{"title":"Erythrophagocytosis by Blasts and Numerous Cytoplasmic Granules in a Child with De Novo T-lymphoblastic Leukemia","authors":"Fang Long, Wenwen Song, Xue Li, Li Li, Ting Li, Yun Zhang","doi":"10.4274/tjh.galenos.2023.2023.0242","DOIUrl":"10.4274/tjh.galenos.2023.2023.0242","url":null,"abstract":"","PeriodicalId":23362,"journal":{"name":"Turkish Journal of Hematology","volume":" ","pages":"271-272"},"PeriodicalIF":2.6,"publicationDate":"2023-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10701313/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9895037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-05Epub Date: 2023-10-04DOI: 10.4274/tjh.galenos.2023.2023.0295
Mehmet Baysal, Fehmi Hindilerden, Elif Gülsüm Ümit, Ahmet Muzaffer Demir, Fatma Keklik Karadağ, Güray Saydam, Seval Akpınar, Burhan Turgut, Vildan Özkocaman, Fahir Özkalemkaş, Rafiye Çiftçiler, Can Özlü, Sinan Demircioğlu, Yıldız İpek, Reyhan Diz Küçükkaya
Objective: In recent years, new developments have been incorporated into daily practice in the management of immune thrombotic thrombocytopenic purpura (iTTP). In particular, clinical scoring systems could help clinicians with clinical decision-making and early recognition. However, older patients frequently present with more organ involvement and in unusual ways. The ways in which age could affect these clinical prediction scoring systems remain unclear. We evaluated the use of PLASMIC and French scores in patients over 60 years of age.
Materials and methods: We performed a retrospective cross-sectional analysis of patients over 60 years of age with a presumptive diagnosis of iTTP between 2014 and 2022 at 10 centers. We calculated PLASMIC and French scores and compared our data with a single-center analysis of younger patients presenting with thrombotic microangiopathy.
Results: Our study included 30 patients over 60 years of age and a control group of 28 patients younger than 60 years. The diagnostic sensitivity and specificity of a French score of ≥1 were lower in older patients compared to the control group (78.9% vs. 100% and 18.2% vs. 57.1%, respectively). The diagnostic sensitivity and specificity of a PLASMIC score of ≥5 were 100% vs. 95% and 27.3% vs. 100% for the study group and control group, respectively. Our study showed a higher mortality rate in older patients compared to the control group (30% vs. 7.1%, p=0.043).
Conclusion: For a limited number of patients (n=6), our results showed that rituximab can reduce mortality. Given that the reliability of clinical prediction scores for iTTP in older patients may be lower, more caution must be undertaken in interpreting their results.
目的:近年来，免疫血栓性血小板减少性紫癜(iTTP)治疗的新进展已纳入日常实践。特别是，临床评分系统可以帮助临床医生进行临床决策和早期识别。然而，老年患者经常出现更多的器官受累和不寻常的方式。年龄可能影响这些临床预测评分系统的方式尚不清楚。我们评估了PLASMIC和French评分在60岁以上患者中的应用。材料和方法:我们对2014年至2022年间10个中心的60岁以上推定诊断为iTTP的患者进行了回顾性横断面分析。我们计算了PLASMIC和French评分，并将我们的数据与出现血栓性微血管病变的年轻患者的单中心分析进行了比较。结果:我们的研究包括30例60岁以上的患者和28例60岁以下的对照组患者。老年患者法国评分≥1的诊断敏感性和特异性较对照组低(分别为78.9%对100%和18.2%对57.1%)。在研究组和对照组中，PLASMIC评分≥5的诊断敏感性和特异性分别为100%对95%和27.3%对100%。我们的研究显示，老年患者的死亡率高于对照组(30% vs. 7.1%， p=0.043)。结论:对于有限数量的患者(n=6)，我们的结果显示利妥昔单抗可以降低死亡率。鉴于老年患者iTTP临床预测评分的可靠性可能较低，在解释其结果时必须更加谨慎。
{"title":"Immune Thrombotic Thrombocytopenic Purpura in Elderly Patients: The Roles of PLASMIC and French Scores","authors":"Mehmet Baysal, Fehmi Hindilerden, Elif Gülsüm Ümit, Ahmet Muzaffer Demir, Fatma Keklik Karadağ, Güray Saydam, Seval Akpınar, Burhan Turgut, Vildan Özkocaman, Fahir Özkalemkaş, Rafiye Çiftçiler, Can Özlü, Sinan Demircioğlu, Yıldız İpek, Reyhan Diz Küçükkaya","doi":"10.4274/tjh.galenos.2023.2023.0295","DOIUrl":"10.4274/tjh.galenos.2023.2023.0295","url":null,"abstract":"<p><strong>Objective: </strong>In recent years, new developments have been incorporated into daily practice in the management of immune thrombotic thrombocytopenic purpura (iTTP). In particular, clinical scoring systems could help clinicians with clinical decision-making and early recognition. However, older patients frequently present with more organ involvement and in unusual ways. The ways in which age could affect these clinical prediction scoring systems remain unclear. We evaluated the use of PLASMIC and French scores in patients over 60 years of age.</p><p><strong>Materials and methods: </strong>We performed a retrospective cross-sectional analysis of patients over 60 years of age with a presumptive diagnosis of iTTP between 2014 and 2022 at 10 centers. We calculated PLASMIC and French scores and compared our data with a single-center analysis of younger patients presenting with thrombotic microangiopathy.</p><p><strong>Results: </strong>Our study included 30 patients over 60 years of age and a control group of 28 patients younger than 60 years. The diagnostic sensitivity and specificity of a French score of ≥1 were lower in older patients compared to the control group (78.9% vs. 100% and 18.2% vs. 57.1%, respectively). The diagnostic sensitivity and specificity of a PLASMIC score of ≥5 were 100% vs. 95% and 27.3% vs. 100% for the study group and control group, respectively. Our study showed a higher mortality rate in older patients compared to the control group (30% vs. 7.1%, p=0.043).</p><p><strong>Conclusion: </strong>For a limited number of patients (n=6), our results showed that rituximab can reduce mortality. Given that the reliability of clinical prediction scores for iTTP in older patients may be lower, more caution must be undertaken in interpreting their results.</p>","PeriodicalId":23362,"journal":{"name":"Turkish Journal of Hematology","volume":" ","pages":"251-257"},"PeriodicalIF":2.6,"publicationDate":"2023-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10701326/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41137857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-05Epub Date: 2023-06-14DOI: 10.4274/tjh.galenos.2023.2023.0181
Yang Su, Jiwei Zhao, Xiaoming Fan, Wei Yang, Jinlin Liu
{"title":"Round Promyelocyte Cells with Round Nuclei: Clues to the Diagnosis of <i>ZBTB16-RARA</i> Acute Promyelocytic Leukemia","authors":"Yang Su, Jiwei Zhao, Xiaoming Fan, Wei Yang, Jinlin Liu","doi":"10.4274/tjh.galenos.2023.2023.0181","DOIUrl":"10.4274/tjh.galenos.2023.2023.0181","url":null,"abstract":"","PeriodicalId":23362,"journal":{"name":"Turkish Journal of Hematology","volume":" ","pages":"273-274"},"PeriodicalIF":2.6,"publicationDate":"2023-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10701318/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9624660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Diagnostic Accuracy of Serum Galactomannan Assay in Children with Acute Myeloid Leukemia: Effect of the Revised EORTC/MSGERC 2020 Criteria","authors":"Gülhadiye Avcu, Nihal Karadaş, Şebnem Önen Göktepe, Dilek Yeşim Metin, Deniz Yılmaz Karapınar","doi":"10.4274/tjh.galenos.2023.2023.0285","DOIUrl":"10.4274/tjh.galenos.2023.2023.0285","url":null,"abstract":"","PeriodicalId":23362,"journal":{"name":"Turkish Journal of Hematology","volume":" ","pages":"278-280"},"PeriodicalIF":2.6,"publicationDate":"2023-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10701317/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41155383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-01DOI: 10.4274/tjh.galenos.2023.2023.0239
Hamza Sümter, Soycan Mızrak, Serdar Ceylaner, Duran Canatan
{"title":"Hb Andrew-Minneapolis Variant in a Turkish Family","authors":"Hamza Sümter, Soycan Mızrak, Serdar Ceylaner, Duran Canatan","doi":"10.4274/tjh.galenos.2023.2023.0239","DOIUrl":"https://doi.org/10.4274/tjh.galenos.2023.2023.0239","url":null,"abstract":"","PeriodicalId":23362,"journal":{"name":"Turkish Journal of Hematology","volume":"57 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135048562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The purpose of this study was to identify risk factors and improve preventive strategies for febrile neutropenia (FEN) in children with leukemia who were receiving ciprofloxacin prophylaxis. The study included 100 children with leukemia [n=80 with acute lymphoblastic leukemia and n=20 with acute myeloblastic leukemia (AML)]. Patients were divided into two groups based on whether they had three or fewer FEN episodes (Group 1) or more than three FEN episodes (Group 2). Group 1 contained 63 (63%) of the 100 patients, while Group 2 contained 37 (37%). Older age (≥7 years), leukemia type, prolonged neutropenia (>10 days), and the presence of neutropenia and hypogammaglobulinemia at diagnosis were all risk factors for having more than three FEN episodes. Our findings suggest that, in addition to ciprofloxacin prophylaxis, identifying risk factors and improving preventive strategies could help reduce FEN episodes in children with leukemia.Bu çalışmanın amacı, siprofloksasin profilaksisi alan lösemili çocuklarda febril nötropeni (FEN) için risk faktörlerini belirlemek ve önleyici stratejileri geliştirmektir. Çalışmaya lösemili 100 çocuk dahil edildi (akut lenfoblastik lösemi n=80 ve akut myeloid lösemi (AML) n=20). Hastalar üç ve üçten az FEN atağı (Grup 1) veya üçten fazla FEN atağı (Grup 2) geçirmelerine göre 2 gruba ayrıldı. Yüz hastanın 63’ünü (%63) Grup 1, kalan 37’sini (%37) Grup 2 oluşturdu. İleri yaş (≥7 yaş), lösemi tipi, uzamış nötropeni (>10 gün), tanı anında nötropeni ve hipogamaglobulinemi varlığı üçten fazla FEN atağı için anlamlı risk faktörleriydi. Bulgularımız, siprofloksasin profilaksisine ek olarak, lösemili çocuklarda risk faktörlerinin belirlenmesinin ve önleyici stratejilerin geliştirilmesinin FEN atağını azaltmaya yardımcı olabileceğine işaret etmektedir.
本研究的目的是确定接受环丙沙星预防的白血病儿童发热性中性粒细胞减少症(FEN)的危险因素和改进预防策略。本研究纳入100例白血病患儿[n=80急性淋巴细胞白血病和n=20急性髓母细胞白血病]。根据患者是否有三次或更少的FEN发作(第1组)或超过三次FEN发作(第2组)将患者分为两组。100例患者中，第1组有63例(63%)，第2组有37例(37%)。年龄较大(≥7岁)、白血病类型、长时间中性粒细胞减少(bbb10天)、诊断时存在中性粒细胞减少和低γ -球蛋白血症都是超过3次FEN发作的危险因素。我们的研究结果表明，除了环丙沙星预防外，识别危险因素和改进预防策略可以帮助减少白血病儿童FEN的发作。但是çalışmanın amacyi, siprofloksasin profilaksisi alan lösemili ocuklarda febril nötropeni (FEN)风险faktörlerini belirlemek ve önleyici stratejileri gelitirmektir。Çalışmaya lösemili 100 ocuk dahil edildi (akut lenfoblastik lösemi n=80)和akut myeloid lösemi (AML) n=20)。Hastalar üç ve ten az FEN atağı(1组)veya ten fazla FEN atağı(2组)gemelerine göre 2 gruba ayrıldı。y z hastanın 63′ünü(%63)组1,kalan 37′sini(%37)组2 olu turdu。İleri yaku(≥7 yaku)， lösemi tipi, uzamış nötropeni (bbb10 g n)， tanyi anında nötropeni ve hipogamaglobulinemi varlığı ten fazla FEN atağı iin anlamlyi risk faktörleriydi。Bulgularımız, siprofloksasin profilaksisine ek olarak, lösemili ocuklarda risk faktörlerinin belirlenmesinin ve önleyici stratejilerin gelitirilmesinin FEN atağını azaltmaya yardımcı olabileceğine iaret etmektedir。
{"title":"Identifying Risk Factors and Improving Preventive Strategies for Febrile Neutropenia in Children with Leukemia Receiving Ciprofloxacin Prophylaxis","authors":"Zühre Kaya, Nurettin Alıcı, Serap Kırkız, Ülker Koçak","doi":"10.4274/tjh.galenos.2023.2023-0116","DOIUrl":"https://doi.org/10.4274/tjh.galenos.2023.2023-0116","url":null,"abstract":"The purpose of this study was to identify risk factors and improve preventive strategies for febrile neutropenia (FEN) in children with leukemia who were receiving ciprofloxacin prophylaxis. The study included 100 children with leukemia [n=80 with acute lymphoblastic leukemia and n=20 with acute myeloblastic leukemia (AML)]. Patients were divided into two groups based on whether they had three or fewer FEN episodes (Group 1) or more than three FEN episodes (Group 2). Group 1 contained 63 (63%) of the 100 patients, while Group 2 contained 37 (37%). Older age (≥7 years), leukemia type, prolonged neutropenia (>10 days), and the presence of neutropenia and hypogammaglobulinemia at diagnosis were all risk factors for having more than three FEN episodes. Our findings suggest that, in addition to ciprofloxacin prophylaxis, identifying risk factors and improving preventive strategies could help reduce FEN episodes in children with leukemia.Bu çalışmanın amacı, siprofloksasin profilaksisi alan lösemili çocuklarda febril nötropeni (FEN) için risk faktörlerini belirlemek ve önleyici stratejileri geliştirmektir. Çalışmaya lösemili 100 çocuk dahil edildi (akut lenfoblastik lösemi n=80 ve akut myeloid lösemi (AML) n=20). Hastalar üç ve üçten az FEN atağı (Grup 1) veya üçten fazla FEN atağı (Grup 2) geçirmelerine göre 2 gruba ayrıldı. Yüz hastanın 63’ünü (%63) Grup 1, kalan 37’sini (%37) Grup 2 oluşturdu. İleri yaş (≥7 yaş), lösemi tipi, uzamış nötropeni (>10 gün), tanı anında nötropeni ve hipogamaglobulinemi varlığı üçten fazla FEN atağı için anlamlı risk faktörleriydi. Bulgularımız, siprofloksasin profilaksisine ek olarak, lösemili çocuklarda risk faktörlerinin belirlenmesinin ve önleyici stratejilerin geliştirilmesinin FEN atağını azaltmaya yardımcı olabileceğine işaret etmektedir.","PeriodicalId":23362,"journal":{"name":"Turkish Journal of Hematology","volume":"73 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136081135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-01DOI: 10.4274/tjh.galenos.2023.2023-0089
Hakan Göker, Olgu Erkin Çınar, Haluk Demiroğlu, Ümit Yavuz Malkan, Elifcan Aladağ Karakulak, Yahya Büyükaşık
{"title":"Venetoclax and Azacitidine Treatment in Relapsed Acute Myeloid Leukemia after Hematopoietic Stem Cell Transplantation: A Cohort Study in the Real-World Setting of a Tertiary Center","authors":"Hakan Göker, Olgu Erkin Çınar, Haluk Demiroğlu, Ümit Yavuz Malkan, Elifcan Aladağ Karakulak, Yahya Büyükaşık","doi":"10.4274/tjh.galenos.2023.2023-0089","DOIUrl":"https://doi.org/10.4274/tjh.galenos.2023.2023-0089","url":null,"abstract":"","PeriodicalId":23362,"journal":{"name":"Turkish Journal of Hematology","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136081132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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