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Colorectal cancer chemoprevention: aspirin, other NSAID and COX-2 inhibitors. 结直肠癌化学预防:阿司匹林,其他非甾体抗炎药和COX-2抑制剂。
Pub Date : 2000-06-01 DOI: 10.1046/j.1440-1622.2000.01844.x
G A Kune
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引用次数: 25
Changing patterns of severe craniomaxillofacial trauma in Auckland over eight years. 奥克兰八年来严重颅颌面创伤的变化模式。
Pub Date : 2000-06-01 DOI: 10.1046/j.1440-1622.2000.01836.x
C D Adams, J S Januszkiewcz, J Judson

Background: This study was performed to review the changing pattern of incidence of severe craniomaxillofacial (CMF) trauma in Auckland over 8 years (1989-1997) and to audit the involvement of the regional plastic surgery service.

Methods: A review of prospectively collected admission data of patients admitted to the Auckland Hospital Department of Critical Care Medicine (DCCM) with severe CMF trauma during 1997. A comparison is made with similar data from 1989. Injury severity was defined using the Injury Severity Score (ISS).

Results: Twenty-six patients with severe CMF trauma were admitted to Auckland Hospital DCCM in 1997. Their average ISS was 35. Eighty per cent had a significant head injury. Sixty-two per cent had injuries due to road traffic accidents (RTA) and 42% had positive blood alcohol levels, including 37% of the RTA victims. Twenty-three per cent had their surgical care provided by the regional plastic surgery service. In 1989, 55 patients were admitted to DCCM with severe CMF trauma. The average ISS was 36. Ninety-five per cent had a significant head injury. Seventy-three per cent had injuries due to RTA and 55% had positive blood alcohol, including 60% of the RTA group.

Conclusions: Patients with severe CMF trauma make up a significant proportion of trauma admissions to DCCM and have a high incidence of life-threatening injuries. A multidisciplinary approach is essential. The nature and severity of these injuries has not changed over the last decade. There has been a clear decrease in the incidence of these injuries. This seems to be due to a profound decrease in the rate of RTA associated with alcohol intoxication.

背景:本研究回顾了奥克兰8年来(1989-1997)严重颅颌面外伤发生率的变化模式,并审计了区域整形外科服务的参与情况。方法:回顾性分析1997年奥克兰医院重症医学科(DCCM)重症CMF创伤患者的住院资料。与1989年的类似数据进行了比较。使用损伤严重程度评分(ISS)定义损伤严重程度。结果:1997年奥克兰医院DCCM收治了26例重度CMF外伤患者。他们的平均ISS是35。80%的人有严重的头部损伤。62%的人因道路交通事故受伤,42%的人血液酒精含量呈阳性,其中包括37%的道路交通事故受害者。23%的人接受了区域整形外科服务机构提供的手术护理。1989年,55例患者因严重CMF创伤而入院。国际空间站的平均年龄是36岁。95%的人有严重的头部损伤。73%的人因RTA受伤,55%的人血液酒精呈阳性,其中60%的人服用RTA。结论:严重CMF创伤患者在DCCM创伤入院患者中占很大比例,且危及生命的损伤发生率高。多学科方法至关重要。这些伤害的性质和严重程度在过去十年中没有改变。这些伤害的发生率已经明显下降。这似乎是由于与酒精中毒相关的RTA率大幅下降。
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引用次数: 55
Early experience with clinical indicators in surgery. 对外科临床指标的早期经验。
Pub Date : 2000-06-01 DOI: 10.1046/j.1440-1622.2000.01863.x
B T Collopy, L Rodgers, P Woodruff, J Williams

Background: In 1997 a set of 53 clinical indicators developed by the Royal Australasian College of Surgeons (RACS) and the Australian Council on Healthcare Standards (ACHS) Care Evaluation Programme (CEP), was introduced into the ACHS Evaluation and Quality Improvement Programme (EQuIP). The clinical indicators covered 20 different conditions or procedures for eight specialty groups and were designed to act as flags to possible problems in surgical care.

Methods: The development process took several years and included a literature review, field testing, and revision of the indicators prior to approval by the College council. In their first year 155 health-care organizations (HCO) addressed the indicators and this rose to 210 in 1998. Data were received from all states and both public and private facilities.

Results: The collected data for 1997 and 1998 for some of the indicators revealed rates which were comparable with those reported in the international literature. For example, the rates of bile duct injury in laparoscopic cholecystectomy were 0.7 and 0.53%, respectively; the mortality rates for coronary artery graft surgery were 2.5 and 2.1%, respectively; the mortality rates after elective abdominal aortic aneurysm repair were 2.5 and 3.7%, respectively; and the post-tonsillectomy reactionary haemorrhage rates were 0.9 and 1.3%, respectively. Results for some indicators differed appreciably from other reports, flagging the need for further investigation; for example, the negative histology rates for appendectomy in children were 18.6 and 21.2%, respectively, and the rates for completeness of excision of malignant skin tumours were 90.7 and 90%, respectively. The significance of these figures, however, depends upon validation of the data and their reliability and reproducibility. Because reliability can be finally determined only at the hospital level they are of limited value for broader comparison.

Conclusion: The process of review established for the indicator set has led to refinement of some indicators through improvement of definitions, and to a considerable reduction in the number of indicators to 29 (covering 18 procedures), for the second version of the indicators (which was introduced for use from January 1999). The clinical indicator programme, as it has with other disciplines, hopefully will provide a stimulus to the modification and improvement of surgical practice. Clinician ownership should enhance the collection of reliable data and hence their usefulness.

背景:1997年,澳大利亚皇家外科医师学院(RACS)和澳大利亚保健标准委员会(ACHS)制定的一套53项临床指标(CEP)被纳入澳大利亚保健标准委员会的评估和质量改进方案(EQuIP)。临床指标涵盖了8个专科组的20种不同条件或程序,旨在作为外科护理中可能出现问题的标志。方法:开发过程耗时数年,包括文献综述、实地测试和指标修订,然后由学院理事会批准。在第一年,有155个保健组织处理了这些指标,1998年增加到210个。从各州以及公共和私人设施收到了数据。结果:1997年和1998年收集的一些指标的数据显示,这些比率与国际文献中报告的比率相当。例如,腹腔镜胆囊切除术中胆管损伤率分别为0.7和0.53%;冠状动脉移植手术死亡率分别为2.5%和2.1%;择期腹主动脉瘤修复术后死亡率分别为2.5%和3.7%;扁桃体切除术后的反应性出血率分别为0.9%和1.3%。一些指标的结果与其他报告明显不同,表明需要进一步调查;例如,儿童阑尾切除术的组织学阴性率分别为18.6%和21.2%,恶性皮肤肿瘤的完全切除率分别为90.7%和90%。然而,这些数字的意义取决于数据的验证及其可靠性和可重复性。由于可靠性最终只能在医院层面确定,因此它们对更广泛的比较价值有限。结论:为指标集建立的审查进程通过改进定义使一些指标得到完善,并使指标第二版(从1999年1月开始使用)的指标数量大幅减少到29个(涵盖18个程序)。临床指标计划,正如它与其他学科一样,有望为外科实践的修改和改进提供刺激。临床医生的所有权应该加强可靠数据的收集,从而提高数据的实用性。
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引用次数: 8
Can adhesions be prevented? 粘连可以预防吗?
Pub Date : 2000-06-01 DOI: 10.1046/j.1440-1622.2000.01854.x
B P Waxman
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引用次数: 6
Embolization as a treatment for bleeding post-total hip arthroplasty. 全髋关节置换术后出血的栓塞治疗。
Pub Date : 2000-06-01 DOI: 10.1046/j.1440-1622.2000.01845.x
D J Lum, P C Poon
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引用次数: 7
Intramuscular haemangioma of the medial pterygoid. 翼状内侧肌内血管瘤。
Pub Date : 2000-06-01 DOI: 10.1046/j.1440-1622.2000.01847.x
M S Kenali, P G Bridger
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引用次数: 0
Testicular torsion: time is the enemy. 睾丸扭转:时间是敌人。
Pub Date : 2000-06-01 DOI: 10.1046/j.1440-1622.2000.01853.x
P J Dunne, B S O'Loughlin

Background: The acute scrotum is a diagnostic dilemma, and testicular torsion is of primary interest because of its fertility problems for the patient and medico-legal issues for the surgeon. The present study aimed to correlate operative findings of patients with suspected testicular torsion with certain clinical variables and investigations to see if diagnosis and outcome could be improved.

Methods: A total of 99 patients underwent scrotal exploration for suspected testicular torsion at the Royal Brisbane Hospital between 1990 and 1995. Colour Doppler ultrasound, white blood count and urine microscopy results were documented, along with the patient's age and duration of testicular pain.

Results: Fifty-six patients were found to have torsion, and the testicular loss rate was 23%. Patients who experienced testicular pain for longer than 12 h had a testicular loss rate of 67%. A negative urine microscopy was suggestive of testicular torsion, but was not diagnostic. The white blood count did not aid in the diagnosis. Colour Doppler ultrasound of the scrotum was used on nine occasions with three false negative results and a sensitivity of only 57%.

Conclusions: Time is the enemy when managing the acute scrotum. No investigation substantially improves clinical diagnosis enough to warrant any delay in definitive surgical intervention.

背景:急性阴囊是一个诊断困境,睾丸扭转是主要的兴趣,因为它的生育问题的病人和医学法律问题的外科医生。本研究旨在将疑似睾丸扭转患者的手术表现与某些临床变量和调查相关联,以了解是否可以改善诊断和预后。方法:1990年至1995年在布里斯班皇家医院对99例疑似睾丸扭转患者行阴囊探查术。记录了彩色多普勒超声、白细胞计数和尿液显微镜结果,以及患者的年龄和睾丸疼痛的持续时间。结果:56例患者出现扭转,睾丸丢失率为23%。睾丸疼痛超过12小时的患者睾丸丢失率为67%。尿镜检阴性提示睾丸扭转,但不能诊断。白细胞计数对诊断没有帮助。阴囊彩色多普勒超声检查9次,假阴性3次,灵敏度仅为57%。结论:治疗急性阴囊时,时间是最大的敌人。没有一项调查能实质性地提高临床诊断,足以保证最终手术干预的任何延迟。
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引用次数: 77
Surgical adhesions: evidence for adsorption of surfactant to peritoneal mesothelium. 手术粘连:表面活性剂在腹膜间皮吸附的证据。
Pub Date : 2000-06-01 DOI: 10.1046/j.1440-1622.2000.01841.x
Y Chen, B A Hills

Background: It has been speculated that the formation of surgical adhesions must be preceded by physical adhesion of the two surfaces, a process normally prevented by a lining of adsorbed surface-active phospholipid (surfactant) acting as both a superb boundary (solid-to-solid) lubricant and a release (antistick) agent. Animal trials administering exogenous surfactant as a dry powder (ALEC) have previously demonstrated a reduction of 80% in abdominal adhesions.

Methods: Incubation of rat peritoneum (both live and excised) with radiolabelled dipalmitoyl phosphatidylcholine (DPPC) has been used to demonstrate adsorption; while the normal lining of surfactant in the human abdominal cavity has been confirmed by epifluorescence microscopy using Phosphin E as the hydrophobic probe.

Aims: The overall aim is to confirm that peritoneal mesothelium has a lining of surfactant known for its lubricating and release properties, and that this lining can be enhanced by the adsorption of exogenous material.

Results: Adsorption of DPPC to peritoneal mesothelium was 470 ng/cm2 (n = 8) ex vivo and 598 ng/cm2 (n = 18) in vivo, these rates being enhanced by EggPG by 62% ex vivo and 47% in vivo to reach the equivalent of almost three close-packed monolayers.

Conclusions: These results can explain the reduction in surgical adhesions previously reported in animals by administering ALEC (7:3 DPPC:EggPG) as a highly surface-active dry powder, although it is now used in saline suspension to treat respiratory distress syndrome in newborns, in whom it has no side-effects. These findings would appear to justify clinical trials for dry ALEC in suppressing surgical adhesions with minimal risk of an adverse reaction. The results of these trials are also discussed and found to be compatible with the known ability of surfactant to resist physical adhesion by fibronectin, the tacky 'glue' by which fibroblasts attach to surfaces as the first step in formation of fibrinous adhesions.

背景:据推测,手术粘连的形成必须在两个表面的物理粘连之前,这一过程通常由一层吸附的表面活性磷脂(表面活性剂)来防止,它既是一种极好的边界(固体到固体)润滑剂,也是一种释放(防粘)剂。在动物实验中,外源性表面活性剂作为干粉(ALEC)已被证明可以减少80%的腹部粘连。方法:用放射性标记的双棕榈酰磷脂酰胆碱(DPPC)对大鼠腹膜(活的和切除的)进行孵育,以证明其吸附作用;以磷蛋白E为疏水探针,用荧光显微镜证实了人腹腔表面活性剂的正常衬里。目的:总体目的是确认腹膜间皮具有表面活性剂的内衬,其润滑和释放特性,并且这种内衬可以通过外源物质的吸附而增强。结果:DPPC在腹膜间皮上的体外吸附量为470 ng/cm2 (n = 8),体内吸附量为598 ng/cm2 (n = 18),鸡蛋pg在体外和体内的吸附量分别提高了62%和47%,几乎相当于三层紧密堆积的单层膜。结论:这些结果可以解释先前报道的通过给药ALEC (7:3 DPPC:EggPG)作为一种高表面活性干粉减少手术粘连的动物,尽管它现在被用于生理盐水悬浮液中治疗新生儿呼吸窘迫综合征,对新生儿没有副作用。这些发现似乎证明了干亚历克在抑制手术粘连方面的临床试验具有最小的不良反应风险。这些试验的结果也被讨论并发现与已知的表面活性剂抵抗纤维连接蛋白物理粘附的能力是相容的,纤维连接蛋白是成纤维细胞附着在表面的粘性“胶水”,是纤维粘连形成的第一步。
{"title":"Surgical adhesions: evidence for adsorption of surfactant to peritoneal mesothelium.","authors":"Y Chen,&nbsp;B A Hills","doi":"10.1046/j.1440-1622.2000.01841.x","DOIUrl":"https://doi.org/10.1046/j.1440-1622.2000.01841.x","url":null,"abstract":"<p><strong>Background: </strong>It has been speculated that the formation of surgical adhesions must be preceded by physical adhesion of the two surfaces, a process normally prevented by a lining of adsorbed surface-active phospholipid (surfactant) acting as both a superb boundary (solid-to-solid) lubricant and a release (antistick) agent. Animal trials administering exogenous surfactant as a dry powder (ALEC) have previously demonstrated a reduction of 80% in abdominal adhesions.</p><p><strong>Methods: </strong>Incubation of rat peritoneum (both live and excised) with radiolabelled dipalmitoyl phosphatidylcholine (DPPC) has been used to demonstrate adsorption; while the normal lining of surfactant in the human abdominal cavity has been confirmed by epifluorescence microscopy using Phosphin E as the hydrophobic probe.</p><p><strong>Aims: </strong>The overall aim is to confirm that peritoneal mesothelium has a lining of surfactant known for its lubricating and release properties, and that this lining can be enhanced by the adsorption of exogenous material.</p><p><strong>Results: </strong>Adsorption of DPPC to peritoneal mesothelium was 470 ng/cm2 (n = 8) ex vivo and 598 ng/cm2 (n = 18) in vivo, these rates being enhanced by EggPG by 62% ex vivo and 47% in vivo to reach the equivalent of almost three close-packed monolayers.</p><p><strong>Conclusions: </strong>These results can explain the reduction in surgical adhesions previously reported in animals by administering ALEC (7:3 DPPC:EggPG) as a highly surface-active dry powder, although it is now used in saline suspension to treat respiratory distress syndrome in newborns, in whom it has no side-effects. These findings would appear to justify clinical trials for dry ALEC in suppressing surgical adhesions with minimal risk of an adverse reaction. The results of these trials are also discussed and found to be compatible with the known ability of surfactant to resist physical adhesion by fibronectin, the tacky 'glue' by which fibroblasts attach to surfaces as the first step in formation of fibrinous adhesions.</p>","PeriodicalId":22494,"journal":{"name":"The Australian and New Zealand journal of surgery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2000-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1046/j.1440-1622.2000.01841.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21687544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Popliteal artery compression by a tibial osteochondroma with associated thrombosis and distal embolization. 腘动脉受压胫骨骨软骨瘤伴血栓形成和远端栓塞。
Pub Date : 2000-06-01 DOI: 10.1046/j.1440-1622.2000.01848.x
J M Hemli, M S Barakate, V Puttaswamy, M Appleberg
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引用次数: 7
Prevalence and aetiology of lymphoedema after breast cancer treatment in southern Tasmania. 塔斯马尼亚南部乳腺癌治疗后淋巴水肿的患病率和病因学。
Pub Date : 2000-06-01 DOI: 10.1046/j.1440-1622.2000.01839.x
T L Edwards

Background: Lymphoedema can be a devastating complication of surgical treatment for breast cancer. There is a lack of research on its prevalence in Australia which has hindered the development of measures to combat the condition. The aims of this study were to establish the prevalence and investigate the aetiology of upper limb lymphoedema in women treated for breast cancer in the years 1994-1996 in southern Tasmania.

Methods: A standard volumetric water displacement technique was used to measure the arms of 201 women. A subjective assessment of swelling was also made by each patient. Factors analysed for statistical association with lymphoedema were: patient characteristics, type of treatment and tumour, and lymph node pathology.

Results: The overall objective prevalence rate, regardless of treatment type, was 11%; whereas, the subjective rate was 23.4%. The objective prevalence for procedures involving axillary surgery was 14.2%. Significant statistical associations were found between arm size and body mass index at time of assessment (r = 0.15, P = 0.04); type of surgery (Chi-squared test = 11.06, P = 0.05); surgery to axilla (U = 2515.5, P = 0.002); tumour size (r = 0.17, P = 0.03); and tumour grade (Chi-squared test = 6.5 1, P = 0.04). No significant relationship was found between lymphoedema and axillary irradiation, number of lymph nodes removed, age or handedness of the patient.

Conclusions: Women receiving axillary dissection as part of their breast cancer treatment carry a significant risk of developing lymphoedema, regardless of the extent of surgery. The causative role of axillary irradiation was not supported. Future research should concentrate on less invasive alternatives to axillary dissection, such as sentinal lymph node biopsy.

背景:淋巴水肿是乳腺癌手术治疗的严重并发症。缺乏对其在澳大利亚的流行情况的研究,这阻碍了对抗这种情况的措施的发展。本研究的目的是确定1994-1996年塔斯马尼亚南部接受乳腺癌治疗的妇女上肢淋巴水肿的患病率并调查其病因。方法:采用标准容积排水量法对201名女性的手臂进行测量。每位患者还对肿胀进行了主观评估。分析与淋巴水肿有统计学关联的因素有:患者特征、治疗方式和肿瘤类型、淋巴结病理。结果:不论何种治疗方式,总客观患病率为11%;主观率为23.4%。包括腋窝手术的客观患病率为14.2%。评估时臂长与体重指数存在显著的统计学关联(r = 0.15, P = 0.04);手术类型(卡方检验= 11.06,P = 0.05);腋窝手术(U = 2515.5, P = 0.002);肿瘤大小(r = 0.17, P = 0.03);肿瘤分级(χ 2检验= 6.5 1,P = 0.04)。淋巴水肿与腋窝照射、淋巴结切除数、患者年龄或惯用手性无明显关系。结论:接受腋窝清扫作为乳腺癌治疗的一部分的妇女,无论手术的程度如何,都有发生淋巴水肿的显著风险。不支持腋窝照射的致病作用。未来的研究应集中在较少侵入性的替代腋窝清扫,如前哨淋巴结活检。
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引用次数: 90
期刊
The Australian and New Zealand journal of surgery
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