Pub Date : 2019-05-11DOI: 10.1002/9781119356752.CH7
E. Hone, Florence Lim, I. Martins
{"title":"Fat and Lipid Metabolism and the Involvement of Apolipoprotein E in Alzheimer's Disease","authors":"E. Hone, Florence Lim, I. Martins","doi":"10.1002/9781119356752.CH7","DOIUrl":"https://doi.org/10.1002/9781119356752.CH7","url":null,"abstract":"","PeriodicalId":222038,"journal":{"name":"Neurodegeneration and Alzheimer's Disease","volume":"233237 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123278928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-05-11DOI: 10.1002/9781119356752.CH8
M. Sharman, G. Verdile, S. Kirubakaran, G. Münch
{"title":"Inflammation in Alzheimer's Disease, and Prevention with Antioxidants and Phenolic Compounds - What Are the Most Promising Candidates?","authors":"M. Sharman, G. Verdile, S. Kirubakaran, G. Münch","doi":"10.1002/9781119356752.CH8","DOIUrl":"https://doi.org/10.1002/9781119356752.CH8","url":null,"abstract":"","PeriodicalId":222038,"journal":{"name":"Neurodegeneration and Alzheimer's Disease","volume":"47 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127464506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-05-11DOI: 10.1002/9781119356752.CH2
S. Fuller, H. Sohrabi, Kathryn Goozee, A. Sankaranarayanan, R. Martins
Neurodegenerative diseases are a heterogeneous group of disorders or conditions characterised by the progressive degeneration of the structure and function of the central nervous system or the peripheral nervous system. Some are considered to be caused by protein misfolding, some involve disruptions to intracellular processes such as mitochondrial function or protein degradation pathways, and some are genetic in origin. Whatever the original cause of the disease, the greatest risk factor for most of these diseases is increasing age. This book is mostly focused on Alzheimer's disease (AD), yet in this chapter we describe Alzheimer's as well as other major neurodegenerative conditions to demonstrate both similarities and differences.
{"title":"Alzheimer's Disease and Other Neurodegenerative Diseases","authors":"S. Fuller, H. Sohrabi, Kathryn Goozee, A. Sankaranarayanan, R. Martins","doi":"10.1002/9781119356752.CH2","DOIUrl":"https://doi.org/10.1002/9781119356752.CH2","url":null,"abstract":"Neurodegenerative diseases are a heterogeneous group of disorders or conditions characterised by the progressive degeneration of the structure and function of the central nervous system or the peripheral nervous system. Some are considered to be caused by protein misfolding, some involve disruptions to intracellular processes such as mitochondrial function or protein degradation pathways, and some are genetic in origin. Whatever the original cause of the disease, the greatest risk factor for most of these diseases is increasing age. This book is mostly focused on Alzheimer's disease (AD), yet in this chapter we describe Alzheimer's as well as other major neurodegenerative conditions to demonstrate both similarities and differences.","PeriodicalId":222038,"journal":{"name":"Neurodegeneration and Alzheimer's Disease","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131297221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-05-11DOI: 10.1002/9781119356752.CH9
H. Sohrabi, M. Weinborn
This chapter discusses some of the neurocognitive deficits experienced in the Alzheimer's disease (AD) conditions, with the primary focus on different stages of dementia due to AD. It discusses the cognitive functions affected during the natural course of AD and other neurodegenerative diseases. The chapter discusses the most common neurocognitive features of AD as well as other common types of dementias. Attention and working memory deficits are commonly seen in AD patients. Following the amnestic phase of AD, attention is the second cognitive function to be affected, long before difficulties with other cognitive functions including language and praxis. There is a gradual major shift in cognitive and clinical examination, using online and computerised measures. The traditional neuropsychological approach of 'in‐person' testing should adapt and make use of such an unprecedented approach that can bring big‐data available for clinical practice, establishing psychometric basis of the available measures, and providing an avenue to develop new measures.
{"title":"Cognitive Impairments in Alzheimer's Disease and Other Neurodegenerative Diseases","authors":"H. Sohrabi, M. Weinborn","doi":"10.1002/9781119356752.CH9","DOIUrl":"https://doi.org/10.1002/9781119356752.CH9","url":null,"abstract":"This chapter discusses some of the neurocognitive deficits experienced in the Alzheimer's disease (AD) conditions, with the primary focus on different stages of dementia due to AD. It discusses the cognitive functions affected during the natural course of AD and other neurodegenerative diseases. The chapter discusses the most common neurocognitive features of AD as well as other common types of dementias. Attention and working memory deficits are commonly seen in AD patients. Following the amnestic phase of AD, attention is the second cognitive function to be affected, long before difficulties with other cognitive functions including language and praxis. There is a gradual major shift in cognitive and clinical examination, using online and computerised measures. The traditional neuropsychological approach of 'in‐person' testing should adapt and make use of such an unprecedented approach that can bring big‐data available for clinical practice, establishing psychometric basis of the available measures, and providing an avenue to develop new measures.","PeriodicalId":222038,"journal":{"name":"Neurodegeneration and Alzheimer's Disease","volume":"69 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126076088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-05-11DOI: 10.1002/9781119356752.CH14
S. Pedrini, M. Morici, R. Martins
{"title":"Current and Prospective Treatments for Alzheimer's Disease (and Other Neurodegenerative Diseases)","authors":"S. Pedrini, M. Morici, R. Martins","doi":"10.1002/9781119356752.CH14","DOIUrl":"https://doi.org/10.1002/9781119356752.CH14","url":null,"abstract":"","PeriodicalId":222038,"journal":{"name":"Neurodegeneration and Alzheimer's Disease","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130725678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-05-11DOI: 10.1002/9781119356752.OTH1
C. Brennan, M. Brennan, W. Fernando, S. Fuller, R. Martins
{"title":"Final Thoughts Regarding Alzheimer'\u0000s Disease, Diet, and Health","authors":"C. Brennan, M. Brennan, W. Fernando, S. Fuller, R. Martins","doi":"10.1002/9781119356752.OTH1","DOIUrl":"https://doi.org/10.1002/9781119356752.OTH1","url":null,"abstract":"","PeriodicalId":222038,"journal":{"name":"Neurodegeneration and Alzheimer's Disease","volume":"91 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125977084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-05-11DOI: 10.1002/9781119356752.CH11
W. Fernando, C. Brennan, R. Martins
{"title":"The Products of Fermentation and Their Effects on Metabolism, Alzheimer's Disease, and Other Neurodegenerative Diseases: Role of Short-Chain Fatty Acids (SCFA)","authors":"W. Fernando, C. Brennan, R. Martins","doi":"10.1002/9781119356752.CH11","DOIUrl":"https://doi.org/10.1002/9781119356752.CH11","url":null,"abstract":"","PeriodicalId":222038,"journal":{"name":"Neurodegeneration and Alzheimer's Disease","volume":"68 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121797339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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