Pub Date : 2019-08-01DOI: 10.1002/3527600418.mb7521d0034
A. Hartwig, M. Arand
Das krebserzeugende Potential von Ethylenoxid wurde erstmals 1984 beurteilt. Ethylenoxid ist ein alkylierendes Agens und reagiert mit Hydroxyl-, Sulfhydryl-, Aminound Carboxylgruppen von Makromolekülen. Vergiftungen bei akuten Expositionsbedingungen sind durch lokale Reizungen auf Haut und Schleimhaut und durch systemische Wirkungen auf ZNS, Herz und andere Organe gekennzeichnet. Systemische Wirkungen werden auch infolge ausschließlich resorptiver Aufnahme über die Haut hervorgerufen. Deswegen ist Ethylenoxid seit 1984 mit „H“ markiert. Ethylenoxid erwies sich in vitro und in vivo als mutagen. Ethylenoxid besitzt im Tierexperiment ein eindeutig krebserzeugendes Potential und ist seit 1984 in die Kategorie 2 für krebserzeugende Stoffe der MAKund BAT-Werte-Liste eingestuft. Für Ethylenoxid liegt eine Dokumentation einer Korrelation von Stoffkonzentration in der Luft am Arbeitsplatz zur Stoffbzw. Metabolitenkonzentration im biologischen Material vor (EKA; Greim und Lehnert 2001).
乙烯的潜在危险在1984年首次被评估。乙烯是一种碱性乙酰氨基乳酸，二氧化氢、二氧化水、氨基酸和碳酸钾发生反应。在曝光的环境下，人会中毒，其特征是地方刺激皮肤和黏膜，以及令铁、心脏和其他器官神经系统受到严重影响。系统的影响也由完全吸收皮肤产生。从1984年起乙烯就被标为" H "。膝盖在vitro和体内被证明具有变异乙烯在动物实验中具有明确的致癌潜力，而且自1984年以来已被在肠和芽索引中被列为次等致癌物质。乙烯是一个文档，记录了工作场所空气中物质浓度与物质或物质间的关系。生物物质的代谢浓度《德国汽车杂志》
{"title":"Ethylenoxid [MAK value documentation in German language, 2019]","authors":"A. Hartwig, M. Arand","doi":"10.1002/3527600418.mb7521d0034","DOIUrl":"https://doi.org/10.1002/3527600418.mb7521d0034","url":null,"abstract":"Das krebserzeugende Potential von Ethylenoxid wurde erstmals 1984 beurteilt. Ethylenoxid ist ein alkylierendes Agens und reagiert mit Hydroxyl-, Sulfhydryl-, Aminound Carboxylgruppen von Makromolekülen. Vergiftungen bei akuten Expositionsbedingungen sind durch lokale Reizungen auf Haut und Schleimhaut und durch systemische Wirkungen auf ZNS, Herz und andere Organe gekennzeichnet. Systemische Wirkungen werden auch infolge ausschließlich resorptiver Aufnahme über die Haut hervorgerufen. Deswegen ist Ethylenoxid seit 1984 mit „H“ markiert. Ethylenoxid erwies sich in vitro und in vivo als mutagen. Ethylenoxid besitzt im Tierexperiment ein eindeutig krebserzeugendes Potential und ist seit 1984 in die Kategorie 2 für krebserzeugende Stoffe der MAKund BAT-Werte-Liste eingestuft. Für Ethylenoxid liegt eine Dokumentation einer Korrelation von Stoffkonzentration in der Luft am Arbeitsplatz zur Stoffbzw. Metabolitenkonzentration im biologischen Material vor (EKA; Greim und Lehnert 2001).","PeriodicalId":22742,"journal":{"name":"The MAK-Collection for Occupational Health and Safety","volume":"273 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79978066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-08-01DOI: 10.1002/3527600418.mb744067verd0067
A. Hartwig, Michael Arand
{"title":"Zirkonium und seine Verbindungen (außer Zirkoniumdioxid) [MAK value documentation in German language, 2019]","authors":"A. Hartwig, Michael Arand","doi":"10.1002/3527600418.mb744067verd0067","DOIUrl":"https://doi.org/10.1002/3527600418.mb744067verd0067","url":null,"abstract":"","PeriodicalId":22742,"journal":{"name":"The MAK-Collection for Occupational Health and Safety","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87292039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-08-01DOI: 10.1002/3527600418.mb10731d0067
A. Hartwig, Michael Arand
{"title":"Methylformiat (Ameisensäuremethylester) [MAK value documentation in German language, 2019]","authors":"A. Hartwig, Michael Arand","doi":"10.1002/3527600418.mb10731d0067","DOIUrl":"https://doi.org/10.1002/3527600418.mb10731d0067","url":null,"abstract":"","PeriodicalId":22742,"journal":{"name":"The MAK-Collection for Occupational Health and Safety","volume":"48 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90509402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-08-01DOI: 10.1002/3527600418.mb6756d0067
A. Hartwig, M. Arand
{"title":"Methanol [MAK value documentation in German language, 2019]","authors":"A. Hartwig, M. Arand","doi":"10.1002/3527600418.mb6756d0067","DOIUrl":"https://doi.org/10.1002/3527600418.mb6756d0067","url":null,"abstract":"","PeriodicalId":22742,"journal":{"name":"The MAK-Collection for Occupational Health and Safety","volume":"53 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83816223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-08-01DOI: 10.1002/3527600418.mb7508d0067
A. Hartwig, M. Arand
{"title":"Ethanthiol [MAK value documentation in German language, 2019]","authors":"A. Hartwig, M. Arand","doi":"10.1002/3527600418.mb7508d0067","DOIUrl":"https://doi.org/10.1002/3527600418.mb7508d0067","url":null,"abstract":"","PeriodicalId":22742,"journal":{"name":"The MAK-Collection for Occupational Health and Safety","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78944269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-08-01DOI: 10.1002/3527600418.mb46019d0067
A. Hartwig, M. Arand
German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has re‐evaluated the maximum concentration at the workplace (MAK value) and the Pregnancy Risk Group of oxalonitrile [460‐19‐5]. There are no new data. The MAK value of 5 ml/m3 was determined in analogy to the more toxic metabolite hydrogen cyanide. The MAK value for hydrogen cyanide of 1.9 ml/m3 was derived from the human detoxification capacity per kg body weight with a respiratory volume of 10 m3. Therefore, the increased respiratory volume at the workplace has already been accounted for. The MAK value of oxalonitrile, which was set at 5 ml/m3 to reflect the 2.5‐fold higher acute toxicity of hydrogen cyanide, can be retained. This is also the case for Peak Limitation Category II and the excursion factor of 2 because no irritation was observed in humans below 16 ml/m3. There are no developmental toxicity studies. Therefore, oxalonitrile is assigned to Pregnancy Risk Group D.
{"title":"Oxalsäuredinitril [MAK value documentation in German language, 2019]","authors":"A. Hartwig, M. Arand","doi":"10.1002/3527600418.mb46019d0067","DOIUrl":"https://doi.org/10.1002/3527600418.mb46019d0067","url":null,"abstract":"German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has re‐evaluated the maximum concentration at the workplace (MAK value) and the Pregnancy Risk Group of oxalonitrile [460‐19‐5]. \u0000There are no new data. The MAK value of 5 ml/m3 was determined in analogy to the more toxic metabolite hydrogen cyanide. The MAK value for hydrogen cyanide of 1.9 ml/m3 was derived from the human detoxification capacity per kg body weight with a respiratory volume of 10 m3. Therefore, the increased respiratory volume at the workplace has already been accounted for. The MAK value of oxalonitrile, which was set at 5 ml/m3 to reflect the 2.5‐fold higher acute toxicity of hydrogen cyanide, can be retained. This is also the case for Peak Limitation Category II and the excursion factor of 2 because no irritation was observed in humans below 16 ml/m3. \u0000There are no developmental toxicity studies. Therefore, oxalonitrile is assigned to Pregnancy Risk Group D.","PeriodicalId":22742,"journal":{"name":"The MAK-Collection for Occupational Health and Safety","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88178522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-08-01DOI: 10.1002/3527600418.mb131423d0067
A. Hartwig
{"title":"Zirkoniumdioxid (alveolengängige Fraktion) [MAK value documentation in German language, 2019]","authors":"A. Hartwig","doi":"10.1002/3527600418.mb131423d0067","DOIUrl":"https://doi.org/10.1002/3527600418.mb131423d0067","url":null,"abstract":"","PeriodicalId":22742,"journal":{"name":"The MAK-Collection for Occupational Health and Safety","volume":"111 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88287284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-08-01DOI: 10.1002/3527600418.mb5889d0035
A. Hartwig, M. Arand
Lindan wurde 1998 in die Kategorie 4 für krebserzeugende Arbeitsstoffe eingestuft. Nach den damals gültigen Kriterien war eine Einstufung in eine Kategorie für erbgutverändernde Arbeitsstoffe nicht erforderlich. Da mittlerweile neue Kriterien für die Einstufung von Stoffen in Kategorien für Keimzellmutagene erarbeitet wurden (vgl. Begründung „Keimzellmutagene“ 2000 unter „Allgemeines“), beschäftigt sich der vorliegende Nachtrag mit einer Bewertung der Daten zur Genotoxizität und Mutagenität von Lindan im Hinblick auf die neu definierten Einstufungskriterien. Im Zuge der Überarbeitung der Kurzzeitwert-Kategorien erfolgt eine Überprüfung der Spitzenbegrenzung.
{"title":"Lindan [MAK value documentation in German language, 2019]","authors":"A. Hartwig, M. Arand","doi":"10.1002/3527600418.mb5889d0035","DOIUrl":"https://doi.org/10.1002/3527600418.mb5889d0035","url":null,"abstract":"Lindan wurde 1998 in die Kategorie 4 für krebserzeugende Arbeitsstoffe eingestuft. Nach den damals gültigen Kriterien war eine Einstufung in eine Kategorie für erbgutverändernde Arbeitsstoffe nicht erforderlich. Da mittlerweile neue Kriterien für die Einstufung von Stoffen in Kategorien für Keimzellmutagene erarbeitet wurden (vgl. Begründung „Keimzellmutagene“ 2000 unter „Allgemeines“), beschäftigt sich der vorliegende Nachtrag mit einer Bewertung der Daten zur Genotoxizität und Mutagenität von Lindan im Hinblick auf die neu definierten Einstufungskriterien. Im Zuge der Überarbeitung der Kurzzeitwert-Kategorien erfolgt eine Überprüfung der Spitzenbegrenzung.","PeriodicalId":22742,"journal":{"name":"The MAK-Collection for Occupational Health and Safety","volume":"70 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72953013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-08-01DOI: 10.1002/3527600418.mb588833d0067
A. Hartwig, M. Arand
{"title":"Isobornylacrylat [MAK value documentation in German language, 2019]","authors":"A. Hartwig, M. Arand","doi":"10.1002/3527600418.mb588833d0067","DOIUrl":"https://doi.org/10.1002/3527600418.mb588833d0067","url":null,"abstract":"","PeriodicalId":22742,"journal":{"name":"The MAK-Collection for Occupational Health and Safety","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83679685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-08-01DOI: 10.1002/3527600418.mb0234fasd0067
A. Hartwig, M. Arand
{"title":"Aluminiumsilikatfasern (Refractory Ceramic Fibres, RCF) [MAK value documentation in German language, 2019]","authors":"A. Hartwig, M. Arand","doi":"10.1002/3527600418.mb0234fasd0067","DOIUrl":"https://doi.org/10.1002/3527600418.mb0234fasd0067","url":null,"abstract":"","PeriodicalId":22742,"journal":{"name":"The MAK-Collection for Occupational Health and Safety","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90842159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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