Pub Date : 2024-09-18DOI: 10.1080/14767058.2024.2404111
Marti D. Soffer, Alberto Muniz Rodriguez, Caitlin S. Haxel, Christina Ronai, Kaitlyn E. James, Joanne S. Chiu
Fetal cardiac anomalies are the most commonly diagnosed structural anomalies. In these cases, Maternal-Fetal Medicine (MFM) specialists are tasked with counseling patients on a spectrum of diagnose...
{"title":"The impact of specialty training and physician attitudes on fetal cardiac counseling","authors":"Marti D. Soffer, Alberto Muniz Rodriguez, Caitlin S. Haxel, Christina Ronai, Kaitlyn E. James, Joanne S. Chiu","doi":"10.1080/14767058.2024.2404111","DOIUrl":"https://doi.org/10.1080/14767058.2024.2404111","url":null,"abstract":"Fetal cardiac anomalies are the most commonly diagnosed structural anomalies. In these cases, Maternal-Fetal Medicine (MFM) specialists are tasked with counseling patients on a spectrum of diagnose...","PeriodicalId":22921,"journal":{"name":"The Journal of Maternal-Fetal & Neonatal Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142248930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-17DOI: 10.1080/14767058.2024.2399304
Simon Shenhav,Iris Harel,Ido Solt,Amit Shenhav,Shlomo Fytlovich,Dorit Aharoni,Avi Rimler,Eyal Y Anteby,Yaniv S Ovadia
PURPOSEPreeclampsia (PE) is a common complication of pregnancy that carries significant risks for both the mother and the fetus, and is frequently accompanied by hyperuricemia, yet the exact source of elevated uric acid (UA) levels remains partially elucidated. Several potential origins for increased UA levels include abnormal renal function, increased tissue breakdown, and increased activity of the enzyme Xanthine Oxidase (XO). The aim of the study was to determine serum levels of UA and XO not only in maternal serum, but also in umbilical vein (UV) and umbilical artery (UA) and explore their possible role in PE development.METHODSA prospective case-control pilot study was conducted in women who were found positive for PE with severe features, and had elevated UA levels above 6 mg/dL, with normotensive pregnant women serving as controls. Renal function, UA and XO levels were measured in maternal, UV and UA serums immediately after delivery. They were then compared between PE (n = 21) and control (n = 18) groups, as well as across all mediums (maternal, UV and UA) among the total study sample (N = 39). Diastolic blood pressure (DBP) was also measured immediately following delivery.RESULTSThe mean serum maternal creatinine levels did not differ significantly between groups (0.65 ± 0.03 vs 0.6 ± 0.07, p = 0.13). Both mean maternal serum UA and XO concentrations were higher in PE group than in control (7.3 ± 1.2 vs 4.2 ± 0.9, p < 0.01 and 3.6 ± 3.5 Vs 1.7 ± 0.8, p < 0.01, respectively). The mean UV and UA serum XO concentrations were significantly higher in PE group compared to control (4.2 ± 3.6 vs 2.2 ± 1.4, p < 0.01 and 4.2 ± 3.6 vs 2.1 ± 1.5, p < 0.01, respectively). Polynomial fit correlation test demonstrated a significant association between maternal DBP and UV XO concentration for all the total study participants (p = 0.03).CONCLUSIONDespite preserved renal functions, UA and XO levels were elevated in women with PE. Importantly, this pattern was found to be applied to the feto-placental unit as well, which may indicate an active involvement of the fetus in the hypoxic process. Further study is needed to clarify the possible role of the feto-placental unit in pregnancies complicated by PE.
目的先兆子痫（PE）是一种常见的妊娠并发症，对母亲和胎儿都有很大的风险，而且经常伴有高尿酸血症，但尿酸（UA）水平升高的确切来源仍未部分阐明。尿酸水平升高的几个潜在来源包括肾功能异常、组织分解增加和黄嘌呤氧化酶（XO）活性增加。本研究旨在确定母体血清、脐静脉（UV）和脐动脉（UA）中的 UA 和 XO 水平，并探讨它们在 PE 发生过程中可能发挥的作用。方法对发现 PE 阳性且特征严重、UA 水平升高超过 6 mg/dL 的孕妇进行前瞻性病例对照试验研究，并以血压正常的孕妇作为对照。在分娩后立即对母体、紫外线和 UA 血清中的肾功能、UA 和 XO 水平进行了测量。然后对 PE 组（n = 21）和对照组（n = 18）进行比较，并对所有研究样本（n = 39）中的所有介质（母体、紫外线和 UA）进行比较。结果各组之间的产妇血清肌酐平均水平无显著差异（0.65 ± 0.03 vs 0.6 ± 0.07，P = 0.13）。PE 组产妇平均血清 UA 和 XO 浓度均高于对照组（分别为 7.3 ± 1.2 vs 4.2 ± 0.9，p < 0.01 和 3.6 ± 3.5 vs 1.7 ± 0.8，p < 0.01）。与对照组相比，PE 组血清 XO 的平均 UV 和 UA 浓度明显更高（分别为 4.2 ± 3.6 vs 2.2 ± 1.4，p < 0.01 和 4.2 ± 3.6 vs 2.1 ± 1.5，p < 0.01）。多项式拟合相关性检验表明，在所有研究参与者中，母体 DBP 与紫外线 XO 浓度之间存在显著关联（P = 0.03）。重要的是，这种模式也适用于胎儿-胎盘单元，这可能表明胎儿积极参与了缺氧过程。要弄清胎盘-胎儿单位在 PE 并发症妊娠中可能扮演的角色，还需要进一步的研究。
{"title":"Fetoplacental unit involvement in uric acid production in women with severe preeclampsia: a prospective case control pilot study.","authors":"Simon Shenhav,Iris Harel,Ido Solt,Amit Shenhav,Shlomo Fytlovich,Dorit Aharoni,Avi Rimler,Eyal Y Anteby,Yaniv S Ovadia","doi":"10.1080/14767058.2024.2399304","DOIUrl":"https://doi.org/10.1080/14767058.2024.2399304","url":null,"abstract":"PURPOSEPreeclampsia (PE) is a common complication of pregnancy that carries significant risks for both the mother and the fetus, and is frequently accompanied by hyperuricemia, yet the exact source of elevated uric acid (UA) levels remains partially elucidated. Several potential origins for increased UA levels include abnormal renal function, increased tissue breakdown, and increased activity of the enzyme Xanthine Oxidase (XO). The aim of the study was to determine serum levels of UA and XO not only in maternal serum, but also in umbilical vein (UV) and umbilical artery (UA) and explore their possible role in PE development.METHODSA prospective case-control pilot study was conducted in women who were found positive for PE with severe features, and had elevated UA levels above 6 mg/dL, with normotensive pregnant women serving as controls. Renal function, UA and XO levels were measured in maternal, UV and UA serums immediately after delivery. They were then compared between PE (n = 21) and control (n = 18) groups, as well as across all mediums (maternal, UV and UA) among the total study sample (N = 39). Diastolic blood pressure (DBP) was also measured immediately following delivery.RESULTSThe mean serum maternal creatinine levels did not differ significantly between groups (0.65 ± 0.03 vs 0.6 ± 0.07, p = 0.13). Both mean maternal serum UA and XO concentrations were higher in PE group than in control (7.3 ± 1.2 vs 4.2 ± 0.9, p < 0.01 and 3.6 ± 3.5 Vs 1.7 ± 0.8, p < 0.01, respectively). The mean UV and UA serum XO concentrations were significantly higher in PE group compared to control (4.2 ± 3.6 vs 2.2 ± 1.4, p < 0.01 and 4.2 ± 3.6 vs 2.1 ± 1.5, p < 0.01, respectively). Polynomial fit correlation test demonstrated a significant association between maternal DBP and UV XO concentration for all the total study participants (p = 0.03).CONCLUSIONDespite preserved renal functions, UA and XO levels were elevated in women with PE. Importantly, this pattern was found to be applied to the feto-placental unit as well, which may indicate an active involvement of the fetus in the hypoxic process. Further study is needed to clarify the possible role of the feto-placental unit in pregnancies complicated by PE.","PeriodicalId":22921,"journal":{"name":"The Journal of Maternal-Fetal & Neonatal Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142248931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Preeclampsia (PE) is a pregnancy-specific hypertensive disorder. Late-onset (Lo)-PE can cause serious complications in both the mother and child. This study aimed to explore biomarkers for elucidat...
{"title":"Targeted metabolomic analysis of early-trimester serum identifies potential mechanisms for late-onset preeclampsia","authors":"Chihiro Okoshi, Hyo Kyozuka, Takahiro Omoto, Toma Fukuda, Tsuyoshi Murata, Shun Yasuda, Hirotaka Isogami, Miho Okutsu-Ono, Akiko Sato, Koichi Hashimoto, Hidekazu Nishigori, Keiya Fujimori","doi":"10.1080/14767058.2024.2401970","DOIUrl":"https://doi.org/10.1080/14767058.2024.2401970","url":null,"abstract":"Preeclampsia (PE) is a pregnancy-specific hypertensive disorder. Late-onset (Lo)-PE can cause serious complications in both the mother and child. This study aimed to explore biomarkers for elucidat...","PeriodicalId":22921,"journal":{"name":"The Journal of Maternal-Fetal & Neonatal Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142268430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-16DOI: 10.1080/14767058.2024.2389979
Zhiwei Wu, Jinzao Chen, Kaijian Huang, Yiming Li, Jianbin Chen, Bin Lin, Chunhua Lin, Guoyan Pan
Pre-eclampsia (PE) and gestational hypertension (GH) are two different categories of hypertensive disorders of pregnancy. Given earlier observational research, the relationship between sex hormone-...
{"title":"Causal association of sex hormone-binding globulin on gestational hypertension and pre-eclampsia: a two-sample Mendelian randomization study","authors":"Zhiwei Wu, Jinzao Chen, Kaijian Huang, Yiming Li, Jianbin Chen, Bin Lin, Chunhua Lin, Guoyan Pan","doi":"10.1080/14767058.2024.2389979","DOIUrl":"https://doi.org/10.1080/14767058.2024.2389979","url":null,"abstract":"Pre-eclampsia (PE) and gestational hypertension (GH) are two different categories of hypertensive disorders of pregnancy. Given earlier observational research, the relationship between sex hormone-...","PeriodicalId":22921,"journal":{"name":"The Journal of Maternal-Fetal & Neonatal Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142268429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-18DOI: 10.1080/14767058.2024.2364980
Published in The Journal of Maternal-Fetal & Neonatal Medicine (Vol. 37, No. 1, 2024)
发表于《母胎与新生儿医学杂志》（第 37 卷第 1 期，2024 年）
{"title":"Statement of Retraction: Omega-3 fatty acid supplementation affects pregnancy outcomes in gestational diabetes: a randomized, double-blind, placebo-controlled trial","authors":"","doi":"10.1080/14767058.2024.2364980","DOIUrl":"https://doi.org/10.1080/14767058.2024.2364980","url":null,"abstract":"Published in The Journal of Maternal-Fetal & Neonatal Medicine (Vol. 37, No. 1, 2024)","PeriodicalId":22921,"journal":{"name":"The Journal of Maternal-Fetal & Neonatal Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141522282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-18DOI: 10.1080/14767058.2024.2364976
Published in The Journal of Maternal-Fetal & Neonatal Medicine (Vol. 37, No. 1, 2024)
发表于《母胎与新生儿医学杂志》（第 37 卷第 1 期，2024 年）
{"title":"Statement of retraction: effect of daily consumption of probiotic yoghurt on lipid profiles in pregnant women: a randomized controlled clinical trial","authors":"","doi":"10.1080/14767058.2024.2364976","DOIUrl":"https://doi.org/10.1080/14767058.2024.2364976","url":null,"abstract":"Published in The Journal of Maternal-Fetal & Neonatal Medicine (Vol. 37, No. 1, 2024)","PeriodicalId":22921,"journal":{"name":"The Journal of Maternal-Fetal & Neonatal Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141501593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-18DOI: 10.1080/14767058.2024.2364977
Published in The Journal of Maternal-Fetal & Neonatal Medicine (Vol. 37, No. 1, 2024)
发表于《母胎与新生儿医学杂志》（第 37 卷第 1 期，2024 年）
{"title":"Statement of Retraction: Effect of multivitamin versus multivitamin-mineral supplementation on metabolic profiles and biomarkers of oxidative stress in pregnant women: a double-blind randomized clinical trial","authors":"","doi":"10.1080/14767058.2024.2364977","DOIUrl":"https://doi.org/10.1080/14767058.2024.2364977","url":null,"abstract":"Published in The Journal of Maternal-Fetal & Neonatal Medicine (Vol. 37, No. 1, 2024)","PeriodicalId":22921,"journal":{"name":"The Journal of Maternal-Fetal & Neonatal Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141522344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-18DOI: 10.1080/14767058.2024.2364981
Published in The Journal of Maternal-Fetal & Neonatal Medicine (Vol. 37, No. 1, 2024)
发表于《母胎与新生儿医学杂志》（第 37 卷第 1 期，2024 年）
{"title":"Statement of Retraction: The effects of vitamin E supplementation on endometrial thickness, and gene expression of vascular endothelial growth factor and inflammatory cytokines among women with implantation failure","authors":"","doi":"10.1080/14767058.2024.2364981","DOIUrl":"https://doi.org/10.1080/14767058.2024.2364981","url":null,"abstract":"Published in The Journal of Maternal-Fetal & Neonatal Medicine (Vol. 37, No. 1, 2024)","PeriodicalId":22921,"journal":{"name":"The Journal of Maternal-Fetal & Neonatal Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141522345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-18DOI: 10.1080/14767058.2024.2364982
Published in The Journal of Maternal-Fetal & Neonatal Medicine (Vol. 37, No. 1, 2024)
发表于《母胎与新生儿医学杂志》（第 37 卷第 1 期，2024 年）
{"title":"Statement of Retraction: The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes","authors":"","doi":"10.1080/14767058.2024.2364982","DOIUrl":"https://doi.org/10.1080/14767058.2024.2364982","url":null,"abstract":"Published in The Journal of Maternal-Fetal & Neonatal Medicine (Vol. 37, No. 1, 2024)","PeriodicalId":22921,"journal":{"name":"The Journal of Maternal-Fetal & Neonatal Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141741724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-18DOI: 10.1080/14767058.2024.2364983
Published in The Journal of Maternal-Fetal & Neonatal Medicine (Vol. 37, No. 1, 2024)
发表于《母胎与新生儿医学杂志》（第 37 卷第 1 期，2024 年）
{"title":"Statement of Retraction: The effect of zinc and vitamin E cosupplementation on metabolic status and its related gene expression in patients with gestational diabetes","authors":"","doi":"10.1080/14767058.2024.2364983","DOIUrl":"https://doi.org/10.1080/14767058.2024.2364983","url":null,"abstract":"Published in The Journal of Maternal-Fetal & Neonatal Medicine (Vol. 37, No. 1, 2024)","PeriodicalId":22921,"journal":{"name":"The Journal of Maternal-Fetal & Neonatal Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141532573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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