"11 ","pages":"121-31"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18905234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1993-01-01DOI: 10.1007/978-3-642-78451-4_7
D N Stephens, L Turski, G H Jones, K G Steppuhn, H H Schneider
{"title":"Abecarnil: a novel anxiolytic with mixed full agonist/partial agonist properties in animal models of anxiety and sedation.","authors":"D N Stephens, L Turski, G H Jones, K G Steppuhn, H H Schneider","doi":"10.1007/978-3-642-78451-4_7","DOIUrl":"https://doi.org/10.1007/978-3-642-78451-4_7","url":null,"abstract":"","PeriodicalId":20892,"journal":{"name":"Psychopharmacology series","volume":"11 ","pages":"79-95"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18905238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1993-01-01DOI: 10.1007/978-3-642-78010-3_18
P Vestergaard, L F Gram, P Kragh-Sørensen, P Bech, N Reisby, T G Bolwig
The DUAG studies showed that in well-designed and rigorously executed multisite drug trials three representatives (citalopram, paroxetine, and moclobemide) from two classes of recent antidepressant drugs were less effective than the standard reference drug, clomipramine. The most important reasons for the superiority of clomipramine was probably that clomipramine was given in a high and fixed dose of 150 mg per day throughout the entire treatment period and that patient compliance was ensured through drug monitoring. When the DUAG studies are compared with "no difference" studies, the difference between DUAG and others lies not so much in a different efficacy of the test drugs but in the efficacy of the reference drugs, where clomipramine in the DUAG studies was more effective than reference tricyclics in most other studies with flexible dose regimens. A relatively high rate of adverse drug reactions with clomipramine administered in high and fixed doses was probably due to a considerable interindividual variability in the pharmacokinetic properties. (Gram 1990), and the development of side effects may be predicted and prevented when better knowledge of plasma concentration and dose-response relations for classical tricyclic antidepressants allow individual dose adjustments. Such studies are under way with in the DUAG. The results of such studies may reduce the need for new antidepressants which, although less toxic than the classical tricyclics, may prove to be also less potent. The DUAG studies were performed in hospitalized, moderately to severely, endogeneously depressed adult patients and conclusions from the DUAG studies about the superiority of clomipramine over three recent antidepressants cannot readily be generalized to cover less homogeneous groups of outpatients with milder depression.(ABSTRACT TRUNCATED AT 250 WORDS)
{"title":"Therapeutic potentials of recently introduced antidepressants. Danish University Antidepressant Group.","authors":"P Vestergaard, L F Gram, P Kragh-Sørensen, P Bech, N Reisby, T G Bolwig","doi":"10.1007/978-3-642-78010-3_18","DOIUrl":"https://doi.org/10.1007/978-3-642-78010-3_18","url":null,"abstract":"<p><p>The DUAG studies showed that in well-designed and rigorously executed multisite drug trials three representatives (citalopram, paroxetine, and moclobemide) from two classes of recent antidepressant drugs were less effective than the standard reference drug, clomipramine. The most important reasons for the superiority of clomipramine was probably that clomipramine was given in a high and fixed dose of 150 mg per day throughout the entire treatment period and that patient compliance was ensured through drug monitoring. When the DUAG studies are compared with \"no difference\" studies, the difference between DUAG and others lies not so much in a different efficacy of the test drugs but in the efficacy of the reference drugs, where clomipramine in the DUAG studies was more effective than reference tricyclics in most other studies with flexible dose regimens. A relatively high rate of adverse drug reactions with clomipramine administered in high and fixed doses was probably due to a considerable interindividual variability in the pharmacokinetic properties. (Gram 1990), and the development of side effects may be predicted and prevented when better knowledge of plasma concentration and dose-response relations for classical tricyclic antidepressants allow individual dose adjustments. Such studies are under way with in the DUAG. The results of such studies may reduce the need for new antidepressants which, although less toxic than the classical tricyclics, may prove to be also less potent. The DUAG studies were performed in hospitalized, moderately to severely, endogeneously depressed adult patients and conclusions from the DUAG studies about the superiority of clomipramine over three recent antidepressants cannot readily be generalized to cover less homogeneous groups of outpatients with milder depression.(ABSTRACT TRUNCATED AT 250 WORDS)</p>","PeriodicalId":20892,"journal":{"name":"Psychopharmacology series","volume":"10 ","pages":"190-8"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19347991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1993-01-01DOI: 10.1007/978-3-642-78010-3_19
K Brøsen, S H Sindrup, E Skjelbo, K K Nielsen, L F Gram
{"title":"Role of genetic polymorphism in psychopharmacology--an update.","authors":"K Brøsen, S H Sindrup, E Skjelbo, K K Nielsen, L F Gram","doi":"10.1007/978-3-642-78010-3_19","DOIUrl":"https://doi.org/10.1007/978-3-642-78010-3_19","url":null,"abstract":"","PeriodicalId":20892,"journal":{"name":"Psychopharmacology series","volume":"10 ","pages":"199-211"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19347992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"6th International Meeting on Clinical Pharmacology in Psychiatry. Proceedings. Geneva, Switzerland, 5-7 June 1991.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":20892,"journal":{"name":"Psychopharmacology series","volume":"10 ","pages":"1-268"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19095370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1993-01-01DOI: 10.1007/978-3-642-78010-3_1
S G Dahl, O Edvardsen, I Sylte
{"title":"Molecular modeling of neurotransmitter receptors and ligands.","authors":"S G Dahl, O Edvardsen, I Sylte","doi":"10.1007/978-3-642-78010-3_1","DOIUrl":"https://doi.org/10.1007/978-3-642-78010-3_1","url":null,"abstract":"","PeriodicalId":20892,"journal":{"name":"Psychopharmacology series","volume":"10 ","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19381446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1993-01-01DOI: 10.1007/978-3-642-78451-4_8
W Löscher
{"title":"Abecarnil shows reduced tolerance development and dependence potential in comparison to diazepam: animal studies.","authors":"W Löscher","doi":"10.1007/978-3-642-78451-4_8","DOIUrl":"https://doi.org/10.1007/978-3-642-78451-4_8","url":null,"abstract":"","PeriodicalId":20892,"journal":{"name":"Psychopharmacology series","volume":"11 ","pages":"96-112"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18905239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1993-01-01DOI: 10.1007/978-3-642-78010-3_24
J M Davis, Z Wang
{"title":"Power analysis for correlation of plasma level and clinical data.","authors":"J M Davis, Z Wang","doi":"10.1007/978-3-642-78010-3_24","DOIUrl":"https://doi.org/10.1007/978-3-642-78010-3_24","url":null,"abstract":"","PeriodicalId":20892,"journal":{"name":"Psychopharmacology series","volume":"10 ","pages":"253-64"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19095377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
扫码关注我们
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号