Pub Date : 2021-09-05DOI: 10.1183/13993003.congress-2021.pa374
G. Trakada, Vlasios K. Dimitriadis, A. Amfilochiou, Dimitra Siopi, Vasiliki Paschidou, C. Alexopoulou, Georgia Varsou, A. Konstantinidis, P. Steiropoulos, A. Pataka, C. Karachristos, M. Agrafiotis, Anastasia Chasiotou, Charikleia Tselepi, A. Kallianos, M. Fountoulaki, A. Gounidis, Konstantinos Porpodis, E. Kondili, P. Natsiavas, V. Tsara
{"title":"Prevalence of Cardiometabolic Disease in the Greek Sleep Apnea Patients Cohort","authors":"G. Trakada, Vlasios K. Dimitriadis, A. Amfilochiou, Dimitra Siopi, Vasiliki Paschidou, C. Alexopoulou, Georgia Varsou, A. Konstantinidis, P. Steiropoulos, A. Pataka, C. Karachristos, M. Agrafiotis, Anastasia Chasiotou, Charikleia Tselepi, A. Kallianos, M. Fountoulaki, A. Gounidis, Konstantinos Porpodis, E. Kondili, P. Natsiavas, V. Tsara","doi":"10.1183/13993003.congress-2021.pa374","DOIUrl":"https://doi.org/10.1183/13993003.congress-2021.pa374","url":null,"abstract":"","PeriodicalId":21645,"journal":{"name":"Sleep and control of breathing","volume":"95 3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87680755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-09-05DOI: 10.1183/13993003.congress-2021.pa748
Aurelia Reiser, M. Furian, A. Buergin, L. Mayer, M. Lichtblau, S. Schneider, P. Bader, P. Appenzeller, L. Muralt, M. Mademilov, Shoira Aydaralieva, A. Abdraeva, Aybermet Muratbekova, T. Sooronbaev, S. Ulrich, K. Bloch
{"title":"Effect of acetazolamide on visuomotor performance at altitude in healthy people older than 40 years: RCT","authors":"Aurelia Reiser, M. Furian, A. Buergin, L. Mayer, M. Lichtblau, S. Schneider, P. Bader, P. Appenzeller, L. Muralt, M. Mademilov, Shoira Aydaralieva, A. Abdraeva, Aybermet Muratbekova, T. Sooronbaev, S. Ulrich, K. Bloch","doi":"10.1183/13993003.congress-2021.pa748","DOIUrl":"https://doi.org/10.1183/13993003.congress-2021.pa748","url":null,"abstract":"","PeriodicalId":21645,"journal":{"name":"Sleep and control of breathing","volume":"32 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82779446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-09-05DOI: 10.1183/13993003.congress-2021.oa4386
A. Prigent, C. Pellen, J. Texereau, S. Bailly, N. Coquerel, R. Gervais, J. Liégaux, R. Luraine, J. Renaud, Serandour Anne Laure, J. Pépin
{"title":"Cheyne-Stokes respiration tracked by CPAP telemonitoring can detect serious cardiac events","authors":"A. Prigent, C. Pellen, J. Texereau, S. Bailly, N. Coquerel, R. Gervais, J. Liégaux, R. Luraine, J. Renaud, Serandour Anne Laure, J. Pépin","doi":"10.1183/13993003.congress-2021.oa4386","DOIUrl":"https://doi.org/10.1183/13993003.congress-2021.oa4386","url":null,"abstract":"","PeriodicalId":21645,"journal":{"name":"Sleep and control of breathing","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81505070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-09-05DOI: 10.1183/13993003.congress-2021.pa381
T. Imen, Ayeb Jihen, Omrane Amira, K. Souhir, B. Yosra, K. B. Nadia, B. Soumaya, Baili Hassen, Bouzgarrou Lamia, K. Jalel, B. Leila
{"title":"Quality of life impairment in patients with obstructive sleep apnea","authors":"T. Imen, Ayeb Jihen, Omrane Amira, K. Souhir, B. Yosra, K. B. Nadia, B. Soumaya, Baili Hassen, Bouzgarrou Lamia, K. Jalel, B. Leila","doi":"10.1183/13993003.congress-2021.pa381","DOIUrl":"https://doi.org/10.1183/13993003.congress-2021.pa381","url":null,"abstract":"","PeriodicalId":21645,"journal":{"name":"Sleep and control of breathing","volume":"44 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88416002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-09-05DOI: 10.1183/13993003.congress-2021.pa2087
A. Rajhan, Gavin Comber, M. McGee, Ann Cooper, A. Thomas, M. Allen
{"title":"Delivering sleep services in the COVID-19 era","authors":"A. Rajhan, Gavin Comber, M. McGee, Ann Cooper, A. Thomas, M. Allen","doi":"10.1183/13993003.congress-2021.pa2087","DOIUrl":"https://doi.org/10.1183/13993003.congress-2021.pa2087","url":null,"abstract":"","PeriodicalId":21645,"journal":{"name":"Sleep and control of breathing","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84180934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-09-05DOI: 10.1183/13993003.congress-2021.pa738
N. Skjodt, R. S. Platt
{"title":"Positive airway pressure emergent Cheyne-Stokes breathing","authors":"N. Skjodt, R. S. Platt","doi":"10.1183/13993003.congress-2021.pa738","DOIUrl":"https://doi.org/10.1183/13993003.congress-2021.pa738","url":null,"abstract":"","PeriodicalId":21645,"journal":{"name":"Sleep and control of breathing","volume":"34 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89713548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-09-07DOI: 10.1101/2021.06.03.21258051
A. Zamani, Ş. Yosunkaya, Adil Zamani, H. Vatansev, A. Arslan, M. Yıldırım
Background and aim: The obstructive sleep apnea (OSA) is a common, complex and polygenic disease and it has high risk of serious complications. The human leukocyte antigen (HLA) system plays a crucial role in the regulation of immune function by discriminating self from non-self. In recent years there has been rapid advancement in "Next Generation Sequencing" technology. It enables the detection of HLA alleles in four or even six digits, providing a high level of precision. The aim of the present study was to investigate the genetic variants at HLA-A,-B,-C,-DQB1 and -DRB1 loci in OSA patients and unrelated healthy individuals by targeted NGS in the Turkish population. Materials methods: Fifty newly diagnosed patients with OSA and 50 control subjects were enrolled in the study. OSA diagnosis was made by utilizing the apnea-hypopnea index (AHI)[≥]5 in overnight polysomnography (PSG). Blood samples were obtained in the morning, after PSG. Controls were randomly selected from healthy volunteers who had a low risk for OSA. Genotyping of HLA-A, B, C, DRB1 and DQB1 genes were performed by using next generation sequencing. Results: HLA-A*02:01, HLA-C*03:03:01, HLA-C*14:03, HLA DRB1*04:05 alleles were found more frequently in OSA patients, but not in the controls (p=0.036, p=0.007, p=0.043 and 0.013, respectively). The allele frequencies of HLA-A*03:01 and HLA-B*35:02 were significantly higher in controls compared to OSA patients (p=0.024 and p=0.043). Conclusion: These results suggest that HLA-A*02:01, HLA-C*03:03:01, HLA-C*14:03, HLA DRB1*04:05 alleles may play a predisposing role in the Turkish population with OSA. In addition, HLA-A*03:01 and HLA-B*35:02 alleles may be protective in this population.
背景与目的:阻塞性睡眠呼吸暂停(OSA)是一种常见、复杂、多基因的疾病，其并发症发生率高。人类白细胞抗原(HLA)系统在免疫功能的调节中起着至关重要的作用。近年来，“下一代测序”技术发展迅速。它可以检测四位数甚至六位数的HLA等位基因，提供了高水平的精度。本研究的目的是通过靶向NGS在土耳其人群中研究OSA患者和非相关健康个体中HLA-A、-B、-C、-DQB1和-DRB1位点的遗传变异。材料方法:新诊断的OSA患者50例，对照组50例。利用夜间多导睡眠图(PSG)的呼吸暂停低通气指数(AHI)[≥]5进行OSA诊断。经PSG治疗后，于上午采集血样。对照组是从患阻塞性睡眠呼吸暂停综合症风险较低的健康志愿者中随机选择的。对HLA-A、B、C、DRB1和DQB1基因进行下一代测序分型。结果:HLA- a *02:01、HLA- c *03:03:01、HLA- c *14:03、HLA DRB1*04:05等位基因在OSA患者中较常见(p=0.036、p=0.007、p=0.043、0.013)。对照组HLA-A*03:01和HLA-B*35:02等位基因频率显著高于OSA患者(p=0.024和p=0.043)。结论:HLA- a *02:01、HLA- c *03:03:01、HLA- c *14:03、HLA DRB1*04:05等位基因可能在土耳其人OSA发病中起易感作用。此外，HLA-A*03:01和HLA-B*35:02等位基因可能在该人群中具有保护作用。
{"title":"Relationship between obstructive sleep apnea and human leukocyte antigen variants","authors":"A. Zamani, Ş. Yosunkaya, Adil Zamani, H. Vatansev, A. Arslan, M. Yıldırım","doi":"10.1101/2021.06.03.21258051","DOIUrl":"https://doi.org/10.1101/2021.06.03.21258051","url":null,"abstract":"Background and aim: The obstructive sleep apnea (OSA) is a common, complex and polygenic disease and it has high risk of serious complications. The human leukocyte antigen (HLA) system plays a crucial role in the regulation of immune function by discriminating self from non-self. In recent years there has been rapid advancement in \"Next Generation Sequencing\" technology. It enables the detection of HLA alleles in four or even six digits, providing a high level of precision. The aim of the present study was to investigate the genetic variants at HLA-A,-B,-C,-DQB1 and -DRB1 loci in OSA patients and unrelated healthy individuals by targeted NGS in the Turkish population. Materials methods: Fifty newly diagnosed patients with OSA and 50 control subjects were enrolled in the study. OSA diagnosis was made by utilizing the apnea-hypopnea index (AHI)[≥]5 in overnight polysomnography (PSG). Blood samples were obtained in the morning, after PSG. Controls were randomly selected from healthy volunteers who had a low risk for OSA. Genotyping of HLA-A, B, C, DRB1 and DQB1 genes were performed by using next generation sequencing. Results: HLA-A*02:01, HLA-C*03:03:01, HLA-C*14:03, HLA DRB1*04:05 alleles were found more frequently in OSA patients, but not in the controls (p=0.036, p=0.007, p=0.043 and 0.013, respectively). The allele frequencies of HLA-A*03:01 and HLA-B*35:02 were significantly higher in controls compared to OSA patients (p=0.024 and p=0.043). Conclusion: These results suggest that HLA-A*02:01, HLA-C*03:03:01, HLA-C*14:03, HLA DRB1*04:05 alleles may play a predisposing role in the Turkish population with OSA. In addition, HLA-A*03:01 and HLA-B*35:02 alleles may be protective in this population.","PeriodicalId":21645,"journal":{"name":"Sleep and control of breathing","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72918888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-09-07DOI: 10.1183/13993003.congress-2020.2544
Andrea Herranz Mochales, Caterina Ribot Quetglas, Maria Barceló Nicolau, Ainhoa Álvarez Ruiz De Larriaga, A. Bennasar, Amanda Iglesias Coma, Daniel Morell Garcia, Mónica Bravo, Jose Antonio Peña Zarza, Margarita Bosch Artigues, María Paloma Giménez Carrero, J. D. Cantolla, J. M. Trigo, Mercedes Codina Marcet, P. Rodríguez, Carla Pía Martínez, María Concepción Piñas Cebrián, Maria Cerdà Moncadas, Andrés Sánchez Barón, A. Fernández
{"title":"Influence of Obstructive Sleep Apnea on systemic inflammation in pregnancy","authors":"Andrea Herranz Mochales, Caterina Ribot Quetglas, Maria Barceló Nicolau, Ainhoa Álvarez Ruiz De Larriaga, A. Bennasar, Amanda Iglesias Coma, Daniel Morell Garcia, Mónica Bravo, Jose Antonio Peña Zarza, Margarita Bosch Artigues, María Paloma Giménez Carrero, J. D. Cantolla, J. M. Trigo, Mercedes Codina Marcet, P. Rodríguez, Carla Pía Martínez, María Concepción Piñas Cebrián, Maria Cerdà Moncadas, Andrés Sánchez Barón, A. Fernández","doi":"10.1183/13993003.congress-2020.2544","DOIUrl":"https://doi.org/10.1183/13993003.congress-2020.2544","url":null,"abstract":"","PeriodicalId":21645,"journal":{"name":"Sleep and control of breathing","volume":"36 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73776220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-09-07DOI: 10.1183/13993003.congress-2020.1344
W. Chumpangern, N. Chirakalwasan
Background: Tele-monitoring system is the promising wireless technology which possibly enhances the adherence to CPAP therapy, since the efficacy of CPAP in reducing OSA-related cardiovascular events is proportionally related to the adherence. Methods: A prospective randomized controlled trial enrolled 60 Asian adults with moderate-to-severe OSA. Thirty patients each were randomized to CPAP with tele-monitoring system (TM group) or CPAP with usual care (UC group). Tele-monitoring system functions by transferring CPAP-usage data via cellular network. If there were any triggers occurring 2 nights consecutively (use hour 27 L/min or AHI>5/hr), the investigator contacted patients. The primary outcome was the 4-week CPAP usage hour per night. The secondary outcome included % good adherence, median leakage per night, adverse events from CPAP therapy, sleep quality improvement and daytime sleepiness reduction. Results: Seventy percent of participants were male and average AHI was 50.3/hr. The 4-week CPAP usage hour per night was insignificantly higher in TM group (5.16 ±1.47 hr/night vs 4.42 ±1.91 hr/night, p-value = 0.18). However, % good adherence was significantly higher in TM group (64.2% vs 34.4%, p-value = 0.0024). Median leakage per night was also significant lower in TM group. Significant sleep quality improvement was observed in TM group. Overall adverse events and daytime sleepiness reduction were not significantly different. Conclusion: The tele-monitoring system implementation in CPAP insignificantly increased the nightly hour usage and significantly improved adherence as well as sleep quality among Asian moderate-to-severe OSA.
背景:远程监测系统是一种很有前途的无线技术，它可能会提高CPAP治疗的依从性，因为CPAP治疗减少osa相关心血管事件的疗效与依从性成正比。方法:一项前瞻性随机对照试验纳入了60名患有中重度OSA的亚洲成年人。30例患者随机分为远程监护CPAP组(TM组)和常规护理CPAP组(UC组)。远程监控系统通过蜂窝网络传输cpap使用数据。如果连续2晚出现任何触发(使用小时27l /min或AHI>5/hr)，研究者联系患者。主要终点为4周CPAP每晚使用小时数。次要结局包括良好依从率、每晚中位数渗漏、CPAP治疗不良事件、睡眠质量改善和白天嗜睡减少。结果:70%的参与者为男性，平均AHI为50.3/hr。TM组4周CPAP每晚使用小时数显著高于TM组(5.16±1.47小时/晚vs 4.42±1.91小时/晚，p值= 0.18)。而TM组良好依从率明显高于TM组(64.2% vs 34.4%， p值= 0.0024)。TM组每晚渗漏中位数也显著降低。TM组患者睡眠质量明显改善。总的不良事件和白天嗜睡的减少没有显著差异。结论:在亚洲中重度OSA患者中，CPAP远程监测系统的实施不显著增加了夜间睡眠时间的使用，显著改善了依从性和睡眠质量。
{"title":"Tele-monitoring system implementation in continuous positive airway pressure therapy in Asian obstructive sleep apnea","authors":"W. Chumpangern, N. Chirakalwasan","doi":"10.1183/13993003.congress-2020.1344","DOIUrl":"https://doi.org/10.1183/13993003.congress-2020.1344","url":null,"abstract":"Background: Tele-monitoring system is the promising wireless technology which possibly enhances the adherence to CPAP therapy, since the efficacy of CPAP in reducing OSA-related cardiovascular events is proportionally related to the adherence. Methods: A prospective randomized controlled trial enrolled 60 Asian adults with moderate-to-severe OSA. Thirty patients each were randomized to CPAP with tele-monitoring system (TM group) or CPAP with usual care (UC group). Tele-monitoring system functions by transferring CPAP-usage data via cellular network. If there were any triggers occurring 2 nights consecutively (use hour 27 L/min or AHI>5/hr), the investigator contacted patients. The primary outcome was the 4-week CPAP usage hour per night. The secondary outcome included % good adherence, median leakage per night, adverse events from CPAP therapy, sleep quality improvement and daytime sleepiness reduction. Results: Seventy percent of participants were male and average AHI was 50.3/hr. The 4-week CPAP usage hour per night was insignificantly higher in TM group (5.16 ±1.47 hr/night vs 4.42 ±1.91 hr/night, p-value = 0.18). However, % good adherence was significantly higher in TM group (64.2% vs 34.4%, p-value = 0.0024). Median leakage per night was also significant lower in TM group. Significant sleep quality improvement was observed in TM group. Overall adverse events and daytime sleepiness reduction were not significantly different. Conclusion: The tele-monitoring system implementation in CPAP insignificantly increased the nightly hour usage and significantly improved adherence as well as sleep quality among Asian moderate-to-severe OSA.","PeriodicalId":21645,"journal":{"name":"Sleep and control of breathing","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83312955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-09-07DOI: 10.1183/13993003.congress-2020.2535
S. Pini, M. Rizzi, M. Saad, P. Gaboardi, M. Pecis, D. Radovanovic, P. Santus
{"title":"Prevalence of gastroesophageal reflux symptoms in obstructive sleep apnea","authors":"S. Pini, M. Rizzi, M. Saad, P. Gaboardi, M. Pecis, D. Radovanovic, P. Santus","doi":"10.1183/13993003.congress-2020.2535","DOIUrl":"https://doi.org/10.1183/13993003.congress-2020.2535","url":null,"abstract":"","PeriodicalId":21645,"journal":{"name":"Sleep and control of breathing","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85253600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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