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The use of babassu agro-industrial residues in animal feed, in addition to being an economic option of great importance in reducing the environmental impact in regions of the Brazilian Cerrado, provides the production of good quality foods of animal origin due to its nutritional characteristics. However, information related to the nutritional components of babassu by-industrial residues has not yet been sufficiently explored. The aim of this study was to evaluate the nutritional potential of some by-products from the babassu production chain through chemical composition and in situ degradability analyses. The experiment was conducted in a completely randomized experimental design, with 4 by-products from babassu processing (cake, greasy, fine flour, and 95 µm flour) and 5 replications. The by-products differ in terms of chemical composition, except for the hemicellulose content. For the degradability of fraction "a" of dry matter, it presented a higher percentage for 95 µm flour. Fine flour and 95 µm flour presented the highest fractions "b" and "c," potential, and effective degradability of dry matter. For the degradation of crude protein, the highest percentages of potential and effective degradability were observed for greasy and 95 µm flour. The highest standardized potentially degradable fraction and the highest passage rate were obtained by 95 µm flour, which also showed greater degradation for dry matter, crude protein, and neutral detergent fiber. Among the by-products studied, the babassu cake has superior chemical composition; however, the 95 µm flour presented nutritional value and satisfactory rumen degradation to be used as an additive or in partial replacement of traditional concentrates.

Background: The Babon River is one of the drainage channels in Semarang, Indonesia, that is used for drinking water, irrigated agriculture of paddy fields and gardens, fish farming media, and the disposal of industrial wastewater. This study aimed to assess the spatial distribution of metals in the sediment of the Babon River through the utilization of different pollution indices. These indices included concentration factor (Cf), contamination factor (CF), enrichment factor (EF), geoaccumulation index (Igeo), sediment pollution index (SPI), threshold effect level (TEL), and probable effect level (PEL).

Methods: Seven sampling locations were sampled for water and sediment in April, June, and September of 2021. The measurement of the metal was conducted using an atomic absorption spectrophotometer.

Results: The findings of the study demonstrated that sediments with a predominant sand texture exhibited higher levels of Cd and Pb, while the sediments characterized by a predominant clay texture had a higher concentration of Cr. Upon analyzing the Cf, CF, EF, Igeo, and SPI data, it has been confirmed that the sediment in the Babon River has substantial levels of Cd, Cr, and Pb. According to the TEL and PEL values, it can be observed that the presence of Cd and Pb has detrimental effects on the biological health of the benthic biota.

Conclusions: The aquatic biota and the benthic environment may be subject to adverse effects in the event where the concentration of metals in the sediment is higher than the natural concentration of metals.

Background: Nontyphoidal salmonella (NTS) are responsible for food-borne gastroenteritis and bacteremia, in immunosuppressed individuals. Antibiotic resistance in NTS is on the rise. This study reports the prevalence and antimicrobial susceptibility of nontyphoidal salmonella in clinical samples. Study Design. This is a hospital record-based cross-sectional, retrospective study.

Methods: In our study, inpatient samples such as blood (n = 13546), urine (n = 11,333), pus (n = 1,010), and stool (n = 926) samples were cultured to isolate etiological agents in the microbiology department from January 2017 to June 2019. Relevant details such as duration of fever, platelet count, hemoglobin, WBC count, immune status, and mode of treatment were noted from the medical records. Data were analyzed, and continuous variables were expressed as mean and categorical variables as percentages.

Results: A total of 24 NTS serovars were isolated, which included ten isolates from blood, five each from urine and pus, and four from stool samples. Of the NTS, five were Salmonella enterica subsp. enterica, three were S.enterica serovar Typhimurium, one was S.enterica subsp. diarizonae, and 15 S.enterica serovars could not be serologically differentiated. All were susceptible to ampicillin, chloramphenicol, and cefuroxime. However, 16.6% of NTS was resistant to ceftriaxone, 4% to cotrimoxazole, 58% to ciprofloxacin, and 75% to nalidixic acid.

Conclusions: A low prevalence of NTS responsible for invasive infections is seen in this part of the country. Few isolates were resistant to more than one antibiotic. A higher rate of resistance to ceftriaxone is the cause of concern. Awareness of the distribution of NTS serogroups is of epidemiological and public health significance.

The Wof-Washa Natural State Forest (WWNSF) in Ethiopia harbors remarkable biodiversity but faces threats from local communities, climate change, and a lack of awareness regarding its preservation. Although numerous studies exist, the economic value of the forest's ecosystem services (FESs) has been largely overlooked. Thus, the purposes of this study were to identify FESs, estimate their total economic value, and assess challenges with possible strategies for sustainable forest management. The research employed Google Earth to estimate forest area and socioeconomic surveys with field visits to gather data from 368 participants for analyzing the FESs, monetary values, and challenges with possible strategies. Analyses included descriptive statistics, total economic valuation (TEV), and an ordinary least squares regression model. The study revealed that the WWNSF provides crucial provisioning services (timber, honey, water, and firewood), regulating services (soil erosion control and climate change mitigation), and supporting services (soil formation and nutrient cycling). The forest's annual contribution to sampled households averaged $1152.30, with regulating and cultural services valued at $14,112 and $622.00, respectively. The study also revealed that male-headed households, larger families, and those having limited farmland and off-farm income depended more heavily on the forest. Therefore, farmland scarcity, settlements, and tree harvesting for firewood, timber, and agricultural tools, as well as the lack of employment opportunities, were the main challenges encountered in the study area. This suggests that despite degradation and reduction in size due to human pressures, the WWNSF remains a significant source of socioeconomic and ecological benefits, supporting local livelihoods and biodiversity. To ensure the forest's restoration, prioritizing community participation, promoting family planning, providing alternative income opportunities especially for youth, and balancing resource use with conservation efforts are possible strategies that should be taken into account.

Since its discovery, numerous studies have shown the role of the microbiota in well-being and disease. The gut microbiota represents an essential factor that plays a multidirectional role that affects not just the gut but also other parts of the body, including the brain, endocrine system, humoral system, immune system, and metabolic pathways, as well as host-microbiome interactions. Through a comprehensive analysis of existing literature using the desktop research methodology, this review elucidates the mechanisms by which gut microbiota dysbiosis contributes to metabolic dysfunction, including obesity, dyslipidaemia, hypertension, atherosclerosis, hyperuricemia, and hyperglycaemia. Furthermore, it examines the bidirectional communication pathways between gut microbiota and host metabolism, highlighting the role of microbial-derived metabolites, immune modulation, and gut barrier integrity in shaping metabolic homeostasis. Importantly, the review identifies promising therapeutic strategies targeting the gut microbiota as potential interventions for metabolic syndrome, including probiotics, prebiotics, symbiotics, dietary modifications, and faecal microbiota transplantation. By delineating the bidirectional interactions between gut microbiota and metabolic syndrome, the review not only advances our understanding of disease pathophysiology but also underscores the potential for innovative microbiota-based interventions to mitigate the global burden of metabolic syndrome and its associated complications.

This study aimed to investigate the impact of the Edmodo mobile learning environment on promoting psychological security among university students with visual impairments, at both the undergraduate and postgraduate levels. The researchers employed a combination of descriptive and quasiexperimental methodologies. The primary study sample consisted of 20 visually impaired students from Beni Suef University, divided equally between an experimental group (10 students) and a control group (10 students). To achieve the research objectives, the Psychological Security Scale was utilized and the experimental group received an intervention involving the implementation of a mobile learning environment using Edmodo. The data analysis revealed a statistically significant difference between the experimental and control groups in the postassessment, with the experimental group demonstrating an elevated sense of psychological security. Furthermore, the experimental group showed significant improvements in the pre- and postassessments, favoring the latter, with a standard score of 3.781. No significant differences were observed between the postassessment and the follow-up evaluation of the experimental group, with a standard score of 0.471, indicating the continuous effectiveness of the Edmodo mobile learning environment in enhancing the psychological security of visually impaired university students. This efficacy was sustained even one month after the student's graduation, as evidenced by the follow-up assessment.

Yield stability, alongside high yield potential and broad adaptation to various agroclimatic environments, is a key objective for rice breeders aiming to ensure food security. This study aimed to explore the most suitable and stable Boro rice genotypes for Bangladesh. Ten Boro rice genotypes underwent testing in four environments during the 2022 Boro season to investigate genotype-environment interaction (GEI) and yield stability performance. The experiment utilized three replications of a completely randomized block design. Yield stability performance was assessed through combined analysis and the additive main effects and multiplicative interaction (AMMI) model. The combined ANOVA revealed that the environment explained 10.23%, while GEI accounted for 9.17%, and the genotypes captured 80.60% of the variance, significantly impacting grain yield. Significance was observed in the environment, genotype main effects, and GEI. Analysis indicated that BRRI dhan 68 yielded the highest (6,754 kg·ha^-1) and BRRI dhan 88 the lowest (5,620 kg·ha^-1) among the investigated genotypes. In addition, genotypes BRRI dhan 84, BRRI dhan 81, and BRRI dhan 67 exhibited the highest grain yields. The Rangpur environment demonstrated considerable stability across the four environments with a high mean value of grain yield (7,206 kg·ha^-1). Therefore, the AMMI model emerges as a valuable tool for identifying the most suitable and stable Boro rice genotypes with high-yielding potential across various regions in Bangladesh, as well as under diverse conditions.

Stevia (Stevia rebaudiana), recognized for its low-calorie, sugar-free attributes, and various health benefits, has potential applications beyond human consumption, particularly in agriculture. This study explored the potential uses of Stevia in both agricultural and healthcare contexts by examining its plant-inhibitory, cytotoxic, and antioxidant effects. The methanolic extract of Stevia leaves was fractionated into hexane, ethyl acetate, chloroform, and water fractions. These fractions were then subjected to the bioassay analyses above and underwent identification of their chemical constituents. The results indicated that the ethyl acetate fraction demonstrated significant inhibitory effects on weed germination and growth of Beggars tick (Bidens frondosa) (100% inhibition at 1000 ppm of dose). This fraction also exhibited the highest antioxidant activity, total phenolic, and total flavonoid contents (IC₅₀ DPPH = 18.67 μg/mL, 103.50 mg GAE/g fraction, and 410.16 mg QE/g fraction, respectively). In contrast, the chloroform fraction showed the highest cytotoxic effect (LC₅₀ = 700.01 ppm) in the brine shrimp (Artemia salina) mortality evaluation. Pearson's correlation analysis revealed a positive correlation among plant inhibitory effects, antioxidant potentials, and phenolic/flavonoid contents of Stevia. FTIR spectra confirmed the presence of phenols and nonpolar components in the ethyl acetate and chloroform fractions. In addition, GC-MS analysis successfully identified Stevia's key constituents, including tetracontane, hexadecane, hexadecanoic acid, methyl ester in the ethyl acetate fraction, and spiro [4.5] decan-7-one and 6-hydroxy-4,4,7a-trimethyl-5,6,7,7a-tetrahydrobenzofuran-2(4H)-one in the chloroform fraction. This study underscores the potential of S. rebaudiana as a source of natural antioxidants and herbicides, offering valuable insights into its diverse applications in agriculture.

Background: Phytochemicals are considered the reliable source for the treatment of infection including malaria. Especially, phenols are known as potentially toxic to the growth and development of pathogens, among which flavonoids are the most extensively studied and play more intensive roles in ethnopharmacology. The immunological effect and role of T. diversifolia flavonoids-rich extract in treatment of malaria have therefore been examined in this study.

Methods: In vitro test against Plasmodium falciparum and 4-day suppressive and Rane's tests against Plasmodium berghei in mice were used to evaluate the antimalarial activities. TNF-α and INF-γ levels, phagocytic tests, and production of oxygen and nitrogen radical were assessed to appreciate the immunomodulatory activity. One-way analysis of variance followed by post hoc Student's t tests was used for data analysis.

Results: T. diversifolia flavonoids-rich extract at the concentrations ranging from 0.0004 mg/ml significantly (p < 0.05) inhibited in a concentration-dependent manner the growth of trophozoite up to 100% inhibition with 0.025 mg/ml at 24 and 48 hrs. Moreover, T. diversifolia flavonoids-rich extract reduced the level of parasitemia and improved in a dose-dependent manner the survival time of infected mice significantly (p < 0.05) compared to their control in 4-day suppressive test as well as in Rane's test. Additionally, T. diversifolia flavonoids-rich extract increased the TNF-α and INF-γ levels in rats infected by P. berghei. Furthermore, the flavonoid-rich extract enhanced weight of spleen in the rats, the metabolic and phagocytic activities of the peritoneal cells, and the concentration of nitric oxide and oxygen radicals in methylprednisolone-immunocompromised rats compared to the control (p < 0.05).

Conclusion: The study has revealed that T. diversifolia flavonoids-rich extract through its antiplasmodial and phagocytic activities is a promising treatment of malaria.

Globally, cardiovascular diseases are still the leading cause of death. Numerous methods are used to diagnose cardiovascular pathologies; there is still a place for straightforward and noninvasive techniques, such as electrocardiogram (ECG). Depolarization and repolarization parameters, including QT interval and its derivatives, are well studied. However, the Tpeak-Tend interval is a novel and promising ECG marker with growing evidence for its potential role in predicting malignant arrhythmias. In this review, we discuss the association between the Tpeak-Tend interval and several cardiovascular diseases, including long QT syndrome, cardiomyopathies, heart failure, myocardial infarction, and obesity, which constitutes one of the risk factors for cardiovascular diseases.