首页 > 最新文献

Spie Newsroom最新文献

英文 中文
Fast, automated 3D modeling of building interiors 快速、自动化的建筑内部3D建模
Pub Date : 2017-09-21 DOI: 10.1117/2.2201709.07
Karen Thomas
{"title":"Fast, automated 3D modeling of building interiors","authors":"Karen Thomas","doi":"10.1117/2.2201709.07","DOIUrl":"https://doi.org/10.1117/2.2201709.07","url":null,"abstract":"","PeriodicalId":22075,"journal":{"name":"Spie Newsroom","volume":"37 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83000283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sensors based on silicon photonic crystal mirrors with engineered phase 基于工程相位硅光子晶体反射镜的传感器
Pub Date : 2017-09-18 DOI: 10.1117/2.1201707.006818
O. Solgaard
The miniaturization of optical systems introduces benefits similar to those for electronics, i.e., making fabrication efficient, simplifying packaging, and reducing cost. Scaling optics to smaller sizes presents a number of challenges, however. This is particularly true for optical sensors that are exposed to the environment. In such systems, the components must scale well, lend themselves to efficient parallel manufacturing, and be mechanically and chemically robust enough to perform reliably and with good long-term stability. Mirrors are indispensable components in many optics applications. However, traditional mirror technologies do not perform well in miniaturized optical sensors. Metal mirrors are not sufficiently mechanically or chemically robust. This shortcoming complicates fabrication and packaging, and makes operation of the sensors in challenging environments impossible. Bragg mirrors consisting of multiple dielectric layers are sufficiently hardy for such applications, but do not scale well. The mirror thickness is determined by the desired wavelength and the required reflectivity, and thus cannot be reduced to fit the requirements of miniaturized systems. Photonic crystal (PC) mirrors are simple devices that lend themselves readily to straightforward fabrication by standard integrated-circuit manufacturing technologies. In their simplest form, PCs consist of a plate of semiconducting material with a periodic array of holes: see Figure 1(a). The principle of PC operation is different from other mirror technologies because PCs depend on interference between different pathways. As illustrated in Figure 1(b), a plane wave incident on a PC has two available pathways for transmission: a direct path, as through a homogeneous plate; and an indirect path that involves Figure 1. (a) In its simplest form, a photonic crystal (PC) mirror is a high-index plate with a periodic array of holes. The array can be 2D, as shown here, or 1D, as in a high-index grating. (b) The high reflectivity of PC mirrors is caused by interference. Incident light is transmitted through the PC as a plane wave as well as through the excitation of guided resonances. These two pathways through the PC interfere and determine the reflection and transmission spectra.
光学系统的小型化带来了与电子产品类似的好处,即使制造效率提高,简化包装和降低成本。然而,将光学元件缩小到更小的尺寸会带来许多挑战。对于暴露在环境中的光学传感器来说尤其如此。在这样的系统中,组件必须具有良好的可扩展性,适合于高效的并行制造,并且在机械和化学上足够强大,能够可靠地运行并具有良好的长期稳定性。反射镜是许多光学应用中不可缺少的部件。然而,传统的反射镜技术在小型化光学传感器中表现不佳。金属镜在机械上或化学上都不够坚固。这一缺点使制造和包装复杂化,并使传感器在具有挑战性的环境中无法运行。由多个介电层组成的布拉格反射镜对于这种应用来说足够耐用,但不能很好地缩放。反射镜的厚度取决于所需的波长和所需的反射率,因此不能缩小以适应小型化系统的要求。光子晶体(PC)反射镜是一种简单的器件,易于通过标准集成电路制造技术直接制造。在其最简单的形式中,pc由半导体材料板和周期性孔阵列组成:见图1(a)。PC机的工作原理不同于其他镜像技术,因为PC机依赖于不同路径之间的干扰。如图1(b)所示,入射到PC上的平面波有两种可用的传播路径:一种是直接路径,如通过均匀板;以及包含图1的间接路径。(a)最简单的形式,光子晶体(PC)镜是一个具有周期性孔阵列的高折射率板。阵列可以是二维的,如图所示,也可以是一维的,如高折射率光栅。(b) PC反射镜的高反射率是由干扰引起的。入射光以平面波的形式通过PC传输,也通过引导共振的激发传输。这两种途径通过PC干涉,确定了反射光谱和透射光谱。
{"title":"Sensors based on silicon photonic crystal mirrors with engineered phase","authors":"O. Solgaard","doi":"10.1117/2.1201707.006818","DOIUrl":"https://doi.org/10.1117/2.1201707.006818","url":null,"abstract":"The miniaturization of optical systems introduces benefits similar to those for electronics, i.e., making fabrication efficient, simplifying packaging, and reducing cost. Scaling optics to smaller sizes presents a number of challenges, however. This is particularly true for optical sensors that are exposed to the environment. In such systems, the components must scale well, lend themselves to efficient parallel manufacturing, and be mechanically and chemically robust enough to perform reliably and with good long-term stability. Mirrors are indispensable components in many optics applications. However, traditional mirror technologies do not perform well in miniaturized optical sensors. Metal mirrors are not sufficiently mechanically or chemically robust. This shortcoming complicates fabrication and packaging, and makes operation of the sensors in challenging environments impossible. Bragg mirrors consisting of multiple dielectric layers are sufficiently hardy for such applications, but do not scale well. The mirror thickness is determined by the desired wavelength and the required reflectivity, and thus cannot be reduced to fit the requirements of miniaturized systems. Photonic crystal (PC) mirrors are simple devices that lend themselves readily to straightforward fabrication by standard integrated-circuit manufacturing technologies. In their simplest form, PCs consist of a plate of semiconducting material with a periodic array of holes: see Figure 1(a). The principle of PC operation is different from other mirror technologies because PCs depend on interference between different pathways. As illustrated in Figure 1(b), a plane wave incident on a PC has two available pathways for transmission: a direct path, as through a homogeneous plate; and an indirect path that involves Figure 1. (a) In its simplest form, a photonic crystal (PC) mirror is a high-index plate with a periodic array of holes. The array can be 2D, as shown here, or 1D, as in a high-index grating. (b) The high reflectivity of PC mirrors is caused by interference. Incident light is transmitted through the PC as a plane wave as well as through the excitation of guided resonances. These two pathways through the PC interfere and determine the reflection and transmission spectra.","PeriodicalId":22075,"journal":{"name":"Spie Newsroom","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81016347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
2D Flexible and Emerging Devices and Applications 二维柔性和新兴设备和应用
Pub Date : 2017-09-14 DOI: 10.1117/2.2201709.03
Karen Thomas
{"title":"2D Flexible and Emerging Devices and Applications","authors":"Karen Thomas","doi":"10.1117/2.2201709.03","DOIUrl":"https://doi.org/10.1117/2.2201709.03","url":null,"abstract":"","PeriodicalId":22075,"journal":{"name":"Spie Newsroom","volume":"77 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81223167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Photonics industry thriving in Poland 光子学产业在波兰蓬勃发展
Pub Date : 2017-09-14 DOI: 10.1117/2.2201709.10
S. G. Anderson
{"title":"Photonics industry thriving in Poland","authors":"S. G. Anderson","doi":"10.1117/2.2201709.10","DOIUrl":"https://doi.org/10.1117/2.2201709.10","url":null,"abstract":"","PeriodicalId":22075,"journal":{"name":"Spie Newsroom","volume":"96 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81431129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Autonomous Remote Sensing - A Tale of Evolving, Emerging and Converging Technologies (Part 2) 自主遥感——发展、新兴和融合技术的故事(第二部分)
Pub Date : 2017-09-12 DOI: 10.1117/2.2201709.02
R. Higgons
Traditionally, remote sensing has been defined as the acquisition of information about an object or phenomenon without making physical contact. However, the emergence of new sensing techniques, miniaturisation of electronics, more powerful software, and an everincreasing range of applications has led to this definition being expanded to include terrestrial based remote sensing and remote embedded sensing. At the same time, the emergence of technologies and applications for autonomy have led to a dramatic expansion in the use of remote sensing technologies in these autonomous systems and to the development of remote sensing systems that are themselves autonomous. Autonomous remote sensing systems (ARS) are the culmination of long-term development of existing technologies, emergence of disruptive new technical capabilities, and convergence of sensors, optics, electronics, and communications technologies.
传统上,遥感被定义为在不进行物理接触的情况下获取有关物体或现象的信息。然而,新的传感技术的出现、电子设备的小型化、更强大的软件以及应用范围的不断扩大,导致这一定义被扩展到包括地面遥感和遥感嵌入式。与此同时,自主技术和应用的出现,导致遥感技术在这些自主系统中的应用急剧扩大,并导致自主遥感系统的发展。自主遥感系统(ARS)是现有技术长期发展、颠覆性新技术能力的出现以及传感器、光学、电子和通信技术融合的结果。
{"title":"Autonomous Remote Sensing - A Tale of Evolving, Emerging and Converging Technologies (Part 2)","authors":"R. Higgons","doi":"10.1117/2.2201709.02","DOIUrl":"https://doi.org/10.1117/2.2201709.02","url":null,"abstract":"Traditionally, remote sensing has been defined as the acquisition of information about an object or phenomenon without making physical contact. However, the emergence of new sensing techniques, miniaturisation of electronics, more powerful software, and an everincreasing range of applications has led to this definition being expanded to include terrestrial based remote sensing and remote embedded sensing. At the same time, the emergence of technologies and applications for autonomy have led to a dramatic expansion in the use of remote sensing technologies in these autonomous systems and to the development of remote sensing systems that are themselves autonomous. Autonomous remote sensing systems (ARS) are the culmination of long-term development of existing technologies, emergence of disruptive new technical capabilities, and convergence of sensors, optics, electronics, and communications technologies.","PeriodicalId":22075,"journal":{"name":"Spie Newsroom","volume":"129 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81718137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Autonomous Remote Sensing - A Tale of Evolving, Emerging and Converging Technologies (Part 1) 自主遥感——发展、新兴和融合技术的故事(上)
Pub Date : 2017-09-11 DOI: 10.1117/2.2201709.01
R. Higgons
{"title":"Autonomous Remote Sensing - A Tale of Evolving, Emerging and Converging Technologies (Part 1)","authors":"R. Higgons","doi":"10.1117/2.2201709.01","DOIUrl":"https://doi.org/10.1117/2.2201709.01","url":null,"abstract":"","PeriodicalId":22075,"journal":{"name":"Spie Newsroom","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91248991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A deep-UV plasmonic nanolaser with hyperbolic metamaterials 双曲型超材料的深紫外等离子体纳米激光器
Pub Date : 2017-09-05 DOI: 10.1117/2.1201704.006757
K. Shen, Yuh-Jen Cheng, D. Tsai
In recent years, plasmonic nanostructured materials have been used to enhance light emission by creating localized electric fields that confine light fields to regions below the diffraction limit of the material, resulting in efficient lightmatter interactions.1 Plasmonic nanolasers based on these materials have been developed by using, for example, a dielectric nanowire or nanorod gain material—the laser amplification medium—placed on a metal film or silica/metal structure to form a Fabry-Pérot cavity resonator (an arrangement of mirrors for multiple light reflection).2, 3 However, the nanowire or nanorod length in these plasmonic nanolasers is often fairly long (several micrometers) and it is not easy to control the nanowire/nanorod orientation, which limits the potential applications of these devices. Here, we discuss our recent work using a metal-dielectric hyperbolic metamaterial (HMM)—a material engineered to exhibit extreme anisotropy upon interaction with light—as a plasmonic cavity to demonstrate a 289nm UV plasmonic nanolaser. Although the quantum well heterostructures used in these nanolasers, which increase the strength of electro-optical interactions, have a low internal quantum efficiency of 30%, the strong light-matter coupling introduced by the HMM plasmonic cavity can still bring the devices above the lasing threshold. The dispersion relation (the effect of a dispersive medium on the properties of a light wave) of the stacked metal-dielectric HMM is given by:
近年来,等离子体纳米结构材料已被用于增强光发射,通过创建局部电场,将光场限制在材料的衍射极限以下的区域,从而产生有效的光物质相互作用基于这些材料的等离子体纳米激光器已经被开发出来,例如,使用介电纳米线或纳米棒增益材料——激光放大介质——放置在金属薄膜或二氧化硅/金属结构上,形成法布里-帕姆罗特腔谐振器(一种用于多次光反射的镜子排列)。然而,这些等离子体纳米激光器中的纳米线或纳米棒长度通常相当长(几微米),并且纳米线/纳米棒的方向不易控制,这限制了这些器件的潜在应用。在这里,我们讨论了我们最近的工作,使用金属介电双曲超材料(HMM) -一种在与光相互作用时表现出极端各向异性的材料-作为等离子体腔来演示289nm紫外等离子体纳米激光器。虽然这些纳米激光器中使用的量子阱异质结构增加了电光相互作用的强度,但内部量子效率较低,只有30%,但HMM等离子体腔引入的强光-物质耦合仍然可以使器件超过激光阈值。叠层金属介质HMM的色散关系(色散介质对光波性质的影响)由下式给出:
{"title":"A deep-UV plasmonic nanolaser with hyperbolic metamaterials","authors":"K. Shen, Yuh-Jen Cheng, D. Tsai","doi":"10.1117/2.1201704.006757","DOIUrl":"https://doi.org/10.1117/2.1201704.006757","url":null,"abstract":"In recent years, plasmonic nanostructured materials have been used to enhance light emission by creating localized electric fields that confine light fields to regions below the diffraction limit of the material, resulting in efficient lightmatter interactions.1 Plasmonic nanolasers based on these materials have been developed by using, for example, a dielectric nanowire or nanorod gain material—the laser amplification medium—placed on a metal film or silica/metal structure to form a Fabry-Pérot cavity resonator (an arrangement of mirrors for multiple light reflection).2, 3 However, the nanowire or nanorod length in these plasmonic nanolasers is often fairly long (several micrometers) and it is not easy to control the nanowire/nanorod orientation, which limits the potential applications of these devices. Here, we discuss our recent work using a metal-dielectric hyperbolic metamaterial (HMM)—a material engineered to exhibit extreme anisotropy upon interaction with light—as a plasmonic cavity to demonstrate a 289nm UV plasmonic nanolaser. Although the quantum well heterostructures used in these nanolasers, which increase the strength of electro-optical interactions, have a low internal quantum efficiency of 30%, the strong light-matter coupling introduced by the HMM plasmonic cavity can still bring the devices above the lasing threshold. The dispersion relation (the effect of a dispersive medium on the properties of a light wave) of the stacked metal-dielectric HMM is given by:","PeriodicalId":22075,"journal":{"name":"Spie Newsroom","volume":"77 4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88040775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Manipulating second-harmonic light from semiconductor nanocrystals 操纵半导体纳米晶体的二次谐波光
Pub Date : 2017-09-01 DOI: 10.1117/2.1201705.006852
D. Neshev, R. Camacho-Morales, M. Rahmani, S. Kruk, Lei Wang, Lei Xu, D. Smirnova, A. Solntsev, A. Miroshnichenko, H. Tan, F. Karouta, S. Naureen, K. Vora, L. Carletti, C. Angelis, C. Jagadish, Y. Kivshar
Among the nonlinear behaviors exhibited by light, secondharmonic generation (SHG)1 is one of the most important. In SHG, the frequency of an incident light beam is doubled inside of a nonlinear crystal: see Figure 1(a) and (b). SHG is nowadays employed in many applications, including laser sources and nonlinear microscopy. SHG usually relies on bulk nonlinear crystals—see Figure 1(b)—such as lithium niobate, potassium titanyl phosphate, or beta barium borate. Unfortunately, these materials are difficult to integrate with other devices (due to the difficulties inherent in their manufacturing and machining) and are not costeffective. Furthermore, special phase-matching conditions are often required in order to obtain useful conversion efficiencies. Although the output beam profile in bulk crystals can be engineered by complex periodic poling,2 this technique is not easily accessible (due to its requirement for a spatially inhomogeneous distribution of high voltages across the crystals). To overcome these issues, it would be useful if we could replace bulk nonlinear crystals with ultrathin surfaces composed of nanocrystals that can generate SHG with high efficiency. Such nonlinear ‘metasurfaces’ could also be used to manipulate the SHG radiation pattern to form complex beams with arbitrary patterns: see Figure 1(c–e). This may sound like science fiction, but optical technology is rapidly advancing toward achieving Figure 1. (a) Schematic of the nonlinear process of second-harmonic generation (SHG), which doubles the frequency of light in a crystal. (b) A conventional SHG process within a bulk nonlinear crystal, generating a blue Gaussian beam in the forward direction. (c) SHG from small objects, such as anisotropic molecules, is emitted in both forward and backward directions, resulting in a dipolar radiation pattern resembling a figure eight. (d) For larger nanocrystals, the emission can differ in forward and backward directions due to the interference of several resonant modes (multipoles) inside the nanocrystal. (e) Our goal of initiating SHG within small nanocrystals to design a radiation pattern that creates a complex beam shape (e.g., a kangaroo) with high conversion efficiency. !: Angular frequency. .2/: Second-order susceptibility.
在光表现出的非线性行为中,二次谐波(SHG)是最重要的非线性行为之一。在SHG中,入射光束的频率在非线性晶体内翻倍:见图1(a)和(b)。SHG现在被用于许多应用,包括激光源和非线性显微镜。SHG通常依赖于块状非线性晶体(见图1(b)),如铌酸锂、磷酸钛酸钾或硼酸钡。不幸的是,这些材料很难与其他设备集成(由于其制造和加工中固有的困难)并且不具有成本效益。此外,为了获得有效的转换效率,通常需要特殊的相位匹配条件。虽然块状晶体的输出光束轮廓可以通过复杂的周期性极化来设计,但这种技术并不容易实现(由于它要求在晶体上的高电压在空间上的不均匀分布)。为了克服这些问题,如果我们可以用纳米晶体组成的超薄表面代替大块非线性晶体,可以高效地产生SHG,这将是有用的。这种非线性“超表面”也可以用来操纵SHG辐射方向图,形成具有任意图案的复杂光束:见图1(c-e)。这可能听起来像科幻小说,但光学技术正在迅速向图1所示的方向发展。(a)二次谐波产生(SHG)的非线性过程示意图,它使晶体中的光频率加倍。(b)在块状非线性晶体内的常规SHG过程,在正向产生蓝色高斯光束。(c)来自小物体,例如各向异性分子的SHG向正向和反向发射,产生类似8字形的偶极辐射图。(d)对于较大的纳米晶体,由于纳米晶体内部几种共振模式(多极)的干扰,发射在正向和反向上可能不同。(e)我们的目标是在小纳米晶体内启动SHG,以设计一种辐射模式,产生具有高转换效率的复杂光束形状(例如袋鼠)。:角频率。.2/:二阶磁化率。
{"title":"Manipulating second-harmonic light from semiconductor nanocrystals","authors":"D. Neshev, R. Camacho-Morales, M. Rahmani, S. Kruk, Lei Wang, Lei Xu, D. Smirnova, A. Solntsev, A. Miroshnichenko, H. Tan, F. Karouta, S. Naureen, K. Vora, L. Carletti, C. Angelis, C. Jagadish, Y. Kivshar","doi":"10.1117/2.1201705.006852","DOIUrl":"https://doi.org/10.1117/2.1201705.006852","url":null,"abstract":"Among the nonlinear behaviors exhibited by light, secondharmonic generation (SHG)1 is one of the most important. In SHG, the frequency of an incident light beam is doubled inside of a nonlinear crystal: see Figure 1(a) and (b). SHG is nowadays employed in many applications, including laser sources and nonlinear microscopy. SHG usually relies on bulk nonlinear crystals—see Figure 1(b)—such as lithium niobate, potassium titanyl phosphate, or beta barium borate. Unfortunately, these materials are difficult to integrate with other devices (due to the difficulties inherent in their manufacturing and machining) and are not costeffective. Furthermore, special phase-matching conditions are often required in order to obtain useful conversion efficiencies. Although the output beam profile in bulk crystals can be engineered by complex periodic poling,2 this technique is not easily accessible (due to its requirement for a spatially inhomogeneous distribution of high voltages across the crystals). To overcome these issues, it would be useful if we could replace bulk nonlinear crystals with ultrathin surfaces composed of nanocrystals that can generate SHG with high efficiency. Such nonlinear ‘metasurfaces’ could also be used to manipulate the SHG radiation pattern to form complex beams with arbitrary patterns: see Figure 1(c–e). This may sound like science fiction, but optical technology is rapidly advancing toward achieving Figure 1. (a) Schematic of the nonlinear process of second-harmonic generation (SHG), which doubles the frequency of light in a crystal. (b) A conventional SHG process within a bulk nonlinear crystal, generating a blue Gaussian beam in the forward direction. (c) SHG from small objects, such as anisotropic molecules, is emitted in both forward and backward directions, resulting in a dipolar radiation pattern resembling a figure eight. (d) For larger nanocrystals, the emission can differ in forward and backward directions due to the interference of several resonant modes (multipoles) inside the nanocrystal. (e) Our goal of initiating SHG within small nanocrystals to design a radiation pattern that creates a complex beam shape (e.g., a kangaroo) with high conversion efficiency. !: Angular frequency. .2/: Second-order susceptibility.","PeriodicalId":22075,"journal":{"name":"Spie Newsroom","volume":"112 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79605170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Photonics enables real-time imaging radar with ultra-high resolution 光子学使实时成像雷达具有超高分辨率
Pub Date : 2017-08-28 DOI: 10.1117/2.2201708.05
Fangzheng Zhang, S. Pan
{"title":"Photonics enables real-time imaging radar with ultra-high resolution","authors":"Fangzheng Zhang, S. Pan","doi":"10.1117/2.2201708.05","DOIUrl":"https://doi.org/10.1117/2.2201708.05","url":null,"abstract":"","PeriodicalId":22075,"journal":{"name":"Spie Newsroom","volume":"241 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76751908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Visualizing and quantifying drug uptake in skin 皮肤中药物摄取的可视化和量化
Pub Date : 2017-08-25 DOI: 10.1117/2.1201705.006809
C. Evans, K. F. Chan, T. Prow, Sam Osseiran
The study of drug uptake, distribution, and activity within skin is a necessary but problematic requirement in the development and translation of compounds from the bench to the bedside. Drug delivery into the skin is highly complex, due in part to the natural barrier function of the stratum corneum in addition to the many different routes of transdermal entry of drugs. Moreover, skin is not uniform throughout the body or across age groups. For example, epidermal thickness changes 30-fold from the thick skin of the fingertips (485 m) to the thin skin of the face and eyelids (17 m).1 Transdermal delivery can occur over a wide range of timescales (from seconds to hours), and the number of potential cellular targets necessitates quantification on the micrometer scale.2 Optical imaging tools are well-suited to meet these challenges, in particular for the uptake of drugs within the first millimeter of skin. Fluorescence, Raman, and nonlinear optical imaging techniques offer subcellular resolution, rapid real-time 3D image acquisition, and the ability to quantitatively analyze imaging data for both pharmacokinetic and pharmacodynamic information. Optical tools are unique in that they also offer the ability to quantify drugs via phenomena that emerge from their structure, including light absorption, fluorescence, and molecular vibrations. This is particularly useful as most pharmaceuticals are small molecules, where modification to include a reporter can completely change the behavior and thus uptake of the compound. Fluorescence imaging methods can be particularly powerful in measuring the uptake and distribution of drugs. We have been developing a topical acne gel, BPX-01, that is currently in a clinical Phase 2b dose-finding study. BPX-01 is an anhydrous hydrophilic topical gel with solubilized minocycline for enhanced cutaneous delivery and bioavailability to target Figure 1. Conventional fluorescence microscopy images of ex vivo human facial skin specimens. (a) Control, and those treated with (b) 1% BPX-01 (a topical acne gel) and (c) 4% BPX-01 at 24 hours. Minocycline fluorescence is shown in red.
研究药物在皮肤内的吸收、分布和活性是一个必要但有问题的要求,在开发和转化化合物从实验室到床边。药物进入皮肤是非常复杂的,部分原因是角质层的天然屏障功能以及药物经皮进入的许多不同途径。此外,全身或不同年龄层的皮肤并不均匀。例如,从指尖的厚皮肤(485米)到面部和眼睑的薄皮肤(17米),表皮厚度变化了30倍透皮给药可以发生在很宽的时间尺度范围内(从几秒到几小时),潜在细胞靶标的数量需要在微米尺度上进行量化光学成像工具非常适合应对这些挑战,特别是在皮肤的第一毫米内吸收药物。荧光、拉曼和非线性光学成像技术提供亚细胞分辨率、快速实时3D图像采集以及定量分析成像数据的能力,以获得药代动力学和药效学信息。光学工具的独特之处在于,它们还提供了通过从其结构中出现的现象(包括光吸收、荧光和分子振动)来量化药物的能力。这是特别有用的,因为大多数药物都是小分子,其中修改包括一个报告可以完全改变行为,从而吸收化合物。荧光成像方法在测量药物的摄取和分布方面特别有效。我们一直在开发一种局部痤疮凝胶BPX-01,目前正处于临床2b期剂量研究中。BPX-01是一种无水亲水性外用凝胶,可溶解二甲胺四环素,增强皮肤给药和靶向生物利用度。离体人体面部皮肤标本的常规荧光显微镜图像。(a)对照组和(b) 1% BPX-01(一种局部痤疮凝胶)和(c) 4% BPX-01治疗24小时的对照组。米诺环素荧光显示为红色。
{"title":"Visualizing and quantifying drug uptake in skin","authors":"C. Evans, K. F. Chan, T. Prow, Sam Osseiran","doi":"10.1117/2.1201705.006809","DOIUrl":"https://doi.org/10.1117/2.1201705.006809","url":null,"abstract":"The study of drug uptake, distribution, and activity within skin is a necessary but problematic requirement in the development and translation of compounds from the bench to the bedside. Drug delivery into the skin is highly complex, due in part to the natural barrier function of the stratum corneum in addition to the many different routes of transdermal entry of drugs. Moreover, skin is not uniform throughout the body or across age groups. For example, epidermal thickness changes 30-fold from the thick skin of the fingertips (485 m) to the thin skin of the face and eyelids (17 m).1 Transdermal delivery can occur over a wide range of timescales (from seconds to hours), and the number of potential cellular targets necessitates quantification on the micrometer scale.2 Optical imaging tools are well-suited to meet these challenges, in particular for the uptake of drugs within the first millimeter of skin. Fluorescence, Raman, and nonlinear optical imaging techniques offer subcellular resolution, rapid real-time 3D image acquisition, and the ability to quantitatively analyze imaging data for both pharmacokinetic and pharmacodynamic information. Optical tools are unique in that they also offer the ability to quantify drugs via phenomena that emerge from their structure, including light absorption, fluorescence, and molecular vibrations. This is particularly useful as most pharmaceuticals are small molecules, where modification to include a reporter can completely change the behavior and thus uptake of the compound. Fluorescence imaging methods can be particularly powerful in measuring the uptake and distribution of drugs. We have been developing a topical acne gel, BPX-01, that is currently in a clinical Phase 2b dose-finding study. BPX-01 is an anhydrous hydrophilic topical gel with solubilized minocycline for enhanced cutaneous delivery and bioavailability to target Figure 1. Conventional fluorescence microscopy images of ex vivo human facial skin specimens. (a) Control, and those treated with (b) 1% BPX-01 (a topical acne gel) and (c) 4% BPX-01 at 24 hours. Minocycline fluorescence is shown in red.","PeriodicalId":22075,"journal":{"name":"Spie Newsroom","volume":"124 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87851071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
期刊
Spie Newsroom
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1