Pub Date : 2021-05-12DOI: 10.9734/bpi/tipr/v3/1705f
D. Díaz, M. E. Iglesias, R. B. Vallejo, M. Díaz
Onychomycosis is a fungal infection of nails that is widespread and difficult to treat because of the impermeable nature of human nails. Topically applied anti-fungal agents cannot penetrate this structure, and treatment regimens often resort to systemic antifungals with concomitant side effects. One recent clinical study suggested that mechanical fenestration of the nail using an intelligent nail drill might be a possible solution to this problem. In this work, an in vitro model of the transungual delivery of antifungal agents is presented, which utilizes real nail tissue and an inline flow system. This system was deployed to measure transungual delivery of ciclopirox and determined that nail fenestration improved drug delivery by 3–4-fold after 42 days. This study bolsters the argument that nail fenestration should be accepted as a pretreatment for onychomycosis and offers a way of evaluating new drugs or formulations designed to combat this condition. The in vitro model described herein would be an excellent system to directly measure transungual delivery of antifungal agents prior to clinical trials.
{"title":"Research on Transungual Delivery of Ciclopirox is Increased 3–4-Fold by Mechanical Fenestration of Human Nail Plate in an in vitro Model","authors":"D. Díaz, M. E. Iglesias, R. B. Vallejo, M. Díaz","doi":"10.9734/bpi/tipr/v3/1705f","DOIUrl":"https://doi.org/10.9734/bpi/tipr/v3/1705f","url":null,"abstract":"Onychomycosis is a fungal infection of nails that is widespread and difficult to treat because of the impermeable nature of human nails. Topically applied anti-fungal agents cannot penetrate this structure, and treatment regimens often resort to systemic antifungals with concomitant side effects. One recent clinical study suggested that mechanical fenestration of the nail using an intelligent nail drill might be a possible solution to this problem. In this work, an in vitro model of the transungual delivery of antifungal agents is presented, which utilizes real nail tissue and an inline flow system. This system was deployed to measure transungual delivery of ciclopirox and determined that nail fenestration improved drug delivery by 3–4-fold after 42 days. This study bolsters the argument that nail fenestration should be accepted as a pretreatment for onychomycosis and offers a way of evaluating new drugs or formulations designed to combat this condition. The in vitro model described herein would be an excellent system to directly measure transungual delivery of antifungal agents prior to clinical trials.","PeriodicalId":22329,"journal":{"name":"Technological Innovation in Pharmaceutical Research Vol. 3","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79365929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-05-12DOI: 10.9734/bpi/tipr/v3/1696c
H. Rivai, Renny Puspita, Sesry Misfadhila
Development and validation of loperamide hydrochloride tablet method of analysis have been done by using the absorbance method and area under the curve method. This study used methanol and hydrochloric acid 0.1 N (9:1) as the best solvent with maximum absorption at wavelength 259.00 nm. The linearity of loperamide hydrochloride was obtained in the concentration range 200-600 ppm with a correlation coefficient value with the absorbance method and the areas under the curve method were 0.9998 and 0.9865, respectively. The results showed that the levels of loperamide hydrochloride in generic tablets obtained by absorbance method and the area under the curve method were 105.71% and 96.20%, respectively. The results of determination of loperamide levels in tablets of trademark obtained by absorbance method and the area under the curve method were 102.85% and 98.57%, respectively. The level of both samples met the requirements of Pharmacopoeia Indonesia edition V that is 90% -110%. The analysis of loperamide hydrochloride in tablets by ultraviolet-visible spectrophotometry by absorbance method is valid while the area under the curve method is invalid for analysis of loperamide hydrochloride in tablets.
{"title":"Recent Study on Development and Validation of Loperamide Hydrochloride Tablet Analysis Method with Absorbance and Area under Curve Methods Spectrophotometrically","authors":"H. Rivai, Renny Puspita, Sesry Misfadhila","doi":"10.9734/bpi/tipr/v3/1696c","DOIUrl":"https://doi.org/10.9734/bpi/tipr/v3/1696c","url":null,"abstract":"Development and validation of loperamide hydrochloride tablet method of analysis have been done by using the absorbance method and area under the curve method. This study used methanol and hydrochloric acid 0.1 N (9:1) as the best solvent with maximum absorption at wavelength 259.00 nm. The linearity of loperamide hydrochloride was obtained in the concentration range 200-600 ppm with a correlation coefficient value with the absorbance method and the areas under the curve method were 0.9998 and 0.9865, respectively. The results showed that the levels of loperamide hydrochloride in generic tablets obtained by absorbance method and the area under the curve method were 105.71% and 96.20%, respectively. The results of determination of loperamide levels in tablets of trademark obtained by absorbance method and the area under the curve method were 102.85% and 98.57%, respectively. The level of both samples met the requirements of Pharmacopoeia Indonesia edition V that is 90% -110%. The analysis of loperamide hydrochloride in tablets by ultraviolet-visible spectrophotometry by absorbance method is valid while the area under the curve method is invalid for analysis of loperamide hydrochloride in tablets.","PeriodicalId":22329,"journal":{"name":"Technological Innovation in Pharmaceutical Research Vol. 3","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83662562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-12-15DOI: 10.51142/issues-journal-3-1-5
R. Sharples
{"title":"Karen activism at the Thai-Burma borderlands","authors":"R. Sharples","doi":"10.51142/issues-journal-3-1-5","DOIUrl":"https://doi.org/10.51142/issues-journal-3-1-5","url":null,"abstract":"","PeriodicalId":22329,"journal":{"name":"Technological Innovation in Pharmaceutical Research Vol. 3","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78033179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-12-15DOI: 10.51142/issues-journal-3-1-2
A. Pollio
{"title":"The Cloud, geographical advantage, and the metaphors of the Earth","authors":"A. Pollio","doi":"10.51142/issues-journal-3-1-2","DOIUrl":"https://doi.org/10.51142/issues-journal-3-1-2","url":null,"abstract":"","PeriodicalId":22329,"journal":{"name":"Technological Innovation in Pharmaceutical Research Vol. 3","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88436138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-12-15DOI: 10.51142/issues-journal-3-1-4
R. K. Thakur
{"title":"Resisting a riot in Bodoland, Northeast India","authors":"R. K. Thakur","doi":"10.51142/issues-journal-3-1-4","DOIUrl":"https://doi.org/10.51142/issues-journal-3-1-4","url":null,"abstract":"","PeriodicalId":22329,"journal":{"name":"Technological Innovation in Pharmaceutical Research Vol. 3","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79446075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-12-15DOI: 10.51142/issues-journal-3-1-1
Layli Uddin
{"title":"A view from the Roof: Space and politics in South Asia","authors":"Layli Uddin","doi":"10.51142/issues-journal-3-1-1","DOIUrl":"https://doi.org/10.51142/issues-journal-3-1-1","url":null,"abstract":"","PeriodicalId":22329,"journal":{"name":"Technological Innovation in Pharmaceutical Research Vol. 3","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77485905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-03-01DOI: 10.1142/9789811211461_fmatter
{"title":"FRONT MATTER","authors":"","doi":"10.1142/9789811211461_fmatter","DOIUrl":"https://doi.org/10.1142/9789811211461_fmatter","url":null,"abstract":"","PeriodicalId":22329,"journal":{"name":"Technological Innovation in Pharmaceutical Research Vol. 3","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72575379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-03-01DOI: 10.1142/9789811211461_0002
Juan Vicente García Manjón
The following sections are included:The Process and Management of InnovationInnovation ModelsReferences
包括以下部分:创新的过程与管理、创新模式、参考文献
{"title":"INNOVATION AS A PROCESS","authors":"Juan Vicente García Manjón","doi":"10.1142/9789811211461_0002","DOIUrl":"https://doi.org/10.1142/9789811211461_0002","url":null,"abstract":"The following sections are included:The Process and Management of InnovationInnovation ModelsReferences","PeriodicalId":22329,"journal":{"name":"Technological Innovation in Pharmaceutical Research Vol. 3","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79094059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-03-01DOI: 10.1142/9789811211461_bmatter
{"title":"BACK MATTER","authors":"","doi":"10.1142/9789811211461_bmatter","DOIUrl":"https://doi.org/10.1142/9789811211461_bmatter","url":null,"abstract":"","PeriodicalId":22329,"journal":{"name":"Technological Innovation in Pharmaceutical Research Vol. 3","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76545404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.9734/bpi/tipr/v3/4069d
B. Tripathy, S. Panda, S. Sahoo, S. K. Mishra, L. Nayak
{"title":"Phytochemical Examination and Hepatoprotective Impact of Stem Bark of Oroxylum indicum (L) Vent. on Carbon Tetrachloride Induced Hepatotoxicity in Rat","authors":"B. Tripathy, S. Panda, S. Sahoo, S. K. Mishra, L. Nayak","doi":"10.9734/bpi/tipr/v3/4069d","DOIUrl":"https://doi.org/10.9734/bpi/tipr/v3/4069d","url":null,"abstract":"","PeriodicalId":22329,"journal":{"name":"Technological Innovation in Pharmaceutical Research Vol. 3","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81874828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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