Pub Date : 2023-11-03DOI: 10.1007/s43450-023-00472-w
Thi Van Anh Nguyen, Thi Minh Hang Nguyen, Hong Luyen Le, Duc Huy Bui
{"title":"Antithrombotic Activity of the Steroids and ent-Kaurane Diterpenoids from Canna indica Rhizomes","authors":"Thi Van Anh Nguyen, Thi Minh Hang Nguyen, Hong Luyen Le, Duc Huy Bui","doi":"10.1007/s43450-023-00472-w","DOIUrl":"https://doi.org/10.1007/s43450-023-00472-w","url":null,"abstract":"","PeriodicalId":21258,"journal":{"name":"Revista Brasileira de Farmacognosia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135818819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-03DOI: 10.1007/s43450-023-00473-9
Gerlânia de Oliveira Leite, Bruna Bayer Palma, Michele Rorato Sagrillo, Larissa Finger Schaffer, Israel Junio Martins dos Santos, Roselei Fachinetto, Caroline Wagner
{"title":"Evaluation of (–)-α-Bisabolol Toxicity in Drosophila melanogaster and Human Blood Peripheral Mononuclear and Red Cells","authors":"Gerlânia de Oliveira Leite, Bruna Bayer Palma, Michele Rorato Sagrillo, Larissa Finger Schaffer, Israel Junio Martins dos Santos, Roselei Fachinetto, Caroline Wagner","doi":"10.1007/s43450-023-00473-9","DOIUrl":"https://doi.org/10.1007/s43450-023-00473-9","url":null,"abstract":"","PeriodicalId":21258,"journal":{"name":"Revista Brasileira de Farmacognosia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135818820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-31DOI: 10.1007/s43450-023-00475-7
Oluwakemi Adeleke, Stephen Adefegha, Ganiyu Oboh
{"title":"Co-administration of Acarbose with Aqueous Extract of Root and Leaf of Sphenocentrum jollyanum Accelerates Wound Closure in Type 2 Diabetic Rats","authors":"Oluwakemi Adeleke, Stephen Adefegha, Ganiyu Oboh","doi":"10.1007/s43450-023-00475-7","DOIUrl":"https://doi.org/10.1007/s43450-023-00475-7","url":null,"abstract":"","PeriodicalId":21258,"journal":{"name":"Revista Brasileira de Farmacognosia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135808574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-30DOI: 10.1007/s43450-023-00477-5
Amanda Maria Barros Alves, Sonia Maria Costa Siqueria, Nadia Aguiar Portela Pinheiro, Alissa Ellen Queiroz Ribeiro Campos, Jane Eire Silva Alencar de Menezes, Maria Kueirislene Amâncio Ferreira, Icaro Gusmão Pinto Vieira, Antonio Wlisses da Silva, Márcia Machado Marinho, Emmanuel Silva Marinho, Hélcio Silva dos Santos
{"title":"Anxiolytic and Hypoglycemic Effect of Pectins from Galician Lemon Citrus Fruit on Adult Zebrafish (Danio rerio): An In Vivo and In Sílico Approach","authors":"Amanda Maria Barros Alves, Sonia Maria Costa Siqueria, Nadia Aguiar Portela Pinheiro, Alissa Ellen Queiroz Ribeiro Campos, Jane Eire Silva Alencar de Menezes, Maria Kueirislene Amâncio Ferreira, Icaro Gusmão Pinto Vieira, Antonio Wlisses da Silva, Márcia Machado Marinho, Emmanuel Silva Marinho, Hélcio Silva dos Santos","doi":"10.1007/s43450-023-00477-5","DOIUrl":"https://doi.org/10.1007/s43450-023-00477-5","url":null,"abstract":"","PeriodicalId":21258,"journal":{"name":"Revista Brasileira de Farmacognosia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136019602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-29DOI: 10.1007/s43450-023-00470-y
Alaa Behairy, Ashraf Elkomy, Faten Elsayed, Mohamed M. S. Gaballa, Ahmed Soliman, Mohamed Aboubakr
Abstract Methotrexate is a chemotherapy medication frequently used to treat various forms of cancer. The purpose of this research was to examine if the administration of Arthrospira platensis (Spirulina) and/or thymoquinone could ameliorate the liver injury resulting from methotrexate. The rats were randomly assigned to seven groups, each containing seven rats. The groups included a control group that received only saline, a group that received A. platensis orally at a dose of 500 mg/kg, a group that received thymoquinone orally at a dose of 10 mg/kg, a group that received a single i.p. dose of 20 mg/kg methotrexate, a group that received both A. platensis and methotrexate, a group that received both thymoquinone and methotrexate, and a group that received A. platensis , thymoquinone, and methotrexate. The injection of methotrexate caused an increase in the levels of alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, cholesterol, triacylglycerides, and low-density lipoprotein-cholesterol, and a decrease in high-density lipoprotein-cholesterol (HDL-cholesterol). The liver tissues also showed an increase in malondialdehyde and a decrease in reduced glutathione, superoxide dismutase, and catalase, along with pathological lesions and increased expression of TNF-α and caspase-3. However, administration of A. platensis and thymoquinone alone or in combination reduced the toxicity and apoptosis induced by methotrexate. Graphical Abstract
{"title":"Spirulina and Thymoquinone Protect Against Methotrexate-Induced Hepatic Injury in Rats","authors":"Alaa Behairy, Ashraf Elkomy, Faten Elsayed, Mohamed M. S. Gaballa, Ahmed Soliman, Mohamed Aboubakr","doi":"10.1007/s43450-023-00470-y","DOIUrl":"https://doi.org/10.1007/s43450-023-00470-y","url":null,"abstract":"Abstract Methotrexate is a chemotherapy medication frequently used to treat various forms of cancer. The purpose of this research was to examine if the administration of Arthrospira platensis (Spirulina) and/or thymoquinone could ameliorate the liver injury resulting from methotrexate. The rats were randomly assigned to seven groups, each containing seven rats. The groups included a control group that received only saline, a group that received A. platensis orally at a dose of 500 mg/kg, a group that received thymoquinone orally at a dose of 10 mg/kg, a group that received a single i.p. dose of 20 mg/kg methotrexate, a group that received both A. platensis and methotrexate, a group that received both thymoquinone and methotrexate, and a group that received A. platensis , thymoquinone, and methotrexate. The injection of methotrexate caused an increase in the levels of alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, cholesterol, triacylglycerides, and low-density lipoprotein-cholesterol, and a decrease in high-density lipoprotein-cholesterol (HDL-cholesterol). The liver tissues also showed an increase in malondialdehyde and a decrease in reduced glutathione, superoxide dismutase, and catalase, along with pathological lesions and increased expression of TNF-α and caspase-3. However, administration of A. platensis and thymoquinone alone or in combination reduced the toxicity and apoptosis induced by methotrexate. Graphical Abstract","PeriodicalId":21258,"journal":{"name":"Revista Brasileira de Farmacognosia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136157524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-24DOI: 10.1007/s43450-023-00474-8
Eman Zekry Attia, Iman A. M. Abdel-Rahman, Omar M. Aly, Hani Saber, Mohammed I. Rushdi, Usama Ramadan Abdelmohsen
Abstract Ethanol extracts of Caulerpa racemose (Forsskål) J.Agardh, 1873, Dictyopteris acrostichoides (J.Agardh) Bornet, 1885, Halimeda opuntia (Linnaeus) J.V.Lamouroux, 1816, and Polycladia myrica (S.G.Gmelin) Draima, Ballesteros, F.Rousseau & T.Thibaut, 2010, were tested for their cytotoxicity against human hepatoma, human breast adenocarcinoma, and human colon adenocarcinoma cell lines. Dictyopteris acrostichoides displayed cytotoxicity against human hepatoma, human breast adenocarcinoma, and human colon adenocarcinoma with IC 50 values of 11.65, 9.28, and 16.86 µg/ml, respectively, in comparison to doxorubicin as a positive control (IC 50 5.72, 5.17, and 5.81 µg/ml, respectively). Metabolic profiling of the D. acrostichoides extract characterized seventeen metabolites. In silico analysis indicated 1-(3-oxo-undecyldisulfanyl)-undecan-3-one was the most active epidermal growth factor receptor inhibitor, while 1-(3-oxo-undecyldisulfanyl)-undecan-3-one and di(3-acetoxy-5-undecenyl) disulfide were the most active vascular endothelial growth factor inhibitors. Furthermore, the ethanol extract of D. acrostichoides was tested against epidermal growth factor receptor kinase (IC 50 0.11 µg/ml) compared to lapatinib as a positive control (IC 50 0.03 µg/ml), and against vascular endothelial growth factor (IC 50 0.276 µg/ml) compared to sorafenib as a positive control (IC 50 0.049 µg/ml). Graphical Abstract
{"title":"In Vitro Cytotoxic Potential of Ethanol Extract of Dictyopteris acrostichoides Against Human Cancer Cells","authors":"Eman Zekry Attia, Iman A. M. Abdel-Rahman, Omar M. Aly, Hani Saber, Mohammed I. Rushdi, Usama Ramadan Abdelmohsen","doi":"10.1007/s43450-023-00474-8","DOIUrl":"https://doi.org/10.1007/s43450-023-00474-8","url":null,"abstract":"Abstract Ethanol extracts of Caulerpa racemose (Forsskål) J.Agardh, 1873, Dictyopteris acrostichoides (J.Agardh) Bornet, 1885, Halimeda opuntia (Linnaeus) J.V.Lamouroux, 1816, and Polycladia myrica (S.G.Gmelin) Draima, Ballesteros, F.Rousseau & T.Thibaut, 2010, were tested for their cytotoxicity against human hepatoma, human breast adenocarcinoma, and human colon adenocarcinoma cell lines. Dictyopteris acrostichoides displayed cytotoxicity against human hepatoma, human breast adenocarcinoma, and human colon adenocarcinoma with IC 50 values of 11.65, 9.28, and 16.86 µg/ml, respectively, in comparison to doxorubicin as a positive control (IC 50 5.72, 5.17, and 5.81 µg/ml, respectively). Metabolic profiling of the D. acrostichoides extract characterized seventeen metabolites. In silico analysis indicated 1-(3-oxo-undecyldisulfanyl)-undecan-3-one was the most active epidermal growth factor receptor inhibitor, while 1-(3-oxo-undecyldisulfanyl)-undecan-3-one and di(3-acetoxy-5-undecenyl) disulfide were the most active vascular endothelial growth factor inhibitors. Furthermore, the ethanol extract of D. acrostichoides was tested against epidermal growth factor receptor kinase (IC 50 0.11 µg/ml) compared to lapatinib as a positive control (IC 50 0.03 µg/ml), and against vascular endothelial growth factor (IC 50 0.276 µg/ml) compared to sorafenib as a positive control (IC 50 0.049 µg/ml). Graphical Abstract","PeriodicalId":21258,"journal":{"name":"Revista Brasileira de Farmacognosia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135266598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-24DOI: 10.1007/s43450-023-00476-6
Priscila de Souza, Camile C. Cechinel-Zanchett, Tuani Aimê K. dos Santos Melo, Isadora Leal Figueiredo, Valdir Cechinel-Filho, Luiz Carlos Klein-Junior
{"title":"Diuretic, Saluretic, and Ca2+-Sparing Effect of the Polygala cyparissias Methanol Extract, a Native Brazilian Medicinal Plant","authors":"Priscila de Souza, Camile C. Cechinel-Zanchett, Tuani Aimê K. dos Santos Melo, Isadora Leal Figueiredo, Valdir Cechinel-Filho, Luiz Carlos Klein-Junior","doi":"10.1007/s43450-023-00476-6","DOIUrl":"https://doi.org/10.1007/s43450-023-00476-6","url":null,"abstract":"","PeriodicalId":21258,"journal":{"name":"Revista Brasileira de Farmacognosia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135265909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-18DOI: 10.1007/s43450-023-00469-5
Luis Apaza Ticona, Belén Hervás Povo, Ángel Rumbero Sánchez
{"title":"Spectroscopical Analysis of Andean Plant Species with Anti-inflammatory, Antioxidant, and Antibacterial Activities","authors":"Luis Apaza Ticona, Belén Hervás Povo, Ángel Rumbero Sánchez","doi":"10.1007/s43450-023-00469-5","DOIUrl":"https://doi.org/10.1007/s43450-023-00469-5","url":null,"abstract":"","PeriodicalId":21258,"journal":{"name":"Revista Brasileira de Farmacognosia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135824648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-18DOI: 10.1007/s43450-023-00445-z
Luana Marilia Santos Oliveira, Thaysnara Batista Brito, Jose Guedes de Sena Filho, Sócrates Cabral de Holanda Cavalcanti
{"title":"Synthesis of Natural Product Derivatives as Larvicides Against Aedes aegypti","authors":"Luana Marilia Santos Oliveira, Thaysnara Batista Brito, Jose Guedes de Sena Filho, Sócrates Cabral de Holanda Cavalcanti","doi":"10.1007/s43450-023-00445-z","DOIUrl":"https://doi.org/10.1007/s43450-023-00445-z","url":null,"abstract":"","PeriodicalId":21258,"journal":{"name":"Revista Brasileira de Farmacognosia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135823805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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