Pub Date : 2021-12-31DOI: 10.47363/jbbr/2021(3)141
U. Masood
In biology mutation is a change in the nucleotide sequences of the DNA of an organism Mainly there are three types of mutation: point mutation, deletion and insertions. Once the mutation has been defined allele specific oligonucleotide hybridization, amplification, heteroduplex formation method referred to as a diagnostic method some advance technique like CRISPR cas9 system is using for selected mutagenesis. Using restriction method system we can detect a mutation. Let’s say you have a DNA sample with fluorescent labeled from patient and you want to make sure that gene you are interested is in healthy gene. We can design different short fragment sequences to scan through DNA or find specific gene or mutation. The sequences scan the DNA if the sequences does not find targeted gene it does not bind to it its means that no fluorescence color appears under UV-light each different short fragment sequences is label with different colors. If the different short fragments sequence does not bind to the DNA or specific gene or area this means that there will be no color appear under UV light this part or gene will be separated from the DNA by using Restriction enzyme to do a Sanger sequencing gel electrophoresis. Result of the Sanger sequencing will provide the information about sequence of unknown part or gene of the DNA this method is easier and cost economic method instead of Next generation sequencing method [1-7].
{"title":"Unknown Mutation Detection via Restriction Hybridization Method Instead of Using Next Generation Sequencing Method","authors":"U. Masood","doi":"10.47363/jbbr/2021(3)141","DOIUrl":"https://doi.org/10.47363/jbbr/2021(3)141","url":null,"abstract":"In biology mutation is a change in the nucleotide sequences of the DNA of an organism Mainly there are three types of mutation: point mutation, deletion and insertions. Once the mutation has been defined allele specific oligonucleotide hybridization, amplification, heteroduplex formation method referred to as a diagnostic method some advance technique like CRISPR cas9 system is using for selected mutagenesis. Using restriction method system we can detect a mutation. Let’s say you have a DNA sample with fluorescent labeled from patient and you want to make sure that gene you are interested is in healthy gene. We can design different short fragment sequences to scan through DNA or find specific gene or mutation. The sequences scan the DNA if the sequences does not find targeted gene it does not bind to it its means that no fluorescence color appears under UV-light each different short fragment sequences is label with different colors. If the different short fragments sequence does not bind to the DNA or specific gene or area this means that there will be no color appear under UV light this part or gene will be separated from the DNA by using Restriction enzyme to do a Sanger sequencing gel electrophoresis. Result of the Sanger sequencing will provide the information about sequence of unknown part or gene of the DNA this method is easier and cost economic method instead of Next generation sequencing method [1-7].","PeriodicalId":219036,"journal":{"name":"Journal of Biotechnology & Bioinformatics Research","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131635059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-31DOI: 10.47363/jbbr/2021(3)140
V. Gota, Kharghar Navi India Education in Cancer, Diana Varghese, Shayma Karbelkar
Biosimilars are biologic products that are highly similar to a licensed reference biologic, with no clinically meaningful differences in quality characteristics, biological activity, safety, or efficacy. Biosimilars can help to fulfill unmet medical needs due to their cost effectiveness while at the same time being as efficacious as the innovator drug. They can also improve patient access to otherwise costly innovator biologics. India has the largest number of approved biosimilars as compared to the US and Europe. However, the numbers of clinical studies that are conducted to prove the biosimilarity are lesser than the number of biosimilars approved, which is evident by the number of CTRI registrations done. Some studies have shown the quality of biosimilars approved and marketed in India to be inferior to the innovator drug. This raises concerns regarding the quality of the biosimilars. In this review, the similarities and differences in the guidelines, the approval process, and quality enforcement measures prevailing in the three regulatory regions of USA, Europe and India are discussed. Changes in the approval process and post approval monitoring of drugs and manufacturing facilities are recommended in order to ensure sustained quality standards of drugs entering the market.
{"title":"Current State of Regulatory Oversight of Biosimilars in India and Its Implications on the Quality of Drugs: A Comparative Assessment with EU and FDA Regulations","authors":"V. Gota, Kharghar Navi India Education in Cancer, Diana Varghese, Shayma Karbelkar","doi":"10.47363/jbbr/2021(3)140","DOIUrl":"https://doi.org/10.47363/jbbr/2021(3)140","url":null,"abstract":"Biosimilars are biologic products that are highly similar to a licensed reference biologic, with no clinically meaningful differences in quality characteristics, biological activity, safety, or efficacy. Biosimilars can help to fulfill unmet medical needs due to their cost effectiveness while at the same time being as efficacious as the innovator drug. They can also improve patient access to otherwise costly innovator biologics. India has the largest number of approved biosimilars as compared to the US and Europe. However, the numbers of clinical studies that are conducted to prove the biosimilarity are lesser than the number of biosimilars approved, which is evident by the number of CTRI registrations done. Some studies have shown the quality of biosimilars approved and marketed in India to be inferior to the innovator drug. This raises concerns regarding the quality of the biosimilars. In this review, the similarities and differences in the guidelines, the approval process, and quality enforcement measures prevailing in the three regulatory regions of USA, Europe and India are discussed. Changes in the approval process and post approval monitoring of drugs and manufacturing facilities are recommended in order to ensure sustained quality standards of drugs entering the market.","PeriodicalId":219036,"journal":{"name":"Journal of Biotechnology & Bioinformatics Research","volume":"40 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121042982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-31DOI: 10.47363/jbbr/2021(3)139
V. Zaichick
Role of chemical elements (ChE) in etiology and pathogenesis of Riedel’s disease (RD) is unclear. The aim of this exploratory study was to assess whether there were significant changes in thyroid tissue levels of eight ChE (Br, Ca Cl, I, K, Mg, Mn, and Na) are present in the fibrotic transformed thyroid. Eight ChE of thyroid tissue were determined in 6 patients with RD. The control group included thyroid tissue samples from 105 healthy individuals. Measurements were conducted using non-destructive instrumental neutron activation analysis with high-resolution spectrometry of short-lived radionuclides. Reduced mean values of Ca and I content in 6.3 and 6.7 times, respectively, while elevated level of Br in 5.1 times were found in thyroid with RD in comparison with normal level. Because considerable changes in some ChE contents in tissue of thyroid with RD were found, it is reasonable to assume that the levels of these ChE in affected thyroid tissue can be used as RD markers. However, this topic needs additional studies.
{"title":"Comparison between Bromine, Calcium, Chlorine, Iodine, Potassium, Magnesium, Manganese, and Sodium Contents in Normal Thyroid and Riedel’s Struma","authors":"V. Zaichick","doi":"10.47363/jbbr/2021(3)139","DOIUrl":"https://doi.org/10.47363/jbbr/2021(3)139","url":null,"abstract":"Role of chemical elements (ChE) in etiology and pathogenesis of Riedel’s disease (RD) is unclear. The aim of this exploratory study was to assess whether there were significant changes in thyroid tissue levels of eight ChE (Br, Ca Cl, I, K, Mg, Mn, and Na) are present in the fibrotic transformed thyroid. Eight ChE of thyroid tissue were determined in 6 patients with RD. The control group included thyroid tissue samples from 105 healthy individuals. Measurements were conducted using non-destructive instrumental neutron activation analysis with high-resolution spectrometry of short-lived radionuclides. Reduced mean values of Ca and I content in 6.3 and 6.7 times, respectively, while elevated level of Br in 5.1 times were found in thyroid with RD in comparison with normal level. Because considerable changes in some ChE contents in tissue of thyroid with RD were found, it is reasonable to assume that the levels of these ChE in affected thyroid tissue can be used as RD markers. However, this topic needs additional studies.","PeriodicalId":219036,"journal":{"name":"Journal of Biotechnology & Bioinformatics Research","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115327583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-09-30DOI: 10.47363/jbbr/2021(3)136
Siniša Franjić, Dario Galić
Medical informatics is a scientific discipline that deals with the theory and practice of information processes in medical work, where information processes mean the coverage, transmission, storage and conversion of data. In other words, medical informatics is a scientific discipline that deals with the processing of all types of data in medicine.
{"title":"A Few Words about Medical Informatics","authors":"Siniša Franjić, Dario Galić","doi":"10.47363/jbbr/2021(3)136","DOIUrl":"https://doi.org/10.47363/jbbr/2021(3)136","url":null,"abstract":"Medical informatics is a scientific discipline that deals with the theory and practice of information processes in medical work, where information processes mean the coverage, transmission, storage and conversion of data. In other words, medical informatics is a scientific discipline that deals with the processing of all types of data in medicine.","PeriodicalId":219036,"journal":{"name":"Journal of Biotechnology & Bioinformatics Research","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115197196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-09-30DOI: 10.47363/jbbr/2021(3)138
Aamir Jalal Al-Mosawi
Background: The year 2020 witnessed the rapid spread of covid-19 pandemic in Iraq and in almost all the countries in the world. This spread has created a serious health crises and a public health emergency in Iraq and throughout the world. Throughout the world, healthcare systems have been negatively influenced by the pandemic and experienced unexpected changes. We have previously provided several descriptions of the Iraq health care system from its evolution. However, little is known about the health care system in Iraq during the first year of the coves pandemic. The aim of this paper is provide a description of the healthcare system in Iraq during the year 2020, the first year of covid-19 global pandemic. Materials and Methods: The available unpublished and published data about the Iraqi healthcare system during the first year of covid-19 pandemic, the year 2020 were examined. The data included more than 100 relevant unpublished and published information documents including journal articles, books, official reports of the Iraqi Ministry of Planning and Iraqi Ministry of Health. In addition, relevant useful data available at internet web sites were also reviewed. The available relevant data were classified into categories including; demographic data relevant to healthcare, Data related to covid-19 disease in Iraq, data related to the organizational structure of the healthcare system, data related to national healthcare policies including national healthcare mission, vision, strategic goals and plans, data related to healthcare system financing, data about healthcare services delivery, data about the workforce in the Iraq healthcare system, data related to child health and maternal, data about notifiable infectious disease, data about chronic disorders and the main causes of morbidity and mortality, and data about medical education and healthcare education. Many relevant healthcare data for three provinces (The Kurdish provinces in the north of Iraq) of the eighteen provinces in Iraq were not available in English or Arabic. Results: The population of Iraq in 2020 was estimated at 40.150.174 (20.284.823 males and 19.865.351 females). During the year 2020, 595291 cases of covid-19 disease were registered by the Iraqi Ministry of Health. 12813 (2.15%) patients died and 537841 (90.3%) patients experienced recovery. The organizational structure of the Iraq health system, the backbone of the Iraq healthcare system witnessed no important change from the description before covid-19 global pandemic in 2019. The declared mission and vision of the Iraqi Ministry of Health for the year 2020 were the same mission and vision of the Iraqi Ministry of Health that were declared in 2018. In 2020, the Iraqi Ministry of Health declared a strategic plan which included a vision and mission statements for the health information system. The first year of covid-19 pandemic in Iraq was not associated with an important increase in the number of primary healthcare centers.
{"title":"Iraq Healthcare System During the First Year of Covid-19 Pandemic","authors":"Aamir Jalal Al-Mosawi","doi":"10.47363/jbbr/2021(3)138","DOIUrl":"https://doi.org/10.47363/jbbr/2021(3)138","url":null,"abstract":"Background: The year 2020 witnessed the rapid spread of covid-19 pandemic in Iraq and in almost all the countries in the world. This spread has created a serious health crises and a public health emergency in Iraq and throughout the world. Throughout the world, healthcare systems have been negatively influenced by the pandemic and experienced unexpected changes. We have previously provided several descriptions of the Iraq health care system from its evolution. However, little is known about the health care system in Iraq during the first year of the coves pandemic. The aim of this paper is provide a description of the healthcare system in Iraq during the year 2020, the first year of covid-19 global pandemic. Materials and Methods: The available unpublished and published data about the Iraqi healthcare system during the first year of covid-19 pandemic, the year 2020 were examined. The data included more than 100 relevant unpublished and published information documents including journal articles, books, official reports of the Iraqi Ministry of Planning and Iraqi Ministry of Health. In addition, relevant useful data available at internet web sites were also reviewed. The available relevant data were classified into categories including; demographic data relevant to healthcare, Data related to covid-19 disease in Iraq, data related to the organizational structure of the healthcare system, data related to national healthcare policies including national healthcare mission, vision, strategic goals and plans, data related to healthcare system financing, data about healthcare services delivery, data about the workforce in the Iraq healthcare system, data related to child health and maternal, data about notifiable infectious disease, data about chronic disorders and the main causes of morbidity and mortality, and data about medical education and healthcare education. Many relevant healthcare data for three provinces (The Kurdish provinces in the north of Iraq) of the eighteen provinces in Iraq were not available in English or Arabic. Results: The population of Iraq in 2020 was estimated at 40.150.174 (20.284.823 males and 19.865.351 females). During the year 2020, 595291 cases of covid-19 disease were registered by the Iraqi Ministry of Health. 12813 (2.15%) patients died and 537841 (90.3%) patients experienced recovery. The organizational structure of the Iraq health system, the backbone of the Iraq healthcare system witnessed no important change from the description before covid-19 global pandemic in 2019. The declared mission and vision of the Iraqi Ministry of Health for the year 2020 were the same mission and vision of the Iraqi Ministry of Health that were declared in 2018. In 2020, the Iraqi Ministry of Health declared a strategic plan which included a vision and mission statements for the health information system. The first year of covid-19 pandemic in Iraq was not associated with an important increase in the number of primary healthcare centers.","PeriodicalId":219036,"journal":{"name":"Journal of Biotechnology & Bioinformatics Research","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127946248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-09-07DOI: 10.47363/jbbr/2021(3)137
Inass Omer Mohamed Malik, H. M. Hamadnalla
The date palm (Phoenix dactylifera L.) is one of mankind’s oldest cultivated plants. A date palm fruit is an important component of the diet in most of the hot arid and semi-arid regions of the world. The Present study aimed at investigating two heavy metals (lead, Pb) and (cadmium, Cd) as mg/kg in three date palm cultivars cultivated in Sudan (Gondalia, Barakawi and Kulma). The results showed insignificant (p ≥ 0.05) concentration of the two heavy metals (cadmium and lead) between the various cultivars in the four local market (sites) (Libya, Bahri, Soug Sitta and workshop). Cadmium concentration was ranged from (0.006 - 0.043 mg/kg) and lead (0.02 - 0.029 mg/kg) for all cultivars at the four locations. Although most of the cultivars had comparable concentration of cadmium, workshop showed the highest (0.043 mg/kg) cadmium. Soug Sitta showed the highest levels of lead (0.029 mg/kg) among the other four locations. Results revealed that that cadmium concentrations of the study at low concentrations if compared with limit of CODEX ALIMENTARIUS COMMISSION (2011) inverse to lead concentration. Finally, new ways of exhibition and packaging of date should introduced for safety and protection from any contaminant and heavy metals, which was set as a recommendation.
{"title":"Measurment Heavy Metals of Three Cultivars of Date (Phoenixdactylifera L.) From Sudan","authors":"Inass Omer Mohamed Malik, H. M. Hamadnalla","doi":"10.47363/jbbr/2021(3)137","DOIUrl":"https://doi.org/10.47363/jbbr/2021(3)137","url":null,"abstract":"The date palm (Phoenix dactylifera L.) is one of mankind’s oldest cultivated plants. A date palm fruit is an important component of the diet in most of the hot arid and semi-arid regions of the world. The Present study aimed at investigating two heavy metals (lead, Pb) and (cadmium, Cd) as mg/kg in three date palm cultivars cultivated in Sudan (Gondalia, Barakawi and Kulma). The results showed insignificant (p ≥ 0.05) concentration of the two heavy metals (cadmium and lead) between the various cultivars in the four local market (sites) (Libya, Bahri, Soug Sitta and workshop). Cadmium concentration was ranged from (0.006 - 0.043 mg/kg) and lead (0.02 - 0.029 mg/kg) for all cultivars at the four locations. Although most of the cultivars had comparable concentration of cadmium, workshop showed the highest (0.043 mg/kg) cadmium. Soug Sitta showed the highest levels of lead (0.029 mg/kg) among the other four locations. Results revealed that that cadmium concentrations of the study at low concentrations if compared with limit of CODEX ALIMENTARIUS COMMISSION (2011) inverse to lead concentration. Finally, new ways of exhibition and packaging of date should introduced for safety and protection from any contaminant and heavy metals, which was set as a recommendation.","PeriodicalId":219036,"journal":{"name":"Journal of Biotechnology & Bioinformatics Research","volume":"235 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121423525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-06-30DOI: 10.47363/jbbr/2021(3)133
R. Bharathi, N. Santhi
A series of chalcones were synthesised by condensation of appropriate acetophenones with appropriate aromatic aldehydes, and their anti-inflammatory activities were investigated. In comparison to standard drugs, some have been found to have important activity. In silico docking, tests on chalcones were shown to be more selective to COX-2. Further anti-inflammatory results were supported by docking studies with COX-2. The results from the anti-inflammatory and docking indicate that the synthesised compounds 3b, 3g and 3h can be seen as therapeutic drugs.
{"title":"Synthesis, Characterization, In-Silico Docking Study and In-Vitro AntiInflammatory Activities of Novel Chalcone Derivatives","authors":"R. Bharathi, N. Santhi","doi":"10.47363/jbbr/2021(3)133","DOIUrl":"https://doi.org/10.47363/jbbr/2021(3)133","url":null,"abstract":"A series of chalcones were synthesised by condensation of appropriate acetophenones with appropriate aromatic aldehydes, and their anti-inflammatory activities were investigated. In comparison to standard drugs, some have been found to have important activity. In silico docking, tests on chalcones were shown to be more selective to COX-2. Further anti-inflammatory results were supported by docking studies with COX-2. The results from the anti-inflammatory and docking indicate that the synthesised compounds 3b, 3g and 3h can be seen as therapeutic drugs.","PeriodicalId":219036,"journal":{"name":"Journal of Biotechnology & Bioinformatics Research","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130259320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-06-30DOI: 10.47363/jbbr/2021(3)129
Su Zihui, Xu-Yuan Peng
The deinking effect of printing paper filled with CaSiO3 and CaSiO3/French chalk was investigated. As a result, it shows that the two kinds of paper samples have better deinking effect, and the whiteness of the former is slightly higher than that of the latter. However, the strength index of the former is slightly lower than that of the latter. The adhesive removal effect of the paper sample filled with CaSiO3 is better than that of the paper filled with CaSiO3/ French chalk powder.
{"title":"Evaluation of Deinking Performance of Active Calcium Silicate Filled Paper","authors":"Su Zihui, Xu-Yuan Peng","doi":"10.47363/jbbr/2021(3)129","DOIUrl":"https://doi.org/10.47363/jbbr/2021(3)129","url":null,"abstract":"The deinking effect of printing paper filled with CaSiO3 and CaSiO3/French chalk was investigated. As a result, it shows that the two kinds of paper samples have better deinking effect, and the whiteness of the former is slightly higher than that of the latter. However, the strength index of the former is slightly lower than that of the latter. The adhesive removal effect of the paper sample filled with CaSiO3 is better than that of the paper filled with CaSiO3/ French chalk powder.","PeriodicalId":219036,"journal":{"name":"Journal of Biotechnology & Bioinformatics Research","volume":"37 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122136806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-06-30DOI: 10.47363/jbbr/2021(3)132
B. Riccardi, S. Resta, Rita Storelli
Numerous evidence and clinical trials have been published in recent years on the role of silicon for the maintenance of general well-being and of bones in particular. However, no study has so far investigated which fundamental contribution to health could provide silicon when taken with other trace elements in cases, very frequent, of their insufficient contribution. In this work we present a preliminary open-air study on a group of patients, using an original and innovative formulation containing organic SI G5 plus other trace elements, for the prevention and treatment of osteoarticular diseases of various origins.
{"title":"Preliminary Study on the Homeostatic Role of Organic Silicon and Trace Elements for Osteoarticular Well-Being","authors":"B. Riccardi, S. Resta, Rita Storelli","doi":"10.47363/jbbr/2021(3)132","DOIUrl":"https://doi.org/10.47363/jbbr/2021(3)132","url":null,"abstract":"Numerous evidence and clinical trials have been published in recent years on the role of silicon for the maintenance of general well-being and of bones in particular. However, no study has so far investigated which fundamental contribution to health could provide silicon when taken with other trace elements in cases, very frequent, of their insufficient contribution. In this work we present a preliminary open-air study on a group of patients, using an original and innovative formulation containing organic SI G5 plus other trace elements, for the prevention and treatment of osteoarticular diseases of various origins.","PeriodicalId":219036,"journal":{"name":"Journal of Biotechnology & Bioinformatics Research","volume":"68 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131570369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-06-30DOI: 10.47363/jbbr/2021(3)131
M. Kuman
{"title":"Uncertanty Principle? Are Quantum Events Influenced by our Conscious or Subconscious?… and Why?","authors":"M. Kuman","doi":"10.47363/jbbr/2021(3)131","DOIUrl":"https://doi.org/10.47363/jbbr/2021(3)131","url":null,"abstract":"","PeriodicalId":219036,"journal":{"name":"Journal of Biotechnology & Bioinformatics Research","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124073339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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