Pub Date : 2022-06-10DOI: 10.1007/s13530-022-00133-w
Murugasamy Mayilsamy, S. Sangeetha, M. Nakamura, Shunkei Ko, M. Govarthanan, K. Vimalkumar
{"title":"Screening of PCDDs/Fs and DL-PCBs by AhR-CALUX bioassay in bovine milk and environment ash from India","authors":"Murugasamy Mayilsamy, S. Sangeetha, M. Nakamura, Shunkei Ko, M. Govarthanan, K. Vimalkumar","doi":"10.1007/s13530-022-00133-w","DOIUrl":"https://doi.org/10.1007/s13530-022-00133-w","url":null,"abstract":"","PeriodicalId":23194,"journal":{"name":"Toxicology and Environmental Health Sciences","volume":"14 1","pages":"223 - 234"},"PeriodicalIF":1.7,"publicationDate":"2022-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43964785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-07DOI: 10.1007/s13530-022-00132-x
N. Suhail, S. Fatima, A. Alsharidah, Tehreem Aftab, N. Banu
{"title":"Effect of chronic unpredictable stress on the chemopreventive potential of Quercetin in experimental carcinogenesis","authors":"N. Suhail, S. Fatima, A. Alsharidah, Tehreem Aftab, N. Banu","doi":"10.1007/s13530-022-00132-x","DOIUrl":"https://doi.org/10.1007/s13530-022-00132-x","url":null,"abstract":"","PeriodicalId":23194,"journal":{"name":"Toxicology and Environmental Health Sciences","volume":"14 1","pages":"213 - 222"},"PeriodicalIF":1.7,"publicationDate":"2022-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48848193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-01DOI: 10.1007/s13530-022-00131-y
Varsha Chauhan, Manisha, S. K. Shukla, Priyanka Munjal
{"title":"Current analytical trends of abuse of tramadol and its forensic significance","authors":"Varsha Chauhan, Manisha, S. K. Shukla, Priyanka Munjal","doi":"10.1007/s13530-022-00131-y","DOIUrl":"https://doi.org/10.1007/s13530-022-00131-y","url":null,"abstract":"","PeriodicalId":23194,"journal":{"name":"Toxicology and Environmental Health Sciences","volume":"19 3","pages":"111 - 129"},"PeriodicalIF":1.7,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41292046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-01Epub Date: 2022-05-17DOI: 10.1016/j.jbc.2022.102037
Joanna A Ruszkiewicz, Alexander Bürkle, Aswin Mangerich
NAD+ is a versatile biomolecule acting as a master regulator and substrate in various cellular processes, including redox regulation, metabolism, and various signaling pathways. In this article, we concisely and critically review the role of NAD+ in mechanisms promoting genome maintenance. Numerous NAD+-dependent reactions are involved in the preservation of genome stability, the cellular DNA damage response, and other pathways regulating nucleic acid metabolism, such as gene expression and cell proliferation pathways. Of note, NAD+ serves as a substrate to ADP-ribosyltransferases, sirtuins, and potentially also eukaryotic DNA ligases, all of which regulate various aspects of DNA integrity, damage repair, and gene expression. Finally, we critically analyze recent developments in the field as well as discuss challenges associated with therapeutic actions intended to raise NAD+ levels.
NAD+ 是一种用途广泛的生物大分子，在氧化还原调节、新陈代谢和各种信号通路等多种细胞过程中充当主调节因子和底物。在本文中，我们简明扼要地回顾了 NAD+ 在促进基因组维护机制中的作用。许多依赖 NAD+ 的反应都参与了基因组稳定性的维护、细胞 DNA 损伤反应以及其他调节核酸代谢的途径，如基因表达和细胞增殖途径。值得注意的是，NAD+ 可作为 ADP 核糖转移酶、sirtuins 以及真核 DNA 连接酶的底物，所有这些酶都能调节 DNA 完整性、损伤修复和基因表达的各个方面。最后，我们对该领域的最新进展进行了批判性分析，并讨论了旨在提高 NAD+ 水平的治疗行动所面临的挑战。
{"title":"Fueling genome maintenance: On the versatile roles of NAD<sup>+</sup> in preserving DNA integrity.","authors":"Joanna A Ruszkiewicz, Alexander Bürkle, Aswin Mangerich","doi":"10.1016/j.jbc.2022.102037","DOIUrl":"10.1016/j.jbc.2022.102037","url":null,"abstract":"<p><p>NAD<sup>+</sup> is a versatile biomolecule acting as a master regulator and substrate in various cellular processes, including redox regulation, metabolism, and various signaling pathways. In this article, we concisely and critically review the role of NAD<sup>+</sup> in mechanisms promoting genome maintenance. Numerous NAD<sup>+</sup>-dependent reactions are involved in the preservation of genome stability, the cellular DNA damage response, and other pathways regulating nucleic acid metabolism, such as gene expression and cell proliferation pathways. Of note, NAD<sup>+</sup> serves as a substrate to ADP-ribosyltransferases, sirtuins, and potentially also eukaryotic DNA ligases, all of which regulate various aspects of DNA integrity, damage repair, and gene expression. Finally, we critically analyze recent developments in the field as well as discuss challenges associated with therapeutic actions intended to raise NAD<sup>+</sup> levels.</p>","PeriodicalId":23194,"journal":{"name":"Toxicology and Environmental Health Sciences","volume":"5 1","pages":"102037"},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9194868/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74530128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-20DOI: 10.1007/s13530-022-00129-6
A. Salau, S. Osineye, A. Lateef
{"title":"Nanotoxicological investigations of cocoa pod husk extract-mediated silver nanoparticles in selected tissues of albino rats","authors":"A. Salau, S. Osineye, A. Lateef","doi":"10.1007/s13530-022-00129-6","DOIUrl":"https://doi.org/10.1007/s13530-022-00129-6","url":null,"abstract":"","PeriodicalId":23194,"journal":{"name":"Toxicology and Environmental Health Sciences","volume":"14 1","pages":"193 - 202"},"PeriodicalIF":1.7,"publicationDate":"2022-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49547910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-06DOI: 10.1007/s13530-022-00128-7
Hamidreza Mokarami, Saham Choobineh, Fatemeh Rahimian, E. Soleimani
{"title":"Respiratory symptoms among crop farmers and comparison with a general population sample: a cross-sectional study","authors":"Hamidreza Mokarami, Saham Choobineh, Fatemeh Rahimian, E. Soleimani","doi":"10.1007/s13530-022-00128-7","DOIUrl":"https://doi.org/10.1007/s13530-022-00128-7","url":null,"abstract":"","PeriodicalId":23194,"journal":{"name":"Toxicology and Environmental Health Sciences","volume":"14 1","pages":"187 - 192"},"PeriodicalIF":1.7,"publicationDate":"2022-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46786104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-22DOI: 10.1007/s13530-022-00126-9
Hee-taek Kim, Hye-Su Park, Yong-Min Kim, In-Chul Lee, Sang-Jun Lee, Jae‐Suk Choi
{"title":"Double-blind randomized placebo-controlled study of the efficacy and safety of hair loss prevention shampoo containing salicylic acid, panthenol, and niacinamide in alopecia patients","authors":"Hee-taek Kim, Hye-Su Park, Yong-Min Kim, In-Chul Lee, Sang-Jun Lee, Jae‐Suk Choi","doi":"10.1007/s13530-022-00126-9","DOIUrl":"https://doi.org/10.1007/s13530-022-00126-9","url":null,"abstract":"","PeriodicalId":23194,"journal":{"name":"Toxicology and Environmental Health Sciences","volume":"14 1","pages":"173 - 185"},"PeriodicalIF":1.7,"publicationDate":"2022-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44453636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-19DOI: 10.1007/s13530-022-00127-8
I. Legakis, A. Barbouni, G. Chrousos
{"title":"The importance of toxic environmental substances in the development of thyroid cancer","authors":"I. Legakis, A. Barbouni, G. Chrousos","doi":"10.1007/s13530-022-00127-8","DOIUrl":"https://doi.org/10.1007/s13530-022-00127-8","url":null,"abstract":"","PeriodicalId":23194,"journal":{"name":"Toxicology and Environmental Health Sciences","volume":"14 1","pages":"101 - 109"},"PeriodicalIF":1.7,"publicationDate":"2022-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49062370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-04DOI: 10.1007/s13530-022-00125-w
T. G. Atere, O. O. Oladokun, O. Osuntokun, K. I. Adedokun, J. Fatoki, S. A. Olawumi, O. Tokunbo, O. Obembe, O. Afolabi
{"title":"Modulatory effects of phenolics extract of Costus afer leaves on cadmium induced nephrotoxicity and hepatoxicity in Wistar rats","authors":"T. G. Atere, O. O. Oladokun, O. Osuntokun, K. I. Adedokun, J. Fatoki, S. A. Olawumi, O. Tokunbo, O. Obembe, O. Afolabi","doi":"10.1007/s13530-022-00125-w","DOIUrl":"https://doi.org/10.1007/s13530-022-00125-w","url":null,"abstract":"","PeriodicalId":23194,"journal":{"name":"Toxicology and Environmental Health Sciences","volume":"14 1","pages":"157 - 172"},"PeriodicalIF":1.7,"publicationDate":"2022-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43556247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-02-07DOI: 10.1007/s13530-021-00114-5
Y. Valova, M. Ziatdinova, G. F. Mukhammadieva, D. Karimov, A. Fazlyeva, N. Khusnutdinova, T. Yakupova, E. F. Repina
{"title":"Gene expression regulating the cell cycle and gene of antioxidant protection system in toxic hepatitis","authors":"Y. Valova, M. Ziatdinova, G. F. Mukhammadieva, D. Karimov, A. Fazlyeva, N. Khusnutdinova, T. Yakupova, E. F. Repina","doi":"10.1007/s13530-021-00114-5","DOIUrl":"https://doi.org/10.1007/s13530-021-00114-5","url":null,"abstract":"","PeriodicalId":23194,"journal":{"name":"Toxicology and Environmental Health Sciences","volume":"14 1","pages":"13 - 18"},"PeriodicalIF":1.7,"publicationDate":"2022-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45918690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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