Pub Date : 2023-04-01DOI: 10.33545/pathol.2023.v6.i2b.523
Sherouk Mohammed El-Behiry, M. Watany, Gamal F. El-Naggar, Hesham Ahmed Elsrougy
Background: The main factor causing chronic kidney disease, which progressively leads to end-stage renal failure, is diabetic nephropathy (DN). This study aims to shed light on the importance of osteo-inductive factor (OIF) as a sensitive indicator for the early identification of DN Methods: On 80 participants, this prospective cohort observational research was conducted. A total of 60 of them had diabetes mellitus type 2 based on ADA 2019 guidelines. Four equal groups of patients were created: 20 healthy people made up the group 1 (control group), followed by type 2 diabetes patients with normo-albuminuria in groups 2, micro-albuminuria in groups 3, and macro-albuminuria in groups 4. Results
{"title":"Osteoinductive factor as a significant marker for the diagnosis of early diabetic nephropathy","authors":"Sherouk Mohammed El-Behiry, M. Watany, Gamal F. El-Naggar, Hesham Ahmed Elsrougy","doi":"10.33545/pathol.2023.v6.i2b.523","DOIUrl":"https://doi.org/10.33545/pathol.2023.v6.i2b.523","url":null,"abstract":"Background: The main factor causing chronic kidney disease, which progressively leads to end-stage renal failure, is diabetic nephropathy (DN). This study aims to shed light on the importance of osteo-inductive factor (OIF) as a sensitive indicator for the early identification of DN Methods: On 80 participants, this prospective cohort observational research was conducted. A total of 60 of them had diabetes mellitus type 2 based on ADA 2019 guidelines. Four equal groups of patients were created: 20 healthy people made up the group 1 (control group), followed by type 2 diabetes patients with normo-albuminuria in groups 2, micro-albuminuria in groups 3, and macro-albuminuria in groups 4. Results","PeriodicalId":232143,"journal":{"name":"International Journal of Clinical and Diagnostic Pathology","volume":"34 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124462061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-01DOI: 10.33545/pathol.2023.v6.i2a.516
Dr. Ankita Machhar, Dr. Darshit Kateshiya, Dr. Asha J Satvara
Background: The aim of the study was to identify histopathological pattern involving in ovarian neoplasm which where received for histopathological evaluation at tertiary health care centre over a period of 2 year in Pathology department at Guru Gobind Government Hospital,
{"title":"Histopathological spectrum of ovarian neoplasms at tertiary health care hospital","authors":"Dr. Ankita Machhar, Dr. Darshit Kateshiya, Dr. Asha J Satvara","doi":"10.33545/pathol.2023.v6.i2a.516","DOIUrl":"https://doi.org/10.33545/pathol.2023.v6.i2a.516","url":null,"abstract":"Background: The aim of the study was to identify histopathological pattern involving in ovarian neoplasm which where received for histopathological evaluation at tertiary health care centre over a period of 2 year in Pathology department at Guru Gobind Government Hospital,","PeriodicalId":232143,"journal":{"name":"International Journal of Clinical and Diagnostic Pathology","volume":"53 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125111550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gastrointestinal stromal tumours are the most common mesenchymal neoplasms of the gastrointestinal tract. They should be differentiated from other types of mesenchymal tumours. GISTs harbour specific activating mutations in the KIT or platelet-derived growth factor receptor a (PDGFRA) receptor tyrosine kinases, which makes them responsive to pharmacologic inhibitors. The advances in the identification of GISTs, by its molecular and immunohistochemical basis, have led to a better understanding of the rare gastrointestinal tract tumours with predictable behaviour and outcome, replacing the older terminologies like leiomyoma, schwannoma or leiomyosarcoma. This report presents a case of 64 yr. old male recently operated on for a rare sclerosing epithelioid variant of the gastrointestinal tumour.
{"title":"Gastrointestinal stromal tumour-sclerosing epithelioid a rare variant: A case report","authors":"Rajinder Singh, Yasmin Muhammed, Ajay Sharma, Jasbir Singh","doi":"10.33545/pathol.2023.v6.i2b.522","DOIUrl":"https://doi.org/10.33545/pathol.2023.v6.i2b.522","url":null,"abstract":"Gastrointestinal stromal tumours are the most common mesenchymal neoplasms of the gastrointestinal tract. They should be differentiated from other types of mesenchymal tumours. GISTs harbour specific activating mutations in the KIT or platelet-derived growth factor receptor a (PDGFRA) receptor tyrosine kinases, which makes them responsive to pharmacologic inhibitors. The advances in the identification of GISTs, by its molecular and immunohistochemical basis, have led to a better understanding of the rare gastrointestinal tract tumours with predictable behaviour and outcome, replacing the older terminologies like leiomyoma, schwannoma or leiomyosarcoma. This report presents a case of 64 yr. old male recently operated on for a rare sclerosing epithelioid variant of the gastrointestinal tumour.","PeriodicalId":232143,"journal":{"name":"International Journal of Clinical and Diagnostic Pathology","volume":"57 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128571660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-01DOI: 10.33545/pathol.2023.v6.i2b.519
Dr. Prakhar Gupta, Dhwani Pandya, Dr. Nandini J Desai
Introduction: Thalassemia is inherited blood disorder characterized by decreased hemoglobin with two main types-alpha and beta thalassemia. There are two main varieties of β thalassaemia, β0 thalassaemia, in which no β globin is produced, and β+ thalassaemia, in which some β globin is produced, but less than normal. As the patient is diagnosed, regular blood transfusions and chelating treatment is given lifelong. In this study, we observed the haematological profiles of multi transfused thalassemia major patients with the accompanying complications. Aims and Objectives: To study the clinical features with RBC parameters, serum ferritin levels, chelation therapy and prevalence of blood transfusion related infection in multi transfused beta thalassemia major patients. Materials and Method: In this cross sectional study, total 90 diagnosed thalassemia major patients were taken with their complete history, physical examination and laboratory parameters such as-complete blood counts. All the patients were monitored for serum ferritin levels and chelation therapy along with screening for transfusion transmitted infections over a year. All the data were compiled and appropriate statistical analysis was done. Results: In present study out of 90 patients, 54 patients were males and 36 patients were females. Mean age of 15.26 ± 7.04 years with 68.9% (N=62) of cases required twice monthly transfusion, 30.0% (n=27) cases required once a month transfusion. 25 cases were found to be HCV+ (27.78%), 3 were HIV + (3.3%) and 62 cases were n on-reactive (68.89%). On first post transfusion CBC we found that 30 cases (33.33%) were found to be adequately transfused with levels > 10 gm%, where as in second results 34 cases (37.78%) were found to be adequately transfused with levels >10 gm%. Mean of average yearly average ferritin values in the study duration was found to be 4724 ± 287.65 ng/mL. The chelating agent dose was with mean 1040 mg and standard deviation 476.19. Conclusion: In the present study, it is concluded that haematological parameters like Haematocrit, Red Blood Cell mass, Haemoglobin and Mean Corpuscular volume had large covariances and Serum Ferritin levels was positively correlated with chelation therapy along with increased rate of transfusion transmitted infections in multi transfused thalassemia major patients.
{"title":"Hematologic profiles of Beta thalassemia major patients: An institutional cross-sectional study","authors":"Dr. Prakhar Gupta, Dhwani Pandya, Dr. Nandini J Desai","doi":"10.33545/pathol.2023.v6.i2b.519","DOIUrl":"https://doi.org/10.33545/pathol.2023.v6.i2b.519","url":null,"abstract":"Introduction: Thalassemia is inherited blood disorder characterized by decreased hemoglobin with two main types-alpha and beta thalassemia. There are two main varieties of β thalassaemia, β0 thalassaemia, in which no β globin is produced, and β+ thalassaemia, in which some β globin is produced, but less than normal. As the patient is diagnosed, regular blood transfusions and chelating treatment is given lifelong. In this study, we observed the haematological profiles of multi transfused thalassemia major patients with the accompanying complications. Aims and Objectives: To study the clinical features with RBC parameters, serum ferritin levels, chelation therapy and prevalence of blood transfusion related infection in multi transfused beta thalassemia major patients. Materials and Method: In this cross sectional study, total 90 diagnosed thalassemia major patients were taken with their complete history, physical examination and laboratory parameters such as-complete blood counts. All the patients were monitored for serum ferritin levels and chelation therapy along with screening for transfusion transmitted infections over a year. All the data were compiled and appropriate statistical analysis was done. Results: In present study out of 90 patients, 54 patients were males and 36 patients were females. Mean age of 15.26 ± 7.04 years with 68.9% (N=62) of cases required twice monthly transfusion, 30.0% (n=27) cases required once a month transfusion. 25 cases were found to be HCV+ (27.78%), 3 were HIV + (3.3%) and 62 cases were n on-reactive (68.89%). On first post transfusion CBC we found that 30 cases (33.33%) were found to be adequately transfused with levels > 10 gm%, where as in second results 34 cases (37.78%) were found to be adequately transfused with levels >10 gm%. Mean of average yearly average ferritin values in the study duration was found to be 4724 ± 287.65 ng/mL. The chelating agent dose was with mean 1040 mg and standard deviation 476.19. Conclusion: In the present study, it is concluded that haematological parameters like Haematocrit, Red Blood Cell mass, Haemoglobin and Mean Corpuscular volume had large covariances and Serum Ferritin levels was positively correlated with chelation therapy along with increased rate of transfusion transmitted infections in multi transfused thalassemia major patients.","PeriodicalId":232143,"journal":{"name":"International Journal of Clinical and Diagnostic Pathology","volume":"61 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134626792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-01DOI: 10.33545/pathol.2023.v6.i2a.518
P. Khanna, Nishi Tandon
Introduction: Oral cancer is one of the most common malignancies and has a significant association with tobacco chewing. Micro RNA 21 (mi-RNA 21) has been identified as oncogenic RNA, implicated in etio-pathogenesis of various neoplastic lesions. Objective: (i) To assess the microRNA 21 expression in oral cancer patients with history of tobacco chewing habits and (ii) to carry out its clinicopathological correlation. Material and Method: The present study was carried out as a case-control study, for a two year period in which a total of 20 biopsy tissue specimen obtained from oral cancer patients having tobacco chewing habits were enrolled as cases and an equal number of biopsy tissue specimen obtained from age, and sex-matched patients of oral leukoplakia were enrolled as controls. Clinical details, personal habits were noted and histopathological assessment was done. miRNA21 was done using Taq Man microRNA assay (ABI) using Polymerase Chain Reaction (PCR).Real time PCR results was analyzed and expressed as relative miRNA expression of the threshold cycle (CT) values. Mean values were compared using independent samples ‘t’-test and ANOVA using SPSS 21.0 software. p-value less than 0.05 indicated a statistically significant association. Results: Mean age of cases was 52.65±7.82 years, majority of cases were males (85%). Among cases, majority (70%) had clinical stage I and were histo-pathologically well differentiated (75%). There were 3 (15%) cases with metastasis. Mean relative miRNA 21 expression were significantly higher in cases (10.53±3.52) as compared to that in controls (8.76±1.16) (p=0.029). Relative miRNA21 values showed a significant increasing trend with increasing clinical stage, histopathological grade and metastasis. Conclusion: miRNA21 expression was able to differentiate between leukoplakia and oral cancer cases. miRNA21 also showed a significant correlation with clinicopathological factors.
口腔癌是最常见的恶性肿瘤之一，与咀嚼烟草有显著的相关性。微RNA 21 (mi-RNA 21)已被确定为致癌RNA，与各种肿瘤病变的发病机制有关。目的:(1)评估有咀嚼烟草习惯的口腔癌患者microRNA 21的表达情况，(2)探讨其临床病理相关性。材料与方法:本研究采用病例对照研究，为期2年，选取有咀嚼烟草习惯的口腔癌患者活检组织标本20例作为病例，选取年龄、性别相匹配的口腔白斑患者活检组织标本等量作为对照。记录临床细节、个人习惯并进行组织病理学评估。miRNA21采用聚合酶链式反应(PCR)检测Taq Man microRNA assay (ABI)。Real time PCR结果分析并表达为阈值周期(CT)值的相对miRNA表达。均值比较采用独立样本t检验，方差分析采用SPSS 21.0软件。p值小于0.05表示有统计学意义。结果:患者平均年龄为52.65±7.82岁，男性居多(85%)。大多数病例(70%)为临床I期，组织病理分化良好(75%)。有转移3例(15%)。患者miRNA 21的平均相对表达量(10.53±3.52)明显高于对照组(8.76±1.16)(p=0.029)。相对miRNA21值随临床分期、组织病理分级及转移程度的增加呈显著升高趋势。结论:miRNA21表达在口腔白斑与口腔癌之间具有一定的鉴别价值。miRNA21也与临床病理因素有显著相关性。
{"title":"Clinicopathological correlation of microRNA 21 expression in oral cancer patients with tobacco chewing habits","authors":"P. Khanna, Nishi Tandon","doi":"10.33545/pathol.2023.v6.i2a.518","DOIUrl":"https://doi.org/10.33545/pathol.2023.v6.i2a.518","url":null,"abstract":"Introduction: Oral cancer is one of the most common malignancies and has a significant association with tobacco chewing. Micro RNA 21 (mi-RNA 21) has been identified as oncogenic RNA, implicated in etio-pathogenesis of various neoplastic lesions. Objective: (i) To assess the microRNA 21 expression in oral cancer patients with history of tobacco chewing habits and (ii) to carry out its clinicopathological correlation. Material and Method: The present study was carried out as a case-control study, for a two year period in which a total of 20 biopsy tissue specimen obtained from oral cancer patients having tobacco chewing habits were enrolled as cases and an equal number of biopsy tissue specimen obtained from age, and sex-matched patients of oral leukoplakia were enrolled as controls. Clinical details, personal habits were noted and histopathological assessment was done. miRNA21 was done using Taq Man microRNA assay (ABI) using Polymerase Chain Reaction (PCR).Real time PCR results was analyzed and expressed as relative miRNA expression of the threshold cycle (CT) values. Mean values were compared using independent samples ‘t’-test and ANOVA using SPSS 21.0 software. p-value less than 0.05 indicated a statistically significant association. Results: Mean age of cases was 52.65±7.82 years, majority of cases were males (85%). Among cases, majority (70%) had clinical stage I and were histo-pathologically well differentiated (75%). There were 3 (15%) cases with metastasis. Mean relative miRNA 21 expression were significantly higher in cases (10.53±3.52) as compared to that in controls (8.76±1.16) (p=0.029). Relative miRNA21 values showed a significant increasing trend with increasing clinical stage, histopathological grade and metastasis. Conclusion: miRNA21 expression was able to differentiate between leukoplakia and oral cancer cases. miRNA21 also showed a significant correlation with clinicopathological factors.","PeriodicalId":232143,"journal":{"name":"International Journal of Clinical and Diagnostic Pathology","volume":"2002 17","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132678334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-01DOI: 10.33545/pathol.2023.v6.i2a.510
Dr. Arpita Makwana, Dr. Muskan Sorathya, Dr. Nandini J Desai
{"title":"A correlation study of cervical cytology on pap smear with cervical biopsy in a tertiary care hospital (1 Year Study)","authors":"Dr. Arpita Makwana, Dr. Muskan Sorathya, Dr. Nandini J Desai","doi":"10.33545/pathol.2023.v6.i2a.510","DOIUrl":"https://doi.org/10.33545/pathol.2023.v6.i2a.510","url":null,"abstract":"","PeriodicalId":232143,"journal":{"name":"International Journal of Clinical and Diagnostic Pathology","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128791651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-01DOI: 10.33545/pathol.2023.v6.i2a.512
Shireesha M, S. Yalavarthi, S. Deshpande, GV Saikumar
{"title":"Histopathological spectrum of lesions of kidney: A morphological study","authors":"Shireesha M, S. Yalavarthi, S. Deshpande, GV Saikumar","doi":"10.33545/pathol.2023.v6.i2a.512","DOIUrl":"https://doi.org/10.33545/pathol.2023.v6.i2a.512","url":null,"abstract":"","PeriodicalId":232143,"journal":{"name":"International Journal of Clinical and Diagnostic Pathology","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126868961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-01DOI: 10.33545/pathol.2023.v6.i2a.515
Dr. Priyanka Nakum, Dr. Shubhada Apoorva Kanhere
The initial diagnosis of metastatic melanoma is relatively uncommon, and the 5-year survival rate is less than 15%. We present a case of late melanoma recurrence that manifested as an in-transit metastasis in the iliac bone, occurring two years after the excision of the tumour. In the present case report; A 59 year female was reported to the outpatient department of the medical college & associated hospital. The patients past medical history stated that she is known case of foot melanoma diagnosis and was operated in 2019. In July 2020, the patient developed recurrence in July 2020. A wide local surgical excision to achieve a 2-centimeter margin with skin graft was undertaken with an associated sentinel lymph node biopsy. Upon follow-up, it was discovered that the patient had been disease-free for a full year. However, the lesion started to reoccur in the period of July 2022. A PET-CT of her whole blood was performed. The patient received IV fluids, antibiotics, analgesics, and other supportive care before being released once the hemodynamics were determined to be stable. A 10-year period of disease-free living cannot usually be regarded as a definitive cure for melanoma. Always let your doctor know if you've previously been diagnosed with melanoma.
{"title":"Recurrent malignant melanoma of the left foot with metastasis: A case report","authors":"Dr. Priyanka Nakum, Dr. Shubhada Apoorva Kanhere","doi":"10.33545/pathol.2023.v6.i2a.515","DOIUrl":"https://doi.org/10.33545/pathol.2023.v6.i2a.515","url":null,"abstract":"The initial diagnosis of metastatic melanoma is relatively uncommon, and the 5-year survival rate is less than 15%. We present a case of late melanoma recurrence that manifested as an in-transit metastasis in the iliac bone, occurring two years after the excision of the tumour. In the present case report; A 59 year female was reported to the outpatient department of the medical college & associated hospital. The patients past medical history stated that she is known case of foot melanoma diagnosis and was operated in 2019. In July 2020, the patient developed recurrence in July 2020. A wide local surgical excision to achieve a 2-centimeter margin with skin graft was undertaken with an associated sentinel lymph node biopsy. Upon follow-up, it was discovered that the patient had been disease-free for a full year. However, the lesion started to reoccur in the period of July 2022. A PET-CT of her whole blood was performed. The patient received IV fluids, antibiotics, analgesics, and other supportive care before being released once the hemodynamics were determined to be stable. A 10-year period of disease-free living cannot usually be regarded as a definitive cure for melanoma. Always let your doctor know if you've previously been diagnosed with melanoma.","PeriodicalId":232143,"journal":{"name":"International Journal of Clinical and Diagnostic Pathology","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128291617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-01DOI: 10.33545/pathol.2023.v6.i2b.520
Dr. Bhakti Dilip Wagle, Dr. Abhay Vilas Deshmukh, Dr. Shubhangi Natthuji Mangam, D. N. Gangane
Background: Caspase-3 is involved in the apoptosis induced by many agents, including antineoplastic drugs in cancers. Loss of caspase-3 expression and activity has been reported in primary human breast cancers. It is suggested that it might promote tumour development by preventing and reducing senescence. It was a retrospective observational pilot study aimed to evaluate the prognostic potential role of caspase-3 in breast cancer patients. Method: It was a retrospective observational pilot study in which fifty breast cancer patients were enrolled. Haematoxylin and eosin-stained slides of the cases were screened to obtain the best paraffin block for IHC, on which immunohistochemical expression of caspase-3 marker was done and studied. It was correlated with the known prognostic markers of breast cancer. Results: Out of 21 cases with moderate caspase-3 staining, 85.7% cases were grade III and 14.2% were grade II. From 16 cases with strong caspase-3 staining, 75% cases were grading III followed by 25% cases of grade II. There was no significant correlation between caspase-3 staining with histological grade, size of tumour, lymph node involvement, ER, PR and Her2/neu status (p=0.68, 0.24, 0.20, 0.68, 0.45 and 0.11 respectively). Correlation of survival was significantly associated with lymph node involvement (p=0.01) while it was insignificant for tumour size and histological grade (p=0.36 and 0.42 respectively). Conclusion: The survival of breast cancer patients was correlated only with lymph node metastasis. It was better with smaller number of lymph node involvement. While, Caspase-3 did not have any direct association with prognostic markers of breast carcinoma like tumour size, grade of tumour, lymph node and ER, PR and HER-2/neu status. It can be probably used as a prognostic biomarker in future if bigger study is able to establish the significance in breast cancer.
{"title":"Can Caspase-3 act as a potential prognostic biomarker in breast cancer? - A retrospective pilot study in central India","authors":"Dr. Bhakti Dilip Wagle, Dr. Abhay Vilas Deshmukh, Dr. Shubhangi Natthuji Mangam, D. N. Gangane","doi":"10.33545/pathol.2023.v6.i2b.520","DOIUrl":"https://doi.org/10.33545/pathol.2023.v6.i2b.520","url":null,"abstract":"Background: Caspase-3 is involved in the apoptosis induced by many agents, including antineoplastic drugs in cancers. Loss of caspase-3 expression and activity has been reported in primary human breast cancers. It is suggested that it might promote tumour development by preventing and reducing senescence. It was a retrospective observational pilot study aimed to evaluate the prognostic potential role of caspase-3 in breast cancer patients. Method: It was a retrospective observational pilot study in which fifty breast cancer patients were enrolled. Haematoxylin and eosin-stained slides of the cases were screened to obtain the best paraffin block for IHC, on which immunohistochemical expression of caspase-3 marker was done and studied. It was correlated with the known prognostic markers of breast cancer. Results: Out of 21 cases with moderate caspase-3 staining, 85.7% cases were grade III and 14.2% were grade II. From 16 cases with strong caspase-3 staining, 75% cases were grading III followed by 25% cases of grade II. There was no significant correlation between caspase-3 staining with histological grade, size of tumour, lymph node involvement, ER, PR and Her2/neu status (p=0.68, 0.24, 0.20, 0.68, 0.45 and 0.11 respectively). Correlation of survival was significantly associated with lymph node involvement (p=0.01) while it was insignificant for tumour size and histological grade (p=0.36 and 0.42 respectively). Conclusion: The survival of breast cancer patients was correlated only with lymph node metastasis. It was better with smaller number of lymph node involvement. While, Caspase-3 did not have any direct association with prognostic markers of breast carcinoma like tumour size, grade of tumour, lymph node and ER, PR and HER-2/neu status. It can be probably used as a prognostic biomarker in future if bigger study is able to establish the significance in breast cancer.","PeriodicalId":232143,"journal":{"name":"International Journal of Clinical and Diagnostic Pathology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127495966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-01DOI: 10.33545/pathol.2023.v6.i2a.514
Dr. Konika Kherajani, Dr. Krina Shah, Dr. Vijay C Popat
{"title":"Occurrence of Oral, Oropharyngeal and Laryngeal Cancers in Saurashtra Region, Gujarat, India A study of 1,006 cases of Oral Lesions","authors":"Dr. Konika Kherajani, Dr. Krina Shah, Dr. Vijay C Popat","doi":"10.33545/pathol.2023.v6.i2a.514","DOIUrl":"https://doi.org/10.33545/pathol.2023.v6.i2a.514","url":null,"abstract":"","PeriodicalId":232143,"journal":{"name":"International Journal of Clinical and Diagnostic Pathology","volume":"97 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123411866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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