{"title":"PREVALENCE OF METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS IN RAW COW'S MILK COLLECTED FROM STORAGE TANKS AND MILK SUPPLY CENTERS IN URMIA CITY, IRAN, AND DETERMINATION OF THEIR ANTIBIOTIC RESISTANCE","authors":"R. Modaresi, H. Tajik, K. Mardani","doi":"10.52547/umj.33.3.183","DOIUrl":"https://doi.org/10.52547/umj.33.3.183","url":null,"abstract":"","PeriodicalId":21996,"journal":{"name":"Studies in Medical Sciences","volume":"76 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73665485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
P. Eini, Mojtaba Hedayat Yaghoobi, Seyede Mahsa Tahai, Ahmad Tahamoli Roudsari, Mohammad-Ali Seif-Rabiei
{"title":"COMPARISON OF SERUM LEVELS OF ANTI-CYCLIC CITRULLINATED PEPTIDE ANTIBODY (ANTI-CCP) AND RHEUMATOID FACTOR LEVEL IN BRUCELLOSIS PATIENTS WITH AND WITHOUT OSTEOARTICULAR SYMPTOMS","authors":"P. Eini, Mojtaba Hedayat Yaghoobi, Seyede Mahsa Tahai, Ahmad Tahamoli Roudsari, Mohammad-Ali Seif-Rabiei","doi":"10.52547/umj.33.3.194","DOIUrl":"https://doi.org/10.52547/umj.33.3.194","url":null,"abstract":"","PeriodicalId":21996,"journal":{"name":"Studies in Medical Sciences","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79077408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Amirabi, Sedigheh Ghasemian dizajmehr, Sima Molla
{"title":"EFFECTIVENESS OF TRANS-OBTURATOR TAPE (TOT) IN THE TREATMENT OF URINARY STRESS INCONTINENCE, CASE REPORT","authors":"A. Amirabi, Sedigheh Ghasemian dizajmehr, Sima Molla","doi":"10.52547/umj.33.3.212","DOIUrl":"https://doi.org/10.52547/umj.33.3.212","url":null,"abstract":"","PeriodicalId":21996,"journal":{"name":"Studies in Medical Sciences","volume":"101 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76267181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"INVESTIGATING THE EFFECT OF VITAMIN D IN PREVENTING THE PROGRESSION OF TRAUMATIC BRAIN INJURIES RELYING ON THE PROCESS OF TAUPATHY AND NEUROINFLAMMATION: A REVIEW STUDY","authors":"J. Jafarzadeh, Vali Musazadeh, P. Shahabi","doi":"10.52547/umj.33.3.200","DOIUrl":"https://doi.org/10.52547/umj.33.3.200","url":null,"abstract":"","PeriodicalId":21996,"journal":{"name":"Studies in Medical Sciences","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79322000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"THE EFFECT OF DIALLYL SULFIDE ON LIPOPOLYSACCHARIDE-INDUCED ACUTE KIDNEY DYSFUNCTION IN THE MOUSE","authors":"Abolfazl Akrami, T. Mombeini, M. Roghani","doi":"10.52547/umj.33.3.160","DOIUrl":"https://doi.org/10.52547/umj.33.3.160","url":null,"abstract":"","PeriodicalId":21996,"journal":{"name":"Studies in Medical Sciences","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90168492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
N. Masoudi, Sardar Sadeghi, M. Pashaei, Mohammad Amin Valizad Hasanloei
{"title":"EVALUATION OF THE RELATIONSHIP BETWEEN SERUM LEVELS OF CARCINOEMBRYONIC ANTIGEN (CEA) AND HOMEOSTASIS MODEL ASSESSMENT OF INSULIN RESISTANCE-2 (HOMA2-IR) IN COLORECTAL CANCER PATIENTS","authors":"N. Masoudi, Sardar Sadeghi, M. Pashaei, Mohammad Amin Valizad Hasanloei","doi":"10.52547/umj.33.3.152","DOIUrl":"https://doi.org/10.52547/umj.33.3.152","url":null,"abstract":"","PeriodicalId":21996,"journal":{"name":"Studies in Medical Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82371202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sahar Akbarizadeh-Khajeh, Ali Farhadi Biregani, A. Doosti
{"title":"A REVIEW ON ADVANCES AND CHALLENGES IN DEVELOPMENT OF MRNA-BASED VACCINES","authors":"Sahar Akbarizadeh-Khajeh, Ali Farhadi Biregani, A. Doosti","doi":"10.52547/umj.33.3.171","DOIUrl":"https://doi.org/10.52547/umj.33.3.171","url":null,"abstract":"","PeriodicalId":21996,"journal":{"name":"Studies in Medical Sciences","volume":"464 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79866873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Shokrzadeh, F. Motafeghi, Shaghayegh Shokrzadeh, Safoura Pourasadollah
{"title":"EVALUATION OF THE ROLE OF HYDROALCOHOLIC EXTRACT OF GINGER (ZINGIBER OFFICINALE L.) AND VITAMIN C ON CELL VIABILITY OF NORMAL GINGIVAL AND SKIN CELLS IN THE PRESENCE OF DRABKIN’S SOLUTION","authors":"M. Shokrzadeh, F. Motafeghi, Shaghayegh Shokrzadeh, Safoura Pourasadollah","doi":"10.52547/umj.33.3.220","DOIUrl":"https://doi.org/10.52547/umj.33.3.220","url":null,"abstract":"","PeriodicalId":21996,"journal":{"name":"Studies in Medical Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83148532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background & Aims : Smith-Lemli-Opitz syndrome (SLOs) is a developmental disorder with an autosomal recessive pattern of inheritance. During pregnancy, if screening tests in the second trimester of pregnancy show an increased risk of SLOs, additional complementary studies including ultrasound and genetic testing on amniotic fluid are performed. This study aimed to investigate the relationship between second trimester screening tests, ultrasound, and amniocentesis findings in SLOs occurrence. Materials & Methods : This study was a cross-sectional descriptive study. 44 pregnant women referred to the perinatology department of Shahid Motahari Medical Education Center with positive results for SLOs were included in the study. The correlation between second trimester screening tests, ultrasound and amniocentesis findings in confirming SLOs as well as DHCR7 gene expression in terms of common IVS8-1G>C mutation were measured. Results : Data showed that one of 44 cases with high-risk second trimester screening test for SLOs was positive for IVS8-1G>C mutation of DHCR7 gene. Conclusion : The findings showed that although positive screening tests are new screening methods for SLOs, genetic tests are also needed for definitive diagnosis.
{"title":"EVALUATION OF THE RELATIONSHIP BETWEEN SECOND TRIMESTER SCREENING TESTS, ULTRASOUND AND AMNIOCENTESIS FINDINGS IN THE DIAGNOSIS OF SMITH-LEMLI-OPTIZ SYNDROME IN HIGH-RISK CASES","authors":"F. Bahadori, Mina Behdad, A. Vahabi","doi":"10.52547/umj.33.2.100","DOIUrl":"https://doi.org/10.52547/umj.33.2.100","url":null,"abstract":"Background & Aims : Smith-Lemli-Opitz syndrome (SLOs) is a developmental disorder with an autosomal recessive pattern of inheritance. During pregnancy, if screening tests in the second trimester of pregnancy show an increased risk of SLOs, additional complementary studies including ultrasound and genetic testing on amniotic fluid are performed. This study aimed to investigate the relationship between second trimester screening tests, ultrasound, and amniocentesis findings in SLOs occurrence. Materials & Methods : This study was a cross-sectional descriptive study. 44 pregnant women referred to the perinatology department of Shahid Motahari Medical Education Center with positive results for SLOs were included in the study. The correlation between second trimester screening tests, ultrasound and amniocentesis findings in confirming SLOs as well as DHCR7 gene expression in terms of common IVS8-1G>C mutation were measured. Results : Data showed that one of 44 cases with high-risk second trimester screening test for SLOs was positive for IVS8-1G>C mutation of DHCR7 gene. Conclusion : The findings showed that although positive screening tests are new screening methods for SLOs, genetic tests are also needed for definitive diagnosis.","PeriodicalId":21996,"journal":{"name":"Studies in Medical Sciences","volume":"38 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82638618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
E. Akbariazar, A. Angaji, P. Pakzad, Isa Abdi Rad, Arash Musarrezaii Aghdam
Background & Aims: Multiple sclerosis (MS) (MIM #126200) is a chronic, inflammatory, demyelinating disorder of the central nervous system (CNS) that is the most common reason for non-traumatic neurological defects among young people. The aim of this study was to evaluate the association between single-nucleotide polymorphisms (SNPs) in genes with vitamin D response elements (VDREs) in their regulatory regions and the risk of relapsing-remitting multiple sclerosis (RR-MS) in the Iranian Azeri population. Materials & Methods : A total of 129RR-MS cases and 200 normal controls from West Azerbaijan were recruited in this study. We genotyped the fourteen MS susceptible variants in genes with vitamin D response elements that emerged from previous genome-wide association studies (GWAS), using Tetra-primer amplification refractory mutation system PCR (T-ARMS-PCR) assay in every participant. Chi-square, Fisher's exact test, and allelic and genotypic regression analysis were used to investigate the association of these polymorphisms with RRMS. Results : Three polymorphisms showed significant association (p-value < 0.05) with RR-MS. In particular, rs4410871 of PVT1 (p-value= 0.035, TT vs CC OR[95%CI]= 2.775 (1.253-6.146)), rs212405 of TAGAP (p-value=0.016, AA vs TT OR[95%CI]= 2.463 (1.255-4.835)), and rs7090512 of IL2RA (p-value= 0.008, CC vs TT OR[95%CI]= 2.865 (1.433-5.731) ) were identified as susceptible risk factors in our group. Conclusion : The current study replicated fourteen susceptible variants in genes with vitamin D response elements and the risk of RR-MS in the Iranian Azeri population, which implies the existence of some similarities between the MS genetic structure of the GWAS populations and the studied Iranian Azeri population.
背景与目的:多发性硬化症(MS) (MIM #126200)是一种慢性、炎症性、脱髓鞘性中枢神经系统(CNS)疾病，是年轻人非创伤性神经系统缺陷的最常见原因。本研究的目的是评估伊朗阿塞拜疆人群中具有维生素D反应元件(VDREs)调控区域基因的单核苷酸多态性(snp)与复发-缓解型多发性硬化症(RR-MS)风险之间的关系。材料与方法:本研究从西阿塞拜疆招募了129RR-MS病例和200名正常对照。我们对先前全基因组关联研究(GWAS)中出现的维生素D反应元件基因中的14个MS易感变异进行了基因分型，对每个参与者使用四引物扩增难解突变系统PCR (T-ARMS-PCR)测定。采用卡方检验、Fisher精确检验、等位基因和基因型回归分析来研究这些多态性与RRMS的关系。结果:3个多态性与RR-MS呈显著相关(p值< 0.05)。其中，PVT1基因rs4410871 (p值= 0.035,TT vs CC OR[95%CI]= 2.775(1.253 ~ 6.146))、TAGAP基因rs212405 (p值=0.016,AA vs TT OR[95%CI]= 2.463(1.255 ~ 4.835))、IL2RA基因rs7090512 (p值= 0.008,CC vs TT OR[95%CI]= 2.865(1.433 ~ 5.731))为本组易感危险因素。结论:本研究在伊朗阿塞拜疆人群中复制了14个与维生素D反应因子和RR-MS风险相关的基因易感变异，这表明GWAS人群和所研究的伊朗阿塞拜疆人群的MS遗传结构存在一定的相似性。
{"title":"STUDY OF ASSOCIATION BETWEEN SUSCEPTIBLE VARIANTS IN GENES WITH VITAMIN D RESPONSE ELEMENTS AND THE RISK OF RELAPSING-REMITTING MULTIPLE-SCLEROSIS IN IRANIAN AZERI POPULATION","authors":"E. Akbariazar, A. Angaji, P. Pakzad, Isa Abdi Rad, Arash Musarrezaii Aghdam","doi":"10.52547/umj.33.2.88","DOIUrl":"https://doi.org/10.52547/umj.33.2.88","url":null,"abstract":"Background & Aims: Multiple sclerosis (MS) (MIM #126200) is a chronic, inflammatory, demyelinating disorder of the central nervous system (CNS) that is the most common reason for non-traumatic neurological defects among young people. The aim of this study was to evaluate the association between single-nucleotide polymorphisms (SNPs) in genes with vitamin D response elements (VDREs) in their regulatory regions and the risk of relapsing-remitting multiple sclerosis (RR-MS) in the Iranian Azeri population. Materials & Methods : A total of 129RR-MS cases and 200 normal controls from West Azerbaijan were recruited in this study. We genotyped the fourteen MS susceptible variants in genes with vitamin D response elements that emerged from previous genome-wide association studies (GWAS), using Tetra-primer amplification refractory mutation system PCR (T-ARMS-PCR) assay in every participant. Chi-square, Fisher's exact test, and allelic and genotypic regression analysis were used to investigate the association of these polymorphisms with RRMS. Results : Three polymorphisms showed significant association (p-value < 0.05) with RR-MS. In particular, rs4410871 of PVT1 (p-value= 0.035, TT vs CC OR[95%CI]= 2.775 (1.253-6.146)), rs212405 of TAGAP (p-value=0.016, AA vs TT OR[95%CI]= 2.463 (1.255-4.835)), and rs7090512 of IL2RA (p-value= 0.008, CC vs TT OR[95%CI]= 2.865 (1.433-5.731) ) were identified as susceptible risk factors in our group. Conclusion : The current study replicated fourteen susceptible variants in genes with vitamin D response elements and the risk of RR-MS in the Iranian Azeri population, which implies the existence of some similarities between the MS genetic structure of the GWAS populations and the studied Iranian Azeri population.","PeriodicalId":21996,"journal":{"name":"Studies in Medical Sciences","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84760214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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