Abstract Introduction Halitophobia is also known as false halitosis or psychosomatic halitosis. This pseudo-pathology originates from the somatization of the compulsive idea that the patient has bad breath in the absence of oral pathology. Case Presentation A patient addressed dental surgery complaining of a self-diagnosed halitosis. The dental consultation did not find any dental problem that could cause bad breath. She was referred to a general practitioner for further investigations to rule out a general condition. The investigations revealed a perfectly healthy person, without any chronic ailment that could cause bad breath. The patient refused to consult a psychologist or psychiatrist, considering that she does not have a mental health problem. Conclusions Patients with a suspicion of psychogenic halitosis require psychiatric counseling, and dentists have to be prepared with an efficient strategy for the correct management of these patients.
{"title":"Pseudohalitosis – More than a Complicated Multidisciplinary Case","authors":"Alessandra-Aniela Cerghedi, Denisa-Paula Trif, Andreea Salcudean, Cristina Molnar-Varlam","doi":"10.2478/jim-2023-0008","DOIUrl":"https://doi.org/10.2478/jim-2023-0008","url":null,"abstract":"Abstract Introduction Halitophobia is also known as false halitosis or psychosomatic halitosis. This pseudo-pathology originates from the somatization of the compulsive idea that the patient has bad breath in the absence of oral pathology. Case Presentation A patient addressed dental surgery complaining of a self-diagnosed halitosis. The dental consultation did not find any dental problem that could cause bad breath. She was referred to a general practitioner for further investigations to rule out a general condition. The investigations revealed a perfectly healthy person, without any chronic ailment that could cause bad breath. The patient refused to consult a psychologist or psychiatrist, considering that she does not have a mental health problem. Conclusions Patients with a suspicion of psychogenic halitosis require psychiatric counseling, and dentists have to be prepared with an efficient strategy for the correct management of these patients.","PeriodicalId":234618,"journal":{"name":"Journal of Interdisciplinary Medicine","volume":"54 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134995021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abstract Endometriosis is a chronic inflammatory gynecological disease affecting 190 million women or 10% of women of reproductive age worldwide. The disease is marked by the presence of endometrial-like tissue outside the uterus, being associated in many cases with chronic pain and infertility. The current recommendations of international professional societies underline the need for laparoscopy, eventually followed by histological verification, as the gold standard for diagnosis. However, many societies recommend the initiation of specific treatment before obtaining a definitive surgical diagnosis. Various national and international societies have released guidelines for endometriosis assessment based on biomarkers; however, none of these recommendations proved to be clinically useful or able to replace diagnostic laparoscopy. In recent years it was demonstrated that oxidative stress, defined as an imbalance between reactive oxygen species and antioxidants that is directly linked with an increased inflammatory response in the peritoneal cavity, may be involved in the pathophysiology of endometriosis. The identification of a genetic predisposition for endometriosis can identify the patients at risk and may help clinicians promptly initiate therapeutic management of their patients in order to ameliorate their prognosis.
{"title":"Paradigm Shift for Endometriosis and the Potential Role of Genetic Testing – Going Beyond the 2022 ESHRE Guidelines for Endometriosis","authors":"Traian Irimia, Andrada Crișan, Teodora Cotruș, Vlad Tudorache, Mariam Dalaty, Marian Melinte, Ioana Melinte","doi":"10.2478/jim-2023-0006","DOIUrl":"https://doi.org/10.2478/jim-2023-0006","url":null,"abstract":"Abstract Endometriosis is a chronic inflammatory gynecological disease affecting 190 million women or 10% of women of reproductive age worldwide. The disease is marked by the presence of endometrial-like tissue outside the uterus, being associated in many cases with chronic pain and infertility. The current recommendations of international professional societies underline the need for laparoscopy, eventually followed by histological verification, as the gold standard for diagnosis. However, many societies recommend the initiation of specific treatment before obtaining a definitive surgical diagnosis. Various national and international societies have released guidelines for endometriosis assessment based on biomarkers; however, none of these recommendations proved to be clinically useful or able to replace diagnostic laparoscopy. In recent years it was demonstrated that oxidative stress, defined as an imbalance between reactive oxygen species and antioxidants that is directly linked with an increased inflammatory response in the peritoneal cavity, may be involved in the pathophysiology of endometriosis. The identification of a genetic predisposition for endometriosis can identify the patients at risk and may help clinicians promptly initiate therapeutic management of their patients in order to ameliorate their prognosis.","PeriodicalId":234618,"journal":{"name":"Journal of Interdisciplinary Medicine","volume":"68 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134995190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ovidiu-Ioan Șușu, Rareș Vodă, Klara Brînzaniuc, Tamás Csaba Sipos, Zsuzsanna Pap
Abstract Introduction The sural nerve is a sensitive nerve whose function is to provide sensory supply for the posterolateral aspect of the distal third of the leg and the lateral side of the dorsum of the foot. This nerve is formed in the upper third of the calf from the terminal branches of the tibial and common peroneal nerves and the communicating branch of the sural nerve. Objectives The aim of our study is to showcase two anatomical variants of the sural nerve. Materials and methods Two formalin-preserved cadavers, one male and one female, embalmed using formalin 4% were dissected with the intent of being used as teaching materials for the students attending anatomy classes at the “George Emil Palade” University of Medicine, Pharmacy, Science and Technology of Târgu Mureș, Romania. Results In both cases, less common anatomical variations of the formation of sural nerve were discovered. On the male cadaver, we identified the sural nerve as a continuation of the medial sural cutaneous nerve. The lateral sural cutaneous nerve and the communicating branch of the sural nerve were both absent. On the female cadaver, we identified both the medial sural cutaneous nerve and the lateral sural cutaneous nerve. The sural nerve was, however, a continuation of only the lateral sural cutaneous nerve, with the medial sural cutaneous nerve as an independent branch. Conclusions We described two anatomical variants of the sural nerve, which are less common than those documented in the literature.
{"title":"A Cadaveric Study of Two Uncommon Cases of Sural Nerve Complex Variation","authors":"Ovidiu-Ioan Șușu, Rareș Vodă, Klara Brînzaniuc, Tamás Csaba Sipos, Zsuzsanna Pap","doi":"10.2478/jim-2023-0007","DOIUrl":"https://doi.org/10.2478/jim-2023-0007","url":null,"abstract":"Abstract Introduction The sural nerve is a sensitive nerve whose function is to provide sensory supply for the posterolateral aspect of the distal third of the leg and the lateral side of the dorsum of the foot. This nerve is formed in the upper third of the calf from the terminal branches of the tibial and common peroneal nerves and the communicating branch of the sural nerve. Objectives The aim of our study is to showcase two anatomical variants of the sural nerve. Materials and methods Two formalin-preserved cadavers, one male and one female, embalmed using formalin 4% were dissected with the intent of being used as teaching materials for the students attending anatomy classes at the “George Emil Palade” University of Medicine, Pharmacy, Science and Technology of Târgu Mureș, Romania. Results In both cases, less common anatomical variations of the formation of sural nerve were discovered. On the male cadaver, we identified the sural nerve as a continuation of the medial sural cutaneous nerve. The lateral sural cutaneous nerve and the communicating branch of the sural nerve were both absent. On the female cadaver, we identified both the medial sural cutaneous nerve and the lateral sural cutaneous nerve. The sural nerve was, however, a continuation of only the lateral sural cutaneous nerve, with the medial sural cutaneous nerve as an independent branch. Conclusions We described two anatomical variants of the sural nerve, which are less common than those documented in the literature.","PeriodicalId":234618,"journal":{"name":"Journal of Interdisciplinary Medicine","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134995018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abstract Introduction Sweet syndrome, also called acute febrile neutrophilic dermatosis, is a rare disorder characterized by skin lesions accompanied by high fever and elevated inflammatory markers. Case Presentation In January 2023, a 73-year-old Caucasian male was diagnosed with acute myeloblastic leukemia and subsequently chemotherapy with azacitidine and venetoclax was initiated. One week after the second round of chemotherapy with azacitidine, the patient developed a fever of 39˚C. Physical examination revealed purple plaques on the skin of the head, neck, and arms associated with pain but not itching. Initially, the plaques appeared at the site of the subcutaneous azacitidine injection (left upper extremity) and then began to spread. The infectious diseases consultation established the diagnosis of multiple abscesses. Antibiotic therapy was initiated with meropenemum and linezolidum, and later colistin was associated, but the skin lesions and the patient’s condition worsened. A dermatology consultation was performed, which established the diagnosis of Sweet syndrome, and subsequently corticosteroid therapy was started. The skin lesions started to improve after 3 days. Conclusions Sweet syndrome is a rare condition that is difficult to diagnose because of the wide spectrum of differential diagnoses.
{"title":"Sweet Syndrome in a Patient with Acute Leukemia on Azacitidine and Venetoclax Treatment","authors":"Maria Gabriela Rezmuves, Marcela Cristina Candea, Raluca Sipos-Craciun, Ligia Ariana Bancu, Agnes Zsuzsanna Szasz, Smaranda Demian","doi":"10.2478/jim-2023-0011","DOIUrl":"https://doi.org/10.2478/jim-2023-0011","url":null,"abstract":"Abstract Introduction Sweet syndrome, also called acute febrile neutrophilic dermatosis, is a rare disorder characterized by skin lesions accompanied by high fever and elevated inflammatory markers. Case Presentation In January 2023, a 73-year-old Caucasian male was diagnosed with acute myeloblastic leukemia and subsequently chemotherapy with azacitidine and venetoclax was initiated. One week after the second round of chemotherapy with azacitidine, the patient developed a fever of 39˚C. Physical examination revealed purple plaques on the skin of the head, neck, and arms associated with pain but not itching. Initially, the plaques appeared at the site of the subcutaneous azacitidine injection (left upper extremity) and then began to spread. The infectious diseases consultation established the diagnosis of multiple abscesses. Antibiotic therapy was initiated with meropenemum and linezolidum, and later colistin was associated, but the skin lesions and the patient’s condition worsened. A dermatology consultation was performed, which established the diagnosis of Sweet syndrome, and subsequently corticosteroid therapy was started. The skin lesions started to improve after 3 days. Conclusions Sweet syndrome is a rare condition that is difficult to diagnose because of the wide spectrum of differential diagnoses.","PeriodicalId":234618,"journal":{"name":"Journal of Interdisciplinary Medicine","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134995185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abstract Introduction The COVID-19 pandemic that started in 2019 was a modern-world challenge for medical professionals. The SARS-Cov-2 virus targeted the respiratory and, later, the cardiovascular system. We aimed to identify the risk factors and particularities of acute myocardial infarction associated with SARS-Cov-2 infection. Material and Methods This cross-sectional study included 92 patients admitted to the Cardiology Department of Mureș County Emergency Hospital with myocardial infarction, divided into two groups: 46 patients with COVID-19 and 46 patients without COVID-19. Demographic data, risk factors, non-communicable diseases, and laboratory findings were studied and compared. Results The mean age of the patients was 65 years, and the majority were male. The identified risk factors were hypertension, body mass index >25 kg/m2, and dyslipidemia. The risk factors for poor prognosis were leukocyte count, higher neutrophil-lymphocyte ratio, higher monocyte-to-lymphocyte ratio, and higher high sensitivity troponin I levels. Left ventricular ejection fraction was significantly lower in patients with COVID-19. Conclusions COVID-19 is an aggravating factor of acute myocardial infarction. This research highlights the importance of prevention against the SARS-CoV-2 virus.
{"title":"Myocardial Infarction in the Context of COVID-19","authors":"Adrienn Nemeth, Theodora Benedek","doi":"10.2478/jim-2023-0012","DOIUrl":"https://doi.org/10.2478/jim-2023-0012","url":null,"abstract":"Abstract Introduction The COVID-19 pandemic that started in 2019 was a modern-world challenge for medical professionals. The SARS-Cov-2 virus targeted the respiratory and, later, the cardiovascular system. We aimed to identify the risk factors and particularities of acute myocardial infarction associated with SARS-Cov-2 infection. Material and Methods This cross-sectional study included 92 patients admitted to the Cardiology Department of Mureș County Emergency Hospital with myocardial infarction, divided into two groups: 46 patients with COVID-19 and 46 patients without COVID-19. Demographic data, risk factors, non-communicable diseases, and laboratory findings were studied and compared. Results The mean age of the patients was 65 years, and the majority were male. The identified risk factors were hypertension, body mass index >25 kg/m2, and dyslipidemia. The risk factors for poor prognosis were leukocyte count, higher neutrophil-lymphocyte ratio, higher monocyte-to-lymphocyte ratio, and higher high sensitivity troponin I levels. Left ventricular ejection fraction was significantly lower in patients with COVID-19. Conclusions COVID-19 is an aggravating factor of acute myocardial infarction. This research highlights the importance of prevention against the SARS-CoV-2 virus.","PeriodicalId":234618,"journal":{"name":"Journal of Interdisciplinary Medicine","volume":"56 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134995192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dorina Adelina Minciună, Demetra Gabriela Socolov, Attila Szőcs, Doina Ivanov, Tudor Gîscă, Valentin Nechifor, Sándor Budai, Ákos Bálint, Răzvan Socolov
Abstract Background Cervical cancer is the fourth most common female malignancy worldwide. In developing countries, it is the most common subtype of cancer and the third leading cause of cancer mortality among women. Artificial intelligence has the potential to be of real use in the prevention and prompt diagnosis of cervical cancer. The aim of our study was to develop a medical platform consisting of an automated observation sheet containing colposcopy data, a software that would use a machine learning module based on clinical and image data for diagnosis and treatment, and a telemedicine module to enable collaboration between gynecologists. Materials and methods Clinical and colposcopy image data from 136 patients were introduced into a machine learning module designed to generate an algorithm for proposing a preliminary diagnosis and treatment. The clinical and imaging data were corroborated to generate six options: ‘Follow-up’, ‘Pharmacotherapy’, ‘Biopsy’, ‘Curettage’, ‘DTC’, and ‘Conization’. Results Data generated by the machine learning module regarding treatment options were compared with the opinion of gynecologists and yielded an accuracy of 78% for ‘Follow-up’, 81% for ‘Pharmacotherapy’, 84% for ‘Biopsy’, 90% for ‘Curettage’, 96% for ‘DTC’, and 81% for ‘Conization’. Conclusions The developed software can be an important step towards the digitization of existing gynecology offices and the creation of intelligently automated gynecology offices related to prevention and treatment of cervical cancer. More data is needed to improve the accuracy of the developed software.
{"title":"Digitization of Gynecology Using Artificial Intelligence: Cervical Mapping Corroborated With Clinical Data for Conization Necessity","authors":"Dorina Adelina Minciună, Demetra Gabriela Socolov, Attila Szőcs, Doina Ivanov, Tudor Gîscă, Valentin Nechifor, Sándor Budai, Ákos Bálint, Răzvan Socolov","doi":"10.2478/jim-2023-0013","DOIUrl":"https://doi.org/10.2478/jim-2023-0013","url":null,"abstract":"Abstract Background Cervical cancer is the fourth most common female malignancy worldwide. In developing countries, it is the most common subtype of cancer and the third leading cause of cancer mortality among women. Artificial intelligence has the potential to be of real use in the prevention and prompt diagnosis of cervical cancer. The aim of our study was to develop a medical platform consisting of an automated observation sheet containing colposcopy data, a software that would use a machine learning module based on clinical and image data for diagnosis and treatment, and a telemedicine module to enable collaboration between gynecologists. Materials and methods Clinical and colposcopy image data from 136 patients were introduced into a machine learning module designed to generate an algorithm for proposing a preliminary diagnosis and treatment. The clinical and imaging data were corroborated to generate six options: ‘Follow-up’, ‘Pharmacotherapy’, ‘Biopsy’, ‘Curettage’, ‘DTC’, and ‘Conization’. Results Data generated by the machine learning module regarding treatment options were compared with the opinion of gynecologists and yielded an accuracy of 78% for ‘Follow-up’, 81% for ‘Pharmacotherapy’, 84% for ‘Biopsy’, 90% for ‘Curettage’, 96% for ‘DTC’, and 81% for ‘Conization’. Conclusions The developed software can be an important step towards the digitization of existing gynecology offices and the creation of intelligently automated gynecology offices related to prevention and treatment of cervical cancer. More data is needed to improve the accuracy of the developed software.","PeriodicalId":234618,"journal":{"name":"Journal of Interdisciplinary Medicine","volume":"54 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134995011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ovidiu-Ioan Șușu, Rareș Vodă, Tamás Csaba Sipos, Zsuzsanna Pap
Abstract Introduction Osteoporosis is characterized by a reduction in bone mineral density. Among the factors that can contribute to the onset of osteoporosis we can enumerate alcohol consumption, smoking, glucocorticoid therapy, or the presence of diabetes mellitus. The incidence of osteoporosis increases with age. Materials and Methods A total of 183 women over the age of 50, with a mean age of 67.9 ± 7.74 years, were studied to visualize spinal column alterations. From this cohort, 103 patients underwent bone mineral density testing using dual-energy X-ray absorptiometry (DXA) and dorsolumbar radiography, while 80 patients did not undergo DXA testing. Assessment of the degree of vertebral involvement was performed using the Genant semiquantitative method. Results The highest percentage of vertebral fractures was observed in patients aged >70 years (100%). Within the studied cohort, 28% of patients displayed multiple vertebral fractures associated with age (p = 0.01). The most common site for vertebral involvement was the dorsolumbar region (D11–L2) across all age groups (p = 0.35). No statistically significant correlation (p = 0.22) was identified between DXA values and the presence of vertebral fractures, despite a trend of increased incidence of fractures as the T-score decreased. Conclusion Within the cohort, vertebral fractures were identified both in women with normal values of bone mineral density and in those with osteoporosis. Furthermore, the severity of these vertebral fractures did not correlate with bone mineral density values, highlighting the necessity of using both osteodensitometry and spinal radio-graphs for diagnosis.
{"title":"Experience in the Morphological Study of Dorsolumbar Spine Deformities in Women over 50 Years","authors":"Ovidiu-Ioan Șușu, Rareș Vodă, Tamás Csaba Sipos, Zsuzsanna Pap","doi":"10.2478/jim-2023-0010","DOIUrl":"https://doi.org/10.2478/jim-2023-0010","url":null,"abstract":"Abstract Introduction Osteoporosis is characterized by a reduction in bone mineral density. Among the factors that can contribute to the onset of osteoporosis we can enumerate alcohol consumption, smoking, glucocorticoid therapy, or the presence of diabetes mellitus. The incidence of osteoporosis increases with age. Materials and Methods A total of 183 women over the age of 50, with a mean age of 67.9 ± 7.74 years, were studied to visualize spinal column alterations. From this cohort, 103 patients underwent bone mineral density testing using dual-energy X-ray absorptiometry (DXA) and dorsolumbar radiography, while 80 patients did not undergo DXA testing. Assessment of the degree of vertebral involvement was performed using the Genant semiquantitative method. Results The highest percentage of vertebral fractures was observed in patients aged >70 years (100%). Within the studied cohort, 28% of patients displayed multiple vertebral fractures associated with age (p = 0.01). The most common site for vertebral involvement was the dorsolumbar region (D11–L2) across all age groups (p = 0.35). No statistically significant correlation (p = 0.22) was identified between DXA values and the presence of vertebral fractures, despite a trend of increased incidence of fractures as the T-score decreased. Conclusion Within the cohort, vertebral fractures were identified both in women with normal values of bone mineral density and in those with osteoporosis. Furthermore, the severity of these vertebral fractures did not correlate with bone mineral density values, highlighting the necessity of using both osteodensitometry and spinal radio-graphs for diagnosis.","PeriodicalId":234618,"journal":{"name":"Journal of Interdisciplinary Medicine","volume":"57 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134995182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alessandra-Aniela Cerghedi, Zita Fazakas, Melinda Székely, Carmen Biriș, Cristina Molnar-Varlam
Abstract Introduction Acrylic resins are the most frequently used materials for the bases of prostheses, and are also used in the re-optimization and the repair of prostheses. The aim of our study was to investigate whether direct contact with the resin causes decomposition of methyl methacrylate and formation of ketone bodies in the oral cavity. Material and methods The in vitro study included 12 samples of autopolymerized polymethyl methacrylate and 8 samples of thermopolymerized polymethyl methacrylate. Some of the resin samples were intentionally prepared incorrectly, with modified powder to liquid ratios or thermal regime, to be able to compare them with samples prepared according to the manufacturer’s instructions. Some of the samples were immersed in gastric juice or alcohol for 48 h at 37 °C in a thermostatic bath to simulate the environment and temperature of the oral cavity, while others were kept at room temperature. The Legal reaction was used to identify the presence of ketone bodies in the solutions. Results The samples that were prepared incorrectly and were kept at 37 °C were the most affected. The presence of ketone bodies was demonstrated by the formation of a precipitate on the bottom of the test tube and the color change of the solution. Samples that were kept at room temperature were less affected, both from a spectrophotometric and biochemical point of view. Conclusion The quality of polymethyl methacrylate can be improved by respecting the manufacturer’s instructions and work protocols, and by avoiding substances that are considered aggressive, such as gastric juice, alcohol, and local factors in the oral cavity.
{"title":"Denture Base Polymer Biodegradation: In Vitro Study","authors":"Alessandra-Aniela Cerghedi, Zita Fazakas, Melinda Székely, Carmen Biriș, Cristina Molnar-Varlam","doi":"10.2478/jim-2023-0005","DOIUrl":"https://doi.org/10.2478/jim-2023-0005","url":null,"abstract":"Abstract Introduction Acrylic resins are the most frequently used materials for the bases of prostheses, and are also used in the re-optimization and the repair of prostheses. The aim of our study was to investigate whether direct contact with the resin causes decomposition of methyl methacrylate and formation of ketone bodies in the oral cavity. Material and methods The in vitro study included 12 samples of autopolymerized polymethyl methacrylate and 8 samples of thermopolymerized polymethyl methacrylate. Some of the resin samples were intentionally prepared incorrectly, with modified powder to liquid ratios or thermal regime, to be able to compare them with samples prepared according to the manufacturer’s instructions. Some of the samples were immersed in gastric juice or alcohol for 48 h at 37 °C in a thermostatic bath to simulate the environment and temperature of the oral cavity, while others were kept at room temperature. The Legal reaction was used to identify the presence of ketone bodies in the solutions. Results The samples that were prepared incorrectly and were kept at 37 °C were the most affected. The presence of ketone bodies was demonstrated by the formation of a precipitate on the bottom of the test tube and the color change of the solution. Samples that were kept at room temperature were less affected, both from a spectrophotometric and biochemical point of view. Conclusion The quality of polymethyl methacrylate can be improved by respecting the manufacturer’s instructions and work protocols, and by avoiding substances that are considered aggressive, such as gastric juice, alcohol, and local factors in the oral cavity.","PeriodicalId":234618,"journal":{"name":"Journal of Interdisciplinary Medicine","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135144069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Daniel Cernica, Diana Opincariu, Monica Chițu, István Kovács, Theodora Benedek, Imre Benedek
Abstract Background 3D printing has changed the paradigm of personalized medicine. Similarly to fingerprints, there are no two identical hearts; consequently, in cardiology, diagnosis and treatment, either medical, interventional or surgical, must be individualized according to the specific problem of a particular patient. The aim of this proof-of-concept study was to analyze two measurement methods, the planimetric and the photogrammetric method, in the process of creating a 3D-printed model from cardiac computed tomography angiography images and to evaluate the accuracy of an aortic valve anatomical model. Material and methods Cardiac computed tomography images, obtained from 20 patients with severe aortic stenosis, underwent stereolithographic reconstruction using 3D Slicer to create digital 3D models of the aortic valves. Serial measurements of six key elements of the aortic valvular apparatus were measured on the 3D model and compared to the measurements taken on the 2D computed tomography images. Results The differences between the two measurement methods were sub-millimetric in case of the left ventricular outflow tract and the sinotubular junction, and 1.386 mm for the left sinus of Valsalva (p = 0.0412), 0.3476 mm for the right sinus of Valsalva (p = 0.1874), and 0.6905 mm for the non-coronary Valsalva sinuses (p = 0.1353). Sinus heights were also similar, with a difference of 0.0119 mm (p = 0.6521). Conclusion In this study, the results of digital photogrammetry were superimposable to those of computed tomography scan measurements. The accuracy of each 3D-printed model depends on geometric complexity, the level of training of the personnel, and on the resources of each 3D printing laboratory.
3D打印改变了个性化医疗的模式。就像指纹一样，没有两颗完全相同的心脏;因此，在心脏病学中，无论是内科、介入性还是外科的诊断和治疗，都必须根据特定患者的具体问题进行个体化。这项概念验证研究的目的是分析两种测量方法，平面测量法和摄影测量法，在从心脏计算机断层扫描血管造影图像创建3d打印模型的过程中，并评估主动脉瓣解剖模型的准确性。材料与方法:选取20例重度主动脉瓣狭窄患者的心脏计算机断层图像，采用3D切片机进行立体成像重建，建立主动脉瓣的数字3D模型。在三维模型上测量了主动脉瓣装置的六个关键元素的连续测量，并与二维计算机断层扫描图像的测量结果进行了比较。结果左心室流出道及窦管交界处两种测量方法的差异均为亚毫米，左Valsalva窦的差异为1.386 mm (p = 0.0412)，右Valsalva窦的差异为0.3476 mm (p = 0.1874)，非冠状Valsalva窦的差异为0.6905 mm (p = 0.1353)。鼻窦高度相似，相差0.0119 mm (p = 0.6521)。结论在本研究中，数字摄影测量的结果与计算机断层扫描测量的结果是重叠的。每个3D打印模型的准确性取决于几何复杂性、人员的培训水平以及每个3D打印实验室的资源。
{"title":"Accuracy of 3D-Printed Models of Aortic Valves – a Comparative Analysis Between Planimetric and Photogrammetric Measurements","authors":"Daniel Cernica, Diana Opincariu, Monica Chițu, István Kovács, Theodora Benedek, Imre Benedek","doi":"10.2478/jim-2023-0004","DOIUrl":"https://doi.org/10.2478/jim-2023-0004","url":null,"abstract":"Abstract Background 3D printing has changed the paradigm of personalized medicine. Similarly to fingerprints, there are no two identical hearts; consequently, in cardiology, diagnosis and treatment, either medical, interventional or surgical, must be individualized according to the specific problem of a particular patient. The aim of this proof-of-concept study was to analyze two measurement methods, the planimetric and the photogrammetric method, in the process of creating a 3D-printed model from cardiac computed tomography angiography images and to evaluate the accuracy of an aortic valve anatomical model. Material and methods Cardiac computed tomography images, obtained from 20 patients with severe aortic stenosis, underwent stereolithographic reconstruction using 3D Slicer to create digital 3D models of the aortic valves. Serial measurements of six key elements of the aortic valvular apparatus were measured on the 3D model and compared to the measurements taken on the 2D computed tomography images. Results The differences between the two measurement methods were sub-millimetric in case of the left ventricular outflow tract and the sinotubular junction, and 1.386 mm for the left sinus of Valsalva (p = 0.0412), 0.3476 mm for the right sinus of Valsalva (p = 0.1874), and 0.6905 mm for the non-coronary Valsalva sinuses (p = 0.1353). Sinus heights were also similar, with a difference of 0.0119 mm (p = 0.6521). Conclusion In this study, the results of digital photogrammetry were superimposable to those of computed tomography scan measurements. The accuracy of each 3D-printed model depends on geometric complexity, the level of training of the personnel, and on the resources of each 3D printing laboratory.","PeriodicalId":234618,"journal":{"name":"Journal of Interdisciplinary Medicine","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135144840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alexandru Fofiu, Emil M. Arbănaşi, Robert G. Tripon, Shuko Suzuki, Traian V. Chirilă, Tiberiu Băţagă
Abstract Background The study was aimed to evaluate whether a mechanical biaxial tester can be used in a uniaxial mode to evaluate the mechanical properties of tendons. Materials and methods The study was carried out on specimens of porcine superficial digital flexor tendon (n = 9). The mechanical properties (elastic modulus, and stress at 15% strain) were measured two times consecutively in the uniaxial mode with the BioTester® 5000 (CellScale) equipment. Results Values of 0.313 ± 0.096 MPa for the elastic (Young’s) modulus and of 0.702 ± 0.174 MPa for the stress (at 15% strain) were measured, indicating that the porcine superficial digital flexor tendon is not a strong tendon. Conclusions When suitable specimens cannot be obtained for a biaxial evaluation, tendons can be evaluated mechanically in the BioTester® 5000 employing the uniaxial mode.
{"title":"Biomechanical Uniaxial Analysis of Porcine Tendon in the CellScale BioTester® 5000","authors":"Alexandru Fofiu, Emil M. Arbănaşi, Robert G. Tripon, Shuko Suzuki, Traian V. Chirilă, Tiberiu Băţagă","doi":"10.2478/jim-2023-0009","DOIUrl":"https://doi.org/10.2478/jim-2023-0009","url":null,"abstract":"Abstract Background The study was aimed to evaluate whether a mechanical biaxial tester can be used in a uniaxial mode to evaluate the mechanical properties of tendons. Materials and methods The study was carried out on specimens of porcine superficial digital flexor tendon (n = 9). The mechanical properties (elastic modulus, and stress at 15% strain) were measured two times consecutively in the uniaxial mode with the BioTester® 5000 (CellScale) equipment. Results Values of 0.313 ± 0.096 MPa for the elastic (Young’s) modulus and of 0.702 ± 0.174 MPa for the stress (at 15% strain) were measured, indicating that the porcine superficial digital flexor tendon is not a strong tendon. Conclusions When suitable specimens cannot be obtained for a biaxial evaluation, tendons can be evaluated mechanically in the BioTester® 5000 employing the uniaxial mode.","PeriodicalId":234618,"journal":{"name":"Journal of Interdisciplinary Medicine","volume":"124 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135144070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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