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COVID-19 and the cardiovascular system in pregnancy COVID-19与妊娠期心血管系统
Pub Date : 2020-11-04 DOI: 10.24170/17-3-4375
A. Herrey, A. Osman, P. Soma-Pillay, K. Sliwa, N. Ntusi
Pregnancy and coronavirus disease-2019 (COVID-19) share several common features which makes differentiation between the 2 difficult. Both are multisystem disorders, may present with breathlessness, are associated with hypercoagulability and frequently cause significant anxiety in both the patient and those around them. Pregnancy represents a state of partial immune suppression, with pregnant women more vulnerable to viral infections. However, these concerns have not been borne out in clinical practice and have not stood up to epidemiological scrutiny. From limited data available on COVID-19 in pregnancy, the outcomes are mostly favourable. While cardiac disease and hypertension are independent predictors of hospital admission with COVID-19 in pregnancy, the prevalence of cardiac disease in the pregnant COVID-19 population is low. Pregnant women are younger, and asymptomatic SARSCoV-2 infection and favourable outcomes are reported in those below 55 years of age. Indeed, large numbers of asymptomatic cases have been reported in pregnancy, suggesting that pregnant patients with more severe disease courses may be over-represented in the current literature, particularly the early case reports and case series. Cardiovascular involvement in pregnancy includes new-onset hypertension, myocarditis, cardiomyopathy, pulmonary embolism and a pre-eclampsia-like syndrome.
怀孕和2019冠状病毒病(COVID-19)有几个共同特征,这使得两者难以区分。这两种疾病都是多系统疾病,可能出现呼吸困难,与高凝性有关,并经常引起患者及其周围人的严重焦虑。怀孕是一种部分免疫抑制的状态,孕妇更容易受到病毒感染。然而,这些担忧并未在临床实践中得到证实,也没有经受住流行病学的审查。从有限的妊娠期COVID-19数据来看,结果大多是有利的。虽然心脏病和高血压是妊娠期COVID-19住院的独立预测因素,但妊娠COVID-19人群中心脏病的患病率较低。孕妇更年轻,无症状的SARSCoV-2感染和有利的结果在55岁以下的妇女中有报道。事实上,大量无症状病例已经在妊娠期被报道,这表明在目前的文献中,特别是早期病例报告和病例系列中,具有更严重病程的妊娠患者可能被过度代表。妊娠期心血管疾病包括新发高血压、心肌炎、心肌病、肺栓塞和先兆子痫样综合征。
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引用次数: 5
COVID-19 and cardiovascular imaging: a guide for the practising clinician COVID-19与心血管影像学:临床执业医师指南
Pub Date : 2020-11-04 DOI: 10.24170/17-3-4377
R. Meel, B. Cupido, A. Pecoraro, Anton Doubell, W. Lubbe, N. Ntusi
In the ongoing COVID-19 pandemic, patients with cardiac disease have been the worst afflicted with a high mortality. Cardiac imaging forms an integral part of the armamentarium in the management of these patients. This review focuses on providing a general guide to cardiac imaging in the COVID-19 context for the practising clinician in Africa. These recommendations are likely to be modified as further data emerge on the effect of the SARS-CoV-2 virus on the cardiovascular system.
在正在进行的COVID-19大流行中,心脏病患者的死亡率最高。心脏成像在这些病人的治疗中是一个不可或缺的组成部分。本综述的重点是为非洲执业临床医生提供COVID-19背景下心脏成像的一般指南。随着关于SARS-CoV-2病毒对心血管系统影响的进一步数据的出现,这些建议可能会被修改。
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引用次数: 2
Angiotensin converting enzyme inhibitors, angiotensin receptor blockers, mineralocorticoid receptor antagonists and SARS-CoV-2 infection 血管紧张素转换酶抑制剂、血管紧张素受体阻滞剂、矿皮质激素受体拮抗剂与SARS-CoV-2感染
Pub Date : 2020-11-04 DOI: 10.24170/17-3-4383
Pratiksha Valera, P. Letuka, Nontobeko Mathenjwa, N. Ntusi
Angiotensin converting enzyme inhibitors (ACE-Is), angiotensin receptor blockers (ARBs) and mineralocorticoid receptor antagonists (MRAs) reduce morbidity, mortality and hospitalisations from hypertension, chronic kidney disease and heart failure. Patients and clinicians will be aware of the recently publicised interaction between the renin-angiotensin-aldosterone system (RAAS) and SARS-CoV-2, the orthocoronavirus responsible for coronavirus disease 2019 (COVID-19). Consequently, concern has abounded in regard to whether prescribed blockers of the RAAS like ACE-Is, ARBs and MRAs may, in fact, increase or decrease susceptibility to SARS-CoV-2 infection. Limited scientific evidence has been contradictory. Scientists have postulated both potentially harmful and potentially beneficial effects of these drugs on the natural history of COVID-19. Membrane-bound angiotensin-converting enzyme 2 (ACE2) participates in the entry of SARSCoV-2 into human cells, and animal studies show that ACE-Is and ARBs upregulate ACE2 expression, which would theoretically increase risk for or severity of COVID-19. Conversely, RAAS blockers could benefit patients with COVID-19 through various mechanisms: ACE2 converts angiotensin II to angiotensin, which has potentially beneficial vasodilatory and anti-inflammatory properties. Observational studies have failed to provide compelling data on whether COVID-19 patients on RAAS blockers fare better or worse than otherwise similar patients, though there is emerging evidence that RAAS inhibitors may be protective in COVID-19 and are associated with lower cardiovascular and all-cause mortality. Most professional societies, including the World Health Organization and the South African Heart Association and the South African National Department of Health have recommended that patients on RAAS blockers with COVID-19 should continue taking them. In this article, we review the existing evidence for the interplay between RAAS blockers and SARS-CoV-2 infection.
血管紧张素转换酶抑制剂(ACE-Is)、血管紧张素受体阻滞剂(ARBs)和矿皮质激素受体拮抗剂(MRAs)可降低高血压、慢性肾病和心力衰竭的发病率、死亡率和住院率。患者和临床医生将了解最近公布的肾素-血管紧张素-醛固酮系统(RAAS)与SARS-CoV-2(导致2019冠状病毒病(COVID-19)的正冠状病毒)之间的相互作用。因此,诸如ACE-Is、arb和MRAs等RAAS的处方阻滞剂是否会增加或减少对SARS-CoV-2感染的易感性,引起了人们的广泛关注。有限的科学证据是相互矛盾的。科学家们假设这些药物对COVID-19的自然史既有潜在的有害影响,也有潜在的有益影响。膜结合血管紧张素转换酶2 (ACE2)参与SARSCoV-2进入人体细胞,动物研究表明,ACE-Is和ARBs上调ACE2的表达,理论上会增加COVID-19的风险或严重程度。相反,RAAS阻滞剂可以通过多种机制使COVID-19患者受益:ACE2将血管紧张素II转化为血管紧张素,这具有潜在的有益血管扩张和抗炎特性。观察性研究未能提供令人信服的数据,说明使用RAAS阻滞剂的COVID-19患者是否比其他类似患者表现更好或更差,尽管有新证据表明RAAS抑制剂可能对COVID-19具有保护作用,并与较低的心血管和全因死亡率相关。包括世界卫生组织、南非心脏协会和南非国家卫生部在内的大多数专业协会都建议,患有COVID-19的RAAS阻滞剂患者应继续服用。在本文中,我们回顾了RAAS阻滞剂与SARS-CoV-2感染之间相互作用的现有证据。
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引用次数: 2
Arrhythmias and COVID-19 infection 心律失常和COVID-19感染
Pub Date : 2020-11-04 DOI: 10.24170/17-3-4384
A. Chin, Jane Moses, A. Thornton
Arrhythmias can be a clinical manifestation of COVID-19 infection. COVID-19 infection can also be a precipitant of known arrhythmias which can increase the risk of morbidity and mortality. Management of arrhythmias should generally follow standard guidelines of arrhythmia management. Catheter ablation in the midst of the COVID-19 pandemic should be limited to arrhythmias that are immediately life-threatening or which may affect prognosis in the short-term. Some novel treatments like chloroquine, hydroxychloroquine and azithromycin can prolong the QT interval and predispose patients to life-threatening arrhythmias.
心律失常可能是COVID-19感染的临床表现。COVID-19感染也可能是已知心律失常的诱因,这可能增加发病率和死亡率的风险。心律失常的管理一般应遵循心律失常管理的标准指南。在COVID-19大流行期间,导管消融应限于立即危及生命或可能在短期内影响预后的心律失常。一些新的治疗方法,如氯喹、羟氯喹和阿奇霉素,可以延长QT间期,使患者易患危及生命的心律失常。
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引用次数: 1
Evolving concepts of myocardial phenotypes, myocardial injury, cardiovascular consequences and management in patients with SARS-CoV-2 infection SARS-CoV-2感染患者心肌表型、心肌损伤、心血管后果和管理概念的演变
Pub Date : 2020-11-04 DOI: 10.24170/17-3-4392
N. Ntusi, A. Herrey
The COVID-19 pandemic is undoubtedly the greatest public health crisis, the most crucial global health calamity of the century, and the most profound biopsychosocial dilemma for humankind since the Second World War. In December 2019, a novel coronavirus strain causing an interstitial pneumonia and acute respiratory distress syndrome (ARDS) emerged from Wuhan, Hubei Province, China; severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for occurrence of this disease. The World Health Organization named the clinical syndrome caused by SARS-CoV-2 the coronavirus disease 2019 (COVID-19).(1)
新冠肺炎大流行无疑是本世纪最大的公共卫生危机,是本世纪最严重的全球卫生灾难,也是第二次世界大战以来人类面临的最深刻的生物心理社会困境。2019年12月,中国湖北省武汉市出现了一种导致间质性肺炎和急性呼吸窘迫综合征(ARDS)的新型冠状病毒毒株;严重急性呼吸综合征冠状病毒2 (SARS-CoV-2)是导致该病发生的主要原因。世界卫生组织将SARS-CoV-2引起的临床综合征命名为2019冠状病毒病(COVID-19)。
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引用次数: 1
COVID-19 and cardiothoracic surgery: A risk-adjusted approach in the context of a global pandemic 2019冠状病毒病与心胸外科:全球大流行背景下的风险调整方法
Pub Date : 2020-11-04 DOI: 10.24170/17-3-4382
D. Reddy, R. Kleinloog, J. Janson, Rogers Manganyi, J. Brink, P. Zilla
In the face of the novel coronavirus pandemic, the impact of COVID-19 infection has disrupted cardiothoracic surgical services globally. A risk-adjusted approach to restructuring the delivery of cardiothoracic surgical services has been proposed in accordance with international guidance to ensure that the surgical standard of care is maintained in the practice of adult and paediatric cardiac surgery, as well as thoracic surgery. The potential influx of COVID-19 patients with cardio-respiratory complications requiring intensive care management and associated surgical procedures falling within the gamut of the thoracic surgeon, is considered. Finally, the protection of healthcare workers, in particular the surgical team exposed to aerosolising procedures, is outlined.
面对新型冠状病毒大流行,COVID-19感染的影响扰乱了全球心胸外科服务。根据国际指导,提出了一种调整风险的方法,以重组心胸外科服务的提供,以确保在成人和儿童心脏外科以及心胸外科的实践中保持外科护理标准。考虑到伴有心肺并发症的COVID-19患者可能涌入,需要重症监护管理和胸外科医生范围内的相关外科手术。最后,概述了对医疗工作者的保护,特别是接触雾化程序的外科团队。
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引用次数: 1
Interventional cardiology during the COVID-19 epidemic COVID-19流行期间的介入心脏病学
Pub Date : 2020-11-04 DOI: 10.24170/17-3-4376
H. Weich, J. Hitzeroth, Sajidah Khan, D. Kettles, A. Vachiat, M. Ntsekhe
The impact of the COVID-19 pandemic on our lives is unprecedented and major adjustments to our practices as physicians are required. Although our comments are applicable at the time of writing, the situation changes daily and the content of this article should be adjusted accordingly. Cath lab: An unambiguous cath lab protocol should be drawn up for each facility, appropriate to local circumstances. This should include standard procedures in preparation for arrival at the lab, in the performance of procedures, and, importantly, in maintaining due diligence when removing protective gear. All team members should be well trained in these procedures. Acute coronary syndromes: Standard timing for the invasive management of patients should not change during the pandemic. Due to delays often unavoidable during the pandemic, alternative strategies such as thrombolysis may be more readily available and therefore more appropriate. Drugs: The sick COVID-19 patient often represents a pro-thrombotic state and operators should ensure adequate anti-thrombotic therapy. Knowledge of interactions between cardiac drugs and investigational antiviral treatments is important. Elective procedures: Patients with chronic cardiac conditions are at high risk and may require non-urgent procedures to avert major complications. Selecting these cases requires consideration of multiple risks and benefits.
COVID-19大流行对我们生活的影响是前所未有的,作为医生,我们需要对我们的做法进行重大调整。虽然我们的评论在写作时是适用的,但情况每天都在变化,本文的内容也应该相应调整。导管室:应根据当地情况为每个设施制定明确的导管室方案。这应包括准备到达实验室的标准程序,程序的执行,以及重要的是,在脱下防护装备时保持应有的注意。所有团队成员都应该接受这些程序的良好培训。急性冠状动脉综合征:在大流行期间,患者侵入性治疗的标准时间不应改变。由于大流行期间往往不可避免的延误,溶栓等替代战略可能更容易获得,因此也更合适。药物:患病的COVID-19患者通常表现为血栓形成前状态,操作人员应确保充分的抗血栓治疗。了解心脏药物和实验性抗病毒治疗之间的相互作用是很重要的。选择性手术:慢性心脏病患者处于高风险,可能需要非紧急手术以避免主要并发症。选择这些案例需要考虑多种风险和收益。
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引用次数: 1
Direct and indirect effects of the COVID-19 pandemic on children with cardiovascular disease COVID-19大流行对儿童心血管疾病的直接和间接影响
Pub Date : 2020-11-04 DOI: 10.24170/17-3-4381
L. Zühlke, Stephen C. Brown, A. Cilliers, E. Hoosen, J. Lawrenson, Hopewell N. Ntsinjana
Coronavirus 2 (SARS-CoV-2) the causative agent of what we now know as “Coronavirus Disease 2019” (COVID-19), is the most serious global health crisis of our generation, with a significant and far-reaching impact upon health, economy, social cohesion and emotional and mental wellbeing. Although children do not bear the brunt of direct mortality, they are significantly affected in terms of morbidity and interruption to access, continuity and complexity of care, as well as the indirect social and financial effects impacting on their health outcomes. In this review we present some of the most recent data relevant to children with congenital and acquired heart disease, and consider some of the cardiac presentations noted. We discuss the necessary protections to staff in the echo and cardiac catherisation laboratories and present some general recommendations to general paediatricians and communities to ensure the continued health of our patients. Finally, we encourage ongoing registries and biorepositories and support clinical trials to ensure that children also receive new technologies and therapeutics as these become available.
冠状病毒2型(SARS-CoV-2)是我们现在所知的“2019冠状病毒病”(COVID-19)的病原体,是我们这一代最严重的全球健康危机,对健康、经济、社会凝聚力以及情绪和心理健康产生重大而深远的影响。虽然儿童不是直接死亡的主要受害者,但在发病率和获得护理的中断、护理的连续性和复杂性以及影响其健康结果的间接社会和财政影响方面,他们受到了重大影响。在这篇综述中,我们介绍了一些与先天性和获得性心脏病儿童有关的最新数据,并考虑了一些注意到的心脏表现。我们讨论了对超声和心导管实验室工作人员的必要保护,并向普通儿科医生和社区提出了一些一般性建议,以确保患者的持续健康。最后,我们鼓励正在进行的登记和生物储存,并支持临床试验,以确保儿童也能获得新技术和治疗方法。
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引用次数: 1
Radiology of COVID-19 pneumonia COVID-19肺炎放射学
Pub Date : 2020-11-04 DOI: 10.24170/17-3-4373
Q. Said-Hartley, S. Moosa
Coronavirus disease (COVID-19) started as a cluster of pneumonia cases in December 2019 and has rapidly spread across the world, resulting in millions of infections, and approaching one million deaths. In this short review we describe the most common chest x-ray and computed tomography manifestations of the virus as it affects the respiratory system, and make brief references to the common clinical presentations.
冠状病毒病(COVID-19)于2019年12月以肺炎聚集性病例开始,并迅速在全球蔓延,导致数百万人感染,近100万人死亡。在这篇简短的综述中,我们描述了该病毒影响呼吸系统时最常见的胸部x线和计算机断层扫描表现,并简要介绍了常见的临床表现。
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引用次数: 2
Racism in medicine, science and in medical publishing 医学、科学和医学出版中的种族主义
Pub Date : 2020-11-04 DOI: 10.24170/17-3-4386
N. Ntusi
Black Lives Matter is an activist movement which began as a hashtag (#BlackLivesMatter) after George Zimmerman was acquitted in the shooting death of Trayvon Martin, an unarmed African American teenager killed in Florida in July 2013. Black Lives Matter has evolved into a global movement focused on ending systemic bias and structural inequality, and more recently focused on racism in medicine. As a journal that disseminates medical findings and information, we pledge to play our part in eliminating all forms of racism in science, medicine and medical publishing. As academics and scientists, we need to rise to resist injustice and to rebuild a future that is rooted in human rights and true equality. We must cherish the principles of equality, diversity, globalism, empathy and restorative justice, which have been the foundations of the Black Lives Matter Movement.
2013年7月,乔治·齐默尔曼在佛罗里达州枪杀手无寸铁的非洲裔少年特雷沃恩·马丁后被判无罪,“黑人的生命也很重要”成为一项活动,以标签“#黑人的生命也很重要”开始。黑人的命也重要(Black Lives Matter)已经演变成一场全球性的运动,致力于结束系统性偏见和结构性不平等,最近又关注医学领域的种族主义。作为一份传播医学发现和信息的杂志,我们保证为消除科学、医学和医学出版领域的一切形式的种族主义发挥我们的作用。作为学者和科学家,我们需要奋起反抗不公正,重建一个以人权和真正平等为基础的未来。我们必须珍惜平等、多样性、全球主义、同理心和恢复性司法的原则,这些原则一直是“黑人的命也是命”运动的基础。
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引用次数: 0
期刊
The Egyptian Heart Journal
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