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Diagnosing myeloma in general practice: how might earlier diagnosis be achieved? 骨髓瘤的全科诊断:如何实现早期诊断?
Pub Date : 2022-09-29 DOI: 10.3399/bjgp22X720737
L. Smith, J. Carmichael, G. Cook, B. Shinkins, R. Neal
Smith et al describe the issues with the current diagnostic process for myeloma in general practice, explore the potential impact of the COVID-19 pandemic, and identify alternative strategies that may improve the early diagnosis. Around half of myeloma patients have three or more pre-referral consultations and around one-third are diagnosed through emergency presentation. Improving the timeliness of myeloma diagnosis is vital to improving patient outcomes, but is difficult to achieve because of complex, non-specific, and varied presentations. Improving GP education on the salient features of multiple myeloma presentation and the investigations required for diagnosis, alongside ensuring adequate safety netting for patients with persistent, unexplained symptoms, should be urgent priorities. Changes to general practice consultations following the COVID-19 pandemic have made myeloma diagnosis more difficult, and, over the longer term, research is required to develop intelligent and technological strategies that support physician decision making and reduce diagnostic delay.
Smith等人描述了目前骨髓瘤诊断过程中存在的问题,探讨了COVID-19大流行的潜在影响,并确定了可能改善早期诊断的替代策略。大约一半的骨髓瘤患者有三次或更多的转诊前咨询,大约三分之一的患者是通过急诊诊断出来的。提高骨髓瘤诊断的及时性对改善患者预后至关重要,但由于其复杂、非特异性和多种表现,很难实现。提高全科医生对多发性骨髓瘤表现的显著特征的教育和诊断所需的调查,以及确保对持续的、无法解释的症状的患者提供足够的安全网,应该是当务之急。COVID-19大流行后全科医生咨询的变化使骨髓瘤诊断变得更加困难,从长远来看,需要研究制定智能和技术战略,以支持医生决策并减少诊断延误。
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引用次数: 2
Non-alcoholic fatty liver disease: leading the fight in primary care 非酒精性脂肪性肝病:领导初级保健的斗争
Pub Date : 2022-09-29 DOI: 10.3399/bjgp22x720917
M. Theodoreson, Richard Darnton, I. Rowe, R. Parker
IN PRIMARY CARE GPs are no strangers to non-alcoholic fatty liver disease (NAFLD) and are commonly faced with non-specific liver function tests (LFTs) or an incidental finding of steatosis on ultrasound scan (USS). Interpreting these results and conveying their significance to the patient can be a challenge, with huge variation in practice. NAFLD is a spectrum of liver abnormalities from simple fat deposition (steatosis) to inflammation (non-alcoholic steatohepatitis, NASH). Steatohepatitis causes persistent hepatocellular inflammation leading to fibrosis that can, in some individuals, progress to cirrhosis. The disease burden of NAFLD is rising, now the most common liver disease globally, affecting up to 46% of all adults.1 Importantly, only 0.5% of patients are expected to progress to cirrhosis, which carries a risk of liver failure.2 Patients with NAFLD are at greater risk of all-cause mortality and, for most patients, the risk of non-hepatic ill health greatly outweighs the risk of liver-related morbidity.1–3 NAFLD is overwhelmingly associated with modifiable lifestyle factors, with obesity and metabolic syndrome the key drivers.1 This review describes how and when to make a diagnosis of NAFLD, the use of fibrosis markers to identify patients at risk of significant disease, and appropriate follow-up.
在初级保健中,全科医生对非酒精性脂肪性肝病(NAFLD)并不陌生,并且通常面临非特异性肝功能检查(LFTs)或超声扫描(USS)中偶然发现的脂肪变性。解释这些结果并将其重要性传达给患者可能是一项挑战,在实践中存在巨大差异。NAFLD是一系列肝脏异常,从单纯的脂肪沉积(脂肪变性)到炎症(非酒精性脂肪性肝炎,NASH)。脂肪性肝炎引起持续的肝细胞炎症,导致纤维化,在某些个体中,可发展为肝硬化。NAFLD的疾病负担正在上升,现在是全球最常见的肝脏疾病,影响多达46%的成年人重要的是,只有0.5%的患者预计会发展为肝硬化,这有肝功能衰竭的风险NAFLD患者的全因死亡率更高,对大多数患者来说,非肝脏疾病的风险大大超过肝脏相关疾病的风险。1-3 NAFLD与可改变的生活方式因素密切相关,肥胖和代谢综合征是主要驱动因素这篇综述描述了如何以及何时诊断NAFLD,使用纤维化标志物识别有重大疾病风险的患者,以及适当的随访。
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引用次数: 0
Towards new definitions of avoidable hospital admissions 制定可避免住院的新定义
Pub Date : 2022-09-29 DOI: 10.3399/bjgp22x720725
M. Booker, S. Purdy
often represents a major upheaval, with potential for physical, psychological, social, and economic consequences. Hospital admissions are also associated with an increased risk of adverse consequences to both physical and emotional wellbeing. Indeed, the broader negative impacts of the ‘allostatic stress’ of an admission may even outstrip those of physical illness in depleting reserves — a risk that persists beyond discharge.1 In patients with frailty, even a short so-termed ‘ambulatory’ admission is associated with increased mortality and subsequent use of health resources.2 While a hospital admission is rarely relished, there is evidence across international health systems that the COVID19 pandemic has heightened peoples’ desire to stay out of hospital, with an increasing trend of patients delaying or avoiding seeking urgent care altogether for fear of being admitted.3 While specific worries about hospitalacquired infection are undoubtedly a component, it appears that people may be more broadly re-evaluating the pros and cons of unscheduled hospital care as part of their re-framed priorities in the postpandemic era. These new sets of priorities, combined with a renewed urgency (driven by unprecedented demand) to explore alternative models of unscheduled care that don’t require inpatient stays, mean we may need to look again at how we conceptualise the avoidable admission. A major challenge of research in this area is the lack of a single, consistently applied definition of an avoidable admission.4 Academics and clinicians alike have long sought a concise and utilitarian way to define exactly who these patients might be, and in which circumstances alternative care is practical and appropriate. One approach is to define this cohort according to a disease or illness for which there exists a viable care pathway that does not require an inpatient stay. Ambulatory care sensitive conditions (ACSCs) are one such classification, defining conditions where effective person-centred community care may prevent the need for hospital admission.5 Along with others, we have previously utilised a nuanced version of this definition — primary care sensitive conditions (PCSCs) — in which the list of conditions is extended to include ‘situations’ that may not themselves be diagnoses or illnesses, but which may be amenable to timely and holistic primary care input to avoid an admission (for example, social care crises).6 Similarly, the term urgent care sensitive conditions (UCSCs) has been used in the literature to describe when same-day urgent care may prevent further resource use,7 although the definition of urgent care is not itself universally agreed. Basing the study of avoidable admissions on ASCSs alone, however, results in an incomplete understanding of the phenomenon. Recent analysis identified a complex relationship between ACSCs, admissions, and ‘preventable’ emergency care.8 The potential ability of primary care to decrease the number of admissions due to
通常代表重大的剧变,具有潜在的生理、心理、社会和经济后果。入院也与身体和情感健康的不良后果风险增加有关。事实上,入院的“适应压力”带来的更广泛的负面影响甚至可能超过身体疾病在消耗储备方面的影响——这种风险在出院后仍然存在对于身体虚弱的患者,即使是短暂的所谓“门诊”入院也与死亡率增加和随后的卫生资源使用有关虽然入院很少令人高兴,但在国际卫生系统中有证据表明,covid - 19大流行加剧了人们不愿住院的愿望,越来越多的患者因为害怕入院而推迟或避免寻求紧急护理虽然对医院获得性感染的具体担忧无疑是一个组成部分,但人们似乎可能会更广泛地重新评估不定期住院治疗的利弊,作为他们在大流行后时代重新制定优先事项的一部分。这些新的优先事项,再加上(由前所未有的需求驱动的)探索不需要住院的计划外护理的替代模式的新的紧迫性,意味着我们可能需要重新审视我们如何概念化可避免的入院。这方面研究的一个主要挑战是缺乏一个单一的、一致适用的可避免入院的定义长期以来,学者和临床医生都在寻找一种简洁实用的方法来准确定义这些患者可能是谁,以及在哪种情况下替代治疗是实际和适当的。一种方法是根据存在不需要住院治疗的可行护理途径的疾病或疾病来定义这个队列。流动护理敏感病症(ACSCs)就是这样一种分类,它定义了以人为本的有效社区护理可能避免住院的病症与其他人一起,我们之前使用了这个定义的一个微妙的版本-初级保健敏感条件(PCSCs) -其中条件列表扩展到包括可能本身不是诊断或疾病的“情况”,但可能适合及时和全面的初级保健投入,以避免入院(例如,社会护理危机)同样,紧急护理敏感条件(UCSCs)一词已在文献中用于描述当日紧急护理可能阻止进一步资源使用的情况,7尽管紧急护理的定义本身并未得到普遍同意。然而,仅基于ascs可避免入院的研究,导致对这一现象的理解不完整。最近的分析发现了acsc、入院和“可预防”急诊之间的复杂关系初级保健减少因ACSCs(和PCSCs/UCSCs)而入院人数的潜在能力,由于服务提供方式的纯粹差异而受到混淆,这种异质性因COVID-19大流行而进一步加剧。甚至全科医生的可用性和急诊入院之间的关系也不是直截了当的,10这表明这不仅仅是初级保健能力的问题。
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引用次数: 0
Dealing with symptoms in the general population: lessons learned from the Danish Symptom Cohort 处理一般人群的症状:从丹麦症状队列中吸取的教训
Pub Date : 2022-09-29 DOI: 10.3399/bjgp22x720713
K. Balasubramaniam, S. Rasmussen, P. Haastrup, L. M. S. Sætre, J. Søndergaard, D. Jarbøl
symptoms ranging from barely noticeable sensations to disturbing discomforts. The causes vary from normal physiological processes and self-limiting benign conditions to life-threatening diseases. Symptom experiences do not occur as stand-alone events but are influenced by an interchange of biological, psychological, and cultural factors, leading to various ways of interpreting and managing symptoms.1 Consequently, many symptoms are managed privately without consulting the healthcare system;2 however, some symptoms should lead to further investigation as they are alarming from a healthcare perspective and timely investigation is warranted.3,4 GPs play an important role in helping patients interpret symptoms;5 however, the healthcare-seeking process is not simple, and numerous factors, including previous experiences, social relations, and support, may contribute in deciding whether or not to seek health care.6 To elucidate how symptoms are interpreted and managed in the general population, we initiated the Danish Symptom Cohort (DaSC), a nationwide webbased survey. In 2012, we invited 100 000 randomly selected individuals aged >20 years to complete a questionnaire covering 44 predefined symptoms comprising both cancer symptoms as well as common symptoms, for example, back pain, urinary incontinence, and tiredness. If responders confirmed a symptom experience, followup questions were asked concerning onset, influence on daily activities, concerns about the symptom, whether the responder had consulted the GP regarding the symptom, and considerations about contacting the GP with the symptom in question. Responders were also asked about smoking status, alcohol intake, and physical activity. For the invitees, socioeconomic status (education, income, cohabitation status, ethnicity, and labour market affiliation) were then collected from national registers7–11 and linked to survey data. In this editorial we summarise the findings from the DaSC studies, highlighting the lessons learned but also pointing to what needs to be further explored in the 10-year follow-up questionnaire, DaSC II, which was distributed in May 2022. The 34 current publications deriving from the DaSC are available online,12 with details of the results and contextualisation of findings within the existing literature.
症状从几乎不明显的感觉到令人不安的不适。病因多种多样,从正常的生理过程和自限性良性疾病到危及生命的疾病。症状经历不是作为独立事件发生的,而是受到生物、心理和文化因素相互作用的影响,导致解释和处理症状的方式多种多样因此,许多症状是在没有咨询医疗系统的情况下私下处理的;2然而,一些症状应该引起进一步的调查,因为从医疗保健的角度来看,它们是令人担忧的,及时的调查是必要的。3,4全科医生在帮助患者解释症状方面发挥着重要作用;5然而,寻求医疗保健的过程并不简单,许多因素,包括以前的经历、社会关系和支持,可能在决定是否寻求医疗保健方面起作用为了阐明症状是如何在一般人群中解释和管理的,我们发起了丹麦症状队列(DaSC),这是一项全国性的基于网络的调查。2012年,我们随机选择了10万名年龄>20岁的人来完成一份调查问卷,调查内容包括44种预定义的症状,包括癌症症状以及常见症状,例如背痛、尿失禁和疲劳。如果应答者确认有症状经历,则询问有关发病、对日常活动的影响、对症状的担忧、应答者是否就症状咨询过全科医生,以及是否考虑就有问题的症状联系全科医生。应答者还被问及吸烟状况、酒精摄入量和体育活动。对于被邀请者,社会经济地位(教育、收入、同居状况、种族和劳动力市场关系)从国家登记册7 - 11中收集,并与调查数据相关联。在这篇社论中,我们总结了DaSC研究的结果,强调了吸取的教训,但也指出了在2022年5月分发的10年后续调查问卷DaSC II中需要进一步探索的内容。来自DaSC的34个当前出版物可在网上获得,其中12个具有结果的详细信息和现有文献中发现的背景化。
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引用次数: 0
General practice and the Medical Licensing Assessment 一般执业和医疗执照评估
Pub Date : 2022-09-29 DOI: 10.3399/bjgp22x720905
D. McKechnie, Neelam A. Parmar, Sarah Armstrong, Lucy Pratt, L. Pope, H. Alberti, Sophie Park
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引用次数: 1
Actively tackling inactivity 积极解决不运动的问题
Pub Date : 2022-09-01 DOI: 10.3399/bjgp22x720497
Steve Haake, Simon Tobin
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引用次数: 1
Video consultations: a potential gamechanger in clinical education 视频会诊:临床教育的潜在改变者
Pub Date : 2022-09-01 DOI: 10.3399/bjgp22x720509
Richard Darnton, Richard Thomson, J. McKimm
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引用次数: 2
Melanoma risk assessment and management: a qualitative study among Australian GPs 黑色素瘤风险评估和管理:澳大利亚全科医生的定性研究
Pub Date : 2022-06-21 DOI: 10.3399/BJGP.2021.0668
Balakumar Anandasivam, Michael Tam, K. McGeechan, K. Price, Katrina Mclean, M. Tracy, J. Hall, Andrew Knight, K. Vuong
Background Preventive guidelines for melanoma recommend that patients at high risk of melanoma receive targeted screening; however, this requires careful selection of those at high risk. To the authors’ knowledge, there has been no previous research into how all physicians approach the selection and management of high-risk individuals. Melanoma risk-prediction models are available to assist in the identification of high-risk patients but are not routinely used clinically. Aim To examine how GPs assessed and managed melanoma risk, and the opportunities for using melanoma risk-prediction models in primary care. Design and setting Semi-structured telephone interviews were conducted with 20 Australian GPs. Method GPs who had completed a cross-sectional online questionnaire study on melanoma risk were purposively sampled and recruited. Semi-structured telephone interviews were conducted with Australian GPs between 9 July and 10 September 2019. Interviews were audiorecorded, professionally transcribed, and analysed using grounded theory. Results Melanoma risk assessment and its management can be understood as a linear workflow consisting of five clinical process domains with patient selection as the entry point. There was variation between GPs on the identification of melanoma risk factors, melanoma risk estimation, management, and patient education because of intuitive and analytical processes guiding risk assessment, and the influence of patient factors. GPs were largely receptive towards melanoma risk-prediction models, sharing facilitators for and barriers to their potential implementation. Conclusion Further primary care interventions sensitive to existing workflow arrangements may be required to standardise melanoma risk-assessment and management processes.
黑素瘤预防指南建议高危黑素瘤患者接受针对性筛查;然而,这需要仔细选择那些高风险的人。据作者所知,之前还没有关于所有医生如何选择和管理高危患者的研究。黑色素瘤风险预测模型可用于帮助识别高危患者,但在临床上并不常规使用。目的研究全科医生如何评估和管理黑色素瘤风险,以及在初级保健中使用黑色素瘤风险预测模型的机会。设计与设置对20名澳大利亚全科医生进行了半结构化电话访谈。方法有目的地对完成黑素瘤风险横断面在线问卷调查的全科医生进行抽样和招募。2019年7月9日至9月10日期间,对澳大利亚全科医生进行了半结构化电话采访。访谈录音,专业转录,并使用接地理论分析。结果黑色素瘤风险评估及其管理可理解为以患者选择为切入点,由五个临床过程域组成的线性工作流程。全科医生在黑素瘤危险因素的识别、黑素瘤风险评估、管理和患者教育方面存在差异,这是因为指导风险评估的直观和分析过程以及患者因素的影响。全科医生很大程度上接受黑色素瘤风险预测模型,分享其潜在实施的促进因素和障碍。结论根据现有工作流程安排,可能需要进一步的初级保健干预措施来规范黑色素瘤风险评估和管理流程。
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引用次数: 0
Implementing video group consultations in general practice during COVID-19: a qualitative study 在COVID-19期间在全科实践中实施视频小组会诊:一项定性研究
Pub Date : 2022-05-16 DOI: 10.3399/BJGP.2021.0673
C. Papoutsi, S. Shaw, T. Greenhalgh
Background Group consultations have been gaining ground as a novel approach to service delivery. When in-person care was restricted owing to COVID-19, general practice staff began delivering group consultations remotely over video. Aim To examine how multiple interacting influences underpinned implementation and delivery of video group consultations (VGCs). Design and setting Qualitative study in general practice in England. Method a) 32 semi-structured interviews with patients, clinical, and non-clinical staff (from eight GP surgeries in total), NHS policymakers and programme managers, and other stakeholders; b) observation in relevant training and operational meetings; and c) three co-design workshops (21 participants). Thematic analysis was informed by the Planning and Evaluating Remote Consulting Services (PERCS) framework. Results In the first year of the pandemic, VGCs focused on supporting those with long-term conditions or other shared health and social needs. Most patients welcomed clinical and peer input, and the opportunity to access their practice remotely during lockdown. However, not everyone agreed to engage in group-based care or was able to access IT equipment. At practice level, significant work was needed to deliver VGCs, such as setting up the digital infrastructure, gaining team buy-in, developing new patient-facing online facilitation roles, managing background operational processes, protecting online confidentiality, and ensuring professional indemnity cover. Training provided nationally was seen as instrumental in capacity building for VGC implementation. Conclusion Small scale VGC implementation addressed unmet need during the pandemic. However, embedding VGCs in routine care requires rethinking of operational, infrastructural, and clinical processes. Additional research on costs and benefits at service and patient level is needed.
作为一种提供服务的新方法,背景小组协商正在取得进展。当因COVID-19而限制面对面护理时,全科医生开始通过视频远程提供小组咨询。目的探讨多种相互作用的影响如何支撑视频小组咨询(vgc)的实施和交付。设计与设置英国全科医学的定性研究。方法a)对患者、临床和非临床工作人员(总共来自8个全科医生手术)、NHS政策制定者和项目经理以及其他利益相关者进行32次半结构化访谈;B)在相关培训和业务会议上的观摩;c)三个共同设计工作坊(21人)。专题分析是由规划和评价远程咨询服务框架提供的。结果:在大流行的第一年,志愿服务中心侧重于支持那些有长期疾病或其他共同卫生和社会需求的人。大多数患者欢迎临床和同行的意见,并有机会在封锁期间远程访问他们的诊所。然而,并不是每个人都同意参与以团体为基础的护理,或者能够使用IT设备。在实践层面,实现vgc需要做大量的工作,例如建立数字基础设施、获得团队支持、开发新的面向患者的在线促进角色、管理后台操作流程、保护在线机密性以及确保专业赔偿。国家提供的培训被认为有助于建立实施自愿自愿合作伙伴关系的能力。结论小规模VGC的实施解决了大流行期间未满足的需求。然而,在常规护理中嵌入vgc需要重新思考操作、基础设施和临床流程。需要对服务和患者层面的成本和效益进行进一步研究。
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引用次数: 3
Impact of COVID-19 on primary care contacts with children and young people in England: longitudinal trends study 2015–2020 2019冠状病毒病对英格兰儿童和青少年初级保健接触者的影响:2015-2020年纵向趋势研究
Pub Date : 2022-04-04 DOI: 10.3399/BJGP.2021.0643
Kimberley A Foley, E. Maile, A. Bottle, F. Neale, R. Viner, S. Kenny, A. Majeed, D. Hargreaves, S. Saxena
Background The NHS response to COVID-19 altered provision and access to primary care. Aim To examine the impact of COVID-19 on GP contacts with children and young people (CYP) in England. Design and setting A longitudinal trends analysis was undertaken using electronic health records from the Clinical Practice Research Datalink (CPRD) Aurum database. Method All CYP aged <25 years registered with a GP in the CPRD Aurum database were included. The number of total, remote, and face-to-face contacts during the first UK lockdown (March to June 2020) were compared with the mean contacts for comparable weeks from 2015 to 2019. Results In total, 47 607 765 GP contacts with 4 307 120 CYP were included. GP contacts fell 41% during the first lockdown compared with previous years. Children aged 1–14 years had greater falls in total contacts (≥50%) compared with infants and those aged 15–24 years. Face-to-face contacts fell by 88%, with the greatest falls occurring among children aged 1–14 years (>90%). Remote contacts more than doubled, increasing most in infants (over 2.5-fold). Total contacts for respiratory illnesses fell by 74% whereas contacts for common non-transmissible conditions shifted largely to remote contacts, mitigating the total fall (31%). Conclusion During the COVID-19 pandemic, CYP’s contact with GPs fell, particularly for face-to-face assessments. This may be explained by a lower incidence of respiratory illnesses because of fewer social contacts and changing health-seeking behaviour. The large shift to remote contacts mitigated total falls in contacts for some age groups and for common non-transmissible conditions.
背景:NHS应对COVID-19改变了初级保健的提供和可及性。目的了解新冠肺炎疫情对英格兰全科医生接触儿童和青少年(CYP)的影响。设计和设置使用临床实践研究数据链(CPRD) Aurum数据库中的电子健康记录进行纵向趋势分析。方法所有CYP均老化90%。远程接触者增加了一倍多,婴儿增加最多(超过2.5倍)。呼吸道疾病的接触者总数下降了74%,而常见非传染性疾病的接触者主要转为远程接触者,减缓了总下降(31%)。在COVID-19大流行期间,CYP与全科医生的接触减少,特别是面对面评估。这可能是由于社会接触减少和求医行为的改变,呼吸道疾病的发病率较低。向远程接触者的大规模转变减缓了某些年龄组和常见非传染性疾病接触者总数的下降。
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引用次数: 3
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The British Journal of General Practice
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