Pub Date : 2021-07-07DOI: 10.31928/1608-635X-2021.2.5057
V. Tseluyko, L. Yakovleva, S. M. Sukhova, O. Radchenko, T. Pylova, A. Vnukova, K. Kinoshenko, M. I. Karavaitseva
The aim – to study the relationship between the level of NT-proBNP, clinical-anamnestic and echocardiographic parameters in patients with pulmonary embolism (PE).Materials and methods. The study was carried out on 45 patients with PE, which was confirmed by computed tomography. An echocardiographic study was carried out during hospitalization of patients according to the standard protocol. The examination plan of patients, along with standard laboratory tests, included the determination of the level of highly sensitive troponin I, C-reactive peptide (CRP) and NT-proBNP.Results and discussion. The level of NT-proBNP is increased in patients with PE, even in the absence of heart failure (2932±266 pg/ml). There were no significant differences in the level of the indicator depending on the gender of patients (p=0.3), on the presence of arterial hypertension (p=0.92) and the concomitant oncological process (p=0.88). A correlation was found between NT-proBNP level and the size of the right and left atrium: right atrium (p=0.014), left atrium (p=0.025). The relationship between the level of NT-proBNP and the pressure in the pulmonary artery according to ultrasound data was proved (in patients with PE without signs of pulmonary hypertension, the level of NT-proBNP is 405 pg/ml, versus 4067 pg/ml in the group of patients with increased pressure in the pulmonary artery (p=0.0047). A correlation was found between the levels of NT-proBNP and CRP.Conclusions. There is a significant increase in the level of NT-proBNP in patients with PE, the degree of which correlates with an increase in the size of the right atrium and pressure in the pulmonary artery (p=0.0047).
{"title":"NT-proBNP level and lesion of the right ventricle in patients with pulmonary embolism","authors":"V. Tseluyko, L. Yakovleva, S. M. Sukhova, O. Radchenko, T. Pylova, A. Vnukova, K. Kinoshenko, M. I. Karavaitseva","doi":"10.31928/1608-635X-2021.2.5057","DOIUrl":"https://doi.org/10.31928/1608-635X-2021.2.5057","url":null,"abstract":"The aim – to study the relationship between the level of NT-proBNP, clinical-anamnestic and echocardiographic parameters in patients with pulmonary embolism (PE).Materials and methods. The study was carried out on 45 patients with PE, which was confirmed by computed tomography. An echocardiographic study was carried out during hospitalization of patients according to the standard protocol. The examination plan of patients, along with standard laboratory tests, included the determination of the level of highly sensitive troponin I, C-reactive peptide (CRP) and NT-proBNP.Results and discussion. The level of NT-proBNP is increased in patients with PE, even in the absence of heart failure (2932±266 pg/ml). There were no significant differences in the level of the indicator depending on the gender of patients (p=0.3), on the presence of arterial hypertension (p=0.92) and the concomitant oncological process (p=0.88). A correlation was found between NT-proBNP level and the size of the right and left atrium: right atrium (p=0.014), left atrium (p=0.025). The relationship between the level of NT-proBNP and the pressure in the pulmonary artery according to ultrasound data was proved (in patients with PE without signs of pulmonary hypertension, the level of NT-proBNP is 405 pg/ml, versus 4067 pg/ml in the group of patients with increased pressure in the pulmonary artery (p=0.0047). A correlation was found between the levels of NT-proBNP and CRP.Conclusions. There is a significant increase in the level of NT-proBNP in patients with PE, the degree of which correlates with an increase in the size of the right atrium and pressure in the pulmonary artery (p=0.0047).","PeriodicalId":23419,"journal":{"name":"Ukrainian Journal of Cardiology","volume":"45 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84427274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-07-07DOI: 10.31928/1608-635X-2021.2.3341
Y. Zinchenko, T. Mikhalieva, O. Ilchyshyna
The aim – to compare the effectiveness of restoration of sinus rhythm by transesophageal pacing (TEECP) in patients with prolonged episodes of isolated typical atrial flutter (AFl) and in patients with a combination of atrial fibrillation (AF) and AFl.Materials and methods. 325 procedures of TEECP were performed in cases of longlasting episodes of AFl: from 8 days to 2 years (average 68.2±4.76 days). Prior to hospitalization, all subjects underwent ineffective medical cardioversion. The sinus rhythm was restored using TEECP, and in case of its ineffectiveness by means of electropulse therapy (EPT). All patients were divided into two groups: group I (n=237) – patients with a lone atrial flutter, and group II (n=88) – patients with the history of AF or in case of transformation AF into AFl because of antiarrhythmic therapy. Both groups were comparable by age, paroxysm duration, presence of hypertension and organic disorders of the heart conductive system, comorbidities, echocardiographic and hemodynamic parameters. Electrocardiographical parameters revealed no significant differences in the tachycardia cycle length and the average frequency of ventricular contractions.Results and discussion. Patients in the group II were characterized by a significantly longer history of arrhythmia, more severe heart failure, higher frequency of arrhythmia paroxysms and detection of thyroid disorders; recorded significantly lower amplitudes of the F wave on the surface electrocardiogram and A wave on the esophageal electrogram, which was associated with the processes of electrophysiological remodeling of the atria. Also, in contrast to patients with typical AFl, there was a significant decrease in the effectiveness of TEECP (63.6 and 89 %); more frequent use of EPT (10.2 and 3 %) and more often arrhythmia has transformed into a permanent form (25 and 7.2 %).Conclusions. In patients with prolonged episodes of typical AFl, a highly effective method of cardioversion is TEECP, regardless of the arrhythmia duration. In patients with concomitant AF, the restoration of sinus rhythm should be performed by EPT, due to its higher efficancy.
{"title":"Effectiveness of restoration of sinus rhythm in patients with combined atrial fibrillation and atrial flutter","authors":"Y. Zinchenko, T. Mikhalieva, O. Ilchyshyna","doi":"10.31928/1608-635X-2021.2.3341","DOIUrl":"https://doi.org/10.31928/1608-635X-2021.2.3341","url":null,"abstract":"The aim – to compare the effectiveness of restoration of sinus rhythm by transesophageal pacing (TEECP) in patients with prolonged episodes of isolated typical atrial flutter (AFl) and in patients with a combination of atrial fibrillation (AF) and AFl.Materials and methods. 325 procedures of TEECP were performed in cases of longlasting episodes of AFl: from 8 days to 2 years (average 68.2±4.76 days). Prior to hospitalization, all subjects underwent ineffective medical cardioversion. The sinus rhythm was restored using TEECP, and in case of its ineffectiveness by means of electropulse therapy (EPT). All patients were divided into two groups: group I (n=237) – patients with a lone atrial flutter, and group II (n=88) – patients with the history of AF or in case of transformation AF into AFl because of antiarrhythmic therapy. Both groups were comparable by age, paroxysm duration, presence of hypertension and organic disorders of the heart conductive system, comorbidities, echocardiographic and hemodynamic parameters. Electrocardiographical parameters revealed no significant differences in the tachycardia cycle length and the average frequency of ventricular contractions.Results and discussion. Patients in the group II were characterized by a significantly longer history of arrhythmia, more severe heart failure, higher frequency of arrhythmia paroxysms and detection of thyroid disorders; recorded significantly lower amplitudes of the F wave on the surface electrocardiogram and A wave on the esophageal electrogram, which was associated with the processes of electrophysiological remodeling of the atria. Also, in contrast to patients with typical AFl, there was a significant decrease in the effectiveness of TEECP (63.6 and 89 %); more frequent use of EPT (10.2 and 3 %) and more often arrhythmia has transformed into a permanent form (25 and 7.2 %).Conclusions. In patients with prolonged episodes of typical AFl, a highly effective method of cardioversion is TEECP, regardless of the arrhythmia duration. In patients with concomitant AF, the restoration of sinus rhythm should be performed by EPT, due to its higher efficancy.","PeriodicalId":23419,"journal":{"name":"Ukrainian Journal of Cardiology","volume":"34 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81021423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-07-07DOI: 10.31928/1608-635X-2021.2.4249
O. Mitchenko, T. Kolesnik, V. Romanov, K. Timokhova, N. M. Chulaevska, G. Kosova, A. V. Nadyuk
The aim – to optimize the diagnosis of familial hypercholesterolemia (FH) in Ukraine and determine the prevalence of secondary dyslipidemia among people with «possible» FH.Materials and methods. The work was carried out in two stages of population research. At the I stage (2009–2013), in 81 out of 1000 respondents (8.1 %) the level of LDL-C ≥ 5 mmol/l was registered. At the II stage (2019), additional survey of respondents was conducted to identify secondary dyslipidemia.Results and discussion. After additional examination of respondents with «possible» FH on II stage, type 2 diabetes was diagnosed in 20.4 %, hypothyroidism – in 14.3 %, class II–III obesity – in 16.3 %. In 30.6 % of respondents, the understudied comorbid pathology was not detected, and the level of LDL-C decreased on the background of lifestyle modification and statin therapy. The «possible» FH was finally verified in 9 patients with a burdened anamnesis of early coronary artery disease in them and/or their first-degree relatives, as well as with an increased LDL-C and total cholesterol levels on II stage, despite statin therapy.Conclusions. The percent of respondents with «possible» FH on the I stage, based only on criteria of LDL-C ³ 5 mmol/l, was 8.1 %. But after the detection of secondary dyslipidemia, the prevalence of verified FH within urban population was 0.9 %. In the rest cases (80 %), the elevated level of LDL-C was associated with comorbid pathology. The study proves the need for further optimization of the managment of patients with impaired lipid profile to verify primary and secondary hypercholesterolemia.
{"title":"Detection of secondary dyslipidemia among people with «possible» familial hypercholesterolemia in Ukrainian population","authors":"O. Mitchenko, T. Kolesnik, V. Romanov, K. Timokhova, N. M. Chulaevska, G. Kosova, A. V. Nadyuk","doi":"10.31928/1608-635X-2021.2.4249","DOIUrl":"https://doi.org/10.31928/1608-635X-2021.2.4249","url":null,"abstract":"The aim – to optimize the diagnosis of familial hypercholesterolemia (FH) in Ukraine and determine the prevalence of secondary dyslipidemia among people with «possible» FH.Materials and methods. The work was carried out in two stages of population research. At the I stage (2009–2013), in 81 out of 1000 respondents (8.1 %) the level of LDL-C ≥ 5 mmol/l was registered. At the II stage (2019), additional survey of respondents was conducted to identify secondary dyslipidemia.Results and discussion. After additional examination of respondents with «possible» FH on II stage, type 2 diabetes was diagnosed in 20.4 %, hypothyroidism – in 14.3 %, class II–III obesity – in 16.3 %. In 30.6 % of respondents, the understudied comorbid pathology was not detected, and the level of LDL-C decreased on the background of lifestyle modification and statin therapy. The «possible» FH was finally verified in 9 patients with a burdened anamnesis of early coronary artery disease in them and/or their first-degree relatives, as well as with an increased LDL-C and total cholesterol levels on II stage, despite statin therapy.Conclusions. The percent of respondents with «possible» FH on the I stage, based only on criteria of LDL-C ³ 5 mmol/l, was 8.1 %. But after the detection of secondary dyslipidemia, the prevalence of verified FH within urban population was 0.9 %. In the rest cases (80 %), the elevated level of LDL-C was associated with comorbid pathology. The study proves the need for further optimization of the managment of patients with impaired lipid profile to verify primary and secondary hypercholesterolemia.","PeriodicalId":23419,"journal":{"name":"Ukrainian Journal of Cardiology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88875121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-07-07DOI: 10.31928/1608-635X-2021.2.2232
O. Lomakovsky
The aim – to identify a possible relationship between the early development of coronary artery disease and the level of cellular and humoral indicators of adaptive and innate immunity, immune inflammation in order to clarify the effect of the immune system on the early development of atherosclerosis.Materials and methods. IHD patients with stable angina pectoris were divided into two groups: the first group (n=112) included patients with the development of clinical manifestations of IHD after 60 years (65.7±4.3 years), the second group (n=108) – patients with the development of clinical manifestations of coronary artery disease before 45 years (43.7±4.8 years). The material for the immunological study was peripheral venous blood. To determine the parameters of cellular and humoral innate and adaptive immunity in blood serum and supernatants of mononuclear cells, enzyme immunoassay was used.Results and discussion. Comparative characteristics of patients with the development of clinical manifestations of ischemic heart disease up to 45 years compared with patients with their development after 60 years showed: clinical manifestations of dynamic coronary stenosis – in 33 versus 14 % of patients (p=0.046) (R=–0.21; p=0.046), the presence of heredity of ischemic heart disease – in 45 versus 15 % of patients (p=0.030) (R=–0.31; p=0.029), the level of specific antibodies to the damaged aorta is 10 (10–20) versus 5 (0–10) cu (р=0.033) (R=–0.31; p=0.01), the number of activated B cells with a CD40 index was 9.5 (7.0–11.9) versus 7.1 (5.6–9.9) % (p=0.019) (R=–0.32; p=0.018), free radical oxidation of proteins – 5.2 (4.0–6.6) versus 4.2 (1.7–5.7) cu (p=0.006) (R=–0.19; p=0.005), stable metabolite of blood nitric oxide NO2 – 0.95 (0.58–1.06) and 1.04 (0.70–1.54) mg/ml (p=0.036) (R=0.17; p=0.036), IL-2 in mononuclear cells – 18.7 (15.5–21.3) versus 14.5 (11.4–15.7) pg/ml (p=0.019) (R=–0.43; p=0.016). According to factor analysis, the main independent variables were identified: IL-6 (factor 1), functional and metabolic activity of monocytes (factor 2), antibodies to arterial components (factor 3) and CRP (factor 4). Analysis of multivariate linear regression showed the total relationship of the studied factors with the early development of clinical manifestations of coronary artery disease (R=0.30; F=2.5; p=0.048) with the dominant influence of inflammatory CRP (B=0.19; p=0.046) and activity monocytes (B=0.20; p=0.045). A step-by-step analysis of linear regression found a total relationship between the early development of IHD (R=0.41; F=3.7; p=0.017) with CRP (B=0.21; p=0.10), monocyte activity (B=0.22; p=0.08) and antibodies to arterial components (B=0.21; p=0.11).Conclusions. The early development of clinical manifestations of coronary artery disease (up to 45 years) compared with their development after 60 years is associated with a high level of activated B-lymphocytes and antibodies to the tissues of the vascular wall, active synthesis of pro-inflammatory
{"title":"Immune inflammation, cellular and humoral immunity in patients with early development of coronary heart disease","authors":"O. Lomakovsky","doi":"10.31928/1608-635X-2021.2.2232","DOIUrl":"https://doi.org/10.31928/1608-635X-2021.2.2232","url":null,"abstract":"The aim – to identify a possible relationship between the early development of coronary artery disease and the level of cellular and humoral indicators of adaptive and innate immunity, immune inflammation in order to clarify the effect of the immune system on the early development of atherosclerosis.Materials and methods. IHD patients with stable angina pectoris were divided into two groups: the first group (n=112) included patients with the development of clinical manifestations of IHD after 60 years (65.7±4.3 years), the second group (n=108) – patients with the development of clinical manifestations of coronary artery disease before 45 years (43.7±4.8 years). The material for the immunological study was peripheral venous blood. To determine the parameters of cellular and humoral innate and adaptive immunity in blood serum and supernatants of mononuclear cells, enzyme immunoassay was used.Results and discussion. Comparative characteristics of patients with the development of clinical manifestations of ischemic heart disease up to 45 years compared with patients with their development after 60 years showed: clinical manifestations of dynamic coronary stenosis – in 33 versus 14 % of patients (p=0.046) (R=–0.21; p=0.046), the presence of heredity of ischemic heart disease – in 45 versus 15 % of patients (p=0.030) (R=–0.31; p=0.029), the level of specific antibodies to the damaged aorta is 10 (10–20) versus 5 (0–10) cu (р=0.033) (R=–0.31; p=0.01), the number of activated B cells with a CD40 index was 9.5 (7.0–11.9) versus 7.1 (5.6–9.9) % (p=0.019) (R=–0.32; p=0.018), free radical oxidation of proteins – 5.2 (4.0–6.6) versus 4.2 (1.7–5.7) cu (p=0.006) (R=–0.19; p=0.005), stable metabolite of blood nitric oxide NO2 – 0.95 (0.58–1.06) and 1.04 (0.70–1.54) mg/ml (p=0.036) (R=0.17; p=0.036), IL-2 in mononuclear cells – 18.7 (15.5–21.3) versus 14.5 (11.4–15.7) pg/ml (p=0.019) (R=–0.43; p=0.016). According to factor analysis, the main independent variables were identified: IL-6 (factor 1), functional and metabolic activity of monocytes (factor 2), antibodies to arterial components (factor 3) and CRP (factor 4). Analysis of multivariate linear regression showed the total relationship of the studied factors with the early development of clinical manifestations of coronary artery disease (R=0.30; F=2.5; p=0.048) with the dominant influence of inflammatory CRP (B=0.19; p=0.046) and activity monocytes (B=0.20; p=0.045). A step-by-step analysis of linear regression found a total relationship between the early development of IHD (R=0.41; F=3.7; p=0.017) with CRP (B=0.21; p=0.10), monocyte activity (B=0.22; p=0.08) and antibodies to arterial components (B=0.21; p=0.11).Conclusions. The early development of clinical manifestations of coronary artery disease (up to 45 years) compared with their development after 60 years is associated with a high level of activated B-lymphocytes and antibodies to the tissues of the vascular wall, active synthesis of pro-inflammatory","PeriodicalId":23419,"journal":{"name":"Ukrainian Journal of Cardiology","volume":"79 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84146090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-07-07DOI: 10.31928/1608-635X-2021.2.5870
E. Nesukay, R. Kirichenko, T. M. Kornienko, S. Cherniuk, E. Titov, J. J. Giresh, S. V. Lisohub
The article is devoted to cardiac resynchronization therapy (CRT) – the method for chronic heart failure treatment with biventricular pacing. The article examines the history of the method development from the first attempts to eliminate heart dyssynchrony to the present. Over the past 20 years, the method has been improved both in technical terms and in terms of the formation of modern indications for its application. Based on the results of randomized clinical trials to study the effectiveness of the method, the improvement of the testimony and criteria for the selection of patients for the CPT is shown. A clinical case of successful CRT in a patient with cardiomegaly, severe heart failure and complete left bundle brunch block is described.
{"title":"Efficacy of cardiac resynchronization therapy in a patient with cardiomegaly: a review of the literature and a clinical case","authors":"E. Nesukay, R. Kirichenko, T. M. Kornienko, S. Cherniuk, E. Titov, J. J. Giresh, S. V. Lisohub","doi":"10.31928/1608-635X-2021.2.5870","DOIUrl":"https://doi.org/10.31928/1608-635X-2021.2.5870","url":null,"abstract":"The article is devoted to cardiac resynchronization therapy (CRT) – the method for chronic heart failure treatment with biventricular pacing. The article examines the history of the method development from the first attempts to eliminate heart dyssynchrony to the present. Over the past 20 years, the method has been improved both in technical terms and in terms of the formation of modern indications for its application. Based on the results of randomized clinical trials to study the effectiveness of the method, the improvement of the testimony and criteria for the selection of patients for the CPT is shown. A clinical case of successful CRT in a patient with cardiomegaly, severe heart failure and complete left bundle brunch block is described.","PeriodicalId":23419,"journal":{"name":"Ukrainian Journal of Cardiology","volume":"43 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76957423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-03-24DOI: 10.31928/1608-635X-2021.1.6780
S. Kozhukhov, N. V. Dovganich, I. Smolanka, O. F. Ligirda, O. Y. Yarynkina, O. M. Ivankova
Over the past decades, the survival of breast cancer patients has significantly improved with advances in drug treatment and radiation therapy. Classical chemotherapy based primarily on anthracyclines, as well as targeted therapy and immunotherapy, have increased survival in breast cancer patients. However, both conventional chemotherapeutic agents and some new molecules can cause cardiovascular side effects that potentially worsen prognosis. The mechanisms of cardiovascular complications vary greatly depending on the drug type, and may manifest by temporary cardiomyocyte dysfunction or induce irreversible myocardial damage. Breast cancer patients are at high risk of cardiotoxicity because they receive combined cancer treatment and therefore require careful monitoring of heart function, especially with pre-existing cardiovascular diseases or multiple risk factors. Practically, it is possible due to close cooperation between cardiologists and oncologists, resulting in risk stratification of cardiovascular complications before antitumor treatment, individualized therapy, monitoring for early detection of complications, as well as timely use of cardioprotective therapy, both for prevention and treatment of complications that will improve survival and quality of life in breast cancer patients.
{"title":"Cardiovascular toxicity in brest cancer patient: diagnosis, treatment, prevention","authors":"S. Kozhukhov, N. V. Dovganich, I. Smolanka, O. F. Ligirda, O. Y. Yarynkina, O. M. Ivankova","doi":"10.31928/1608-635X-2021.1.6780","DOIUrl":"https://doi.org/10.31928/1608-635X-2021.1.6780","url":null,"abstract":"Over the past decades, the survival of breast cancer patients has significantly improved with advances in drug treatment and radiation therapy. Classical chemotherapy based primarily on anthracyclines, as well as targeted therapy and immunotherapy, have increased survival in breast cancer patients. However, both conventional chemotherapeutic agents and some new molecules can cause cardiovascular side effects that potentially worsen prognosis. The mechanisms of cardiovascular complications vary greatly depending on the drug type, and may manifest by temporary cardiomyocyte dysfunction or induce irreversible myocardial damage. Breast cancer patients are at high risk of cardiotoxicity because they receive combined cancer treatment and therefore require careful monitoring of heart function, especially with pre-existing cardiovascular diseases or multiple risk factors. Practically, it is possible due to close cooperation between cardiologists and oncologists, resulting in risk stratification of cardiovascular complications before antitumor treatment, individualized therapy, monitoring for early detection of complications, as well as timely use of cardioprotective therapy, both for prevention and treatment of complications that will improve survival and quality of life in breast cancer patients.","PeriodicalId":23419,"journal":{"name":"Ukrainian Journal of Cardiology","volume":"8 1","pages":"67-80"},"PeriodicalIF":0.0,"publicationDate":"2021-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78629913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-03-24DOI: 10.31928/1608-635X-2021.1.5665
M. Kolesnyk
Assessment of left ventricular (LV) systolic function is a mandatory component of cardiovascular diseases diagnostics. In clinical practice, the main parameters are the ejection fraction and LV global longitudinal strain. Both parameters have a number of limitations, including dependence on afterload. This review describes a new technique for non-invasive assessment of global and segmental myocardial contractility based on the calculation of myocardial work by analyzing pressure-strain curves. The main advantage of the technique is the ability to take into account the afterload conditions by the traditional measurement of blood pressure on the brachial artery. The characteristics of the key parameters of the methodology (global work index, global constructive work, global effective and wasted work) as well as their normative values are presented. The stages of the analysis and the limitations of the method are described separately. The results of the main pilot studies of myocardial work parameters in various cardiovascular diseases are presented. Possibilities of the technique for characterizing LV segmental function in left bundle branch block, selection of patients for cardiac resynchronization therapy with subsequent response assessment are presented. The diagnostic and prognostic value of the parameters of myocardial work in arterial hypertension, acute and chronic forms of ischemic heart disease, hypertrophic and dilated cardiomyopathy, chronic heart failure are analyzed. The possibilities of the technique in assessing the effectiveness of therapy in patients with heart failure are described. Potential advantages of the parameters of myocardial work over other markers of LV systolic function, such as ejection fraction and global longitudinal strain, have been determined. The review is illustrated with clinical examples of the use of the technique for various cardiovascular diseases from our own practice.
{"title":"Estimation of myocardial work – a new concept of non-invasive left ventricular systolic function assessment","authors":"M. Kolesnyk","doi":"10.31928/1608-635X-2021.1.5665","DOIUrl":"https://doi.org/10.31928/1608-635X-2021.1.5665","url":null,"abstract":"Assessment of left ventricular (LV) systolic function is a mandatory component of cardiovascular diseases diagnostics. In clinical practice, the main parameters are the ejection fraction and LV global longitudinal strain. Both parameters have a number of limitations, including dependence on afterload. This review describes a new technique for non-invasive assessment of global and segmental myocardial contractility based on the calculation of myocardial work by analyzing pressure-strain curves. The main advantage of the technique is the ability to take into account the afterload conditions by the traditional measurement of blood pressure on the brachial artery. The characteristics of the key parameters of the methodology (global work index, global constructive work, global effective and wasted work) as well as their normative values are presented. The stages of the analysis and the limitations of the method are described separately. The results of the main pilot studies of myocardial work parameters in various cardiovascular diseases are presented. Possibilities of the technique for characterizing LV segmental function in left bundle branch block, selection of patients for cardiac resynchronization therapy with subsequent response assessment are presented. The diagnostic and prognostic value of the parameters of myocardial work in arterial hypertension, acute and chronic forms of ischemic heart disease, hypertrophic and dilated cardiomyopathy, chronic heart failure are analyzed. The possibilities of the technique in assessing the effectiveness of therapy in patients with heart failure are described. Potential advantages of the parameters of myocardial work over other markers of LV systolic function, such as ejection fraction and global longitudinal strain, have been determined. The review is illustrated with clinical examples of the use of the technique for various cardiovascular diseases from our own practice.","PeriodicalId":23419,"journal":{"name":"Ukrainian Journal of Cardiology","volume":"17 1","pages":"56-65"},"PeriodicalIF":0.0,"publicationDate":"2021-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88485393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-03-24DOI: 10.31928/1608-635X-2021.1.3542
L. Yena, G. Khrystoforova, M. G. Akhaladze, O. Garkavenko
The aim – to determine the frequency and severity of Frailty syndrome in elderly patients with essential hypertension on the basis of geriatric instruments.Materials and methods. 120 elderly patients with uncomplicated essential hypertension were investigated by conducting a survey on the questionnaire FRAIL and modified phenotype Frailty, Short Physical Performance Battery.Results and discussion. The frequency of Frailty syndrome in elderly hypertensive’s significantly depend on the method used and was 17.2, 10.9 and 11.1 % while exploring the FRAIL questionnaire, the Frailty phenotype and the Short Physical Performance Battery, respectively. The predominant form of physical disorders was prefrail, its registration, depending on the method of diagnosis, varied from 20,2 % up to 68 %. The incidence of Frailty geriatric syndrome increased with age, it was more common in women than in men when measured by the FRAIL questionnaire and the Frailty phenotype.Conclusions. In elderly patients with uncomplicated essential hypertension the registration of Frailty depends on the methods used. PreFrailty proved to be the predominant form of physical disorder.
{"title":"Prevalence of Frailty syndrome in elderly hypertensive patients","authors":"L. Yena, G. Khrystoforova, M. G. Akhaladze, O. Garkavenko","doi":"10.31928/1608-635X-2021.1.3542","DOIUrl":"https://doi.org/10.31928/1608-635X-2021.1.3542","url":null,"abstract":"The aim – to determine the frequency and severity of Frailty syndrome in elderly patients with essential hypertension on the basis of geriatric instruments.Materials and methods. 120 elderly patients with uncomplicated essential hypertension were investigated by conducting a survey on the questionnaire FRAIL and modified phenotype Frailty, Short Physical Performance Battery.Results and discussion. The frequency of Frailty syndrome in elderly hypertensive’s significantly depend on the method used and was 17.2, 10.9 and 11.1 % while exploring the FRAIL questionnaire, the Frailty phenotype and the Short Physical Performance Battery, respectively. The predominant form of physical disorders was prefrail, its registration, depending on the method of diagnosis, varied from 20,2 % up to 68 %. The incidence of Frailty geriatric syndrome increased with age, it was more common in women than in men when measured by the FRAIL questionnaire and the Frailty phenotype.Conclusions. In elderly patients with uncomplicated essential hypertension the registration of Frailty depends on the methods used. PreFrailty proved to be the predominant form of physical disorder.","PeriodicalId":23419,"journal":{"name":"Ukrainian Journal of Cardiology","volume":"2016 1","pages":"35-42"},"PeriodicalIF":0.0,"publicationDate":"2021-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86103364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-03-22DOI: 10.31928/1608-635X-2021.1.1825
V. Tseluyko, T. Pylova, L. Yakovleva
The aim – to define the clinical and anamnestic features of myocardial infarction, which determine the prognosis of patients with myocardial infarction with nonobstructive coronary arteries (MINOCA) in the acute period.Materials and methods. The study included 33 patients with MINOCA (group I), and 73 patients with myocardial infarction (MI) with obstructive coronary artery disease (CAD) (group II) who were hospitalized in Clinical hospital # 8. Angiography, echocardiography, ECG, clinical laboratory tests were performed for all patients.Results and discussion. As a result of a comparative analysis, it was found that the number of women in the group of patients with MINOCA (group I) was significantly higher than in group II (p=0.00001). The prevalence of risk factors such as hyperlipoproteinemia and smoking (p=0.0497; p=0.0096) in group I was lower than in group II. The average level of diastolic blood preasure in group I was significantly higher than in group II (p=0.002911). It was found that in the group I level of hemoglobin (p=0.003834), leukocytes (p=0.000376) and lymphocytes (p=0.003423) was significantly lower than in the group II, in group II diastolic dysfunction type I was prevailed (p=0.0084).Conclusions. Study showed that women were more likely to have MINOCA than men. Proportion of patients with hyperlipidemia and smoking in the group I was lower than in the group II. Patients in the group I more likely had diastolic dysfunction, lower hemoglobin and leukocytes level than in patient with MI with obstructive CAD. Independent factors associated with the development of complications in the acute period of MINOCA were a decrease in diastolic blood preasure, an increase in systolic blood preasure and age (multivariate regression logistic analysis).
{"title":"Myocardial infarction with nonobstructive coronary arteries: clinical characteristics and features of the acute period","authors":"V. Tseluyko, T. Pylova, L. Yakovleva","doi":"10.31928/1608-635X-2021.1.1825","DOIUrl":"https://doi.org/10.31928/1608-635X-2021.1.1825","url":null,"abstract":"The aim – to define the clinical and anamnestic features of myocardial infarction, which determine the prognosis of patients with myocardial infarction with nonobstructive coronary arteries (MINOCA) in the acute period.Materials and methods. The study included 33 patients with MINOCA (group I), and 73 patients with myocardial infarction (MI) with obstructive coronary artery disease (CAD) (group II) who were hospitalized in Clinical hospital # 8. Angiography, echocardiography, ECG, clinical laboratory tests were performed for all patients.Results and discussion. As a result of a comparative analysis, it was found that the number of women in the group of patients with MINOCA (group I) was significantly higher than in group II (p=0.00001). The prevalence of risk factors such as hyperlipoproteinemia and smoking (p=0.0497; p=0.0096) in group I was lower than in group II. The average level of diastolic blood preasure in group I was significantly higher than in group II (p=0.002911). It was found that in the group I level of hemoglobin (p=0.003834), leukocytes (p=0.000376) and lymphocytes (p=0.003423) was significantly lower than in the group II, in group II diastolic dysfunction type I was prevailed (p=0.0084).Conclusions. Study showed that women were more likely to have MINOCA than men. Proportion of patients with hyperlipidemia and smoking in the group I was lower than in the group II. Patients in the group I more likely had diastolic dysfunction, lower hemoglobin and leukocytes level than in patient with MI with obstructive CAD. Independent factors associated with the development of complications in the acute period of MINOCA were a decrease in diastolic blood preasure, an increase in systolic blood preasure and age (multivariate regression logistic analysis).","PeriodicalId":23419,"journal":{"name":"Ukrainian Journal of Cardiology","volume":"93 1","pages":"18-25"},"PeriodicalIF":0.0,"publicationDate":"2021-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83860188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-03-22DOI: 10.31928/1608-635X-2021.1.4351
G. Yemets, O. Telehuzova, G. Mankovsky, A. Maksymenko, Y. Marushko, A. Dovhaliuk, A. Sokol, I. Yemets
The aim – to systematize information on key features of echocardiographic evaluation of transcatheter aortic valve implantation (TAVI) procedure stages and their effectiveness in cardiac surgery, in patients with severe aortic valve stenosis.Materials and methods. We initiated a single-center clinical study to evaluate the XPand device and initial analysis of the primary results was performed. Patients met the inclusion criteria underwent a full range of examinations and TAVI procedures using the XPand device. The key parameters for echocardiographic examination in TAVI, which influence the formation of further procedure strategy, have been determined for the cardiac surgeon.Results and discussion. Based on the determined echocardiographic parameters, we obtained the primary outcomes of TAVI XPand in patients (n=7), the result of implantation was good. Minimal paravalvular insufficiency absence was found in 71.5 % of patients and minimal insufficiency in 14,5 %. In one patient to moderate insufficiency was observed. There was a statistically significant improvement in the ejection fraction (p<0.05) and a decrease in the mean gradient at the aortic valve (p<0.01).Conclusions. Echocardiographic parameters at all TAVI stages in patients over 75 years allow to control the implementation of the procedure and to improve the immediate post procedural outcome. The first experience of using the novel device for transcatheter implantation of the XPand aortic valve prosthesis confirms its effectiveness and safety in elderly patients with severe aortic stenosis.
{"title":"Features of echocardiographic assessment on transcatheter aortic valve implantation multiple stages","authors":"G. Yemets, O. Telehuzova, G. Mankovsky, A. Maksymenko, Y. Marushko, A. Dovhaliuk, A. Sokol, I. Yemets","doi":"10.31928/1608-635X-2021.1.4351","DOIUrl":"https://doi.org/10.31928/1608-635X-2021.1.4351","url":null,"abstract":"The aim – to systematize information on key features of echocardiographic evaluation of transcatheter aortic valve implantation (TAVI) procedure stages and their effectiveness in cardiac surgery, in patients with severe aortic valve stenosis.Materials and methods. We initiated a single-center clinical study to evaluate the XPand device and initial analysis of the primary results was performed. Patients met the inclusion criteria underwent a full range of examinations and TAVI procedures using the XPand device. The key parameters for echocardiographic examination in TAVI, which influence the formation of further procedure strategy, have been determined for the cardiac surgeon.Results and discussion. Based on the determined echocardiographic parameters, we obtained the primary outcomes of TAVI XPand in patients (n=7), the result of implantation was good. Minimal paravalvular insufficiency absence was found in 71.5 % of patients and minimal insufficiency in 14,5 %. In one patient to moderate insufficiency was observed. There was a statistically significant improvement in the ejection fraction (p<0.05) and a decrease in the mean gradient at the aortic valve (p<0.01).Conclusions. Echocardiographic parameters at all TAVI stages in patients over 75 years allow to control the implementation of the procedure and to improve the immediate post procedural outcome. The first experience of using the novel device for transcatheter implantation of the XPand aortic valve prosthesis confirms its effectiveness and safety in elderly patients with severe aortic stenosis.","PeriodicalId":23419,"journal":{"name":"Ukrainian Journal of Cardiology","volume":"2014 1","pages":"43-51"},"PeriodicalIF":0.0,"publicationDate":"2021-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86767269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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