B. R. Deshmukh, Parameswari Akshinthala, N. Katari, Girish K Deshpande, Leela Prasad Kowtharapu, Sreenivasa Rao Battula, R. Gundla
{"title":"Determination of Valbenazine related substances by liquid chromatography method complying with the current regulatory guidelines. Method robustness evaluation by Design of Experiments software","authors":"B. R. Deshmukh, Parameswari Akshinthala, N. Katari, Girish K Deshpande, Leela Prasad Kowtharapu, Sreenivasa Rao Battula, R. Gundla","doi":"10.1002/sscp.202300010","DOIUrl":"https://doi.org/10.1002/sscp.202300010","url":null,"abstract":"","PeriodicalId":21639,"journal":{"name":"SEPARATION SCIENCE PLUS","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2023-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44251338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
V. K. Vashistha, R. Bala, R. V. Pullabhotla, A. Mittal
{"title":"Enantiomeric separation of ketoprofen using Frovatriptan as a chiral derivatizing reagent","authors":"V. K. Vashistha, R. Bala, R. V. Pullabhotla, A. Mittal","doi":"10.1002/sscp.202300087","DOIUrl":"https://doi.org/10.1002/sscp.202300087","url":null,"abstract":"","PeriodicalId":21639,"journal":{"name":"SEPARATION SCIENCE PLUS","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2023-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47180766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sonam Choden, Deki Deki, Suwatchanee Maneeratanachot, N. Lehman, E. Kalkornsurapranee, M. Kaewpet, Dhassida Sooksawat, Itthipon Jeerapan, Apon Numnuam, P. Kanatharana, P. Thavarungkul, Chongdee Thammakhet-Buranachai
{"title":"Polypyrrole‐coated rubber foam sorbent for extraction of fipronil and fipronil sulfone in tea","authors":"Sonam Choden, Deki Deki, Suwatchanee Maneeratanachot, N. Lehman, E. Kalkornsurapranee, M. Kaewpet, Dhassida Sooksawat, Itthipon Jeerapan, Apon Numnuam, P. Kanatharana, P. Thavarungkul, Chongdee Thammakhet-Buranachai","doi":"10.1002/sscp.202300005","DOIUrl":"https://doi.org/10.1002/sscp.202300005","url":null,"abstract":"","PeriodicalId":21639,"journal":{"name":"SEPARATION SCIENCE PLUS","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2023-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42629276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abstract The present study describes sensitive liquid chromatography‐tandem mass spectrometry methods for the analysis of sucralose, mogroside V, neohesperidin dihydrochalcone, rebaudioside A, stevioside, and glycyrrhizic acid. All these compounds are used as sugar substitutes in food, beverages, and dietary supplements, and can be present in environmental and biological samples. The method describes the quantitation at levels as low as 10 ng/ml with a signal‐to‐noise significantly higher than 10 for the lowest standard, indicating a very low limit of quantification for all analytes. The method uses positive ionization liquid chromatography‐tandem mass spectrometry with the molecular ion [M + Cs] + and Cs + fragment ion (M is the analyte). The molecular ion [M + Cs] + is generated by adding a low level of Cs + in the mobile phase of high‐performance liquid chromatography separation. The advantages obtained using [M + Cs] + as molecular ions are related to the high sensitivity and simplicity of the method compared to other liquid chromatography‐tandem mass spectrometry procedures. As proof of functionality, the method was utilized for the analysis of sweeteners in several energy drinks. The high sensitivity of the liquid chromatography‐tandem mass spectrometry method was not needed for this type of analysis but for samples with low levels of sweeteners, the method can be highly beneficial.
{"title":"A liquid chromatography‐tandem mass spectrometry method for the analysis of sucralose and five glycoside sweeteners","authors":"Serban C. Moldoveanu","doi":"10.1002/sscp.202300068","DOIUrl":"https://doi.org/10.1002/sscp.202300068","url":null,"abstract":"Abstract The present study describes sensitive liquid chromatography‐tandem mass spectrometry methods for the analysis of sucralose, mogroside V, neohesperidin dihydrochalcone, rebaudioside A, stevioside, and glycyrrhizic acid. All these compounds are used as sugar substitutes in food, beverages, and dietary supplements, and can be present in environmental and biological samples. The method describes the quantitation at levels as low as 10 ng/ml with a signal‐to‐noise significantly higher than 10 for the lowest standard, indicating a very low limit of quantification for all analytes. The method uses positive ionization liquid chromatography‐tandem mass spectrometry with the molecular ion [M + Cs] + and Cs + fragment ion (M is the analyte). The molecular ion [M + Cs] + is generated by adding a low level of Cs + in the mobile phase of high‐performance liquid chromatography separation. The advantages obtained using [M + Cs] + as molecular ions are related to the high sensitivity and simplicity of the method compared to other liquid chromatography‐tandem mass spectrometry procedures. As proof of functionality, the method was utilized for the analysis of sweeteners in several energy drinks. The high sensitivity of the liquid chromatography‐tandem mass spectrometry method was not needed for this type of analysis but for samples with low levels of sweeteners, the method can be highly beneficial.","PeriodicalId":21639,"journal":{"name":"SEPARATION SCIENCE PLUS","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136355715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Akabari, J. Surati, Sagar Patel, Bhumin Pathak, A. Patel, C. Patel, Sagarkumar K. Patel
{"title":"Development and validation of high‐performance thin layer chromatographic method for simultaneous quantitation of novel combination perindopril erbumine and moxonidine hydrochloride","authors":"A. Akabari, J. Surati, Sagar Patel, Bhumin Pathak, A. Patel, C. Patel, Sagarkumar K. Patel","doi":"10.1002/sscp.202300051","DOIUrl":"https://doi.org/10.1002/sscp.202300051","url":null,"abstract":"","PeriodicalId":21639,"journal":{"name":"SEPARATION SCIENCE PLUS","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2023-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48217613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Simultaneous quantification of Fluticasone propionate and Olopatadine hydrochloride by High‐performance thin‐layer chromatography","authors":"Bhoomi Patel, S. Patel","doi":"10.1002/sscp.202300070","DOIUrl":"https://doi.org/10.1002/sscp.202300070","url":null,"abstract":"","PeriodicalId":21639,"journal":{"name":"SEPARATION SCIENCE PLUS","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2023-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45794562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yuan Liang, Jun Yin, Yu Yang, Ruiyan Huang, Penghui Hu, Chang Shu
{"title":"Simultaneous determination of paclitaxel and dasatinib in rat plasma and pharmacokinetic study on liquid chromatography‐tandem mass spectrometry","authors":"Yuan Liang, Jun Yin, Yu Yang, Ruiyan Huang, Penghui Hu, Chang Shu","doi":"10.1002/sscp.202300055","DOIUrl":"https://doi.org/10.1002/sscp.202300055","url":null,"abstract":"","PeriodicalId":21639,"journal":{"name":"SEPARATION SCIENCE PLUS","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2023-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47147244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abstract This study was designed to enable the development of a simple, fast, and environmentally friendly analytical technique utilizing dispersive liquid‐liquid microextraction based on surface floating organic droplets for selective and quantitative enrichment of trace level pesticide contaminants from different fruit juice samples for subsequent detection by high performance liquid chromatography, combined with a diode array detector. The selective extraction was necessitated in order to isolate the seven multiclass pesticide residues frequently occurring in fruit juice samples. The effects of experimental parameters such as pH of sample solution, type and volume of extraction and dispersive solvents, ionic strength and extraction time were optimized. The optimized method was validated using spiked blank sample and satisfactory results for accuracy, with recoveries ranging from 87.23% to 99.45%, with %relative standard deviation between 1.37 and 8.39, precision in terms of %relative standard deviation ≤ 10.78 and linearity at concentration levels from 3 to 1500 ng/ml, which corresponded with correlation coefficients ≥ 0.998. The limits of detection and the limits of quantification were ranged from 1.3×10 −2 to 5.3×10 −2 and 4.2×10 −2 to 1.8×10 −1 μg/L, respectively. At the end, the method was successfully applied to analyze real fruit juice samples and target analytes were not detected in real samples.
{"title":"Fast surface floating organic droplets based dispersive liquid‐liquid microextraction for trace enrichment of multiclass pesticide residues from different fruit juice samples followed by high performance liquid chromatography–diode array detection analysis","authors":"Habtamu Bekele, Negussie Megersa","doi":"10.1002/sscp.202300042","DOIUrl":"https://doi.org/10.1002/sscp.202300042","url":null,"abstract":"Abstract This study was designed to enable the development of a simple, fast, and environmentally friendly analytical technique utilizing dispersive liquid‐liquid microextraction based on surface floating organic droplets for selective and quantitative enrichment of trace level pesticide contaminants from different fruit juice samples for subsequent detection by high performance liquid chromatography, combined with a diode array detector. The selective extraction was necessitated in order to isolate the seven multiclass pesticide residues frequently occurring in fruit juice samples. The effects of experimental parameters such as pH of sample solution, type and volume of extraction and dispersive solvents, ionic strength and extraction time were optimized. The optimized method was validated using spiked blank sample and satisfactory results for accuracy, with recoveries ranging from 87.23% to 99.45%, with %relative standard deviation between 1.37 and 8.39, precision in terms of %relative standard deviation ≤ 10.78 and linearity at concentration levels from 3 to 1500 ng/ml, which corresponded with correlation coefficients ≥ 0.998. The limits of detection and the limits of quantification were ranged from 1.3×10 −2 to 5.3×10 −2 and 4.2×10 −2 to 1.8×10 −1 μg/L, respectively. At the end, the method was successfully applied to analyze real fruit juice samples and target analytes were not detected in real samples.","PeriodicalId":21639,"journal":{"name":"SEPARATION SCIENCE PLUS","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135363418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Development and validation of a liquid chromatography–tandem mass spectrometry method of a panel of commonly prescribed benzodiazepines in urine samples","authors":"C. Karakukcu, H. Saraçoglu","doi":"10.1002/sscp.202300036","DOIUrl":"https://doi.org/10.1002/sscp.202300036","url":null,"abstract":"","PeriodicalId":21639,"journal":{"name":"SEPARATION SCIENCE PLUS","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2023-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48330228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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