With an initial energy storage of approximately 53.5 kJ, experiments on underwater electrical explosions of metallic wire and thin-wall tube were conducted. Two sets of controlled experiments were designed, and the wire and tube for each set were of the same length, cross-sectional area, and material. Load voltage, circuit current, and shock wave pressure were measured and analyzed, and electric power, energy deposition, and energy deposition rate were also calculated and investigated. Experimental results indicated that the underwater electrical tube explosion (UETE) always has higher and earlier local resistance peak, voltage peak, and electric power peak, as well as faster phase transition and ionization process than the underwater electrical wire explosion (UEWE). In addition, the energy deposition rate from the beginning of discharge or the decrease in current to the voltage peak is significantly increased when replacing a wire with a tube. For the shock-wave characteristics, the peak pressure, energy density, and impulse of the shock wave generated by UETE are greater than that generated by UEWE. The peak pressure at ∼33 cm increased from 21.1 to 24.5 MPa in the first set and from 18.1 to 21.7 MPa in the second when a tube was used instead of a wire. These experimental results help us understand the physical process of UETE and provide an alternative methodology for load design in industrial applications.
{"title":"Underwater electrical explosion of metallic wire and tube: A comparison study","authors":"Shaojie Zhang, Yongmin Zhang, Yong Lu, Hejie Zhao, Cheng Luo, Haodong Wang, Shuangming Wang, Aici Qiu","doi":"10.1063/5.0180925","DOIUrl":"https://doi.org/10.1063/5.0180925","url":null,"abstract":"With an initial energy storage of approximately 53.5 kJ, experiments on underwater electrical explosions of metallic wire and thin-wall tube were conducted. Two sets of controlled experiments were designed, and the wire and tube for each set were of the same length, cross-sectional area, and material. Load voltage, circuit current, and shock wave pressure were measured and analyzed, and electric power, energy deposition, and energy deposition rate were also calculated and investigated. Experimental results indicated that the underwater electrical tube explosion (UETE) always has higher and earlier local resistance peak, voltage peak, and electric power peak, as well as faster phase transition and ionization process than the underwater electrical wire explosion (UEWE). In addition, the energy deposition rate from the beginning of discharge or the decrease in current to the voltage peak is significantly increased when replacing a wire with a tube. For the shock-wave characteristics, the peak pressure, energy density, and impulse of the shock wave generated by UETE are greater than that generated by UEWE. The peak pressure at ∼33 cm increased from 21.1 to 24.5 MPa in the first set and from 18.1 to 21.7 MPa in the second when a tube was used instead of a wire. These experimental results help us understand the physical process of UETE and provide an alternative methodology for load design in industrial applications.","PeriodicalId":23192,"journal":{"name":"Traditional Medicine Research","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2023-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138745344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Chanting is an ancient practice that has been used for centuries to promote spiritual growth and emotional healing. Om chanting, in particular, is a powerful form of chanting that has gained popularity in recent years due to its reported positive effects on mental health. Mental health is a crucial aspect of well-being and has been linked with overall health and quality of life. The World Health Organization (WHO) defines mental health as a state of well-being where an individual realizes their potentials, copes with the stresses of life, works productively, and contributes to their community. However, mental health issues are on the rise globally, with depression, anxiety, and stress levels increasing among people in different age groups.
{"title":"Positive Effects of ‘AUM’ Chanting on Mental Health Well-Being","authors":"Anubha Pundir, Akshya Chauhan","doi":"10.35702/trad.10015","DOIUrl":"https://doi.org/10.35702/trad.10015","url":null,"abstract":"Chanting is an ancient practice that has been used for centuries to promote spiritual growth and emotional healing. Om chanting, in particular, is a powerful form of chanting that has gained popularity in recent years due to its reported positive effects on mental health. Mental health is a crucial aspect of well-being and has been linked with overall health and quality of life. The World Health Organization (WHO) defines mental health as a state of well-being where an individual realizes their potentials, copes with the stresses of life, works productively, and contributes to their community. However, mental health issues are on the rise globally, with depression, anxiety, and stress levels increasing among people in different age groups.","PeriodicalId":23192,"journal":{"name":"Traditional Medicine Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135675214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Khan, Sara Rashed Salem Al Faraji, Mira Said Hamed Almukhaini, Ayaz Mohd, Farrukh Jamal, Samuel S D Premkumar, Priyanka Verma
{"title":"In Vitro Establishment, Hydroponic, Salt Tolerance, Antifungal And Phytochemical Investigations In Important Sand Binder Medicinal Plant Ipomoea Pes-Caprae","authors":"S. Khan, Sara Rashed Salem Al Faraji, Mira Said Hamed Almukhaini, Ayaz Mohd, Farrukh Jamal, Samuel S D Premkumar, Priyanka Verma","doi":"10.35702/trad.10014","DOIUrl":"https://doi.org/10.35702/trad.10014","url":null,"abstract":"","PeriodicalId":23192,"journal":{"name":"Traditional Medicine Research","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2023-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85282942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Xue-yuan Bai, Ayesha T.Tahir, Zheng Yu, Wenbo Cheng, Bo Zhang, Jun Kang
Lumbar spinal stenosis (LSS) is caused by the compression of the nerve root or cauda equina nerve by stenosis of the lumbar spinal canal or intervertebral foramen, and is manifested as chronic low back and leg pain. Danlu Tongdu (DLTD) tablets can relieve chronic pain caused by LSS, but the molecular mechanism remains largely unknown. In this study, the potential molecular mechanism of DLTD tablets in the treatment of LSS was firstly predicted by network pharmacology method. Results showed that DLTD functions in regulating anti-oxidative, apoptosis, and inflammation signaling pathways. Furthermore, the flow cytometry results showed that DLTD tablets efficiently reduced ROS content and inhibited rat neural stem cell apoptosis induced by hydrogen peroxide. DLTD also inhibited the mitochondrial membrane potential damage induced by hydrogen peroxide. Elisa analysis showed that DLTD induced cell cycle related protein, CDK2 and CDK4 and reduced CDKN1A protein expression level. Taken together, our study provided new insights of DLTD in treating LSS through reducing ROS content, decreasing apoptosis by inhibiting CDKN1A and promoting CDK2 and CDK4 expression levels.
{"title":"Danlu Tongdu tablets treat lumbar spinal stenosis through reducing reactive oxygen species and apoptosis by regulating CDK2/CDK4/CDKN1A expression","authors":"Xue-yuan Bai, Ayesha T.Tahir, Zheng Yu, Wenbo Cheng, Bo Zhang, Jun Kang","doi":"10.53388/tmr20230216003","DOIUrl":"https://doi.org/10.53388/tmr20230216003","url":null,"abstract":"Lumbar spinal stenosis (LSS) is caused by the compression of the nerve root or cauda equina nerve by stenosis of the lumbar spinal canal or intervertebral foramen, and is manifested as chronic low back and leg pain. Danlu Tongdu (DLTD) tablets can relieve chronic pain caused by LSS, but the molecular mechanism remains largely unknown. In this study, the potential molecular mechanism of DLTD tablets in the treatment of LSS was firstly predicted by network pharmacology method. Results showed that DLTD functions in regulating anti-oxidative, apoptosis, and inflammation signaling pathways. Furthermore, the flow cytometry results showed that DLTD tablets efficiently reduced ROS content and inhibited rat neural stem cell apoptosis induced by hydrogen peroxide. DLTD also inhibited the mitochondrial membrane potential damage induced by hydrogen peroxide. Elisa analysis showed that DLTD induced cell cycle related protein, CDK2 and CDK4 and reduced CDKN1A protein expression level. Taken together, our study provided new insights of DLTD in treating LSS through reducing ROS content, decreasing apoptosis by inhibiting CDKN1A and promoting CDK2 and CDK4 expression levels.","PeriodicalId":23192,"journal":{"name":"Traditional Medicine Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47095883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Research progress of artesunate in diabetes and its complications","authors":"Yuanmei Guo, Lu-lu Chen, Ying Li, Jia-jia Duan, Chuan Liu, Hong-wei Jiang","doi":"10.53388/tmr20220811001","DOIUrl":"https://doi.org/10.53388/tmr20220811001","url":null,"abstract":"","PeriodicalId":23192,"journal":{"name":"Traditional Medicine Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70824898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
J. Xiong, Jia-Yu Wang, Yi Liu, B. Hao, Yue Zhang, Tiankui Li, Zi-Tong Fu, Q. Qi, Yuliang Zhang, Shishu Sun, Guo-wei Zhang
Background: As of 2023, coronavirus disease 2019 (COVID-19) is still spreading globally. Therefore, we aim to integrate non-critical COVID-19 high-frequency and high-targeting Chinese medicines to provide a reference for clinical prescriptions to improve COVID-19-related symptoms. Materials and methods: The information on non-critical COVID-19 high-frequency Chinese medicines in the diagnosis and treatment of COVID-19 was obtained by the TCM inheritance support platform. Using network pharmacology and molecular docking technology, high-targeting Chinese medicines with good docking activity with COVID-19 receptors angiotensin-converting enzyme-II (ACE2), 3CLpro and tyrosine-protein kinase receptor UFO (AXL) were obtained. A new prescription for non-critical COVID-19 was established by integrating high-frequency and high-targeting Chinese medicines. Rats with acute lung injury induced by lipopolysaccharide were used as the experimental model. The histopathological changes in the lungs of rats in each group were observed by hematoxylin-eosin staining. The lung coefficient of rats was measured. The levels of IL-6, TNF-a, and IL-1ß in serum were detected by enzyme-linked immunosorbent assay. The mRNA and protein levels of ACE2 and AXL in lung tissue were detected by real-time quantitative polymerase chain reaction and western blot. Results: Through data mining, it was found that there were 39 high-frequency traditional Chinese medicines for non-critical COVID-19 in the diagnosis and treatment guidelines. According to network pharmacology and molecular docking, 30 highly targeted traditional Chinese drugs for COVID-19 were found. The new prescriptions for non-critical COVID-19 were comprehensively obtained, including Glycyrrhizae Radix, Ephedra Herba, Amygdalus Communis Vas, Gypsum Fibrosum, Descurainiae Semen, Atractylodes Lancea, Scutellariae Radix, Amomum Tsao-Ko Crevostet, Forsythiae Fructus, Pogostemon cablin, Magnolia Officinalis. Compared with the LPS-induced lung injury model group, the medium dose of the new prescription group had significantly alleviated pathological changes in lung tissue, decreased lung coefficient, decreased contents of IL-6, TNF-a and IL-1ß, and increased mRNA and protein expression of ACE2 and AXL (P < 0.05). Conclusion: Based on data mining, network pharmacology and molecular docking technology, the new prescription for non-critical COVID-19 established by this method has an anti-inflammatory effect on rats with acute lung injury induced by lipopolysaccharide and can provide a reference for clinicians to alleviate the symptoms related to non-critical COVID-19. [ FROM AUTHOR] Copyright of Traditional Medicine Research is the property of TMR Publishing and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This may be abridged. No warranty is given about the a
背景:截至2023年，2019冠状病毒病(COVID-19)仍在全球蔓延。因此，我们的目标是整合非关键的COVID-19高频和高靶向中药，为临床处方提供参考，以改善COVID-19相关症状。材料与方法:通过中医药传承支持平台获取COVID-19非关键高频中药诊治信息。利用网络药理学和分子对接技术，获得与COVID-19受体血管紧张素转换酶- ii (ACE2)、3CLpro和酪氨酸蛋白激酶受体UFO (AXL)对接活性良好的高靶向中药。整合高频、高靶向中药，形成非危重型新方剂。以脂多糖致急性肺损伤大鼠为实验模型。苏木精-伊红染色观察各组大鼠肺组织病理变化。测定大鼠肺系数。采用酶联免疫吸附法检测血清中IL-6、TNF-a、IL-1ß水平。采用实时定量聚合酶链反应和western blot检测肺组织中ACE2和AXL的mRNA和蛋白水平。结果:通过数据挖掘，发现诊疗指南中针对非危重型COVID-19的高频中药有39种。通过网络药理学和分子对接，发现30种靶向性强的新型冠状病毒治疗中药。综合获得非危重型新处方，包括甘草、麻黄、苦杏仁、纤维石膏、景天、苍术、黄芩、草果砂、连翘、广藿香、厚朴等。与lps诱导肺损伤模型组比较，新方中剂量组肺组织病理改变明显减轻，肺系数降低，IL-6、TNF-a、IL-1ß含量降低，ACE2、AXL mRNA及蛋白表达升高(P < 0.05)。结论:基于数据挖掘、网络药理学和分子对接技术，该方法建立的非危重型新冠肺炎方剂对脂多糖急性肺损伤大鼠具有抗炎作用，可为临床医生缓解非危重型新冠肺炎相关症状提供参考。版权归TMR Publishing所有，未经版权所有者明确书面许可，其内容不得复制或通过电子邮件发送到多个网站或发布到listserv。但是，用户可以打印、下载或通过电子邮件发送文章供个人使用。这可以删节。对副本的准确性不作任何保证。用户应参阅原始出版版本的材料的完整。(版权适用于所有人。)
{"title":"Study on prescription medication mode and mechanism of traditional Chinese medicine in the treatment of noncritical COVID-19 based on data mining","authors":"J. Xiong, Jia-Yu Wang, Yi Liu, B. Hao, Yue Zhang, Tiankui Li, Zi-Tong Fu, Q. Qi, Yuliang Zhang, Shishu Sun, Guo-wei Zhang","doi":"10.53388/tmr20221023001","DOIUrl":"https://doi.org/10.53388/tmr20221023001","url":null,"abstract":"Background: As of 2023, coronavirus disease 2019 (COVID-19) is still spreading globally. Therefore, we aim to integrate non-critical COVID-19 high-frequency and high-targeting Chinese medicines to provide a reference for clinical prescriptions to improve COVID-19-related symptoms. Materials and methods: The information on non-critical COVID-19 high-frequency Chinese medicines in the diagnosis and treatment of COVID-19 was obtained by the TCM inheritance support platform. Using network pharmacology and molecular docking technology, high-targeting Chinese medicines with good docking activity with COVID-19 receptors angiotensin-converting enzyme-II (ACE2), 3CLpro and tyrosine-protein kinase receptor UFO (AXL) were obtained. A new prescription for non-critical COVID-19 was established by integrating high-frequency and high-targeting Chinese medicines. Rats with acute lung injury induced by lipopolysaccharide were used as the experimental model. The histopathological changes in the lungs of rats in each group were observed by hematoxylin-eosin staining. The lung coefficient of rats was measured. The levels of IL-6, TNF-a, and IL-1ß in serum were detected by enzyme-linked immunosorbent assay. The mRNA and protein levels of ACE2 and AXL in lung tissue were detected by real-time quantitative polymerase chain reaction and western blot. Results: Through data mining, it was found that there were 39 high-frequency traditional Chinese medicines for non-critical COVID-19 in the diagnosis and treatment guidelines. According to network pharmacology and molecular docking, 30 highly targeted traditional Chinese drugs for COVID-19 were found. The new prescriptions for non-critical COVID-19 were comprehensively obtained, including Glycyrrhizae Radix, Ephedra Herba, Amygdalus Communis Vas, Gypsum Fibrosum, Descurainiae Semen, Atractylodes Lancea, Scutellariae Radix, Amomum Tsao-Ko Crevostet, Forsythiae Fructus, Pogostemon cablin, Magnolia Officinalis. Compared with the LPS-induced lung injury model group, the medium dose of the new prescription group had significantly alleviated pathological changes in lung tissue, decreased lung coefficient, decreased contents of IL-6, TNF-a and IL-1ß, and increased mRNA and protein expression of ACE2 and AXL (P < 0.05). Conclusion: Based on data mining, network pharmacology and molecular docking technology, the new prescription for non-critical COVID-19 established by this method has an anti-inflammatory effect on rats with acute lung injury induced by lipopolysaccharide and can provide a reference for clinicians to alleviate the symptoms related to non-critical COVID-19. [ FROM AUTHOR] Copyright of Traditional Medicine Research is the property of TMR Publishing and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This may be abridged. No warranty is given about the a","PeriodicalId":23192,"journal":{"name":"Traditional Medicine Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70825088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Xiao-yu Shi, Xiao-Dan Bao, Yao Li, Cheng-liang Yin
{"title":"Theanine combined with cisplatin inhibits the proliferation and metastasis of TNBC cells through Akt signaling pathway","authors":"Xiao-yu Shi, Xiao-Dan Bao, Yao Li, Cheng-liang Yin","doi":"10.53388/tmr20221025001","DOIUrl":"https://doi.org/10.53388/tmr20221025001","url":null,"abstract":"","PeriodicalId":23192,"journal":{"name":"Traditional Medicine Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70825151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gastrodia elata , a traditional Chinese medicine belonging to the Orchidaceae family, contains several major components such as gastrodin, polysaccharides of Gastrodia elata , and parishin. The pharmacological studies conducted on Gastrodia elata have revealed a variety of therapeutic properties, including antihypertensive, hypolipidemic, analgesic, and sedative-hypnotic properties. Thus, in this paper, we summarized the pharmacological effects of Gastrodia elata ’s major components, namely gastrodin, polysaccharides of Gastrodia elata , parishin, and different types of Gastrodia elata extracts, on cardiovascular diseases such as atherosclerosis, hypertension, hyperglycemia, myocardial ischemia, myocardial hypoxia, myocarditis, and heart failure. Additionally, we conclude the mechanisms through which these active ingredients exert their therapeutic effects, including antioxidants, anti-inflammatory, and nitric oxide regulation. We provide insights into the therapeutic potential of Gastrodia elata with a detailed review of its pharmacological effects and molecular targets in cardiovascular disease protection and therapy, and can better understand the effect of traditional medicines in cardiovascular disease.
{"title":"Pharmacological effects and mechanisms of Gastrodia elata and its active ingredients in the treatment of cardiovascular diseases","authors":"Xingyan Chen, Yan He, Ji-Yu Chen","doi":"10.53388/tmr20230425001","DOIUrl":"https://doi.org/10.53388/tmr20230425001","url":null,"abstract":"Gastrodia elata , a traditional Chinese medicine belonging to the Orchidaceae family, contains several major components such as gastrodin, polysaccharides of Gastrodia elata , and parishin. The pharmacological studies conducted on Gastrodia elata have revealed a variety of therapeutic properties, including antihypertensive, hypolipidemic, analgesic, and sedative-hypnotic properties. Thus, in this paper, we summarized the pharmacological effects of Gastrodia elata ’s major components, namely gastrodin, polysaccharides of Gastrodia elata , parishin, and different types of Gastrodia elata extracts, on cardiovascular diseases such as atherosclerosis, hypertension, hyperglycemia, myocardial ischemia, myocardial hypoxia, myocarditis, and heart failure. Additionally, we conclude the mechanisms through which these active ingredients exert their therapeutic effects, including antioxidants, anti-inflammatory, and nitric oxide regulation. We provide insights into the therapeutic potential of Gastrodia elata with a detailed review of its pharmacological effects and molecular targets in cardiovascular disease protection and therapy, and can better understand the effect of traditional medicines in cardiovascular disease.","PeriodicalId":23192,"journal":{"name":"Traditional Medicine Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70825872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sadiqa Mosavi, M. Tabarrai, M. Tansaz, H. Salehinia, S. Grylka-Baeschlin, A. Rahmani, S. Shahali
Background: Shilajit is mentioned in the “Kama Sutra” as a potent enhancer of sexual desire. This study aimed to investigate the effects of oral Shilajit tablets on sexual function and sexual quality of life among women of reproductive age. Methods: Forty-eight reproductive-aged women participated in a placebo-controlled triple-blind clinical trial. The intervention group took oral Shilajit tablets (200 mg) twice daily for 60 days and the control group took the placebo. Data collection tools were Sexual Quality of Life-Female and Female Sexual Function Index. Data were collected before the intervention, 30, 60, and 90 days after the start of the study. Results: Forty-three women completed the study. The mean score of total sexual function in the intervention group was significantly higher than before the intervention ( P < 0.001). The mean score of sexual function was 28.93 after 90 days in the intervention group while it was 22.09 in the control group. This finding was observed in most domains of the sexual function index. The mean score of sexual quality of life increased after 60 days of intervention in both groups; however, the difference was not statistically significant ( P = 0.094). Conclusion : The study indicated that Shilajit, as a complementary therapy, may improve sexual function and most of its domains; while there was no effect on improving the quality of sexual life.
{"title":"Effects of oral Shilajit tablets on sexual function and sexual quality of life among reproductive-aged women: a triple-blind randomized clinical trial","authors":"Sadiqa Mosavi, M. Tabarrai, M. Tansaz, H. Salehinia, S. Grylka-Baeschlin, A. Rahmani, S. Shahali","doi":"10.53388/tmr20230305002","DOIUrl":"https://doi.org/10.53388/tmr20230305002","url":null,"abstract":"Background: Shilajit is mentioned in the “Kama Sutra” as a potent enhancer of sexual desire. This study aimed to investigate the effects of oral Shilajit tablets on sexual function and sexual quality of life among women of reproductive age. Methods: Forty-eight reproductive-aged women participated in a placebo-controlled triple-blind clinical trial. The intervention group took oral Shilajit tablets (200 mg) twice daily for 60 days and the control group took the placebo. Data collection tools were Sexual Quality of Life-Female and Female Sexual Function Index. Data were collected before the intervention, 30, 60, and 90 days after the start of the study. Results: Forty-three women completed the study. The mean score of total sexual function in the intervention group was significantly higher than before the intervention ( P < 0.001). The mean score of sexual function was 28.93 after 90 days in the intervention group while it was 22.09 in the control group. This finding was observed in most domains of the sexual function index. The mean score of sexual quality of life increased after 60 days of intervention in both groups; however, the difference was not statistically significant ( P = 0.094). Conclusion : The study indicated that Shilajit, as a complementary therapy, may improve sexual function and most of its domains; while there was no effect on improving the quality of sexual life.","PeriodicalId":23192,"journal":{"name":"Traditional Medicine Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70826075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Qian Peng, Qianzeng Fu, Man Xiao, Shenggang Sang, H. Rong
Background: To explore the pharmacological mechanism of the anti-hepatitis B virus of Phyllanthus urinaria L. through network pharmacological analysis and experimental validation. Method: The active ingredient, target of action and target of action related to hepatitis B were clarified by searching the herb group identification, GeneCards and OMIM databases, and the protein interaction relationship was obtained by using the String database, and the protein interaction network map was constructed by using Cytoscape software. We also performed gene ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analysis of key targets of the anti-hepatitis B action of Phyllanthus urinaria L. and predicted the core targets and pathways of Phyllanthus urinaria L. anti-hepatitis B. The main targets predicted by network pharmacology were then validated by HepG2.2.15 cell experiments. Results: By searching active ingredient targets and hepatitis B disease targets, a total of 19 active ingredients and 64 related targets of action were retrieved from Phyllanthus urinaria L., and a total of 51 common targets were obtained by mapping the obtained hepatitis B disease targets and drug targets. protein protein interaction network analysis indicated that targets including TNF, JUN, AKT1, IL-10, IL-1B, CAT, HMOX1, NFE2L2, and CASP3 and other targets may be the core targets.gene ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analysis showed that the treatment of hepatitis B by Phyllanthus urinaria L. mainly included inflammation and oxidation-related processes, and the signaling pathways mainly included fluid shear stress and atherosclerosis, VEGF, and hepatocellular carcinoma. The results of the in vitro test showed that after the action of different concentrations of the extracts of the Phyllanthus urinaria L. in the safe concentration range on cells HepG2.2.15, HBsAg, HBeAg and hepatitis B virus DNA levels were significantly inhibited, and NFE2L2 and HMOX1 were affecting hepatitis B virus transcription and replication by regulating the oxidative stress response. Conclusion: Using an integrated network pharmacology approach, this study revealed the active components and potential targets of Phyllanthus urinaria L. for the treatment of the hepatitis B virus, providing a theoretical basis for the research and clinical application of Phyllanthus urinaria L..
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