{"title":"Clinical trials in epilepsy: the SANAD study.","authors":"Deana M Gazzola, Jacqueline A French","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":21171,"journal":{"name":"Reviews in neurological diseases","volume":"5 1","pages":"36-7"},"PeriodicalIF":0.0,"publicationDate":"2008-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27388700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Epilepsy.","authors":"Deana M Gazzola, Ruben I Kuzniecky","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":21171,"journal":{"name":"Reviews in neurological diseases","volume":"5 1","pages":"34-6"},"PeriodicalIF":0.0,"publicationDate":"2008-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27388699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Physicians now take for granted that infarction is explained by lack of blood supply and nutrition caused by obstruction of arteries that supply regions of ischemia. Introduction.","authors":"Louis R Caplan","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":21171,"journal":{"name":"Reviews in neurological diseases","volume":"5 Suppl 1 ","pages":"S1-3"},"PeriodicalIF":0.0,"publicationDate":"2008-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27550652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The goal of evidence-based medicine in the treatment of conditions that produce morbidity but have a minimal impact on mortality is arguably to reduce disease impact on patients' lives and to assure that interventions result in more good than harm. Achieving these goals can be demonstrated only with patient input. There is clear evidence that multiple sclerosis has a significant negative impact on health-related quality of life (HRQL). The purpose of incorporating routine HRQL data in clinical practice is to provide a comprehensive assessment of the patient's health status from that person's perspective. This article discusses the types of HRQL measures available for patient assessment and how those data can be routinely collected.
{"title":"Health-related quality of life assessment in multiple sclerosis.","authors":"Deborah M Miller, R Philip Kinkel","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The goal of evidence-based medicine in the treatment of conditions that produce morbidity but have a minimal impact on mortality is arguably to reduce disease impact on patients' lives and to assure that interventions result in more good than harm. Achieving these goals can be demonstrated only with patient input. There is clear evidence that multiple sclerosis has a significant negative impact on health-related quality of life (HRQL). The purpose of incorporating routine HRQL data in clinical practice is to provide a comprehensive assessment of the patient's health status from that person's perspective. This article discusses the types of HRQL measures available for patient assessment and how those data can be routinely collected.</p>","PeriodicalId":21171,"journal":{"name":"Reviews in neurological diseases","volume":"5 2","pages":"56-64"},"PeriodicalIF":0.0,"publicationDate":"2008-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27561681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Donna L Hill, Neil R Miller, Nancy J Newman, Valérie Biousse
These 2 cases presented with acutely raised intracranial pressure and had characteristic CT and MRI changes.
这2例患者表现为急性颅内压升高，并有特征性的CT和MRI改变。
{"title":"A patient with headache and increased intracranial pressure.","authors":"Donna L Hill, Neil R Miller, Nancy J Newman, Valérie Biousse","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>These 2 cases presented with acutely raised intracranial pressure and had characteristic CT and MRI changes.</p>","PeriodicalId":21171,"journal":{"name":"Reviews in neurological diseases","volume":"5 2","pages":"90-1"},"PeriodicalIF":0.0,"publicationDate":"2008-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27561686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Laura Rueff, Jerome J Graber, Melissa Bernbaum, Ruben I Kuzniecky
Immune-related neurologic disorders have long been recognized. A number of specific targets have been identified, including neurons, Purkinje cells, and pre- and postsynaptic receptors. Over the past decade, antibodies against voltage-gated potassium channels (VGKCs) have been reported in a number of neurologic syndromes, such as neuromyotonia, limbic encephalitis, and Morvan's syndrome. Recent advances have supported the pathologic mechanism of VGKC in these disorders, their response to therapy, and the possible mechanisms of peripheral, central, and autonomic dysfunctions seen in these disorders. We present a patient with 1 of these syndromes and review the literature of these disorders.
{"title":"Voltage-gated potassium channel antibody-mediated syndromes: a spectrum of clinical manifestations.","authors":"Laura Rueff, Jerome J Graber, Melissa Bernbaum, Ruben I Kuzniecky","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Immune-related neurologic disorders have long been recognized. A number of specific targets have been identified, including neurons, Purkinje cells, and pre- and postsynaptic receptors. Over the past decade, antibodies against voltage-gated potassium channels (VGKCs) have been reported in a number of neurologic syndromes, such as neuromyotonia, limbic encephalitis, and Morvan's syndrome. Recent advances have supported the pathologic mechanism of VGKC in these disorders, their response to therapy, and the possible mechanisms of peripheral, central, and autonomic dysfunctions seen in these disorders. We present a patient with 1 of these syndromes and review the literature of these disorders.</p>","PeriodicalId":21171,"journal":{"name":"Reviews in neurological diseases","volume":"5 2","pages":"65-72"},"PeriodicalIF":0.0,"publicationDate":"2008-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27561682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Monoclonal gammopathies (MGs) or plasma cell dyscrasias (PCDs) are hematologic disorders that may affect peripheral nerves. An MG is a proliferation of a single clone of neoplastic or nonneoplastic plasma that usually secretes a monoclonal protein (M-protein) serum or urine. If a diagnosis of monoclonal gammopathy of undetermined significance (MGUS) is established, a sudden increase in M-protein levels can indicate malignant transformation of a benign PCD. Roughly 50% of MGUS neuropathies are associated with an IgM gammopathy and the remaining 50% with IgG- and IgA-MGUS-associated neuropathies. MGUS is the most common of the PCDs associated with neurologic disorders, which are easily approached clinically by classifying them as IgM or non-IgM types.
{"title":"Peripheral neuropathies associated with monoclonal gammopathies of undetermined significance.","authors":"John J Kelly","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Monoclonal gammopathies (MGs) or plasma cell dyscrasias (PCDs) are hematologic disorders that may affect peripheral nerves. An MG is a proliferation of a single clone of neoplastic or nonneoplastic plasma that usually secretes a monoclonal protein (M-protein) serum or urine. If a diagnosis of monoclonal gammopathy of undetermined significance (MGUS) is established, a sudden increase in M-protein levels can indicate malignant transformation of a benign PCD. Roughly 50% of MGUS neuropathies are associated with an IgM gammopathy and the remaining 50% with IgG- and IgA-MGUS-associated neuropathies. MGUS is the most common of the PCDs associated with neurologic disorders, which are easily approached clinically by classifying them as IgM or non-IgM types.</p>","PeriodicalId":21171,"journal":{"name":"Reviews in neurological diseases","volume":"5 1","pages":"14-22"},"PeriodicalIF":0.0,"publicationDate":"2008-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27388771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
扫码关注我们
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号