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2018 IEEE 31st International Symposium on Computer-Based Medical Systems (CBMS)最新文献

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A New Approach to Evaluation of Electroencephalograms Inter-Channel Phase Synchronization 脑电信号通道间相位同步评价的新方法
Pub Date : 2018-06-01 DOI: 10.1109/CBMS.2018.00028
R. Tolmacheva, Y. Obukhov, L. Zhavoronkova
Widely used methods of evaluation electroencephalogram (EEG) signals coherence have well-known drawbacks associated with the averaging of the evaluation of coherence in non-overlapping time periods and/or the wide frequency ranges, and the influence of the evaluation of amplitude modulation and noise. The report considers a new approach to the evaluation of phase coherency of EEG signals, consisting of the calculation of the phase of signals wavelet spectra at the points of the ridges. These points, under certain conditions, have property of phase stationarity. In this case, it is not required to conduct mentioned averaging. Evaluations of inter-channel EEG phase coherency using cognitive and motor tests by healthy subjects and patients after traumatic brain injuries are considered. This method allows to distinguish the phase-coupled pairs of EEG leads from uncoupled ones and to determine the phase-coupled pairs of leads specified for a certain test of the EEG record.
广泛使用的脑电图(EEG)信号相干性评估方法存在众所周知的缺陷,这些缺陷与在非重叠时间段和/或宽频率范围内对相干性评估进行平均以及振幅调制和噪声评估的影响有关。本文提出了一种评估脑电信号相位相干性的新方法,包括计算信号在脊点处的小波谱的相位。在一定条件下,这些点具有相位平稳性。在这种情况下,不需要进行上述平均。本文研究了健康人与创伤性脑损伤患者的认知和运动测试对脑通道间相一致性的评价。该方法可以区分相耦合的脑电图导联对和不耦合的导联对,并确定用于脑电图记录的某项测试的导联相耦合对。
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引用次数: 0
Usability Study on Mobile Processes Enabling Remote Therapeutic Interventions 实现远程治疗干预的移动过程的可用性研究
Pub Date : 2018-06-01 DOI: 10.1109/CBMS.2018.00033
Marc Schickler, R. Pryss, W. Schlee, T. Probst, B. Langguth, Johannes Schobel, M. Reichert
Many studies have revealed that therapeutic homework is beneficial for the efficacy of therapies. Interestingly, the latter have been less supported by IT systems so far and, hence, therapeutic opportunities have been neglected. For example, mobile devices can be used to notify patients about assigned homework and help them to accomplish it in a timely manner. In general, the use of mobile devices as well as their sensors seem to be promising for the support of remote therapeutic interventions. In the Albatros project, we have been developing a framework that enables domain experts to flexibly define the homework required in the context of a remote therapeutic intervention. More precisely, the various tasks of a homework can be specified as a mobile process, which is then run on the mobile device of the respective patient. To realize this vision, a configurator component using a model-driven approach was developed. In particular, the Albatros configurator shall relieve domain experts from complex technical issues when defining a homework. The study presented in this paper investigates whether domain experts are actually able to use the configurator component. In particular, the study revealed three insights. First, basic interventions can be easily defined with an acceptable number of errors. Second, for defining complex interventions (e.g., using a sensor when performing an exercise) several issues could be identified that will contribute to improve the Albatros configurator. Third, additional studies are needed to evaluate the overall mental effort of domain experts when using the configurator. Altogether, the Albatros framework may be a reasonable alley to empower domain experts in creating homework in the context of remote therapeutic interventions.
许多研究表明,治疗性家庭作业有利于治疗的效果。有趣的是,到目前为止,后者还没有得到IT系统的支持,因此,治疗机会被忽视了。例如,移动设备可用于通知患者指定的家庭作业,并帮助他们及时完成作业。总的来说,移动设备及其传感器的使用似乎有望支持远程治疗干预。在Albatros项目中,我们一直在开发一个框架,使领域专家能够灵活地定义远程治疗干预背景下所需的作业。更准确地说,家庭作业的各种任务可以指定为一个移动过程,然后在各自患者的移动设备上运行。为了实现这一愿景,开发了一个使用模型驱动方法的配置器组件。特别是,Albatros配置器将在定义作业时将领域专家从复杂的技术问题中解脱出来。本文的研究探讨了领域专家是否真的能够使用配置器组件。该研究特别揭示了三点见解。首先,基本干预措施可以在可接受的误差范围内轻松定义。其次,为了定义复杂的干预措施(例如,在进行练习时使用传感器),可以确定几个问题,这些问题将有助于改进Albatros配置器。第三,需要额外的研究来评估领域专家在使用配置器时的整体心理努力。总之,信天翁框架可能是一个合理的途径,授权领域专家在远程治疗干预的背景下创建家庭作业。
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引用次数: 5
Improving Skin Lesion Segmentation with Generative Adversarial Networks 用生成对抗网络改进皮肤病变分割
Pub Date : 2018-06-01 DOI: 10.1109/CBMS.2018.00086
Federico Bolelli, F. Pollastri, Roberto Paredes Palacios, C. Grana
This paper proposes a novel strategy that employs Generative Adversarial Networks (GANs) to augment data in the image segmentation field, and a Convolutional-Deconvolutional Neural Network (CDNN) to automatically generate lesion segmentation mask from dermoscopic images. Training the CDNN with our GAN generated data effectively improves the state-of-the-art.
本文提出了一种新的策略,利用生成对抗网络(GANs)来增强图像分割领域的数据,并利用卷积-反卷积神经网络(CDNN)从皮肤镜图像中自动生成病变分割掩模。用GAN生成的数据训练CDNN有效地提高了技术水平。
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引用次数: 27
RAFIKI: Retrieval-Based Application for Imaging and Knowledge Investigation RAFIKI:基于检索的影像与知识调查应用
Pub Date : 2018-06-01 DOI: 10.1109/CBMS.2018.00020
Marcos Roberto Nesso Junior, M. Cazzolato, L. C. Scabora, Paulo H. Oliveira, Gabriel Spadon, J. D. Souza, Willian D. Oliveira, D. Y. T. Chino, J. F. Rodrigues, A. Traina, C. Traina
Medical exams, such as CT scans and mammograms, are obtained and stored every day in hospitals all over the world, including images, patient data, and medical reports. It is paramount to have tools and systems to improve computer-aided diagnoses based on such huge volumes of stored information. The Content-Based Image Retrieval (CBIR) is a powerful paradigm to help reaching such a goal, providing physicians with intelligent retrieval tools to present him/her with similar or complementary cases, in which visual characteristics improve textual data. Employing comparative inspection on previous cases, the physician can obtain a more comprehensive understanding of the case he/she is working on. Current hospital systems do not carry native CBIR functionalities yet, relying on add-on subsystems, which often do not adhere to the existing relational database infrastructures. In this work, we propose RAFIKI, a software prototype that extends the Relational Database Management System (RDBMS) PostgreSQL, providing native support for CBIR functionalities, modular extensibility, and seamless integration for data science tools, such as Python and R. We show the applicability of our system by evaluating three clinical scenarios, performing queries over a real-world image dataset of lung exams. Our results spot actual potential in promoting informed decision-making from the physician's perspective. Besides, the system exhibited a higher performance when compared to previous systems found in the literature. Moreover, RAFIKI contributes with a model to establish how to put together CBIR concepts and relational data, providing a powerful design for further development of theoretical and practical concepts and tools.
医学检查,如CT扫描和乳房x光检查,每天都在世界各地的医院获得和存储,包括图像、患者数据和医疗报告。有工具和系统来改进基于如此海量存储信息的计算机辅助诊断是至关重要的。基于内容的图像检索(CBIR)是帮助实现这一目标的强大范例,为医生提供智能检索工具,向他/她展示相似或互补的病例,其中视觉特征改善了文本数据。通过对以往病例的比较检查,医生可以对他/她正在处理的病例有更全面的了解。目前的医院系统还不具备原生的CBIR功能,依赖于附加的子系统,这些子系统通常不遵循现有的关系数据库基础结构。在这项工作中,我们提出了RAFIKI,一个扩展关系数据库管理系统(RDBMS) PostgreSQL的软件原型,为CBIR功能提供本机支持,模块化可扩展性,以及数据科学工具(如Python和r)的无缝集成。我们通过评估三个临床场景,对真实世界的肺部检查图像数据集执行查询来展示我们系统的适用性。我们的研究结果从医生的角度发现了促进知情决策的实际潜力。此外,与文献中发现的系统相比,该系统表现出更高的性能。此外,RAFIKI还提供了一个模型来建立如何将CBIR概念和相关数据组合在一起,为进一步开发理论和实践概念和工具提供了强大的设计。
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引用次数: 5
Predicting Age of Onset in TTR-FAP Patients with Genealogical Features 有家谱特征的TTR-FAP患者的发病年龄预测
Pub Date : 2018-06-01 DOI: 10.1109/CBMS.2018.00042
Maria Pedroto, A. Jorge, João Mendes-Moreira, T. Coelho
This work describes a problem oriented approach to analyze and predict the Age of Onset of Patients diagnosed with Transthyretin Familial Amyloid Polyneuropathy (TTR-FAP). We constructed, from a set of clinical and familial records, three sets of features which represent different characteristics of a patient, before becoming symptomatic. Using those features, we tested a set of machine learning regression methods, namely Decision Tree (Regression Tree), Elastic Net, Lasso, Linear Regression, Random Forest Regressor, Ridge Regression and Support Vector Machine Regressor (SVM). Later, we defined a baseline model that represents the current medical practice to serve as a guideline for us to measure the accuracy of our approach. Our results show a significant improvement of machine learning methods when compared with the current baseline.
本研究描述了一种以问题为导向的方法来分析和预测经甲状腺素家族性淀粉样蛋白多发性神经病(TTR-FAP)患者的发病年龄。我们从一组临床和家族记录中构建了三组特征,这些特征代表了患者在出现症状之前的不同特征。利用这些特征,我们测试了一组机器学习回归方法,即决策树(回归树),弹性网,Lasso,线性回归,随机森林回归,岭回归和支持向量机回归(SVM)。后来,我们定义了一个代表当前医疗实践的基线模型,作为我们衡量方法准确性的指导方针。我们的结果显示,与当前基线相比,机器学习方法有了显著的改进。
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引用次数: 1
DOCToR: The Role of Deep Features in Content-Based Mammographic Image Retrieval 深度特征在基于内容的乳房x线摄影图像检索中的作用
Pub Date : 2018-06-01 DOI: 10.1109/CBMS.2018.00035
R. S. Bressan, D. Alves, Lucas M. Valério, P. Bugatti, P. T. Saito
Nowadays, deep features, obtained from a variety of deep learning architectures, play an important role in several real problems. It is know that transfer learning strategies could be employed to take advantage of such deep features trained under a general context (e.g. ImageNet). However, to the best of our knowledge, the majority of works focus on similar contexts to accomplish such transfer strategies. Thus, in this work we analyze the role of deep features in content-based medical image retrieval, and demonstrate that it is possible to make use of transfer learning from a general context to a specific medical context, like the content-based mammographic image retrieval. To do so, we evaluated several hand-crafted features against deep features acquired from state-of-the-art deep architectures through transfer learning. Extensive experiments on challenging public mammographic image datasets testify that the generalized deep features are able to improve in a great extend the precision of similarity queries both in the traditional process and applying query refinement strategies.
如今,从各种深度学习架构中获得的深度特征在许多实际问题中发挥着重要作用。众所周知,迁移学习策略可以用来利用在一般环境下训练的这种深度特征(例如ImageNet)。然而,据我们所知,大多数作品都是在类似的语境中完成这种迁移策略的。因此,在这项工作中,我们分析了深度特征在基于内容的医学图像检索中的作用,并证明了利用从一般上下文到特定医学上下文的迁移学习是可能的,例如基于内容的乳房x线图像检索。为此,我们评估了几个手工制作的特征与通过迁移学习从最先进的深度架构中获得的深度特征。在具有挑战性的公共乳房x线图像数据集上进行的大量实验证明,广义深度特征能够在很大程度上提高传统过程和应用查询细化策略的相似性查询的精度。
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引用次数: 11
CBMS 2018 Welcome Message and Preface CBMS 2018欢迎辞和序言
Pub Date : 2018-06-01 DOI: 10.1109/cbms.2018.00005
B. Kane
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引用次数: 0
Services Orchestration and Workflow Management in Distributed Medical Imaging Environments 分布式医学成像环境中的服务编排和工作流管理
Pub Date : 2018-06-01 DOI: 10.1109/CBMS.2018.00037
João Rafael Almeida, T. Godinho, Luís Bastião, C. Costa, J. Oliveira
Medical imaging laboratories are supported by information and communication systems commonly denominated as PACS, that encompasses technology for acquisition, archive, distribution and visualization of digital images in network. Concerning the data and workflow management, traditional solutions used in production provide a limited set of services usually configured at system installation. As result, healthcare institutions are not able to fully explore their infrastructure or adapt it to new operational requirements, either for clinical or research procedures. This article proposes a framework for services orchestration and workflow management in distributed medical imaging environments. It was designed for end-user usage and is accessible through a Web portal that allows to document, repeat and allocate procedures and tasks to correct resources, either from information systems or human interventions. It provides an abstraction layer for integration with distinct data sources through standard services, allows the creation of new services through orchestration of existent ones and the scheduling of tasks. Moreover, it includes a logging and alert mechanism integrated with email service. The solution was validated through the specification of two use cases that were deployed in production environment.
医学成像实验室由通常称为PACS的信息和通信系统提供支持,该系统包括网络中数字图像的获取、存档、分发和可视化技术。关于数据和工作流管理,生产中使用的传统解决方案提供了一组有限的服务,通常在系统安装时配置。因此,医疗保健机构无法充分探索其基础设施,也无法使其适应临床或研究程序的新操作需求。本文提出了分布式医学成像环境中服务编排和工作流管理的框架。它是为最终用户使用而设计的,可以通过一个Web门户访问,该门户允许记录、重复和分配过程和任务,以纠正来自信息系统或人工干预的资源。它提供了一个抽象层,用于通过标准服务集成不同的数据源,允许通过编排现有服务和调度任务来创建新服务。此外,它还包括与电子邮件服务集成的日志记录和警报机制。该解决方案通过部署在生产环境中的两个用例的规范进行了验证。
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引用次数: 3
Computerised Interpretation Systems for Cardiotocography for Both Home and Hospital Uses 家庭和医院用心脏造影计算机解释系统
Pub Date : 2018-06-01 DOI: 10.1109/CBMS.2018.00080
Yu Lu, Yongjie Gao, Yuyang Xie, Shunan He
Improving the accuracy and consistency of interpretation results for foetal monitoring has been an active research direction in both obstetrics and gynaecology. In this paper, we have developed computer-aided analysis systems for use both in hospitals and at home that incorporate automatic scoring functions to evaluate the foetal conditions in the cavity of the uterus. These systems can analyse any segment of data in a foetal monitoring record. Our novel systems can accurately identify the CTG patterns, such as FHR baseline, foetal movements, uterine contractions, accelerations and type of decelerations, thus making the interpretation results more accurate. There are two modes of scoring: automatic and manual, and the system consists of a number of popular scoring methods, including the Kreb's, Fischer, and improved Fischer scoring methods and the ACOG three-tier classification methods. According to clinical tests in hospitals, the systems have comparable accuracy to obstetricians' interpretations. Computerised interpretation thus provides a supplement to traditional analysis that could help obstetricians function more effectively.
提高胎儿监护判读结果的准确性和一致性一直是妇产科研究的活跃方向。在本文中,我们开发了用于医院和家庭的计算机辅助分析系统,该系统包含自动评分功能,以评估子宫腔内的胎儿状况。这些系统可以分析胎儿监测记录中的任何数据片段。我们的新系统可以准确识别CTG模式,如FHR基线、胎儿运动、子宫收缩、加速和减速类型,从而使解释结果更加准确。评分有自动和手动两种模式,该系统由许多流行的评分方法组成,包括克雷布评分法、费舍尔评分法、改进的费舍尔评分法和ACOG三层分类方法。根据医院的临床测试,该系统与产科医生的解释具有相当的准确性。因此,计算机解释为传统分析提供了补充,可以帮助产科医生更有效地发挥作用。
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引用次数: 7
Finding Tinnitus Patients with Similar Evolution of Their Ecological Momentary Assessments 耳鸣患者生态瞬时评价演化相似的研究
Pub Date : 2018-06-01 DOI: 10.1109/CBMS.2018.00027
Lakshmi Prasath Muniandi, W. Schlee, R. Pryss, M. Reichert, Johannes Schobel, Robin Kraft, M. Spiliopoulou
Mobile applications can help patients with a chronical disease to record their Ecological Momentary Assessments (EMA) and to get a more precise impression of how their disease manifests itself during day and night and over longer time periods. Such crowdsensing applications contribute to patient empowerment, in which patients monitor their disease and, sometimes, learn to cope better with it. An open question is whether physicians can also be helped in assisting their patients, by understanding similarities and differences in the patients' evolution. We study the EMA of patients with the chronical disease tinnitus, as recorded with the mobile crowdsensing application Track Your Tinnitus. We propose a method that captures similarities in patient evolution, taking account of the differences in the frequency of each patient's EMA recordings. We incorporate this method into a complete workflow that encompasses following components: an algorithm that captures similarities among patients on the basis of their registration data, a method that juxtaposes static patient similarity to EMA-based patient similarity, and a method that identifies those subspaces of the static feature space and those of the EMA-based feature space, which are mainly contributing to patient similarity. We report on our results for the time period recordings from 2014 till 2017 of 450 tinnitus patients from TrackYourTinnitus mobile application.
移动应用程序可以帮助患有慢性疾病的患者记录他们的生态瞬间评估(EMA),并更准确地了解他们的疾病在白天和黑夜以及更长时间内的表现。这种群众感知应用有助于赋予患者权力,患者可以监测自己的疾病,有时还能学会更好地应对疾病。一个悬而未决的问题是,通过了解患者进化过程中的异同点,是否也能帮助医生帮助他们的患者。我们研究慢性疾病耳鸣患者的EMA,通过移动众感应用程序Track Your tinnitus记录。我们提出了一种方法来捕捉患者进化的相似性,同时考虑到每个患者EMA记录频率的差异。我们将该方法整合到一个完整的工作流中,该工作流包含以下组件:一个基于注册数据捕获患者之间相似性的算法,一个将静态患者相似性与基于ema的患者相似性并列的方法,以及一个识别静态特征空间和基于ema的特征空间的子空间的方法,这些子空间主要有助于患者相似性。我们报告了来自TrackYourTinnitus移动应用程序的450名耳鸣患者2014年至2017年的时间段记录结果。
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引用次数: 6
期刊
2018 IEEE 31st International Symposium on Computer-Based Medical Systems (CBMS)
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