{"title":"A clinical trial of an antiserotonin compound, cinanserin, in chronic schizophrenia.","authors":"J M Holden, A Keskiner, P Gannon","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":22771,"journal":{"name":"The Journal of clinical pharmacology and new drugs","volume":"11 3","pages":"220-6"},"PeriodicalIF":0.0,"publicationDate":"1971-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"16038791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The society-to-cell concept as applied to the teaching of pharmacology.","authors":"D E Hutcheon, E T Eckhardt, D D Bonnycastle","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":22771,"journal":{"name":"The Journal of clinical pharmacology and new drugs","volume":"11 3","pages":"161-4"},"PeriodicalIF":0.0,"publicationDate":"1971-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"16299538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Double-blind evaluation of capuride in hospitalized patients suffering from loss of sleep.","authors":"A G Silverman, R Okun","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":22771,"journal":{"name":"The Journal of clinical pharmacology and new drugs","volume":"11 3","pages":"215-9"},"PeriodicalIF":0.0,"publicationDate":"1971-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"16038790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
L C Mendoza, K Hellberg, A Rickart, G Tillich, R J Bing
{"title":"The effect of intravenous ethyl alcohol on the coronary circulation and myocardial contractility of the human and canine heart.","authors":"L C Mendoza, K Hellberg, A Rickart, G Tillich, R J Bing","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":22771,"journal":{"name":"The Journal of clinical pharmacology and new drugs","volume":"11 3","pages":"165-76"},"PeriodicalIF":0.0,"publicationDate":"1971-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"16298968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1971-01-02DOI: 10.1177/009127007101100112
S. Snyder
{"title":"The Psychopharmacology of the Normal Human. Wayne O. Evans and Nathan S. Kline, editors","authors":"S. Snyder","doi":"10.1177/009127007101100112","DOIUrl":"https://doi.org/10.1177/009127007101100112","url":null,"abstract":"","PeriodicalId":22771,"journal":{"name":"The Journal of clinical pharmacology and new drugs","volume":"63 1","pages":"73-74"},"PeriodicalIF":0.0,"publicationDate":"1971-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74092006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1971-01-02DOI: 10.1177/009127007101100113
W. Frosch
{"title":"Aggressive Behaviour. S. Garattini and E. B. Sigg, editors","authors":"W. Frosch","doi":"10.1177/009127007101100113","DOIUrl":"https://doi.org/10.1177/009127007101100113","url":null,"abstract":"","PeriodicalId":22771,"journal":{"name":"The Journal of clinical pharmacology and new drugs","volume":"33 1","pages":"74-75"},"PeriodicalIF":0.0,"publicationDate":"1971-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84756492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1971-01-02DOI: 10.1177/009127007101100114
E. Heimlich, L. Joubert, G. Thomas
I their paper entitled "Methodological Considerations in the Histamine Skin Test" (Joubert and Thomas, J. Clin. Pharm. 10 :165, 1970) the authors present and comment on a number of methodological considerations in a most sophisticated technical and statistical fashion. It is therefore singularly remarkable that they totally ignore variations introduced by the simple method of testing in a purely mechanical fashion. They state "an aqueous solution of histamine containing 0.005 mg in 0.05 ml was injected intradermally with disposable tuberculin syringes" but nowhere examine or discuss the accuracy or reproducibility of this procedure. It is quite clear from a number of published studies that there is wide variability in the "intradermality" of such injections, in the volume delivered biologically to some site in the skin, in the volume dispensed by disposable tuberculin syringes, in the calibration (volumetric scale) of such syringes, in the mechanical ability to control volume delivery from such syringes, and in the amount of 'leakage' or 'waste' during injections. It should be clear that the sum of such variables may lead to test variability which is of at least equal significance to some of the more sophisticated sources of variation considered by the authors and may be a limiting factor on the interpretability of results.
在他们题为“组胺皮肤试验的方法学考虑”的论文中(Joubert和Thomas, J. Clin)。《药学》(Pharm. 10:165, 1970)，作者以最复杂的技术和统计方式提出并评论了一些方法学上的考虑。因此，非常值得注意的是，他们完全忽略了以纯机械方式进行简单测试的方法所带来的变化。他们声明“用一次性结核菌素注射器皮下注射0.05 ml中含有0.005 mg的组胺水溶液”，但没有检查或讨论该程序的准确性或可重复性。从许多已发表的研究中可以很清楚地看出，在此类注射的“皮内注射”、生物输送到皮肤某些部位的体积、一次性结核菌素注射器的分配体积、此类注射器的校准(体积刻度)、控制此类注射器的体积输送的机械能力以及注射过程中的“泄漏”或“浪费”量等方面存在很大差异。应该清楚的是，这些变量的总和可能导致测试变异，这至少与作者考虑的一些更复杂的变异来源具有同等的重要性，并且可能是结果可解释性的限制因素。
{"title":"THE HISTAMINE SKIN TEST","authors":"E. Heimlich, L. Joubert, G. Thomas","doi":"10.1177/009127007101100114","DOIUrl":"https://doi.org/10.1177/009127007101100114","url":null,"abstract":"I their paper entitled \"Methodological Considerations in the Histamine Skin Test\" (Joubert and Thomas, J. Clin. Pharm. 10 :165, 1970) the authors present and comment on a number of methodological considerations in a most sophisticated technical and statistical fashion. It is therefore singularly remarkable that they totally ignore variations introduced by the simple method of testing in a purely mechanical fashion. They state \"an aqueous solution of histamine containing 0.005 mg in 0.05 ml was injected intradermally with disposable tuberculin syringes\" but nowhere examine or discuss the accuracy or reproducibility of this procedure. It is quite clear from a number of published studies that there is wide variability in the \"intradermality\" of such injections, in the volume delivered biologically to some site in the skin, in the volume dispensed by disposable tuberculin syringes, in the calibration (volumetric scale) of such syringes, in the mechanical ability to control volume delivery from such syringes, and in the amount of 'leakage' or 'waste' during injections. It should be clear that the sum of such variables may lead to test variability which is of at least equal significance to some of the more sophisticated sources of variation considered by the authors and may be a limiting factor on the interpretability of results.","PeriodicalId":22771,"journal":{"name":"The Journal of clinical pharmacology and new drugs","volume":"28 1","pages":"76-76"},"PeriodicalIF":0.0,"publicationDate":"1971-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91518974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1971-01-02DOI: 10.1177/009127007101100111
D. Hutcheon, S. Arbeit
{"title":"Clinical Aids in Cardiac Diagnosis. William Dressler","authors":"D. Hutcheon, S. Arbeit","doi":"10.1177/009127007101100111","DOIUrl":"https://doi.org/10.1177/009127007101100111","url":null,"abstract":"","PeriodicalId":22771,"journal":{"name":"The Journal of clinical pharmacology and new drugs","volume":"125 1","pages":"73-73"},"PeriodicalIF":0.0,"publicationDate":"1971-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86812516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1971-01-01DOI: 10.1177/009127007101100102
R I Wang, L C Terry
{"title":"Adverse drug reactions in a veterans administration hospital.","authors":"R I Wang, L C Terry","doi":"10.1177/009127007101100102","DOIUrl":"https://doi.org/10.1177/009127007101100102","url":null,"abstract":"","PeriodicalId":22771,"journal":{"name":"The Journal of clinical pharmacology and new drugs","volume":"11 1","pages":"14-8"},"PeriodicalIF":0.0,"publicationDate":"1971-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/009127007101100102","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"16292019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1971-01-01DOI: 10.1177/009127007101100105
G R Van Petten, G C Becking, R J Withey, H F Lettau
{"title":"Studies on the physiological availability and metabolism of sulfonamides. II. Sulfisoxazole.","authors":"G R Van Petten, G C Becking, R J Withey, H F Lettau","doi":"10.1177/009127007101100105","DOIUrl":"https://doi.org/10.1177/009127007101100105","url":null,"abstract":"","PeriodicalId":22771,"journal":{"name":"The Journal of clinical pharmacology and new drugs","volume":"11 1","pages":"35-41"},"PeriodicalIF":0.0,"publicationDate":"1971-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/009127007101100105","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"16017549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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