Pub Date : 2023-06-07DOI: 10.1007/s43450-023-00413-7
R. Basting, R. Grando, H. Spindola, S. Tinti, N. D. C. A. Queiroz, I. Sousa, J. D. de Carvalho, S. Saad, M. Foglio
{"title":"Pterodon emarginatus: Antinociceptive Synergistic Effect of Geranylgeraniol and Vouacapans Fractions","authors":"R. Basting, R. Grando, H. Spindola, S. Tinti, N. D. C. A. Queiroz, I. Sousa, J. D. de Carvalho, S. Saad, M. Foglio","doi":"10.1007/s43450-023-00413-7","DOIUrl":"https://doi.org/10.1007/s43450-023-00413-7","url":null,"abstract":"","PeriodicalId":21196,"journal":{"name":"Revista Brasileira De Farmacognosia-brazilian Journal of Pharmacognosy","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2023-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47654194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-02DOI: 10.1007/s43450-023-00409-3
Liang-Shu Chen, Dong-Shu Zheng
Acute lung injury and its severe form acute respiratory distress syndrome are lethal lung diseases. So far, effective therapy for the diseases is deficient and the prognosis is poor. Recently, it was found activating nuclear factor erythroid 2-related factor 2 could attenuate the injury including inflammation, oxidative stress, and apoptosis in those diseases. To discover novel therapy, we have evaluated safflor yellow A and explored the underlying mechanisms using Beas-2B cells injured by lipopolysaccharide. As a result, safflor yellow A could improve the viability of Beas-2B cells treated with lipopolysaccharide. Further investigations have revealed safflor yellow A suppressed oxidative stress induced by lipopolysaccharide via reducing reactive oxygen species and malondialdehyde, and elevating superoxide dismutase, catalase, and glutathione peroxidase. Meanwhile, the inflammation resulting from lipopolysaccharide was ameliorated through decreasing the pro-inflammatory cytokines including tumor necrosis factor-α, interleukin-1β, and interleukin-6. It was also found nuclear factor κB was inactivated by safflor yellow A. In addition, safflor yellow A downregulated cysteinyl aspartate specific proteinase-3 and Bcl-2-associated X protein and upregulated B-cell lymphoma-2 to inhibited apoptosis of Beas-2B cells induced by lipopolysaccharide. The activation of nuclear factor erythroid 2-related factor 2 was observed in Beas-2B cells, which was associated with the protective effects of safflor yellow A. And molecular docking elucidated safflor yellow A interacted with Kelch-like ECH-associated protein 1 to activate nuclear factor erythroid 2-related factor 2. These results can provide evidences for the discovery of novel therapy for further evaluation of safflor yellow A in the treatment of acute lung injury and acute respiratory distress syndrome.
{"title":"Safflor Yellow A Protects Beas-2B Cells Against LPS-Induced Injury via Activating Nrf2.","authors":"Liang-Shu Chen, Dong-Shu Zheng","doi":"10.1007/s43450-023-00409-3","DOIUrl":"10.1007/s43450-023-00409-3","url":null,"abstract":"<p><p>Acute lung injury and its severe form acute respiratory distress syndrome are lethal lung diseases. So far, effective therapy for the diseases is deficient and the prognosis is poor. Recently, it was found activating nuclear factor erythroid 2-related factor 2 could attenuate the injury including inflammation, oxidative stress, and apoptosis in those diseases. To discover novel therapy, we have evaluated safflor yellow A and explored the underlying mechanisms using Beas-2B cells injured by lipopolysaccharide. As a result, safflor yellow A could improve the viability of Beas-2B cells treated with lipopolysaccharide. Further investigations have revealed safflor yellow A suppressed oxidative stress induced by lipopolysaccharide via reducing reactive oxygen species and malondialdehyde, and elevating superoxide dismutase, catalase, and glutathione peroxidase. Meanwhile, the inflammation resulting from lipopolysaccharide was ameliorated through decreasing the pro-inflammatory cytokines including tumor necrosis factor-α, interleukin-1β, and interleukin-6. It was also found nuclear factor κB was inactivated by safflor yellow A. In addition, safflor yellow A downregulated cysteinyl aspartate specific proteinase-3 and Bcl-2-associated X protein and upregulated B-cell lymphoma-2 to inhibited apoptosis of Beas-2B cells induced by lipopolysaccharide. The activation of nuclear factor erythroid 2-related factor 2 was observed in Beas-2B cells, which was associated with the protective effects of safflor yellow A. And molecular docking elucidated safflor yellow A interacted with Kelch-like ECH-associated protein 1 to activate nuclear factor erythroid 2-related factor 2. These results can provide evidences for the discovery of novel therapy for further evaluation of safflor yellow A in the treatment of acute lung injury and acute respiratory distress syndrome.</p><p><strong>Graphical abstract: </strong></p>","PeriodicalId":21196,"journal":{"name":"Revista Brasileira De Farmacognosia-brazilian Journal of Pharmacognosy","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2023-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10234683/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9772671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-02DOI: 10.1007/s43450-023-00412-8
V. Carvalho, Juliana dos Santos Carmo, L. M. G. dos Santos, F. D. de Almeida, E. Rocha, A. C. de Macêdo Vieira, Joana Angélica Barbosa Ferreira, Silvana do Couto Jacob, R. Strongin, A. D. da Silva
{"title":"Pharmaceutical Evaluation of Medical Cannabis Extracts Prepared by Artisanal and Laboratory Techniques","authors":"V. Carvalho, Juliana dos Santos Carmo, L. M. G. dos Santos, F. D. de Almeida, E. Rocha, A. C. de Macêdo Vieira, Joana Angélica Barbosa Ferreira, Silvana do Couto Jacob, R. Strongin, A. D. da Silva","doi":"10.1007/s43450-023-00412-8","DOIUrl":"https://doi.org/10.1007/s43450-023-00412-8","url":null,"abstract":"","PeriodicalId":21196,"journal":{"name":"Revista Brasileira De Farmacognosia-brazilian Journal of Pharmacognosy","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2023-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46094299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-01DOI: 10.1007/s43450-023-00410-w
Kiara Cândido Duarte da Silva, Bárbara do Carmo Rodrigues Virote, Maria de Fátima Santos, Tássia Flávia Dias Castro, Moisés Silvestre de Azevedo Martins, W. F. Carneiro, L. D. Solis Murgas
{"title":"Embriotoxic and Antioxidant Effects of Cymbopogon citratus Leaf Volatile Oil on Zebrafish","authors":"Kiara Cândido Duarte da Silva, Bárbara do Carmo Rodrigues Virote, Maria de Fátima Santos, Tássia Flávia Dias Castro, Moisés Silvestre de Azevedo Martins, W. F. Carneiro, L. D. Solis Murgas","doi":"10.1007/s43450-023-00410-w","DOIUrl":"https://doi.org/10.1007/s43450-023-00410-w","url":null,"abstract":"","PeriodicalId":21196,"journal":{"name":"Revista Brasileira De Farmacognosia-brazilian Journal of Pharmacognosy","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43409077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-01DOI: 10.1007/s43450-023-00396-5
Mohammadjavad Sotoudeheian, S. Hoseini, Seyed-Mohamad-Sadegh Mirahmadi, Navid Farahmandian, Hamidreza Pazoki-Toroudi
{"title":"Oleuropein as a Therapeutic Agent for Non-alcoholic Fatty Liver Disease During Hepatitis C","authors":"Mohammadjavad Sotoudeheian, S. Hoseini, Seyed-Mohamad-Sadegh Mirahmadi, Navid Farahmandian, Hamidreza Pazoki-Toroudi","doi":"10.1007/s43450-023-00396-5","DOIUrl":"https://doi.org/10.1007/s43450-023-00396-5","url":null,"abstract":"","PeriodicalId":21196,"journal":{"name":"Revista Brasileira De Farmacognosia-brazilian Journal of Pharmacognosy","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49587806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-01DOI: 10.1007/s43450-023-00411-9
V. Raman, Yan-Hong Wang, S. Saroja, Jianping Zhao, Jane Manfron, B. Avula, A. Chittiboyina, I. Khan
{"title":"Characterization of Calea ternifolia and its Adulterant Chromolaena odorata Using Macro-Microscopy, HPTLC and UHPLC-UV–MS","authors":"V. Raman, Yan-Hong Wang, S. Saroja, Jianping Zhao, Jane Manfron, B. Avula, A. Chittiboyina, I. Khan","doi":"10.1007/s43450-023-00411-9","DOIUrl":"https://doi.org/10.1007/s43450-023-00411-9","url":null,"abstract":"","PeriodicalId":21196,"journal":{"name":"Revista Brasileira De Farmacognosia-brazilian Journal of Pharmacognosy","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46654150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-24DOI: 10.1007/s43450-023-00407-5
Lorencia Taljaard, R. Haynes, F. van der Kooy
{"title":"Artemisia Species and Their Active Constituents for Treating Schistosomiasis","authors":"Lorencia Taljaard, R. Haynes, F. van der Kooy","doi":"10.1007/s43450-023-00407-5","DOIUrl":"https://doi.org/10.1007/s43450-023-00407-5","url":null,"abstract":"","PeriodicalId":21196,"journal":{"name":"Revista Brasileira De Farmacognosia-brazilian Journal of Pharmacognosy","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2023-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41941540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-20DOI: 10.1007/s43450-023-00408-4
Xuemei Gao, Tiancong Zhang, Xiaojing Huang, Xuanrong Huan, Cui He, Yuan Li
{"title":"Cordycepin Inhibits Pathological High Shear-Induced Platelet Aggregation, Activation, and Phosphatidylserine Exposure by Regulating the Phosphorylation of Akt Protein","authors":"Xuemei Gao, Tiancong Zhang, Xiaojing Huang, Xuanrong Huan, Cui He, Yuan Li","doi":"10.1007/s43450-023-00408-4","DOIUrl":"https://doi.org/10.1007/s43450-023-00408-4","url":null,"abstract":"","PeriodicalId":21196,"journal":{"name":"Revista Brasileira De Farmacognosia-brazilian Journal of Pharmacognosy","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2023-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43058779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-13DOI: 10.1007/s43450-023-00401-x
Yutthana Chotritthirong, Yaowared Chulikhit, S. Daodee, Chantana Boonyarat, Juthamart Maneenet, Charinya Khamphukdee, Pakakrong Kwankhao, S. Pitiporn, O. Monthakantirat
{"title":"Possible Mechanisms for the Prevention of Anxiety and Depressive-Like Behavior in a Chronic Mild Stress Mouse Model by the Thai Herbal Medicine with Nelumbo nucifera, Centella asiatica, and Piper nigrum","authors":"Yutthana Chotritthirong, Yaowared Chulikhit, S. Daodee, Chantana Boonyarat, Juthamart Maneenet, Charinya Khamphukdee, Pakakrong Kwankhao, S. Pitiporn, O. Monthakantirat","doi":"10.1007/s43450-023-00401-x","DOIUrl":"https://doi.org/10.1007/s43450-023-00401-x","url":null,"abstract":"","PeriodicalId":21196,"journal":{"name":"Revista Brasileira De Farmacognosia-brazilian Journal of Pharmacognosy","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2023-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49086246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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