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Effect of bispectral index on intra-operative awareness: A meta-analysis of randomized controlled studies 双光谱指数对术中意识的影响:随机对照研究的荟萃分析
IF 1.2 Q2 Medicine Pub Date : 2024-06-04 DOI: 10.4103/sja.sja_74_24
Thomas Cheriyan, Kevin Bai, Shreya Bayyapureddy, A. Dua, Paramvir Singh, Zhuo Sun, Chhaya Patel, Vikas Kumar
Randomized controlled trials (RCTs) investigating the efficacy of bispectral index (BIS) to reduce intra-operative awareness (IOA) have reported conflicting results. The purpose of this meta-analysis is to consolidate results from RCTs to assess the efficacy of BIS in reducing IOA when compared to controls. Secondary outcomes included time to extubation, time to spontaneous and/or verbal eye opening, PACU discharge time, and utilization of inhaled anesthetics. RCTs which reported on one of the primary and/or secondary outcomes were included. Literature search utilized keywords “randomized control trial” and “intraoperative awareness.” Meta-analysis was performed using RevMan 5. Twenty-seven RCTs were included in the study with a total of 35,585 patients, with 18,146 patients in the BIS and 17,439 in the control group. Eighteen of 14,062 patients (0.12%) and 42 of 16,765 (0.25%) reported definite IOA in the BIS and control group, respectively, with no statistically significant difference. BIS was effective in reducing the time to spontaneous eye opening by an average of 1.3 minutes and the time to extubation by an average of 1.97 minutes. There was no difference in PACU discharge times among the groups. There was a significant decrease in consumption of sevoflurane but no difference in desflurane and propofol compared to the control group. While BIS monitoring results in decreased incidence of intra-operative awareness by half, it was not statistically significant. BIS provides modest benefits with regard to reducing the time to extubation, the time to spontaneous eye opening, and consumption of sevoflurane. Level of evidence: I.
研究双光谱指数(BIS)降低术中知觉(IOA)效果的随机对照试验(RCT)报告了相互矛盾的结果。本荟萃分析的目的是整合 RCT 的结果,评估 BIS 与对照组相比在降低 IOA 方面的疗效。次要结果包括拔管时间、自发和/或口头睁眼时间、PACU 出院时间以及吸入麻醉剂的使用情况。 纳入了报告主要和/或次要结果之一的 RCT。文献检索使用的关键词为 "随机对照试验 "和 "术中意识"。使用 RevMan 5 进行了 Meta 分析。 研究共纳入了 27 项随机对照试验,共计 35,585 名患者,其中 18,146 名患者为 BIS 组,17,439 名患者为对照组。BIS 组和对照组分别有 14,062 名患者和 16,765 名患者中的 18 人(0.12%)和 42 人(0.25%)报告了明确的 IOA,差异无统计学意义。BIS 可有效缩短自发睁眼时间,平均缩短 1.3 分钟,缩短拔管时间,平均缩短 1.97 分钟。各组的 PACU 出院时间没有差异。与对照组相比,七氟醚的用量明显减少,但地氟醚和异丙酚的用量没有差异。 虽然 BIS 监测使术中意识丧失的发生率降低了一半,但在统计学上并不显著。BIS 在缩短拔管时间、自发睁眼时间和七氟醚消耗量方面的益处不大。证据等级:I.
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引用次数: 0
How to read P-values and confidence intervals in public health studies 如何阅读公共卫生研究中的 P 值和置信区间
IF 1.2 Q2 Medicine Pub Date : 2024-06-04 DOI: 10.4103/sja.sja_128_24
Alessandro Rovetta, M. Mansournia, Alessandro Vitale, Vincenzo Accurso
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引用次数: 0
Efficacy and safety of adjuvant intrathecal dexamethasone during spinal anesthesia: A systematic review and meta-analysis 脊髓麻醉期间鞘内地塞米松辅助治疗的有效性和安全性:系统回顾和荟萃分析
IF 1.2 Q2 Medicine Pub Date : 2024-06-04 DOI: 10.4103/sja.sja_112_24
T. Tantry, Vasantha Shetty, Aarti Deepak, Sumesh Murali, Murali S. B. Golitadka, Shreejith K. Menon, Sunil P. Shenoy, Dinesh Kadam
The use of intrathecal (IT) dexamethasone during subarachnoid block (SAB) has not been evaluated. There are no pooled data available to decide on the optimal regimen of IT dexamethasone during SAB, irrespective of the type of surgery. There is uncertainty about its dosage, effectiveness, and safety, and a need to establish clear guidelines on its use. Our objective was to evaluate the effectiveness and safety of use of IT dexamethasone during SAB. We performed a meta-analysis (PROSPERO, CRD42022304944) of trials that included patients who underwent a variety of surgical procedures under SAB. Patients received concomitant IT dexamethasone as an adjuvant to spinal local anesthetics. The analyzed outcomes included sensory and motor effects as well as adverse and/or beneficial side effects. Subgroup analysis was planned based on different doses used. Trial sequential analysis (TSA) was used to estimate the required sample size information (RIS) for each outcome. Eighteen studies (2531 participants) were included in this analysis. Addition of IT dexamethasone (4-8 mg) to heavy bupivacaine effectively prolonged the duration of sensory blockade (mean difference, MD = 63.8 minutes; [95% confidence interval, CI, 33.1-94.5], P < 0.0001), two-segment regression time (MD = 20.1[95% CI, 0.96-39.2], P = 0.04) and first rescue analgesic time (MD = 143.3 [95% CI, 90.3-196.0], P = 0.001). Subgroup analyses revealed superior effects of 8 mg dose over 4 mg for sensory and analgesic effects. The effect of dexamethasone on duration of motor blockade was inconclusive. Additionally, lower risk ratios (RRs) were recorded for spinal anesthesia-related hypotension (RR = 0.74 [95% CI, 0.6-0.9], P = 0.0003) and nausea/vomiting (RR = 0.62 [95% CI, 0.41-0.93], P = 0.02) in the dexamethasone group. For outcomes such as sensory blockade, analgesia, and hypotension, the required information size was reached during TSA. In conclusion, IT dexamethasone, used as an adjuvant to spinal local anesthetic, especially at the dose of 8 mg, increases sensory blockade duration and the time for request of the first rescue analgesic. SAB-induced side effects such as hypotension, nausea, and vomiting are lesser with the use of IT dexamethasone. However, further studies are necessary to draw meaningful conclusions on its safety profile.
蛛网膜下腔阻滞(SAB)期间使用鞘内地塞米松的情况尚未进行评估。目前还没有综合数据来确定蛛网膜下腔阻滞期间使用 IT 地塞米松的最佳方案,无论手术类型如何。地塞米松的剂量、有效性和安全性都存在不确定性,因此需要制定明确的使用指南。我们的目的是评估在 SAB 期间使用 IT 地塞米松的有效性和安全性。我们进行了一项荟萃分析(PROSPERO,CRD42022304944),研究对象包括在 SAB 下接受各种外科手术的患者。患者同时接受 IT 地塞米松作为脊髓局麻药的辅助药物。分析结果包括感觉和运动影响以及不良和/或有益副作用。根据所用剂量的不同,计划进行分组分析。试验序列分析(TSA)用于估算每种结果所需的样本量信息(RIS)。本次分析共纳入了 18 项研究(2531 名参与者)。在重型布比卡因中加入 IT 地塞米松(4-8 毫克)可有效延长感觉阻滞的持续时间(平均差,MD = 63.8 分钟;[95% 置信区间,CI,33.1-94.5],P < 0.0001)、两段回归时间(MD = 20.1[95% CI, 0.96-39.2],P = 0.04)和首次镇痛抢救时间(MD = 143.3 [95% CI, 90.3-196.0],P = 0.001)。分组分析显示,8 毫克剂量的感觉和镇痛效果优于 4 毫克。地塞米松对运动阻滞持续时间的影响尚无定论。此外,地塞米松组脊髓麻醉相关低血压(RR = 0.74 [95% CI, 0.6-0.9],P = 0.0003)和恶心/呕吐(RR = 0.62 [95% CI, 0.41-0.93],P = 0.02)的风险比(RRs)较低。对于感觉阻滞、镇痛和低血压等结果,TSA期间达到了所需的信息量。总之,IT 地塞米松作为脊髓局麻药的辅助用药,尤其是 8 毫克剂量时,可延长感觉阻滞时间,并延长首次申请抢救性镇痛药的时间。使用 IT 地塞米松后,SAB 引起的低血压、恶心和呕吐等副作用会减少。不过,要对其安全性得出有意义的结论,还需要进一步的研究。
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引用次数: 0
A case series of fluoroscopy-guided neurolytic splanchnic nerve block for chronic pancreatitis pain 透视引导下神经溶解性脾神经阻滞治疗慢性胰腺炎疼痛的病例系列
IF 1.2 Q2 Medicine Pub Date : 2024-06-04 DOI: 10.4103/sja.sja_86_24
B. Jyothi, M. Mitragotri, D. Ladhad, Madhuri S. Kurdi, Mahesh D. Kurugodiyavar, Sanjivani Jadhav
Splanchnic nerve block (SPN) with local anesthetic and steroid is used to relieve the pain of chronic pancreatitis. However, it does not provide long-lasting relief. We hypothesize that the use of 70% alcohol will give adequate analgesia for more than months. The primary objective was to find out the analgesic efficacy of the use of 70% alcohol with SPN. Secondary objectives included the incidence of side effects, analgesic consumption postintervention, quality of life (QOL) assessed via a self-reported quality of life scale, and repeat block during the 1-year follow-up period. Retrospective analysis of all patients with chronic pancreatitis who received bilateral SPN over the last 4 years. SPN was performed using the posterior retrocrural approach with the patient in the prone position as described in the literature using a 23 G × 90 mm spinal needle bilaterally at the level of T12 using C-arm/fluoroscopy guidance. Data were collected from the procedure book of the pain clinic and medical records. Quantitative data for change in pre- to post-block VAS score was collected using the non-parametric Wilcoxon signed ranks test. The baseline VAS, post-procedure VAS, and VAS at 3 months follow-up was 7.69 ± 1.3,2.44 ± 0.96 and 1.56 ± 1.15. A pairwise comparison of VAS performed between baseline and immediate post-procedure, baseline, and VAS at 3 months was found to be highly significant. Fluoroscopy-guided neurolytic SPN with 70% alcohol gives significant pain relief for more than 3 months. It also leads to improvement in 3 months QOL.
使用局部麻醉剂和类固醇的胰腺神经阻滞术(SPN)可缓解慢性胰腺炎的疼痛。然而,它并不能提供持久的缓解。我们假设使用 70% 的酒精可提供数月以上的充分镇痛。 首要目标是了解使用 70% 酒精和 SPN 的镇痛效果。次要目标包括副作用的发生率、干预后的镇痛剂消耗量、通过自我报告生活质量量表评估的生活质量(QOL)以及 1 年随访期间的重复阻滞情况。 对过去 4 年中接受过双侧 SPN 的所有慢性胰腺炎患者进行回顾性分析。 按照文献中的描述,在C型臂/荧光透视引导下,使用23 G × 90 mm脊柱针在双侧T12水平进行SPN手术。数据来自疼痛诊所的手术记录本和病历。 采用非参数 Wilcoxon 符号秩检验收集阻滞前与阻滞后 VAS 评分变化的定量数据。 基线 VAS、术后 VAS 和 3 个月随访时的 VAS 分别为 7.69 ± 1.3、2.44 ± 0.96 和 1.56 ± 1.15。基线与术后即刻、基线与 3 个月时的 VAS 进行配对比较后发现,结果非常显著。 在透视引导下使用 70% 酒精进行神经溶解 SPN 可明显缓解疼痛,持续时间超过 3 个月。它还能改善 3 个月的 QOL。
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引用次数: 0
Bilateral ultrasound-guided erector spinae plane block for postoperative pain relief in major traumatic spine surgery: A randomized controlled trial 双侧超声引导竖脊肌平面阻滞用于缓解脊柱大创伤手术的术后疼痛:随机对照试验
IF 1.2 Q2 Medicine Pub Date : 2024-06-04 DOI: 10.4103/sja.sja_694_23
Baby Pegu, Babita Gupta, Arshad Ayub
Spine fixation surgery for traumatic vertebral fractures is associated with severe pain and is often difficult to control. Traditionally systemic opioids have been the mainstay of analgesia for these procedures, which can lead to hyperalgesia, nausea, ileus, sedation, cognitive impairment, dependence, etc., limiting usage of opioids. The Erector spinae plane block (ESPB) is a novel ultrasound-guided procedure with easily identifiable sonoanatomy. We hypothesized that a multimodal approach involving ESPB to a conventional analgesic regimen with local infiltration for patients undergoing major traumatic spine surgeries might provide better perioperative analgesia and reduce the need for postoperative opioid requirements. A randomized control prospective trial was conducted on 34 ASA grade I –II patients aged 18 to 65 years who were scheduled to undergo elective posterior spine fixation surgery with ASIA B to E after traumatic spine fracture under general anesthesia. Patients were randomized to Group A which included patients who received general anesthesia with ESPB, and Group B, or the control group, included patients who received general anesthesia with systemic analgesics and postoperative local infiltration without ESPB. Intraoperative total fentanyl consumption, VAS score at 0, 3, 6, 12, 18, and 24 hours, time to activate patient-controlled analgesia (PCA) pump, total morphine consumption, and opioid-related side effects were monitored and compared in both groups. Postoperative PCA morphine consumption was significantly lower in group A patients who received ESPB than those in the control group (17.06 ± 9.59 vs 37.82 ± 9.88 P value = <0.0001). VAS scores at rest and movement at 0, 3, 6, 9, 12, 18, and 24 hours were significantly lower (P value = 0.05) in the ESPB group compared with the control group at all time points. Bilateral ultrasound-guided Erector spinae plane block, when administered in traumatic spine patients undergoing spine fixation surgery, provides better analgesia with statistically decreased VAS scores and less postoperative opioid requirement.
外伤性脊椎骨折的脊椎固定手术会带来剧烈疼痛,而且往往难以控制。传统上,全身性阿片类药物一直是此类手术的主要镇痛药物,但这可能导致痛觉减退、恶心、回肠梗阻、镇静、认知障碍、依赖性等,从而限制了阿片类药物的使用。脊骨后肌平面阻滞(ESPB)是一种新型的超声引导手术,其声像解剖结构易于识别。我们假设,在对接受脊柱大创伤手术的患者进行局部浸润的传统镇痛方案的基础上,采用一种包含 ESPB 的多模式方法,可能会提供更好的围手术期镇痛效果,并减少术后对阿片类药物的需求。 一项随机对照前瞻性试验对 34 名年龄在 18 至 65 岁之间、计划在全身麻醉下接受脊柱创伤性骨折后选择性脊柱后路固定手术并使用 ASIA B 至 E 的 ASA I - II 级患者进行了研究。患者被随机分为 A 组和 B 组,A 组包括接受全身麻醉并使用 ESPB 的患者,B 组或对照组包括接受全身麻醉并使用全身镇痛药和术后局部浸润但不使用 ESPB 的患者。两组患者的术中芬太尼总用量、0、3、6、12、18 和 24 小时的 VAS 评分、启动患者自控镇痛(PCA)泵的时间、吗啡总用量以及与阿片类药物相关的副作用均接受了监测和比较。 接受ESPB治疗的A组患者术后PCA吗啡消耗量明显低于对照组(17.06 ± 9.59 vs 37.82 ± 9.88,P值= <0.0001)。在所有时间点上,ESPB 组与对照组相比,在 0、3、6、9、12、18 和 24 小时休息和运动时的 VAS 评分均显著降低(P 值 = 0.05)。 对接受脊柱固定手术的外伤性脊柱患者进行双侧超声引导下脊柱后凸平面阻滞,可提供更好的镇痛效果,VAS评分明显降低,术后对阿片类药物的需求也更少。
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引用次数: 0
Algorithm for airway management in benign intra-tracheal lesions 气管内良性病变的气道处理算法
IF 1.2 Q2 Medicine Pub Date : 2024-06-04 DOI: 10.4103/sja.sja_975_23
Nadine El Hadi, Jad Hosri, Tamam Tulimat, Usamah Hadi
The authors have conducted a retrospective analysis based on two cases of patients with intra-tracheal pathologies who received treatment from the same surgeon at a tertiary referral center. The effective management of airways in patients with intra-tracheal lesions necessitates close collaboration between surgeons and anesthesiologists. Factors such as the size, location, rigidity of the tumor, and the remaining tracheal lumen space should be carefully considered. In situations where there is near complete obstruction of the trachea and a substantial risk of worsened respiratory function, resorting to cardiopulmonary bypass or extracorporeal membrane oxygenation is advisable. This pilot study aims at devising an algorithm for the airway management of intra-tracheal lesions, although a larger case cohort is needed to assess its applicability and effectiveness.
作者根据在一家三级转诊中心接受同一外科医生治疗的两例气管内病变患者进行了回顾性分析。气管内病变患者气道的有效管理需要外科医生和麻醉师的密切合作。应仔细考虑肿瘤的大小、位置、硬度和剩余气管腔空间等因素。在气管几乎完全阻塞、呼吸功能极有可能恶化的情况下,最好采用心肺旁路或体外膜肺氧合。这项试验性研究旨在为气管内病变的气道管理设计一种算法,但需要更大的病例群来评估其适用性和有效性。
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引用次数: 0
Anesthetic management of a patient with congenital cyanotic heart anomaly for emergency surgery: A case report 先天性紫绀型心脏畸形患者急诊手术的麻醉管理:病例报告
IF 1.2 Q2 Medicine Pub Date : 2024-06-04 DOI: 10.4103/sja.sja_48_24
H. Pahuja, Ravikiran Nikhade, Anjali Bhure, A. Pingley
Among congenital cyanotic heart diseases (CHDs), situs inversus totalis with transposition of great vessels with a large ventricular septal defect (VSD) has a very low incidence of around 1 in 10,000. Hereby, we present a 16-year-old man with the aforementioned cardiac anomaly with cardiac arrhythmias, septic shock, and a history of road traffic accident-causing osteomyelitis of the left thigh requiring incision and drainage. The patient was admitted to the intensive care unit with a high-grade fever, narrow pulse pressure, and atrial fibrillation. The patient was operated on under general anesthesia with endotracheal intubation after optimization. Invasive monitoring, antiarrhythmics, and vasopressors were required intraoperatively, and surgery progressed uneventfully. Furthermore, the patient had undergone a series of debridements after 8 days, which were performed under regional anesthesia uneventfully. This case report represents a plan of action for perioperative anesthetic management and anticipates the difficulties for CHD patients in the course of surgery and subsequential prudence.
在先天性紫绀型心脏病(CHD)中,伴有大血管转位和室间隔缺损(VSD)的全坐位综合征的发病率非常低,约为万分之一。在此,我们介绍一名患有上述心脏畸形、心律失常、脓毒性休克的 16 岁男性患者,他曾因交通事故引发左大腿骨髓炎,需要切开引流。患者因高烧、脉压窄和心房颤动被送入重症监护室。患者在全身麻醉下接受了手术,优化后进行了气管插管。术中需要进行有创监测、使用抗心律失常药物和血管加压药,手术进展顺利。此外,患者还在 8 天后进行了一系列清创手术,这些手术都是在区域麻醉下顺利进行的。本病例报告体现了围手术期麻醉管理的行动计划,并预示了心脏疾病患者在手术过程中可能遇到的困难以及后续的谨慎措施。
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引用次数: 0
Multi-level bilateral ultrasound-guided retrolaminar block for fast-track spinal deformity surgery 多层次双侧超声引导椎板后阻滞,用于快速脊柱畸形手术
IF 1.2 Q2 Medicine Pub Date : 2024-06-04 DOI: 10.4103/sja.sja_122_24
Amarjeet Kumar, Shruti Shrey, Narayan Manjunath, C. Sinha, Prabhat Agrawal
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引用次数: 0
Enhanced perioperative communication elevates patients’ understanding, perception, and satisfaction for anesthesia services: Insights from a survey study 加强围术期沟通可提高患者对麻醉服务的理解、感知和满意度:一项调查研究的启示
IF 1.2 Q2 Medicine Pub Date : 2024-06-04 DOI: 10.4103/sja.sja_104_24
Rishabh Jaju, Saurabh Varshney, Pooja Bihani, Naveen Paliwal, H. M. R. Karim, Dipak Bhuyan
Anesthesiologists’ services extend to many critical areas of any healthcare setup. However, there needs to be more understanding among the public regarding their crucial role. Preanesthesia evaluation (PAE) visits can disseminate information about anesthesiologists and services. We aimed to evaluate patient’s knowledge and the impact of interview-based surveys on increasing knowledge about anesthesiologists and anesthesia services. It was a single-center, cross-sectional survey involving 550 patients aged 18–65 undergoing elective surgeries. Pre- and postoperative interviewer-assisted questionnaires were administered to assess patients’ baseline knowledge and perception of anesthesia and anesthesiologists. Statistical analysis focused on demographic, educational, and previous anesthesia exposure among subgroups; a P-value <0.05 was considered significant. Less than half comprehended anesthesia’s role as a specialist in inducing unconsciousness. 55.3% were unaware of general anesthesia, and 69.6% were unaware of regional anesthesia as a technique. Higher education and previous anesthesia exposure correlated with better awareness with regard to the perioperative role of anesthesiologists and their fields of work (P < 0.05). The postoperative survey indicated good satisfaction with anesthesiologists’ services, which might be attributable to the survey-based interaction. A significant need for more understanding regarding anesthesia and anesthesiologists’ roles still prevails. Interview-based effective communication during PAE visits, perioperative period, and shared decision-making (SDM) improves patients’ knowledge, comprehension, and satisfaction.
麻醉医师的服务涉及任何医疗机构的许多关键领域。然而,公众需要更多地了解他们的关键作用。麻醉前评估(PAE)访问可以传播有关麻醉医师和服务的信息。我们的目的是评估患者对麻醉医师和麻醉服务的了解程度以及访谈式调查对提高患者对麻醉医师和麻醉服务了解程度的影响。 这是一项单中心横断面调查,涉及 550 名年龄在 18-65 岁之间接受择期手术的患者。通过术前和术后由访谈员协助进行的问卷调查来评估患者对麻醉和麻醉医师的基本知识和看法。统计分析的重点是各分组的人口统计学、教育程度和以往的麻醉经历;P 值小于 0.05 即为显著。 只有不到一半的人了解麻醉在诱导昏迷方面的作用。55.3%的人不了解全身麻醉,69.6%的人不了解区域麻醉这种技术。学历越高、以前接触过麻醉的人越了解麻醉师在围手术期的作用及其工作领域(P < 0.05)。术后调查显示,患者对麻醉医生的服务非常满意,这可能与基于调查的互动有关。 对于麻醉和麻醉医师角色的理解仍有很大的需求。在 PAE 访问、围术期和共同决策 (SDM) 期间,基于访谈的有效沟通可提高患者的知识水平、理解能力和满意度。
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引用次数: 0
Anesthetic management of extremely low-birth-weight neonates for laparotomy 极低出生体重新生儿开腹手术的麻醉管理
IF 1.2 Q2 Medicine Pub Date : 2024-06-04 DOI: 10.4103/sja.sja_82_24
Satish Kumar Mishra, Saket Davera, G. Viswanath, Shalendra Singh
Anesthetic management of extremely low-birth-weight (ELBW) neonates is always accompanied by many dilemmas and challenges. Here, we report a case in which 512 g of ELBW newborns underwent exploratory laparotomy for perforation. Anesthesia management of such ELBW infants has not been reported in the literature.
极低出生体重(ELBW)新生儿的麻醉管理总是伴随着许多困境和挑战。在这里,我们报告了一例因穿孔而接受剖腹探查术的 512 克 ELBW 新生儿。此类 ELBW 新生儿的麻醉管理在文献中尚未见报道。
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引用次数: 0
期刊
Saudi Journal of Anaesthesia
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