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Experimental Measurements of Ignition Delay Times of Iso-octane/n-Butanol Blend Mixtures in Rapid Compression Machine (RCM) 异辛烷/正丁醇混合燃料在快速压缩机(RCM)中点火延迟时间的实验测量
Pub Date : 2023-09-30 DOI: 10.4314/tjs.v49i3.6
Myeji Materego, Derek Bradley
Among oxygenated alternative fuels, n-butanol is considered as a promising alternative biofuel which can partially (or fully) replace conventional transportation fuels currently in use. However, before n-butanol can be commercially utilised, its fundamental combustion characteristics need to be fully understood. In this work, the effect of adding n-butanol on autoignition property of iso-octane was studied. Measurements of ignition delay times for the two blends of n-butanol proportions of 30% and 50% by mole weight were made in a Rapid Compression Machine for stoichiometric mixtures at 2.0 MPa and temperature range 651-918 K. n-butanol increased ignition delay times of iso-octane at lower temperatures and hence acted as an octane enhancer, while at higher temperatures delay times were reduced. In the intermediate temperatures there was visually no difference in delay times between the two blends. Throughout the temperature range studied, the delay times of both blends were much closer to those of pure n-butanol which suggests that the combustion chemistry of n-butanol was dominant over that of iso-octane. These results have shown that n-butanol can enhance fuel octane rating and therefore can potentially improve thermal efficiency of SI engines, whilst CI engines can benefit from the reduced delay times at higher temperatures.
在含氧替代燃料中,正丁醇被认为是一种很有前途的替代生物燃料,可以部分(或全部)替代目前使用的传统运输燃料。然而,在正丁醇可以商业化利用之前,需要充分了解其基本的燃烧特性。本文研究了添加正丁醇对异辛烷自燃性能的影响。在化学计量混合物的快速压缩机中,在2.0 MPa和651-918 k的温度范围内,测量了30%和50%摩尔质量比例的正丁醇两种混合物的点火延迟时间,正丁醇在较低温度下增加了异辛烷的点火延迟时间,从而起到了辛烷值增强剂的作用,而在较高温度下延迟时间则减少了。在中等温度下,两种共混物的延迟时间在视觉上没有差异。在研究的温度范围内,两种混合物的延迟时间都与纯正丁醇的延迟时间非常接近,这表明正丁醇的燃烧化学作用比异辛烷的燃烧化学作用更重要。这些结果表明,正丁醇可以提高燃料辛烷值,因此可以潜在地提高SI发动机的热效率,而CI发动机可以从减少高温下的延迟时间中受益。
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引用次数: 0
Effects of Bacillus thuringiensis, Beauveria bassiana, Neem, and a Tomato Intercrop on Diamondback Moth (Plutella xylostella L.) (Lepidoptera: Plutellidae) in Tharaka-Nithi County, Kenya 苏云金芽孢杆菌、球孢白僵菌、印楝和番茄间作对肯尼亚塔拉卡-尼提县小菜蛾(鳞翅目:小菜蛾科)的防治效果
Pub Date : 2023-09-30 DOI: 10.4314/tjs.v49i3.1
Ceciliah N. Ngugi, Jesca N. Mbaka, Hellen W. Muthengi
Cabbage (Brassica oleracea var. capitata) is an important crop in Kenya, ranked 3rd among the exotic vegetables. Diamondback moth (DBM) is a major cabbage pest that can cause a 100% loss in yield if not well managed. Farmers indiscriminately use synthetic pesticides associated with environmental, health, and pest resistance concerns to manage the DBM. To increase the availability of technologies for effective management of DBM in Kenya, three biopesticides; BioPower (Beauveria bassiana 1.0 x 108 CFUs/g), Dipel DF® (Bacillus thuringiensis subsp. kurstaki), Neemraj Super 3000 (Azadirachtin 0.3% EC), and a tomato intercrop were evaluated. Cabbages (30 plants) spaced at 40 cm x 60 cm were established in 6 m x 6 m plots in 3 replicates per treatment. The treatments applications were; B. bassiana 100 g/20 L, B. thuringiensis 20 g/20 L, and neem 20 mL/20 L. A row of tomato intercrop was established in every two rows of cabbage and distilled water was used on the untreated control. Data on the number of damaged leaves, live larvae, and marketable yields for two seasons was collected from five leaves of ten randomly selected cabbage plants. Results showed significant differences (P ≤ 0.05) between the control and treatments in the mean number of live larvae and the number of damaged leaves. However, there were no significant marketable yield differences between the treatments (P ≥ 0.05). In conclusion, the three bio-pesticides and the tomato intercrop were effective against the DBM damage on cabbage leaves and can be part of integrated pest management (IPM) packages for DBM management on cabbage. There is a need to determine why the treatments did not result in meaningful outcomes against the DBM population and cabbage head weights. In addition, a cost-benefit analysis of each treatment is necessary.
白菜(Brassica oleracea var. capitata)是肯尼亚的重要作物,在外来蔬菜中排名第三。小菜蛾(DBM)是一种主要的卷心菜害虫,如果管理不善,可能导致100%的产量损失。农民不分青红皂白地使用与环境、健康和害虫抗性有关的合成农药来管理DBM。为了增加肯尼亚DBM有效管理技术的可用性,三种生物农药;BioPower(白僵菌1.0 × 108 CFUs/g), Dipel DF®(苏云金芽孢杆菌亚种);评价了kurstaki)、Neemraj Super 3000(印楝素0.3% EC)和番茄间作。白菜(30株)在6 m × 6 m的地块上种植,间距为40 cm × 60 cm,每个处理3个重复。处理应用为;球孢白僵菌100 g/20 L,苏云金白僵菌20 g/20 L,印楝草20 mL/20 L,每两行白菜间作一行番茄,用蒸馏水作对照。对随机选择的10株白菜的5片叶子收集了2个季节的受损叶数、活幼虫数和可销售产量的数据。结果表明:对照与处理间的平均活幼虫数和害叶数差异显著(P≤0.05);但各处理间市场产量差异不显著(P≥0.05)。综上所述,3种生物农药和番茄间作对白菜叶片DBM危害均有较好的防治效果,可作为白菜DBM综合治理的组成部分。有必要确定为什么治疗对DBM种群和白菜头重没有产生有意义的结果。此外,有必要对每种治疗方法进行成本效益分析。
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引用次数: 0
Ameliorative Effects of Vitamins C and E on Haematotoxicity and Spleen Histopathology Induced by Dichlorvos Insecticide in Female Wistar Rats 维生素C和E对敌敌畏杀虫剂致雌性Wistar大鼠血液毒性和脾脏组织病理学的改善作用
Pub Date : 2023-06-30 DOI: 10.4314/tjs.v49i2.21
Halima Mfaume, Harishchandra Pratap, Claudius Luziga, Felister Urasa
This research aimed to assess the toxicological effects of dichlorvos insecticide (2,2-dichlorovinyl dimethyl phosphate or DDVP) on haematological indices of female Wistar rats and to investigate the antioxidant properties of vitamins C and E in ameliorating haematotoxicity. The rats were divided into 6 groups; control-water, control-oil, dichlorvos group, dichlorvos + vitamin C group, dichlorvos + vitamin E group and dichlorvos + vitamin C + E group. Dichlorvos and vitamins were orally administered to rats with an interval of half an hour between treatments. The control-oil group was given 2 ml corn oil and the control-water group was given water adlib. The treatments were done for 28 consecutive days and blood samples were taken by cardiac puncture. The following haematological parameters were analysed: RBC, WBC, Hb, PCV, MCV, MCH, MCHC and THR. Bone marrow smears were prepared on 14th and 28th days for various blood stem cells evaluation and spleen tissues for histopathology. There was a significant decrease (p ˂ 0.01) in RBC counts, PCV, MCV and MCH values, whereas the WBC, THR counts and MCHC values increased significantly (p ˂ 0.01) in dichlorvos treated rats as compared to the controls and dichlorvos + vitamins co-treated groups. There were no significant differences in blood parameter counts between controls and dichlorvos + vitamins co-treated groups. In the bone marrow smear of the dichlorvos treated group, there was increased number of megakaryocytes and mature neutrophils. In conclusion, findings from the current study revealed that, vitamins C and E supplements were capable of mitigating the haematotoxic effects induced by dichlorvos insecticide in Wistar rats.
本研究旨在评价敌敌畏杀虫剂(2,2-二氯酰磷酸二甲酯或DDVP)对雌性Wistar大鼠血液学指标的毒理学影响,并探讨维生素C和E对血液毒性的改善作用。将大鼠分为6组;对照水、对照油、敌敌畏组、敌敌畏+维生素C组、敌敌畏+维生素E组、敌敌畏+维生素C + E组。对大鼠口服敌敌畏和维生素,每隔半小时给药。对照组给予玉米油2 ml,对照组给予水adlib。连续治疗28天,穿刺取血。分析以下血液学参数:RBC、WBC、Hb、PCV、MCV、MCH、MCHC和THR。第14天和第28天分别进行骨髓涂片,用于各种造血干细胞评估和脾脏组织病理学检查。与对照组和敌敌畏+维生素共处理组相比,敌敌畏处理大鼠红细胞计数、PCV、MCV和MCH值显著降低(p小于0.01),而WBC、THR计数和MCHC值显著升高(p小于0.01)。对照组与敌敌畏+维生素联合处理组的血液参数计数无显著差异。敌敌畏处理组骨髓涂片中巨核细胞和成熟中性粒细胞增多。综上所述,本研究结果表明,维生素C和维生素E补充剂能够减轻敌敌畏杀虫剂对Wistar大鼠的血液毒性作用。
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引用次数: 0
Efficacy of the Botanical Extracts, Azadirachta indica (Sapindales: Meliaceae) and Tagetes minuta (Asterales: Asteraceae) in the Control of Cabbage Insect Pests in Iringa District, Tanzania 植物提取物印楝和万年青对坦桑尼亚伊林加地区白菜病虫害的防治效果
Pub Date : 2023-06-30 DOI: 10.4314/tjs.v49i2.11
Levocatus M. Rwegoshora, Vendeline E. Tairo, Moses I. Olotu
Although botanical extracts have been widely studied globally, the efficacy of neem and Mexican marigold against cabbage insect pests is scanty. Field experiments were conducted at Kalenga and Mgera in 2022 using a randomized complete block design. Four treatments (neem, Mexican marigold, a mixture of the two extracts and untreated) were replicated three times. In Kalenga, damage levels for treated plots varied significantly from 3.33 to 9.20% and 5.0 to 18.33%, while for untreated plots varied from 37.70 to 45.85% during the rainy and dry seasons, respectively (F(3, 499) = 111.71, p < 0.05). A similar trend was recorded in Mgera, the damage levels varied significantly between treated (4.44–15.83%) and untreated plots (34.40–46.60%) (F(3, 449) = 94.23, p < 0.05). Treated plots had higher marketable cabbage yields (30.6–43.10 t/ha) than untreated plots (4.78–11.20 t/ha), which differed significantly in Kalenga (F (3, 67) = 141.79, p < 0.05) and Mgera (F (3, 67) = 53.36, p < 0.05). These extracts have shown insecticidal properties, can serve as promising candidates for further studies aimed at isolating active compounds for scaling up ecologically friendly strategies of controlling pests and improve the quality of cabbage products.
虽然植物提取物在全球范围内得到了广泛的研究,但印度楝树和墨西哥金盏花对白菜害虫的功效却很少。2022年在Kalenga和Mgera采用随机完全区块设计进行了现场试验。四种处理方法(印楝、墨西哥金盏花、两种提取物的混合物和未经处理的)重复了三次。在卡伦加,雨季和旱季,处理样地的危害程度分别为3.33% ~ 9.20%和5.0 ~ 18.33%,而未处理样地的危害程度分别为37.70% ~ 45.85%,差异显著(F(3,499) = 111.71, p <0.05)。Mgera也有类似的趋势,处理地块(4.44 ~ 15.83%)和未处理地块(34.40 ~ 46.60%)的危害程度差异显著(F(3,449) = 94.23, p <0.05)。处理地块的卷心菜可售产量(30.6 ~ 43.10 t/ha)高于未处理地块(4.78 ~ 11.20 t/ha), Kalenga地区差异显著(F (3,67) = 141.79, p <0.05)和Mgera (F (3,67) = 53.36, p <0.05)。这些提取物具有一定的杀虫特性,为进一步分离活性化合物、扩大生态友好型害虫防治策略和提高白菜产品质量提供了良好的研究前景。
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引用次数: 0
Ethnobotanical Survey, Consumption Pattern and Genetic Conservation of Leafy Vegetables in South-West Nigeria 尼日利亚西南部叶菜的民族植物学调查、消费模式和遗传保护
Pub Date : 2023-06-30 DOI: 10.4314/tjs.v49i2.18
Temitope O Onuminya, Michael I Osundinakin, Oluwatoyin T Ogundipe
Leafy vegetables are important in human nutrition; however, their diversity as seen in the dishes in South western Nigeria appears to be diminishing. Many popular delicacies are no longer available in the markets. Therefore, this research was conducted to identify and document leafy vegetables in South West Nigeria, assess their ethnobotanical uses from questionnaires administered to farmers/sellers, secure their genetic resource base, and improve their value chain in South-West Nigeria. Vegetable samples were collected from different local communities in five South-West states in Nigeria, identified using manual/flora, and authenticated at the University of Lagos Herbarium. One thousand respondents, 200 in each state, participated in the study. Of these, 76.7% were female, while 23.3% were male. A total of twenty-six (26) leafy vegetables were collected. Twenty-one (21) species are indigenous to the study area, while five (5) species are non-indigenous. Ethnobotanical survey on leafy vegetables from farms and markets revealed that Launaea taraxacifolia, Solanum macrocarpon, Solanum nigrum, Solanum aethiopicum, Solanecio biafrae, Crassocephalum crepidioides and Basella alba are of high medicinal value. They can be used solely or as a recipe with other leafy plants in the treatment of various ailments including malaria, typhoid, blood pressure, stomach disorder, heart diseases and gastrointestinal tract infections. These vegetable species have been neglected and underutilized by humans. Generally, a low degree of consumption, extent of consumption, and cash income capacity was recorded, with exception to the commonly cultivated vegetables. Extracted DNA from the leafy vegetables yielded good-quality DNA; this has been deposited in the DNA bank at the University of Lagos. This study has documented indigenous knowledge on leafy vegetables in southwest Nigeria and contributed towards ex-situ conservation of the species in the DNA bank. Keywords: Leafy Vegetables, Ethnobotany, Genetic Conservation, Indigenous knowledge, Underutilized species
叶菜在人体营养中很重要;然而,从尼日利亚西南部的菜肴中可以看出,它们的多样性似乎正在减少。许多受欢迎的美食在市场上已经买不到了。因此,本研究旨在鉴定和记录尼日利亚西南部的叶菜,通过向农民/销售者发放问卷评估其民族植物学用途,确保其遗传资源基础,并改善其价值链。蔬菜样本采集于尼日利亚西南部5个州的不同当地社区,使用手工/植物区系进行鉴定,并在拉各斯大学植物标本室进行鉴定。1000名受访者(每个州200人)参与了这项研究。其中女性占76.7%,男性占23.3%。共收集了26种叶类蔬菜。21种为研究区特有物种,5种为非本地物种。对农场和市场的叶菜进行民族植物学调查发现,蒲公英、大茄、黑茄、埃塞俄比亚茄、白茄、白茄等蔬菜具有较高的药用价值。它们可以单独使用,也可以与其他叶状植物一起用于治疗各种疾病,包括疟疾、伤寒、血压、胃病、心脏病和胃肠道感染。这些蔬菜物种一直被人类忽视和利用不足。一般来说,消费程度、消费范围和现金收入能力都较低,但一般种植的蔬菜除外。从叶菜中提取的DNA得到了高质量的DNA;这已经被存放在拉各斯大学的DNA银行中。这项研究记录了尼日利亚西南部叶菜的本土知识,并为该物种在DNA库中的迁地保护做出了贡献。关键词:叶菜,民族植物学,遗传保护,本土知识,未充分利用物种
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引用次数: 0
Feeding Habits and Diet Composition of the African Sacred Ibis in Selected Water-Logged Sites in Dar es Salaam, Tanzania 在坦桑尼亚达累斯萨拉姆选定的浸水地点,非洲朱鹮的摄食习惯和饮食组成
Pub Date : 2023-06-30 DOI: 10.4314/tjs.v49i2.9
Jared S. Bakuza, Joyce Ndinadyo
The African Sacred Ibises Threskiornis aethiopicus are generalist birds that feed on many invertebrates and some vertebrates. However, the diet composition of local T. aethiopicus populations in wetland areas in Dar es Salaam Tanzania was unknown. Sacred Ibises from eight water-logged areas in Dar es Salaam City, Tanzania were studied to determine their feeding habits and diet composition using direct observations and molecular analysis of faecal samples. Snails species identified from sites frequented by T. aethiopicus included Lymnaea natalensis (61.62%), Melanoides tuberculatus (20.64%), Bulinus sp. (17.66%) and Anisus sp. (0.08%), while molecular analysis of the birds’ diet revealed presence of mostly non-native invasive molluscs (Physa acuta, Planorbella trivolvis and Radix natalensis), fungus (Candida parapsilosis) and protozoan ciliate (Vorticella striata). There was no significant association between bird and snail abundance (r = 0.2141, p > 0.05, ns) although snail diversity showed strong negative relationship (r = -0.7904, p < 0.05). Our findings indicate that the African Sacred Ibises do not preferentially feed on snails, but do so as part of their broader diet. The results confirm that the African Sacred Ibis is a generalist feeder and therefore, ecological impacts of its feeding strategies particularly on invasive snails should be further investigated. Keywords: African Sacred Ibis, feeding, diet, molluscs, generalist
非洲朱鹮Threskiornis aethiopicus是一种多面手鸟类,以许多无脊椎动物和一些脊椎动物为食。然而,坦桑尼亚达累斯萨拉姆湿地地区埃塞俄比亚衣库蝇种群的食性组成尚不清楚。研究人员对坦桑尼亚达累斯萨拉姆市八个水涝地区的朱鹮进行了研究,通过直接观察和粪便样本的分子分析来确定它们的摄食习性和饮食组成。在埃塞褐家螺常居的地点鉴定到的钉螺种类主要有:lynaea natalensis(61.62%)、Melanoides tuberculatus(20.64%)、Bulinus sp.(17.66%)和Anisus sp.(0.08%),食性分子分析显示主要有外来入侵软体动物(Physa acuta、Planorbella trivolvis和Radix natalensis)、真菌(Candida parapsilosis)和原生虫(Vorticella striata)。鸟类和蜗牛丰度之间无显著相关性(r = 0.2141, p >0.05, ns),但蜗牛多样性呈显著负相关(r = -0.7904, p <0.05)。我们的研究结果表明,非洲神圣朱鹮并不优先以蜗牛为食,但这是它们更广泛饮食的一部分。结果表明,非洲朱鹮是一种多面体的取食动物,因此,需要进一步研究其取食策略,特别是对入侵蜗牛的生态影响。 关键词:非洲朱鹮,饲养,饮食,软体动物,通才
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引用次数: 0
Molecular Epidemiology of Antibiotic Resistance among Escherichia coli Isolated from Broiler Chickens Sold at Selected Markets in Dar es Salaam, Tanzania 坦桑尼亚达累斯萨拉姆选定市场出售的肉鸡分离出的大肠杆菌抗生素耐药性的分子流行病学研究
Pub Date : 2023-06-30 DOI: 10.4314/tjs.v49i2.13
Abdilahi H. Kiula, Victor A. Makene
Unwarranted and improper uses of antibiotics in broiler farms contribute to the challenge of antibiotic resistance, making even previously treatable infections, difficult to treat. We conducted a cross sectional study from November 2021 to May 2022 from broiler chicken markets in four districts of Dar es Salaam to determine the extent of antibiotic resistance among E. coli isolates from broiler chickens. A total of 160 E. coli isolates recovered from cloacal swabs were identified by culture and biochemical tests and confirmed by Polymerase Chain Reaction (PCR) assays. Antimicrobial susceptibility testing, targeting seven classes of antibiotics, was performed by disk diffusion method and eleven representative antimicrobial resistance markers corresponding to each antibiotic class were screened by PCR. The highest resistance was found against trimethoprim (75%) and erythromycin (74.37%), while the most common resistance gene was dfrA1 (74.37%) and blaTEM (73.75%). The study also found a high prevalence of multidrug-resistant isolates (84.4%) from at least three antibiotic classes. The results highlight the significant contribution of poultry farming to the spread of antibiotic resistance, with potential consequences for both farmers and human health. Prompt measures are necessary to protect human and animal health..
在肉鸡养殖场中无根据和不当使用抗生素会造成抗生素耐药性的挑战,使以前可以治疗的感染也难以治疗。我们于2021年11月至2022年5月在达累斯萨拉姆四个地区的肉鸡市场进行了一项横断面研究,以确定肉鸡大肠杆菌分离株的抗生素耐药性程度。通过培养和生化试验鉴定了160株大肠杆菌,并采用聚合酶链反应(PCR)方法对其进行了鉴定。采用纸片扩散法对7类抗生素进行药敏试验,并采用PCR方法筛选出11个具有代表性的耐药标记。耐药基因以甲氧苄氨嘧啶(75%)和红霉素(74.37%)最高,dfrA1(74.37%)和blaTEM(73.75%)最常见。该研究还发现,来自至少三种抗生素类别的多重耐药分离株的流行率很高(84.4%)。这些结果突出了家禽养殖对抗生素耐药性传播的重大贡献,对农民和人类健康都有潜在的后果。必须立即采取措施保护人类和动物的健康。
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引用次数: 0
Effects of Roasting Conditions on the Proximate Composition and Functional Properties of Common Bean (Phaseolus vulgaris) Flours 焙烧条件对普通豆粉近似成分及功能特性的影响
Pub Date : 2023-06-30 DOI: 10.4314/tjs.v49i2.23
Rachel Byarugaba, Agnes Nabubuya, John Muyonga, Ali Mwakha
Roasting of dry beans presents the possibility of a value-added product with improved nutritional quality and potential use in different food systems. The effect of roasting on the proximate composition and functional properties of dry beans (Phaseolus vulgaris L.) was determined. Beans were roasted at 140, 170, and 200 °C for 5, 10, and 15 minutes. The moisture, carbohydrate, protein, dietary fibre, total ash and fat contents of the flours ranged from 4.58 to 6.72%, 56.21 to 60.51%, 23.09 to 26.74%, 4.12 to 7.01%, 3.94 to 4.58% and 1.28 to 2.10%, respectively. An increase in roasting temperature and time significantly reduced moisture and carbohydrate contents, but increased fat, fibre and ash contents. Foaming capacity, foam stability, water absorption index, water solubility index and water absorption capacity varied from 6.16 to 45.14%, 2.10 to 30.68%, 4.20 to 5.12 g/g, 10.74 to 17.15 g/g and 1.77 to 2.2 g/g, respectively. Increasing roasting temperature and time impacted functional properties of flours. Pasting properties of bean flour pastes were significantly reduced. Flour from roasted beans (FRBs) can serve as a functional ingredient and nutrient enhancer in the food industry. In order to increase shelf life and nutrient density of bean flours, the beans should be roasted at 200 °C.
烘干豆提供了一种增值产品的可能性,它具有改善营养质量和在不同食品系统中的潜在用途。研究了焙烧对干豆(Phaseolus vulgaris L.)近似成分和功能特性的影响。豆子分别在140、170和200°C的温度下烤5、10和15分钟。面粉的水分、碳水化合物、蛋白质、膳食纤维、总灰分和脂肪含量分别为4.58 ~ 6.72%、56.21 ~ 60.51%、23.09 ~ 26.74%、4.12 ~ 7.01%、3.94 ~ 4.58%和1.28 ~ 2.10%。焙烧温度和时间的增加显著降低了水分和碳水化合物含量,但增加了脂肪、纤维和灰分含量。泡沫容量、泡沫稳定性、吸水指数、水溶性指数和吸水容量分别为6.16 ~ 45.14%、2.10 ~ 30.68%、4.20 ~ 5.12 g/g、10.74 ~ 17.15 g/g和1.77 ~ 2.2 g/g。提高焙烧温度和焙烧时间对面粉的功能性能有影响。豆粉糊的糊化性能明显降低。在食品工业中,焙豆面粉可作为一种功能性成分和营养增强剂。为了增加豆粉的保质期和营养密度,豆粉应在200°C下烘烤。
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引用次数: 0
Investigation of Antidiabetic Activities of Cu(II) Complex of Anacardium occidentale Leaves Crude Extract 西心梗叶粗提物Cu(II)配合物抗糖尿病活性的研究
Pub Date : 2023-06-30 DOI: 10.4314/tjs.v49i2.3
Mary Adelaide Oladipo, Folasade Omobolanle Ajao, Adewusi John Adepoju, Kayode Taiwo Ishola, Deborah Omowumi Afolabi
Many synthetic chemical drugs have been widely used for the treatment of diabetes. However, many of these drugs are not locally available, are less effective, and are unaffordable for many diabetic patients in developing and underdeveloped countries. Therefore, in order to search for a locally available, effective, and cost-effective antidiabetic agent, this study synthesized the Cu(II) complex of crude leaf extract of Anacardium occidentale and investigated its antidiabetic activity in alloxan induced albino rats. The leaf crude extract and its metal complex were characterized using atomic absorption spectroscopy (AAS) and infrared (IR) spectroscopy. Experimental diabetic animals were induced by a single intraperitoneal injection of alloxan monohydrate at a single dose of 140 mg/kg body weight (b.wt.), and animals with fasting blood glucose levels (BGL) > 200 mg/dl were considered diabetic. Metformin was used as a standard drug. Fasting blood glucose level (BGL) and body weight were examined in assessing the antidiabetic activities of the crude extract and its complex in the rats. One-way ANOVA was used to determine the antidiabetic activity at a statistical significance level of p < 0.05. The hypsochromic shifts of C=O and O-H bands in the Cu(II) complex and the high concentration of the metal ion in the metal complex established the coordination of the crude extract with the metal ion. A more significant reduction in the blood glucose level and increase in body weight in alloxan-induced diabetic albino rats was observed when treated with the leaves crude extract and its Cu(II) complex than when treated with the standard drug metformin. It can be concluded that the Cu(II) complex of Anacardium occidentale leaf extract at a dose of 400 mg/kg wt is more effective without abnormal weight gain and could be considered as a potential antidiabetic drug to replace some of the less effective and expensive conventional antidiabetic drugs.
许多合成化学药物已被广泛用于糖尿病的治疗。然而,在发展中国家和不发达国家,许多这些药物在当地无法获得,效果较差,而且对许多糖尿病患者来说负担不起。因此,为了寻找一种局部可用、有效且具有成本效益的降糖药,本研究合成了西心梗粗叶提取物的Cu(II)配合物,并对其在四氧嘧啶诱导的白化大鼠体内的降糖活性进行了研究。采用原子吸收光谱(AAS)和红外光谱(IR)对叶提取物及其金属配合物进行了表征。实验动物以140 mg/kg体重(b.wt.)单次腹腔注射一水四氧嘧啶诱导糖尿病,并将空腹血糖水平(BGL) >200 mg/dl被认为是糖尿病。二甲双胍被用作标准药物。测定大鼠空腹血糖水平(BGL)和体重,评价粗提物及其复合物的抗糖尿病作用。采用单因素方差分析(One-way ANOVA)测定抗糖尿病活性,p <水平具有统计学意义;0.05. Cu(II)配合物中C=O和O- h带的次色移以及金属配合物中金属离子的高浓度建立了粗提物与金属离子的配位关系。在四氧嘧啶诱导的糖尿病白化大鼠中,用叶子粗提取物及其铜(II)复合物治疗比用标准药物二甲双胍治疗更显著地降低了血糖水平,增加了体重。综上所述,在400 mg/kg wt剂量下,西心草叶提取物的Cu(II)配合物更有效,且不会出现体重异常增加,可以考虑作为一种潜在的降糖药物来取代一些效果较差且价格昂贵的常规降糖药物。
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引用次数: 0
The Estimation of Heavy Tails in Non-linear Models 非线性模型中重尾的估计
Pub Date : 2023-06-30 DOI: 10.4314/tjs.v49i2.5
Josephine N. Onyeka-Ubaka, Olaide Abass
A generalized student t distribution technique based on estimation of bilinear generalized autoregressive conditional heteroskedasticity (BL-GARCH) model is introduced. The paper investigates from empirical perspective, aspects of the model related to the economic and financial risk management and its impacts on volatility forecasting. The purposive sampling technique was applied to select four banks for the study, namely First Bank of Nigeria (FBN), Guaranty Trust Bank (GTB), United Bank for Africa (UBA) and Zenith Bank (ZEB). The four banks are selected, because their daily stock prices are considered to be more susceptible to volatility than those of other banks within the sampled period (January 2007–May 2022). The data collected were analyzed using MATLAB R2008b Software. The results show that the newly introduced generalized student t distribution is the most general of all the useful distributions applied in the BL-GARCH model parameter estimation. It serves as a general distribution for obtaining empirical characteristics such as volatility clustering, leptokurtosis and leverage effects between returns and conditional variances as well as capturing heavier and lighter tails in high frequency financial time series data.
介绍了一种基于双线性广义自回归条件异方差(BL-GARCH)模型估计的广义学生t分布技术。本文从实证角度考察了该模型与经济金融风险管理相关的方面及其对波动率预测的影响。采用有目的抽样技术选择四家银行进行研究,即尼日利亚第一银行(FBN),担保信托银行(GTB),非洲联合银行(UBA)和Zenith银行(ZEB)。之所以选择这四家银行,是因为在抽样期间(2007年1月至2022年5月),它们的每日股价被认为比其他银行更容易受到波动的影响。采用MATLAB R2008b软件对采集的数据进行分析。结果表明,新引入的广义学生t分布是用于BL-GARCH模型参数估计的所有有用分布中最通用的。它是获得收益与条件方差之间的波动率聚类、细峰态、杠杆效应等经验特征以及捕捉高频金融时间序列数据的重尾和轻尾的一般分布。
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引用次数: 0
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Tanzania Journal of Science
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