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Proceedings of the 2nd International Conference on Sex Hormones and Pregnancy in Rheumatic Diseases. Trondheim, Norway, 29 August-1 September 1998. 第二届风湿性疾病性激素与妊娠国际会议论文集。特隆赫姆，挪威，1998年8月29日至9月1日。
Scandinavian journal of rheumatology. Supplement
Pub Date : 1998-01-01
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引用次数: 0
Interleukin-3 and pregnancy loss in antiphospholipid syndrome. 白细胞介素-3与抗磷脂综合征的妊娠损失。
Scandinavian journal of rheumatology. Supplement
Pub Date : 1998-01-01 DOI: 10.1080/03009742.1998.11720701
Y Shoenfeld, Y Sherer, P Fishman

Cytokines play an important role in the progression of autoimmune diseases, and therefore it is not surprising that their levels may be altered in some of these diseases. Interleukin-3 (IL-3), which is an hematopoietic growth factor as well as an important factor that aids in embryo implantation and placental development, was found to be decreased both in pregnant women with antiphospholipid syndrome (APS) compared with a control group, and in animal models of APS. Treatment of animals having APS with IL-3 succeeded in prevention of disease manifestations. In this communication we review IL-3 and APS interrelationship, and discuss the role of aspirin and other commonly used drugs, with respect to IL-3 levels in APS.

细胞因子在自身免疫性疾病的进展中起着重要作用，因此它们的水平在某些这些疾病中可能发生改变并不奇怪。白细胞介素-3 (IL-3)是一种造血生长因子，也是帮助胚胎着床和胎盘发育的重要因子。研究发现，与对照组相比，抗磷脂综合征(APS)孕妇和APS动物模型中的白细胞介素-3 (IL-3)均有所下降。用IL-3治疗APS动物成功地预防了疾病的表现。在这篇文章中，我们回顾了IL-3和APS的相互关系，并讨论了阿司匹林和其他常用药物在APS中IL-3水平的作用。
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引用次数: 36
Neonatal lupus and autoantibodies reactive with SSA/Ro-SSB/La. 新生儿狼疮和自身抗体与SSA/Ro-SSB/La反应。
Scandinavian journal of rheumatology. Supplement
Pub Date : 1998-01-01 DOI: 10.1080/03009742.1998.11720702
J P Buyon
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引用次数: 15
Renal lupus in pregnancy. 妊娠期肾性狼疮。
Scandinavian journal of rheumatology. Supplement
Pub Date : 1998-01-01 DOI: 10.1080/03009742.1998.11720772
H Julkunen

The outlook of pregnancy for women with lupus nephritis is usually favourable if the disease has been quiescent for at least 3 months before pregnancy, and if, at conception, serum creatinine is less than 140 mumol/l, proteinuria less than 3 grams/25 hours and blood pressure controlled. The risk of fetal loss is, however, 2-3 times higher than in the normal population and pre-eclampsia, prematurity and fetal growth retardation frequently complicate these pregnancies. Pregnancies in women with lupus nephritis are high-risk pregnancies and they require intense fetal and maternal surveillance.

狼疮性肾炎妇女的妊娠前景通常是有利的，如果疾病在妊娠前至少静止3个月，如果在受孕时，血清肌酐低于140 μ mol/l，蛋白尿低于3克/25小时，血压得到控制。然而，胎儿丢失的风险比正常人群高2-3倍，先兆子痫、早产和胎儿发育迟缓经常使这些妊娠复杂化。狼疮性肾炎患者的妊娠是高危妊娠，需要对胎儿和母体进行严密的监测。
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引用次数: 15
Hypertension in pregnancy and preeclampsia--diagnosis and treatment. 妊娠期高血压和子痫前期——诊断和治疗。
Scandinavian journal of rheumatology. Supplement
Pub Date : 1998-01-01
T Henriksen

Women who have or develop high blood pressure during pregnancy are all at increased risk of complications antenatally, intrapartum and in the puerperium. The increased risk applies to the mother as well to the fetus. Preeclampsia is the most serious form of hypertensive pregnancy complications. Preeclampsia is, however, not primarily a hypertensive disease but a disorder induced by factors dependent on the presence of placenta. The prime target of the placenta dependent factors is the vascular endothelium. Therefore the complications are associated with the vascular system, i.e. intravascular coagulation, bleeding and organ failure following poor perfusion. The fetus is at increased risk due to growth retardation and hypoxia following placental damage. Treatment of the hypertension is first indicated if the blood pressure rises to a level of increased risk of cerebral vascular complications, i.e. above 105-110 mmHg. Delivery is the only causal treatment and is always indicated if severe maternal or fetal complications develop.

在怀孕期间患有或发展为高血压的妇女在产前、产时和产褥期出现并发症的风险都会增加。增加的风险不仅适用于母亲，也适用于胎儿。子痫前期是高血压妊娠并发症中最严重的一种。然而，先兆子痫主要不是一种高血压疾病，而是一种由依赖于胎盘存在的因素引起的疾病。胎盘依赖因子的主要作用靶点是血管内皮。因此，并发症与血管系统有关，即灌注不良后的血管内凝血、出血和器官衰竭。胎盘损伤后，胎儿因发育迟缓和缺氧而风险增加。如果血压升高到脑血管并发症风险增加的水平，即高于105-110毫米汞柱，则首先需要治疗高血压。分娩是唯一的因果治疗，如果出现严重的母体或胎儿并发症，分娩总是指的。
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引用次数: 0
Reproductive events and the risk of development of rheumatoid arthritis. 生殖事件与类风湿关节炎发展的风险。
Scandinavian journal of rheumatology. Supplement
Pub Date : 1998-01-01 DOI: 10.1080/03009742.1998.11720782
A J Silman
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引用次数: 3
Hypertension in pregnancy and preeclampsia--diagnosis and treatment. 妊娠期高血压和子痫前期——诊断和治疗。
Scandinavian journal of rheumatology. Supplement
Pub Date : 1998-01-01 DOI: 10.1080/03009742.1998.11720775
T. Henriksen
Women who have or develop high blood pressure during pregnancy are all at increased risk of complications antenatally, intrapartum and in the puerperium. The increased risk applies to the mother as well to the fetus. Preeclampsia is the most serious form of hypertensive pregnancy complications. Preeclampsia is, however, not primarily a hypertensive disease but a disorder induced by factors dependent on the presence of placenta. The prime target of the placenta dependent factors is the vascular endothelium. Therefore the complications are associated with the vascular system, i.e. intravascular coagulation, bleeding and organ failure following poor perfusion. The fetus is at increased risk due to growth retardation and hypoxia following placental damage. Treatment of the hypertension is first indicated if the blood pressure rises to a level of increased risk of cerebral vascular complications, i.e. above 105-110 mmHg. Delivery is the only causal treatment and is always indicated if severe maternal or fetal complications develop.
在怀孕期间患有或发展为高血压的妇女在产前、产时和产褥期出现并发症的风险都会增加。增加的风险不仅适用于母亲，也适用于胎儿。子痫前期是高血压妊娠并发症中最严重的一种。然而，先兆子痫主要不是一种高血压疾病，而是一种由依赖于胎盘存在的因素引起的疾病。胎盘依赖因子的主要作用靶点是血管内皮。因此，并发症与血管系统有关，即灌注不良后的血管内凝血、出血和器官衰竭。胎盘损伤后，胎儿因发育迟缓和缺氧而风险增加。如果血压升高到脑血管并发症风险增加的水平，即高于105-110毫米汞柱，则首先需要治疗高血压。分娩是唯一的因果治疗，如果出现严重的母体或胎儿并发症，分娩总是指的。
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引用次数: 6
Immunomodulation of experimental antiphospholipid syndrome. 实验性抗磷脂综合征的免疫调节。
Scandinavian journal of rheumatology. Supplement
Pub Date : 1998-01-01 DOI: 10.1080/03009742.1998.11720761
Y Sherer, M Blank, Y Shoenfeld

The various therapeutic modalities which are found to be beneficial in experimental antiphospholipid syndrome include: bone marrow transplantation, anti-CD4 monoclonal antibodies, bromocriptine, intravenous immunoglobulins and anti-idiotypes, interleukin-3, and various anti-coagulant and anti-aggregate agents. The advantage of animal models is the ability to evaluate experimental treatments that cannot be tested directly on patients. In this paper, we review the effect of these agents on animal models of antiphospholipid syndrome, their mechanisms of action, and their clinical implications.

对实验性抗磷脂综合征有益的各种治疗方式包括:骨髓移植、抗cd4单克隆抗体、溴隐亭、静脉注射免疫球蛋白和抗独特型、白细胞介素-3和各种抗凝血和抗聚集剂。动物模型的优点是能够评估不能直接在患者身上进行试验的实验性治疗。本文就这些药物在抗磷脂综合征动物模型中的作用、作用机制及其临床意义进行综述。
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引用次数: 9
Heparin-induced osteoporosis. Heparin-induced骨质疏松症。
Scandinavian journal of rheumatology. Supplement
Pub Date : 1998-01-01 DOI: 10.1080/03009742.1998.11720769
C Nelson-Piercy
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引用次数: 56
Does SLE flare during pregnancy? SLE在怀孕期间会发作吗?
Scandinavian journal of rheumatology. Supplement
Pub Date : 1998-01-01 DOI: 10.1080/03009742.1998.11720771
G Ruiz-Irastorza, M Khamashta, G R Hughes
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引用次数: 8
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