{"title":"Effect of Atrovent administered by inhalation on pulmonary mechanics in patients with obstructive lung disease [proceedings].","authors":"G Koch","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":21458,"journal":{"name":"Scandinavian journal of respiratory diseases. Supplementum","volume":"103 ","pages":"206-7"},"PeriodicalIF":0.0,"publicationDate":"1979-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11373781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The effect of Atrovent in micturition function, double blind cross-over study.","authors":"J F Molkenboer, J G Lardenoye","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":21458,"journal":{"name":"Scandinavian journal of respiratory diseases. Supplementum","volume":"103 ","pages":"154-8"},"PeriodicalIF":0.0,"publicationDate":"1979-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11373913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The effect of ipratropium (Atrovent) 0.125 mg x 4 daily was compared to terbutalin (Bricanyl) 5 mg x 4 daily, given to 19 patients with chronic obstructive airways disease (15 with chronic bronchitis, 10 bronchial asthma, 7 pulmonary emphysema) as inhalation therapy with Monaghan IPPB-M 515, during 2 treatment periods of 3 days. The investigation was carried out as a controlled, double-blind, cross-over comparison. The effect of treatment was evaluated by measurement of PEFR, symptom scores, including the side-effects and the use of rimiterol MDI for the treatment of acute attacks. The PEFR values were all higher than the initial values (P less than 0.001) during the period of treatment (08.00-20,30 hrs). The highest values were recorded at 16.30 hrs, these were PEFR + 31.7% for the Atrovent period and PEFR + 28.0% for the Bricanyl period. No statistically significant difference was observed in the PEFR, symptom scores, side-effects and the use of rimiterol during the Atrovent and Bricanyl treatment periods. The authors suggest that Atrovent is a wellsuited alternative bronchodilatator, particularly for patients with tremor, muscle cramp, and "inner restlessness" following treatment with a beta 2-stimulator.
比较异丙托品(Atrovent) 0.125 mg x 4 d /天与特布他林(Bricanyl) 5 mg x 4 d /天的疗效，19例慢性阻塞性气道疾病患者(15例慢性支气管炎，10例支气管哮喘，7例肺气肿)采用Monaghan IPPB-M 515吸入治疗，疗程为2天，疗程为3天。该调查采用对照、双盲、交叉比较的方式进行。通过测量PEFR、症状评分(包括副作用)和使用利米特罗MDI治疗急性发作来评估治疗效果。治疗期间(08.00 ~ 20,30 h) PEFR值均高于初始值(P < 0.001)。最高值出现在16.30 h, Atrovent期PEFR + 31.7%， Bricanyl期PEFR + 28.0%。在Atrovent和Bricanyl治疗期间，PEFR、症状评分、副作用和利米特罗的使用无统计学差异。作者认为，Atrovent是一种非常适合的支气管扩张剂替代品，特别是对于使用β 2刺激剂治疗后出现震颤、肌肉痉挛和“内心不安”的患者。
{"title":"A comparative study of the bronchodilatating effects of ipratropium and terbutalin inhaled with Monaghan IPPB-M 515 by 19 patients with chronic obstructive airways disease.","authors":"B N Petersen, E Weeke","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The effect of ipratropium (Atrovent) 0.125 mg x 4 daily was compared to terbutalin (Bricanyl) 5 mg x 4 daily, given to 19 patients with chronic obstructive airways disease (15 with chronic bronchitis, 10 bronchial asthma, 7 pulmonary emphysema) as inhalation therapy with Monaghan IPPB-M 515, during 2 treatment periods of 3 days. The investigation was carried out as a controlled, double-blind, cross-over comparison. The effect of treatment was evaluated by measurement of PEFR, symptom scores, including the side-effects and the use of rimiterol MDI for the treatment of acute attacks. The PEFR values were all higher than the initial values (P less than 0.001) during the period of treatment (08.00-20,30 hrs). The highest values were recorded at 16.30 hrs, these were PEFR + 31.7% for the Atrovent period and PEFR + 28.0% for the Bricanyl period. No statistically significant difference was observed in the PEFR, symptom scores, side-effects and the use of rimiterol during the Atrovent and Bricanyl treatment periods. The authors suggest that Atrovent is a wellsuited alternative bronchodilatator, particularly for patients with tremor, muscle cramp, and \"inner restlessness\" following treatment with a beta 2-stimulator.</p>","PeriodicalId":21458,"journal":{"name":"Scandinavian journal of respiratory diseases. Supplementum","volume":"103 ","pages":"178-82"},"PeriodicalIF":0.0,"publicationDate":"1979-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11373917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
No prospective clinical investigations of unselected total materials of bronchial carcinoma have been reported. The clinical profile of 273 patients with histologically verified bronchial carcinoma from a Swedish county during 1971-1976 is presented. The difficulties in making valid comparisons with other literature reports makes it necessary to describe in detail the total material. Such a description is given in the present paper. In order to avoid different selection mechanisms an attempt was made to collect an almost total material. No patients were lost in the follow-up. Autopsy was performed in 95% of the deceased patients. The distribution of the histological WHO groups in the total material was: 44% group I, 18% group II, 29% group III and 9% group IV. The material was used for randomized investigations of radiotherapy, chemotherapy and placebo treatment in inoperable patients with the purpose of studying the quality of survival in addition to survival time. For the measurement of the quality of survival the Carlens vitagram index was used (Carlens et al. 1970). The influence of a general health survey with mass miniature chest X-ray was also studied, since such a survey was performed in the region of the study. The expected 5-year survival is estimated to be 7%. Only 20 patients with resectional therapy without known signs of metastases are expected to survive. Nine (45%) of these patients were discovered by mass miniature chest X-ray and thus for a limited number of patients the detection by the general health survey gives a better prognosis.
未选择支气管癌总材料的前瞻性临床研究尚未报道。本文报告了1971-1976年间瑞典某县273例经组织学证实的支气管癌患者的临床资料。与其他文献报告进行有效比较的困难使得有必要详细描述全部材料。本文给出了这样的描述。为了避免不同的选择机制，我们尝试收集几乎全部的材料。随访中无患者丢失。95%的死者进行了尸检。组织学WHO组在总材料中的分布为:I组44%，II组18%，III组29%，IV组9%。该材料用于无法手术患者放疗、化疗和安慰剂治疗的随机调查，目的是研究生存质量和生存时间。为了测量生存质量，使用了Carlens维生素图指数(Carlens et al. 1970)。还研究了使用大量微型胸部x线进行的一般健康调查的影响，因为这种调查是在研究区域进行的。预计5年生存率为7%。只有20名没有已知转移迹象的切除治疗患者有望存活。这些患者中有9例(45%)是通过大量胸部微型x线发现的，因此对于有限数量的患者，通过一般健康调查发现预后较好。
{"title":"Bronchial carcinoma. I. A prospective five year study on an unselected carcinoma population in a Swedish county.","authors":"E Nõu, B Stenkvist, S Graffman","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>No prospective clinical investigations of unselected total materials of bronchial carcinoma have been reported. The clinical profile of 273 patients with histologically verified bronchial carcinoma from a Swedish county during 1971-1976 is presented. The difficulties in making valid comparisons with other literature reports makes it necessary to describe in detail the total material. Such a description is given in the present paper. In order to avoid different selection mechanisms an attempt was made to collect an almost total material. No patients were lost in the follow-up. Autopsy was performed in 95% of the deceased patients. The distribution of the histological WHO groups in the total material was: 44% group I, 18% group II, 29% group III and 9% group IV. The material was used for randomized investigations of radiotherapy, chemotherapy and placebo treatment in inoperable patients with the purpose of studying the quality of survival in addition to survival time. For the measurement of the quality of survival the Carlens vitagram index was used (Carlens et al. 1970). The influence of a general health survey with mass miniature chest X-ray was also studied, since such a survey was performed in the region of the study. The expected 5-year survival is estimated to be 7%. Only 20 patients with resectional therapy without known signs of metastases are expected to survive. Nine (45%) of these patients were discovered by mass miniature chest X-ray and thus for a limited number of patients the detection by the general health survey gives a better prognosis.</p>","PeriodicalId":21458,"journal":{"name":"Scandinavian journal of respiratory diseases. Supplementum","volume":"104 ","pages":"43-82"},"PeriodicalIF":0.0,"publicationDate":"1979-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11502968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Pharmacokinetics of inhaled substances.","authors":"D S Davies","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":21458,"journal":{"name":"Scandinavian journal of respiratory diseases. Supplementum","volume":"103 ","pages":"44-9"},"PeriodicalIF":0.0,"publicationDate":"1979-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11327622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The relation between permanent administration of Atrovent and the dose of steroids in chronic bronchitis [proceedings].","authors":"Z Ajewski, B Popiak","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":21458,"journal":{"name":"Scandinavian journal of respiratory diseases. Supplementum","volume":"103 ","pages":"205"},"PeriodicalIF":0.0,"publicationDate":"1979-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11373780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Protective and bronchospasmolytic effect of ipratropium bromide in bronchial antigen challenge tests compared to other antiasthmatic drugs.","authors":"E Gonsior, G Schultze-Werninghaus","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":21458,"journal":{"name":"Scandinavian journal of respiratory diseases. Supplementum","volume":"103 ","pages":"219-21"},"PeriodicalIF":0.0,"publicationDate":"1979-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11373783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Exercise provocation in the evaluation of drug therapy in asthma.","authors":"H Poppius","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":21458,"journal":{"name":"Scandinavian journal of respiratory diseases. Supplementum","volume":"103 ","pages":"69-72"},"PeriodicalIF":0.0,"publicationDate":"1979-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11499666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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