Background: Diabetes Mellitus (DM) is associated with significant morbidity and mortality. Diabetic foot syndrome is one of the most common devastating preventable complications of diabetes mellitus (DM). Objectives: We aimed to evaluate the knowledge, Beliefs and Practices (KBP) among Omani patients with type 1 diabetes mellitus (T1DM) regarding DM and Diabetes foot. Design: A cross sectional descriptive study was used. Settings: A secondary care, polyclinic named Bawshar in Muscat, Oman where patients were seen three days per week. Sample Size:A convenient sample of 100 participants between age group 16 to 30 years were involved. Materials and methods: A validated semi- structured questionnaire was used to assess KBP of T1DM with six domains. During the study period from November 2019 to December 2019. .The data was analysed by using Statistical Package for the Social Sciences (SPSS) Statistics Inc., Chicago, US version 20. Results: There were 50 females, 50 males; 5 % of patients were illiterate and 30% of them were working. 65% were students. Only 50% checked their foot regularly and only 55% check there blood glucose regularly .57% don’t know the cause of diabetes, 25% don’t know the complications of the same while 20% don’t know cause of diabetic foot and 25% don’t know the symptoms of diabetic foot. 20% beliefs checking blood glucose is the responsibility of the doctor and 85% beliefs walking bare foot is high risk factor for DM foot. Conclusions: In reality healthcare providers must be trained to counsel people with DM to plan adequate interventions that enable an understanding of the offered information. A well-structured ,Behaviour change counselling (BCC) like Motivational interviewing (MI)are considered the ideal practices for this patients, to prevent DM complications.
背景:糖尿病(DM)与显著的发病率和死亡率相关。糖尿病足综合征是糖尿病(DM)最常见的破坏性可预防并发症之一。目的:我们旨在评估阿曼1型糖尿病(T1DM)患者关于糖尿病和糖尿病足的知识、信念和实践(KBP)。设计:采用横断面描述性研究。环境:阿曼马斯喀特一家名为bashar的二级保健综合诊所，病人每周就诊三天。样本量:选取100名年龄在16至30岁之间的参与者作为方便样本。材料与方法:采用经验证的半结构化问卷对T1DM患者的KBP进行六个领域的评估。研究期间为2019年11月至2019年12月，使用美国芝加哥SPSS统计公司(Statistical Package for the Social Sciences)第20版对数据进行分析。结果:女性50例，男性50例;5%的病人是文盲，30%的病人有工作。65%是学生。只有50%的人定期检查足部，只有55%的人定期检查血糖。57%的人不知道糖尿病的病因，25%的人不知道糖尿病的并发症，20%的人不知道糖尿病足的病因，25%的人不知道糖尿病足的症状。20%的人认为检查血糖是医生的责任，85%的人认为光脚走路是糖尿病足的高风险因素。结论:在现实中，医疗保健提供者必须接受培训，为糖尿病患者提供咨询，以计划适当的干预措施，使他们能够理解所提供的信息。结构良好的行为改变咨询(BCC)，如动机性访谈(MI)，被认为是这种患者预防糖尿病并发症的理想做法。
{"title":"Knowledge, Beliefs and Practices of People diagnosed with Type-1 Diabetes towards Diabetes Mellitus and Diabetic Foot Syndrome","authors":"Shiju Raman Unni, Hani Naguib, M. Mccallum","doi":"10.31579/2641-8975/025","DOIUrl":"https://doi.org/10.31579/2641-8975/025","url":null,"abstract":"Background: Diabetes Mellitus (DM) is associated with significant morbidity and mortality. Diabetic foot syndrome is one of the most common devastating preventable complications of diabetes mellitus (DM). Objectives: We aimed to evaluate the knowledge, Beliefs and Practices (KBP) among Omani patients with type 1 diabetes mellitus (T1DM) regarding DM and Diabetes foot. Design: A cross sectional descriptive study was used. Settings: A secondary care, polyclinic named Bawshar in Muscat, Oman where patients were seen three days per week. Sample Size:A convenient sample of 100 participants between age group 16 to 30 years were involved. Materials and methods: A validated semi- structured questionnaire was used to assess KBP of T1DM with six domains. During the study period from November 2019 to December 2019. .The data was analysed by using Statistical Package for the Social Sciences (SPSS) Statistics Inc., Chicago, US version 20. Results: There were 50 females, 50 males; 5 % of patients were illiterate and 30% of them were working. 65% were students. Only 50% checked their foot regularly and only 55% check there blood glucose regularly .57% don’t know the cause of diabetes, 25% don’t know the complications of the same while 20% don’t know cause of diabetic foot and 25% don’t know the symptoms of diabetic foot. 20% beliefs checking blood glucose is the responsibility of the doctor and 85% beliefs walking bare foot is high risk factor for DM foot. Conclusions: In reality healthcare providers must be trained to counsel people with DM to plan adequate interventions that enable an understanding of the offered information. A well-structured ,Behaviour change counselling (BCC) like Motivational interviewing (MI)are considered the ideal practices for this patients, to prevent DM complications.","PeriodicalId":222395,"journal":{"name":"Diabetes and Islet Biology","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114378528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This editorial aimed to put forward a question if chrono-nutrition can help prevent diabetes through optimizing circadian rhythms of glucose metabolism. With the advancing mechanization, eating behavior (timing, sequence, and frequency) has changed. People are now more willing to eat fast foods at suboptimal times of the circadian period. Growing evidence suggests that untimely eating and lack of exercise can interfere with optimal physiological rhythms of glucose and insulin metabolism that can lead to diabetes. Type 2 diabetes mellitus (T2D) is a foremost metabolic disorder worldwide occurring largely due to suboptimal eating timing and lifestyle. Consuming less sugars and carbohydrates during evening and overnight may help optimize human chrono-physiology. Chrono-nutrition via optimizing the timing of meals is a growing science that needs to be well practiced to help prevent or possibly reduce risks of T2D in today’s complicated life.
{"title":"Can Chrono-Nutrition Help Prevent Diabetes?","authors":"A. Nikkhah","doi":"10.31579/2641-8975/031","DOIUrl":"https://doi.org/10.31579/2641-8975/031","url":null,"abstract":"This editorial aimed to put forward a question if chrono-nutrition can help prevent diabetes through optimizing circadian rhythms of glucose metabolism. With the advancing mechanization, eating behavior (timing, sequence, and frequency) has changed. People are now more willing to eat fast foods at suboptimal times of the circadian period. Growing evidence suggests that untimely eating and lack of exercise can interfere with optimal physiological rhythms of glucose and insulin metabolism that can lead to diabetes. Type 2 diabetes mellitus (T2D) is a foremost metabolic disorder worldwide occurring largely due to suboptimal eating timing and lifestyle. Consuming less sugars and carbohydrates during evening and overnight may help optimize human chrono-physiology. Chrono-nutrition via optimizing the timing of meals is a growing science that needs to be well practiced to help prevent or possibly reduce risks of T2D in today’s complicated life.","PeriodicalId":222395,"journal":{"name":"Diabetes and Islet Biology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132973554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The pancreas in a non-diabetic patient invariably produces a lesser quantum of insulin (basal production). Insulin furnishes glucose homeostasis by keeping the plasma glucose worth in an optimum class throughout the day. It assists transport blood glucose into the body cells where the glucose is metabolized to generate energy. Regular insulin is inserted pre-meal to abrupt the postprandial ascend in glucose levels. It figures hexamers after insertion into the subcutaneous space sluggishing its absorption. Ultra-fast acting commences to act 4-7 minutes before regular apidra and lasts for around 3 hours. The absorption rate of lente insulin is downgraded by the extension of zinc to the insulin preparation. Long-acting insulins furnish basal insulin coverage. Atrophy of subcutaneous fat owing to applicability of further greater accumulated insulin preparations of neutral potenz hydrogen.
{"title":"Role of Insulin: Perspectives","authors":"Gudisa Bereda","doi":"10.31579/2641-8975/030","DOIUrl":"https://doi.org/10.31579/2641-8975/030","url":null,"abstract":"The pancreas in a non-diabetic patient invariably produces a lesser quantum of insulin (basal production). Insulin furnishes glucose homeostasis by keeping the plasma glucose worth in an optimum class throughout the day. It assists transport blood glucose into the body cells where the glucose is metabolized to generate energy. Regular insulin is inserted pre-meal to abrupt the postprandial ascend in glucose levels. It figures hexamers after insertion into the subcutaneous space sluggishing its absorption. Ultra-fast acting commences to act 4-7 minutes before regular apidra and lasts for around 3 hours. The absorption rate of lente insulin is downgraded by the extension of zinc to the insulin preparation. Long-acting insulins furnish basal insulin coverage. Atrophy of subcutaneous fat owing to applicability of further greater accumulated insulin preparations of neutral potenz hydrogen.","PeriodicalId":222395,"journal":{"name":"Diabetes and Islet Biology","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130488473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The growing impact of type 2 diabetes in the majority of the population requires the introduction of better and more secure treatments, but also requires the development of new prevention strategies to reduce the incidence and prevalence of the disease. Significantly, type 2 diabetes is an important preventable disease and can be prevented or delayed by lifestyle intervention. Edible and medicinal macrofungi, mushrooms have been reported having diabetes ameliorating effects. Current study reviews the potentiality of both edible and medicinal mushrooms in preventing and ameliorating the diabetic complications as well as the future aspects of mushrooms against this metabolic disorder.
{"title":"Diabetes Ameliorating Effect of Mushrooms and ameliorating diabetes","authors":"M. Azizur Rahman, Rabeya Akter","doi":"10.31579/2641-8975/026","DOIUrl":"https://doi.org/10.31579/2641-8975/026","url":null,"abstract":"The growing impact of type 2 diabetes in the majority of the population requires the introduction of better and more secure treatments, but also requires the development of new prevention strategies to reduce the incidence and prevalence of the disease. Significantly, type 2 diabetes is an important preventable disease and can be prevented or delayed by lifestyle intervention. Edible and medicinal macrofungi, mushrooms have been reported having diabetes ameliorating effects. Current study reviews the potentiality of both edible and medicinal mushrooms in preventing and ameliorating the diabetic complications as well as the future aspects of mushrooms against this metabolic disorder.","PeriodicalId":222395,"journal":{"name":"Diabetes and Islet Biology","volume":"114 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134100534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The paper was to throw some light on the risk factors for diabetes disability among Bangladeshi adults of 18 years and above residing in both urban and rural areas. In investigating the adults, it was decided to cover 50.1% males and 49.9% females to maintain the national level of sex ratio in the sample. The respondents were interviewed when they were visiting some diagnostic centres in urban and semi-urban areas. The percentage of diabetic respondents included in the sample was 67% and 25.5% of them were suffering for 10 years and above, 6.4% were disable against 4.8% total disable respondents in the sample, and obese adults were 30.2%. Diabetic disable adults in the sample were 4.3%. The most responsible variable for diabetes disability was obesity followed by longer duration of diabetes, sedentary activity, smoking habit, being housewife, being married, etc. These variables were identified on the basis of risk ratio and correlation coefficients of variables and discriminant function scores. Beside these variables, rural people, Muslims, adults of ages 40 – 50 years, illiterate people had more risk of facing the problem of diabetes disability.
{"title":"Identification of Risk Factors for Diabetes Disability among Bangladeshi Adults","authors":"K. Bhuyan","doi":"10.31579/2641-8975/027","DOIUrl":"https://doi.org/10.31579/2641-8975/027","url":null,"abstract":"The paper was to throw some light on the risk factors for diabetes disability among Bangladeshi adults of 18 years and above residing in both urban and rural areas. In investigating the adults, it was decided to cover 50.1% males and 49.9% females to maintain the national level of sex ratio in the sample. The respondents were interviewed when they were visiting some diagnostic centres in urban and semi-urban areas. The percentage of diabetic respondents included in the sample was 67% and 25.5% of them were suffering for 10 years and above, 6.4% were disable against 4.8% total disable respondents in the sample, and obese adults were 30.2%. Diabetic disable adults in the sample were 4.3%. The most responsible variable for diabetes disability was obesity followed by longer duration of diabetes, sedentary activity, smoking habit, being housewife, being married, etc. These variables were identified on the basis of risk ratio and correlation coefficients of variables and discriminant function scores. Beside these variables, rural people, Muslims, adults of ages 40 – 50 years, illiterate people had more risk of facing the problem of diabetes disability.","PeriodicalId":222395,"journal":{"name":"Diabetes and Islet Biology","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116186774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Type 2 Diabetes Mellitus (T2DM) is a common metabolic disorder at a pandemic proportion at present. Often T2DM is associated with microvascular (diabetic nephropathy, neuropathy, and retinopathy) and macrovascular complications (coronary artery disease, peripheral arterial disease, and stroke). Additionally diabetic osteopathy is a significant comorbidity of T2DM and is characterized by micro architectural changes that decrease bone quality leading to an increased risk of fragility fracture.
{"title":"Osteoporosis Prevalence and Correlates in Uncomplicated Type 2 Diabetes Mellitus","authors":"A. Nachankar, J. Sahu","doi":"10.31579/2641-8975/028","DOIUrl":"https://doi.org/10.31579/2641-8975/028","url":null,"abstract":"Type 2 Diabetes Mellitus (T2DM) is a common metabolic disorder at a pandemic proportion at present. Often T2DM is associated with microvascular (diabetic nephropathy, neuropathy, and retinopathy) and macrovascular complications (coronary artery disease, peripheral arterial disease, and stroke). Additionally diabetic osteopathy is a significant comorbidity of T2DM and is characterized by micro architectural changes that decrease bone quality leading to an increased risk of fragility fracture.","PeriodicalId":222395,"journal":{"name":"Diabetes and Islet Biology","volume":"77 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123315743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The information presented here were the analytical results observed from data collected in investigating 995 Bangladeshi adults of 18 years and above. The objective of the investigation was to identify socioeconomic variables which enhance the health hazard obesity kidney disease. The analysis indicated that this health problem was noted among 6.2% respondents and it was predominant among males, non-Muslims, elderly people, lower level educated adults, people belonged to families of medium economy, smokers, adults involved in sedentary activities, diabetic and hypertensive respondents. The prevalence rates among these respondents were 0.074, 0.088, 0.188, 0.099, 0.098, 0.088, 0.075, 0.075 and 0.186, respectively. However, all these socioeconomic variables were not similarly responsible for obesity kidney disease among the adults. The most responsible variable was family expenditure followed by family income, physical labour, age, process food consumption, hypertension and duration of diabetes. These variables were identified by factor analysis.
{"title":"Identification of Socioeconomic Variables Responsible for Obesity Kidney Disease among Bangladeshi Adults","authors":"K. Bhuyan","doi":"10.31579/2641-8975/024","DOIUrl":"https://doi.org/10.31579/2641-8975/024","url":null,"abstract":"The information presented here were the analytical results observed from data collected in investigating 995 Bangladeshi adults of 18 years and above. The objective of the investigation was to identify socioeconomic variables which enhance the health hazard obesity kidney disease. The analysis indicated that this health problem was noted among 6.2% respondents and it was predominant among males, non-Muslims, elderly people, lower level educated adults, people belonged to families of medium economy, smokers, adults involved in sedentary activities, diabetic and hypertensive respondents. The prevalence rates among these respondents were 0.074, 0.088, 0.188, 0.099, 0.098, 0.088, 0.075, 0.075 and 0.186, respectively. However, all these socioeconomic variables were not similarly responsible for obesity kidney disease among the adults. The most responsible variable was family expenditure followed by family income, physical labour, age, process food consumption, hypertension and duration of diabetes. These variables were identified by factor analysis.","PeriodicalId":222395,"journal":{"name":"Diabetes and Islet Biology","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115057764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bodun Oye Olakanmi, O. Olorundare, S. Afolabi, A. Njan, O. Akinola, Olatunde Akanbi, A. Nyamngee, A. Adeneye, E. Iwalewa, J. Ntambi
The antidiabetic effects of crude methanolic extracts of the leaf and twig of Loranthus micranthus was evaluated in Wister rats. To assess this, data were obtained for the determinant parameters of diabetic complications. Streptozotocin was administered for induction of diabetes; diabetic state was confirmed by persistent hyperglycemia (FBG ≥ 300mg/dl) at 72 hours post induction. Invitro inhibitory activity on α- amylase and α-glucosidase was assayed. Serum insulin, TNF-α, Total cholesterol, HDL, LDL, TG, atherogenic index, liver glycogen and glycated haemoglobin were evaluated. Histology of the pancreas was assessed. Phytochemical analysis revealed the presence of unique compounds in both extracts. In-vitro assay showed inhibitory effects of both extracts on α-amylase and α-glucosidase activity. Hyperglycemia was controlled in both extract-treated groups comparable to glibenclamide. Weight loss after diabetic induction was ameliorated in extracts treated groups; serum insulin level of the extracts-treated and glibenclamide treated-group were higher than the diabetic control group. Serum TNF-α level of extracts-treated and glibenclamide-treated groups were significantly lower than the diabetic control group. Glycated haemoglobin levels of diabetic control group were higher than the extracts treated and glibenclamide group. Dyslipidemia observed in the diabetic control group were ameliorated in all extract-treated groups; atherogenic index of diabetic control group was higher than extracts-and-glibenclamide treated groups. Histopathological assessment showed that the leaf and twig extracts of Loranthus micranthus may possess β cell regenerating activity. Findings from this study suggest that the leaf and twig extracts of Loranthus micranthus ameliorate symptoms and complications of streptozotocin-induced diabetes in rats.
{"title":"Assessment of The Effects Of Crude Metabolic Extracts (Leaf And Twig) of Loranthus Micranthus On Streptozotocin Induced Diabetic Rats","authors":"Bodun Oye Olakanmi, O. Olorundare, S. Afolabi, A. Njan, O. Akinola, Olatunde Akanbi, A. Nyamngee, A. Adeneye, E. Iwalewa, J. Ntambi","doi":"10.31579/2641-8975/015","DOIUrl":"https://doi.org/10.31579/2641-8975/015","url":null,"abstract":"The antidiabetic effects of crude methanolic extracts of the leaf and twig of Loranthus micranthus was evaluated in Wister rats. To assess this, data were obtained for the determinant parameters of diabetic complications. Streptozotocin was administered for induction of diabetes; diabetic state was confirmed by persistent hyperglycemia (FBG ≥ 300mg/dl) at 72 hours post induction. Invitro inhibitory activity on α- amylase and α-glucosidase was assayed. Serum insulin, TNF-α, Total cholesterol, HDL, LDL, TG, atherogenic index, liver glycogen and glycated haemoglobin were evaluated. Histology of the pancreas was assessed. Phytochemical analysis revealed the presence of unique compounds in both extracts. In-vitro assay showed inhibitory effects of both extracts on α-amylase and α-glucosidase activity. Hyperglycemia was controlled in both extract-treated groups comparable to glibenclamide. Weight loss after diabetic induction was ameliorated in extracts treated groups; serum insulin level of the extracts-treated and glibenclamide treated-group were higher than the diabetic control group. Serum TNF-α level of extracts-treated and glibenclamide-treated groups were significantly lower than the diabetic control group. Glycated haemoglobin levels of diabetic control group were higher than the extracts treated and glibenclamide group. Dyslipidemia observed in the diabetic control group were ameliorated in all extract-treated groups; atherogenic index of diabetic control group was higher than extracts-and-glibenclamide treated groups. Histopathological assessment showed that the leaf and twig extracts of Loranthus micranthus may possess β cell regenerating activity. Findings from this study suggest that the leaf and twig extracts of Loranthus micranthus ameliorate symptoms and complications of streptozotocin-induced diabetes in rats.","PeriodicalId":222395,"journal":{"name":"Diabetes and Islet Biology","volume":"132 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132980614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bhairav B Tawshikar, S. G. Deshmukh, Yashashree B. Kulkarni
Madhumeha is a disease known since ancient times to the mankind, its upsurge is quiet alarming. On the basis of its symptomatology Madhumeha can be correlated to the features of Diabetes mellitus. Diabetes mellitus is a metabolic disorder of carbohydrate, fat, & protein characterized by hyperglycemia with or without glycosuria. It is associated with long-term potentially catastrophic effects on almost all systems of the body. Ayurveda can provide better management for Madhumeha without hazardous side effects. In Ayurveda, Madhumeha has been described as one among one of the 20 types of Prameha and is a sub-type of Vatika Prameha. In the former type the patients are usually asthenic can be correlated with Type I DM and in the latter type patients are obese and can be equated with Type II DM. Nishakatakadi Kwath has been mentioned in Sahasrayoga under Kashaya Prakaran for Prameha Chikitsa, Nishakatakadi Kwath is being used widely for the treatment of Madhumeha in Kerala. That is why Nishakatakadi Kwath has been selected for the present study. In this study to study various clinical symptoms of madhumeha with special reference to Diabetes Mellitus II. To compare efficacy of Nishkatakadi Kwath with Metformin inthe management of Madhumeha, To observe any possible adverse effect of Nishkatakadi kwath if reported during the study. In the present study Trial and Control groups comprising 30 patients each of Madhumeha (Diabetes Mellitus type II) were treated with Nishkatakadi kwath with tab metformin and Tab Metformin alone respectively. This study shows that both the drugs NISHKATAKADI KWATH with metformin are more effective than METFORMIN in Madhumeha to reduce symptoms and patients score.
{"title":"To Compare Efficacy of Nishkatakadi Kwath with Metformin in Madhumeha With Special Refrence to Diabetes Mellitus ii","authors":"Bhairav B Tawshikar, S. G. Deshmukh, Yashashree B. Kulkarni","doi":"10.31579/2641-8975/029","DOIUrl":"https://doi.org/10.31579/2641-8975/029","url":null,"abstract":"Madhumeha is a disease known since ancient times to the mankind, its upsurge is quiet alarming. On the basis of its symptomatology Madhumeha can be correlated to the features of Diabetes mellitus. Diabetes mellitus is a metabolic disorder of carbohydrate, fat, & protein characterized by hyperglycemia with or without glycosuria. It is associated with long-term potentially catastrophic effects on almost all systems of the body. Ayurveda can provide better management for Madhumeha without hazardous side effects. In Ayurveda, Madhumeha has been described as one among one of the 20 types of Prameha and is a sub-type of Vatika Prameha. In the former type the patients are usually asthenic can be correlated with Type I DM and in the latter type patients are obese and can be equated with Type II DM. Nishakatakadi Kwath has been mentioned in Sahasrayoga under Kashaya Prakaran for Prameha Chikitsa, Nishakatakadi Kwath is being used widely for the treatment of Madhumeha in Kerala. That is why Nishakatakadi Kwath has been selected for the present study. In this study to study various clinical symptoms of madhumeha with special reference to Diabetes Mellitus II. To compare efficacy of Nishkatakadi Kwath with Metformin inthe management of Madhumeha, To observe any possible adverse effect of Nishkatakadi kwath if reported during the study. In the present study Trial and Control groups comprising 30 patients each of Madhumeha (Diabetes Mellitus type II) were treated with Nishkatakadi kwath with tab metformin and Tab Metformin alone respectively. This study shows that both the drugs NISHKATAKADI KWATH with metformin are more effective than METFORMIN in Madhumeha to reduce symptoms and patients score.","PeriodicalId":222395,"journal":{"name":"Diabetes and Islet Biology","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117109073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The most common and most serious diabetic emergencies in type 2 diabetic mellitus (T2DM) individuals are diabetic ketoacidosis and hyperosmolar hyperglycaemic (HH) state or hyperosmolar non-ketotic hyperglycaemia. Hyperosmolar hyperglycemia state is a serious condition caused by extreme hyperglycemia in T2DM. HH is usually characterized by extreme elevations in serum glucose level and hyperosmolality in individuals with no significant ketosis. These metabolic disturbances are the result from synergistic factors mainly insulin deficiency as well as increased levels of counter regulatory hormones viz. glucagon, catecholamines, cortisol, and other growth hormone. Wolfram Syndrome (WS) or DIDMOAD syndrome (Diabetes Insipidus Diabetes Mellitus Optic Atrophy and Deafness) is a rare genetic disorder to be known. DM is typically the first symptom of WS and onset is usually at the age of 6 years. A diabetic coma is a life-threatening and fatal diabetes complication that causes unconsciousness in long term T2DM patients. The severe conditions of both hypo- or hyper- glycemia may cause diabetic coma. Here we are describing the brief about Diabetic emergencies lead to coma and unconsciousness.
{"title":"Diabetes: A Syndrome leads to Coma","authors":"M. Saxena","doi":"10.31579/2688-7517/014","DOIUrl":"https://doi.org/10.31579/2688-7517/014","url":null,"abstract":"The most common and most serious diabetic emergencies in type 2 diabetic mellitus (T2DM) individuals are diabetic ketoacidosis and hyperosmolar hyperglycaemic (HH) state or hyperosmolar non-ketotic hyperglycaemia. Hyperosmolar hyperglycemia state is a serious condition caused by extreme hyperglycemia in T2DM. HH is usually characterized by extreme elevations in serum glucose level and hyperosmolality in individuals with no significant ketosis. These metabolic disturbances are the result from synergistic factors mainly insulin deficiency as well as increased levels of counter regulatory hormones viz. glucagon, catecholamines, cortisol, and other growth hormone. Wolfram Syndrome (WS) or DIDMOAD syndrome (Diabetes Insipidus Diabetes Mellitus Optic Atrophy and Deafness) is a rare genetic disorder to be known. DM is typically the first symptom of WS and onset is usually at the age of 6 years. A diabetic coma is a life-threatening and fatal diabetes complication that causes unconsciousness in long term T2DM patients. The severe conditions of both hypo- or hyper- glycemia may cause diabetic coma. Here we are describing the brief about Diabetic emergencies lead to coma and unconsciousness.","PeriodicalId":222395,"journal":{"name":"Diabetes and Islet Biology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128734636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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